Harald Gröger
PEVZ-ID
320 Publikationen
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2025 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 3000837Ceyhan, Haci-Kubilay, and Gröger, Harald. 2025. “Merging the Biobased Platform Chemicals 5-Hydroxymethyl-2-furfural (5-HMF) and Succinic Anhydride toward a Novel Hydroxy Acid Monomer for Polyester Production”. ACS Sustainable Chemistry & Engineering .
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2024 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2990610Bernhard, Laura Maria, and Gröger, Harald. 2024. “Overcoming a Conceptual Limitation of Industrial epsilon-Caprolactone Production via Chemoenzymatic Synthesis in Organic Medium”. ChemSusChem 17 (22): e202400073.
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2024 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2990617Bernhard, Laura Maria, Zelenska, Kateryna, Takashima, Mirei, Arisawa, Mitsuhiro, Murai, Kenichi, and Gröger, Harald. 2024. “Enantioselective Synthesis of Secondary Amines by Combining Oxidative Rearrangement and Biocatalysis in a One-Pot Process”. Journal of Organic Chemistry 89 (12): 8513–8520.
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2024 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2989106Wagner, Karla, Hummel, Anke, Yang, Jianing, Horino, Satoshi, Kanomata, Kyohei, Akai, Shuji, and Gröger, Harald. 2024. “Protein engineering of lipase A from Candida antarctica to improve esterification of tertiary alcohols.”. Chembiochem : a European journal of chemical biology: e202400082.
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2024 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2999516Spang, Jonas, Bork, Hannah, Belov, Feodor, von Langermann, Jan, Vorholt, Andreas J., and Gröger, Harald. 2024. “One-pot hydroaminomethylation of an alkene under formation of primary amines by combining hydroformylation at elevated syngas pressure and biocatalytic transamination in water”. Organic and Biomolecular Chemistry .
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2024 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2994616Dhiman, Neha, Moustafa, Gamal A. I., Kasama, Kengo, Aoyama, Hiroshi, Kanomata, Kyohei, Gröger, Harald, and Akai, Shuji. 2024. “Dynamic Kinetic Resolution of 2-Hydroxybiaryl Atropisomers via Lipase-Catalyzed Enantioselective <i>O</i>-Acylation”. ChemCatChem 16 (21): e202400932.
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2024 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2993439Ceyhan, Haci-Kubilay, Wagner, Jessica, Hacker, Felix B., and Gröger, Harald. 2024. “Chemoenzymatic Synthesis of Aromatic Vinyl Monomers from Biorenewable 5-Hydroxymethyl-2-Furfural”. ACS Sustainable Chemistry & Engineering .
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2024 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2993087Schmidt, Luca F., Jolly, Logia, Hennecke, Leon, Lopez Haro, Fernando, Gröger, Harald, and Liese, Andreas. 2024. “Benchtop NMR-Based In-Line Analysis of Diastereoselective Enzymatic α-Amino Acid Synthesis: Quantification and Validation”. Organic Process Research & Development.
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2024 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2992234Kato, Shunsuke, Abe, Miteki, Gröger, Harald, and Hayashi, Takashi. 2024. “Reconstitution of Myoglobin with Iron Porphycene Generates an Artificial Aldoxime Dehydratase with Expanded Catalytic Activities”. ACS CATALYSIS.
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2024 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2990758Guntelmann, Tim, Dietz, Karl-Josef, and Gröger, Harald. 2024. “Development of an efficient and scalable bioprocess for the plant hormone 12-OPDA: Overcoming the hurdles of nature's biosynthesis”. Organic and Biomolecular Chemistry .
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2024 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2990755Allahverdiyev, Adil, Yang, Jianing, and Gröger, Harald. 2024. “Catalyst screening for dehydration of primary alcohols from renewable feedstocks under formation of alkenes at energy-saving mild reaction conditions”. Green Chemistry .
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2024 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2988648Bork, Hannah, Naße, Kim E, Vorholt, Andreas J, and Gröger, Harald. 2024. “Merging High-Pressure Syngas Metal Catalysis and Biocatalysis in Tandem One-Pot Processes for the Synthesis of Non-chiral and Chiral Alcohols from Alkenes in Water”. Angewandte Chemie International Edition: e202401989.
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2024 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2988646Gröger, Harald, Horino, Satoshi, Kanomata, Kyohei, and Akai, Shuji. 2024. “Strategies to Design Chemocatalytic Racemization of Tertiary Alcohols: State of the Art & Utilization for Dynamic Kinetic Resolution”. Chemistry - A European Journal : e202304028.
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2024 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2990009Horino, Satoshi, Wagner, Karla, Hummel, Anke, Kanomata, Kyohei, Gröger, Harald, and Akai, Shuji. 2024. “Kinetic Resolution of Cyclic Tertiary Alcohols with Lipase A from <i>Candida Antarctica</i>”. European Journal of Organic Chemistry .
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2024 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2988659Belov, Feodor, Gazizova, Alina, Bork, Hannah, Gröger, Harald, and von Langermann, Jan. 2024. “Crystallization assisted dynamic kinetic resolution for the synthesis of (R)-beta-methylphenethylamine”. ChemBioChem .
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2024 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2986489Salitra, Nadiya, Gurauskis, Jonas, and Gröger, Harald. 2024. “Design of 3D-Printed Heterogeneous Reactor Systems To Overcome Incompatibility Hurdles when Combining Metal and Enzyme Catalysis in a One-Pot Process”. Angewandte Chemie International Edition .
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2024 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2988471Guntermann, Alina, Koch, Luisa, and Gröger, Harald. 2024. “Process Development for the Sustainable and Economic Production of Biobased and Biodegradable High-Performance Lubricants”. ACS Sustainable Chemistry & Engineering .
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2024 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2987378Bookholt, Tom, Qin, Xian, Lilli, Bettina, Enke, Dirk, Huck, Marten, Balkenhohl, Danni, Ruwe, Klara, et al. 2024. “Increased Readiness for Water Splitting: NiO-Induced Weakening of Bonds in Water Molecules as Possible Cause of Ultra-Low Oxygen Evolution Potential”. Small : 2310665.
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2024 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2987522Gröger, Harald, Allahverdiyev, Adil, Yang, Jianing, and Stiehm, Johannes. 2024. “Merging MOF Chemistry & Biocatalysis: A Perspective for Achieving Efficient Organic Synthetic Processes and Applications in the Chemical Industry?”. Advanced Functional Materials.
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2023 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984075Nastke, Alina, and Gröger, Harald. 2023. “Biotransformations with Imine Reductases: Design of a Practical Process Avoiding an Extractive Work-Up by Entrapment of Water and Enzymes in an Immobilized Phase”. European Journal of Organic Chemistry 26 (43): 11.
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2023 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2979715Yavuzer, Hilmi, Yang, Jianing, and Gröger, Harald. 2023. “Rational Biocatalyst Design for a Cyanide-Free Synthesis of Long-Chain Fatty Nitriles from Their Aldoximes”. European Journal of Lipid Science and Technology 125 (5): 2200177.
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2023 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2979709Altemeier, Bastian, and Gröger, Harald. 2023. “Overcoming Thermodynamically Driven Retro-Diels-Alder Reaction through a Cascade One-Pot Process Exemplified for a Bio-Based Platform Chemical”. European Journal of Organic Chemistry 26 (21): e202300018.
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2023 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2982407Koch, Luisa, Guntermann, Alina, Hirschbichler, Katharina, Plass, Carmen, Betke, Tobias, Ma, Ling, Kilthau, Thomas, and Gröger, Harald. 2023. “Sustainable tailor-made and bio-based high-performance lubricants that combine biorenewability, biodegradability and economic efficiency”. Green Chemistry 25 (16): 6398-6404.
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2023 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2980004Ikeda, Kotaro, Harada, Shingo, Hashimoto, Yoshinori, Homma, Haruka, Kono, Masato, Zumbrägel, Nadine, Gröger, Harald, and Nemoto, Tetsuhiro. 2023. “Enantioselective Formal Synthesis of (-)-Catharanthine through Enzyme-Catalyzed Desymmetrization of a meso -Azabicyclo [2.2.2]octane”. Synlett.
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2023 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2979714Hinzmann, Michael, Yavuzer, Hilmi, Bittmann, Maike, and Gröger, Harald. 2023. “Resource Novel approach toward industrial aromatic nitriles via biocatalysis: From rational enzyme design to sustainable, energy-saving technology platform”. Chem Catalysis 3 (4): 100572.
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2023 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2969699Hinzmann, Michael, Yavuzer, Hilmi, Hinzmann, Alessa, and Gröger, Harald. 2023. “Database-driven In Silico-Identification and Characterization of Novel Aldoxime Dehydratases”. Journal of Biotechnology.
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2023 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2968666Choi, Dongil, Takahashi, Noa, Maruoka, Haruka, Harada, Shingo, Nastke, Alina, Gröger, Harald, and Nemoto, Tetsuhiro. 2023. “Synthetic Study of Dragmacidin E: Enantioselective Construction of the Seven-Membered Ring-Fused Indole Skeleton with Contiguous Stereocenters”. Journal of Organic Chemistry, The .
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2022 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2964643Bernhard, Laura Marie, McLachlan, Jill, and Gröger, Harald. 2022. “Process Development of Enantioselective Imine Reductase- Catalyzed Syntheses of Pharmaceutically Relevant Pyrrolidines”. Organic Process Research & Development 26 (7): 2067–2074.
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2022 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2962622Knieper, Madita, Vogelsang, Lara, Guntelmann, Tim, Sproß, Jens, Gröger, Harald, Viehhauser, Andrea, and Dietz, Karl-Josef. 2022. “OPDAylation of Thiols of the Redox Regulatory Network In Vitro”. Antioxidants 11 (5): 855.
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2022 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2962202Schober, Lukas, Tonin, Fabio, Hanefeld, Ulf, and Gröger, Harald. 2022. “Combination of Asymmetric Organo- and Biocatalysis in Flow Processes and Comparison with their Analogous Batch Syntheses”. European Journal of Organic Chemistry , no. 7: e202101035.
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2022 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2968509Hashimoto, Yoshinori, Harada, Shingo, Kato, Ryosuke, Ikeda, Kotaro, Nonnhoff, Jannis, Gröger, Harald, and Nemoto, Tetsuhiro. 2022. “Merging Chemo- and Biocatalysis to Facilitate the Syntheses of Complex Natural Products: Enantioselective Construction of an N-Bridged [3.3.1] Ring System in Indole Terpenoids”. ACS Catalysis 12 (24): 14990-14998.
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2022 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2967875Gröger, Harald, Gallou, Fabrice, and Lipshutz, Bruce H. 2022. “Where Chemocatalysis Meets Biocatalysis: In Water”. Chemical Reviews .
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2022 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2965960Horino, Satoshi, Nishio, Tomoya, Kawanishi, Shinji, Oki, Shinya, Nishihara, Koichi, Ikawa, Takashi, Kanomata, Kyohei, Wagner, Karla, Gröger, Harald, and Akai, Shuji. 2022. “Enantiodivergent Chemoenzymatic Dynamic Kinetic Resolution: Conversion of Racemic Propargyl Alcohols into Both Enantiomers”. Chemistry - A European Journal .
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2022 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2965442Nonnhoff, Jannis, Stammler, Hans-Georg, and Gröger, Harald. 2022. “Enantioselective Synthesis of Thiomorpholines through Biocatalytic Reduction of 3,6-Dihydro-2H-1,4-thiazines Using Imine Reductases”. Journal of Organic Chemistry.
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2022 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2961746Matsui, Daisuke, Muraki, Norifumi, Chen, Ke, Mori, Tomoya, Ingram, Aaron A, Oike, Keiko, Gröger, Harald, Aono, Shigetoshi, and Asano, Yasuhisa. 2022. “Crystal structural analysis of aldoxime dehydratase from Bacillus sp. OxB-1: Importance of surface residues in optimization for crystallization”. Journal of Inorganic Biochemistry 230: 111770.
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2022 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2962334Andreo, Jacopo, Ettlinger, Romy, Zaremba, Orysia, Pena, Quim, Lachelt, Ulrich, de Luis, Roberto Fernandez, Freund, Ralph, et al. 2022. “Reticular Nanoscience: Bottom-Up Assembly Nanotechnology”. Journal of the American Chemical Society.
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2022 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2962828Kasama, Kengo, Hinami, Yuya, Mizuno, Karin, Horino, Satoshi, Nishio, Tomoya, Yuki, Chiharu, Kanomata, Kyohei, Moustafa, Gamal A I, Gröger, Harald, and Akai, Shuji. 2022. “Lipase-Catalyzed Kinetic Resolution of C1-Symmetric Heterocyclic Biaryls”. Chemical and Pharmaceutical Bulletin 70 (5): 391-399.
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2021 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2951154Santi, Micol, Sancineto, Luca, Nascimento, Vanessa, Braun Azeredo, Juliano, Orozco, Erika V M, Andrade, Leandro H, Gröger, Harald, and Santi, Claudio. 2021. “Flow Biocatalysis: A Challenging Alternative for the Synthesis of APIs and Natural Compounds.”. International journal of molecular sciences 22 (3): 990.
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2021 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2957776Adebar, Niklas, Nastke, Alina, Löwe, Jana, and Gröger, Harald. 2021. “Segmentierte Flow‐Prozesse zur Überwindung von Limitierungen der Ganzzell‐Biokatalyse in Gegenwart von organischen Lösungsmitteln”. Angewandte Chemie 133 (29): 15997-16004.
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2021 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2956421Oike, Keiko, Sproß, Jens, Matsui, Daisuke, Asano, Yasuhisa, and Gröger, Harald. 2021. “Protein engineering of the aldoxime dehydratase from Bacillus sp. OxB-1 based on a rational sequence alignment approach”. Scientific reports 11 (1): 14316.
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2021 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2959873Nonnhoff, Jannis, and Gröger, Harald. 2021. “Process Development of the Copper(II)-Catalyzed Dehydration of a Chiral Aldoxime and Rational Selection of the Co-Substrate”. ChemistryOpen .
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2021 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2953003Gröger, Harald, Adenbar, Niklas, Nastke, Alina, and Löwe, Jana. 2021. “Segmented flow processes as an efficient tool to overcome hurdles of whole-cell biocatalysis in organic solvents”. Angewandte Chemie International Edition 60 (29): 15863-15869.
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2021 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2959754Plass, Carmen, Adebar, Niklas, Hiessl, Robert, Kleber, Joscha, Grimm, Axel, Langsch, Angelika, Otter, Rainer, Liese, Andreas, and Gröger, Harald. 2021. “Structure-Performance Guided Design of Sustainable Plasticizers from Biorenewable Feedstocks”. European Journal of Organic Chemistry .
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2021 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2954386Gröger, Harald, Yavuzer, Hilmi, and Asano, Yasuhisa. 2021. “Rationalizing the unprecedented stereochemistry of an enzymatic nitrile synthesis through a combined computational and experimental approach”. Angewandte Chemie International Edition 60 (35): 19162-19168.
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2021 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2948758Binks, Bernard Paul, Bago Rodriguez, Ana Maria, Schober, Lukas, Hinzmann, Alessa, and Gröger, Harald. 2021. “Effect of Particle Wettability and Particle Concentration on the Enzymatic Dehydration of n-Octanaloxime in Pickering Emulsions”. Angewandte Chemie International Edition 60 (3): 1450-1457.
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2021 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2958127Nonnhoff, Jannis, and Gröger, Harald. 2021. “Process Development of a Copper(II)-Catalyzed Dehydration of an N-Acyl Prolinal Oxime: Cascade Process and Application at an Elevated Lab Scale”. Synthesis : Journal of Synthetic Organic Chemistry : ss-2021-z0230-op.
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2021 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2953112Hinzmann, Alessa, Betke, Tobias, Asano, Yasuhisa, and Gröger, Harald. 2021. “Synthetic Processes toward Nitriles without the Use of Cyanide: A Biocatalytic Concept Based on Dehydration of Aldoximes in Water”. Chemistry – A European Journal 27 (17): 5313-5321.
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2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2942026Hinzmann, Alessa, Stricker, Michael, Busch, Jasmin, Glinski, Sylvia, Oike, Keiko, and Gröger, Harald. 2020. “Selective TEMPO-oxidation of alcohols to aldehydes in alternative organic solvents”. European Journal of Organic Chemistry, no. 16: 2399-2408.
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2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2949826Hinzmann, Alessa, Druhmann, Selina Sophie, and Gröger, Harald. 2020. “Synthesis of Bifunctional Molecules for the Production of Polymers Based on Unsaturated Fatty Acids as Bioderived Raw Materials”. Sustainable Chemistry 1 (3): 275-289.
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2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2945835Adebar, Niklas, and Gröger, Harald. 2020. “Heterogeneous Catalysts "on the Move": Flow Chemistry with Fluid Immobilised (Bio)Catalysts”. European Journal of Organic Chemistry 38: 6062-6067.
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2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2950688Deng, Qiulin, Nam Nghiep Tran, Nam Nghiep Tran, Asrami, Mahdieh Razi, Schober, Lukas, Gröger, Harald, and Hessel, Volker. 2020. “Ionic Liquid/Water Continuous-Flow System with Compartmentalized Spaces for Automatic Product Purification of Biotransformation with Enzyme Recycling”. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH 59 (48): 21001-21011.
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2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2950690Plass, Carmen, Hiessl, Robert, Kleber, Joscha, Grimm, Axel, Langsch, Angelika, Otter, Rainer, Liese, Andreas, and Gröger, Harald. 2020. “Towards bio-based plasticizers with reduced toxicity: Synthesis and performance testing of a 3-methylphthalate”. SUSTAINABLE CHEMISTRY AND PHARMACY 18: 100319.
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2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2949613Bakonyi, Daniel, Toelzer, Christine, Stricker, Michael, Hummel, Werner, Niefind, Karsten, and Gröger, Harald. 2020. “Expanding the Application Range of Microbial Oxidoreductases by an Alcohol Dehydrogenase from Comamonas testosteroni with a Broad Substrate Spectrum and pH Profile”. Catalysts 10 (11): 1281.
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2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2949435Telzerow, Aline, Paris, Juraj, Hakansson, Maria, Gonzalez-Sabin, Javier, Rios-Lombardia, Nicolas, Gröger, Harald, Moris, Francisco, Schürmann, Martin, Schwab, Helmut, and Steiner, Kerstin. 2020. “Expanding the Toolbox of (R)-selective Amine Transaminases by Identification and Characterization of new Members”. Chembiochem : a European journal of chemical biology.
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2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2949195Terhorst, M., Plass, Carmen, Hinzmann, Alessa, Guntermann, Alina, Jolmes, T., Roesler, J., Panke, D., et al. 2020. “One-pot synthesis of aldoximes from alkenes via Rh-catalysed hydroformylation in an aqueous solvent system”. Green Chemistry 22 (22): 7974-7982.
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2020 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2944998Oike, Keiko, and Gröger, Harald. 2020. “Process properties of an l-amino acid oxidase from Hebeloma cylindro-sporum for the synthesis of phenylpyruvic acid from l-phenylalanine.”. Journal of biotechnology.
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2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2938773Hinzmann, Alessa, and Gröger, Harald. 2020. “Selective Hydrogenation of Fatty Nitriles to Primary Fatty Amines: Catalyst Evaluation and Optimization Starting from Octanenitrile”. European Journal of Lipid Science and Technology 122 (1): 1900163.
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2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2948631Schlipkoeter, Kim E., Betke, Tobias, Kleber, Joscha, Gröger, Harald, and Liese, Andreas. 2020. “Fatty alcohol synthesis from fatty acids at mild temperature by subsequent enzymatic esterification and metal-catalyzed hydrogenation”. Organic and Biomolecular Chemistry 18 (39): 7862-7867.
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2020 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 2946153Hinzmann, Alessa, and Gröger, Harald. 2020. “Biocatalytic Synthesis of n-Octanenitrile Using an Aldoxime Dehydratase from Bacillus sp. OxB-1”. In Applied Biocatalysis. The Chemist's Enzyme Toolbox, ed. John Whittall and Peter W. Sutton. Hoboken, NJ: Wiley .
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2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2945148Meyer, Timo, Zumbrägel, Nadine, Geerds, Christina, Gröger, Harald, and Niemann, Hartmut. 2020. “Structural Characterization of an S-enantioselective Imine Reductase from Mycobacterium Smegmatis”. Biomolecules 10 (8): 1130.
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2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2944582Löwe, Jana, Dietz, Karl-Josef, and Gröger, Harald. 2020. “From a Biosynthetic Pathway toward a Biocatalytic Process and Chemocatalytic Modifications: Three‐Step Enzymatic Cascade to the Plant Metabolite cis ‐(+)‐12‐OPDA and Metathesis‐Derived Products”. Advanced Science 7 (13): 1902973.
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2020 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2945206Schober, Lukas, Sako, Makoto, Takizawa, Shinobu, Gröger, Harald, and Sasai, Hiroaki. 2020. “Catalytic and enantioselective oxa-Piancatelli reaction using a chiral vanadium complex.”. Chemical communications (Cambridge, England).
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2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2944769Hiessl, Robert, Hennecke, Leon, Plass, Carmen, Kleber, Joscha, Wahlefeld, Stefan, Otter, Rainer, Gröger, Harald, and Liese, Andreas. 2020. “FTIR based kinetic characterisation of an acid-catalysed esterification of 3-methylphthalic anhydride and 2-ethylhexanol”. ANALYTICAL METHODS 12 (24): 3137-3144.
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2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2943227Choi, Ji-Eun, Shinoda, Suguru, Asano, Yasuhisa, and Gröger, Harald. 2020. “Aldoxime Dehydratase Mutants as Improved Biocatalysts for a Sustainable Synthesis of Biorenewables-Based 2-Furonitrile”. Catalysts 10 (4): 362.
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2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2941086Sproß, Jens, Yamashita, Yasunobu, and Gröger, Harald. 2020. “Learning about Enzyme Stability against Organic Co-Solvents from Structural Insights by Ion Mobility Mass Spectrometry.”. Chembiochem : a European journal of chemical biology 21 (14): 1968-1971.
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2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2940492Epping, Miriam S., Wedde, Severin, Grundmann, Armin, Radukic, Marco, Gröger, Harald, Hummel, Anke, and Viefhues, Martina. 2020. “Dielectrophoretic analysis of the impact of isopropyl alcohol on the electric polarisability of Escherichia coli whole-cells”. Analytical Bioanalytical Chemistry 412: 3925–3933.
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2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2943805Gröger, Harald, and Asano, Yasuhisa. 2020. “Cyanide-Free Enantioselective Catalytic Strategies for the Synthesis of Chiral Nitriles”. JOURNAL OF ORGANIC CHEMISTRY 85 (10): 6243-6251.
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2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2942890Higashio, Koichi, Katsuragi, Satoko, Kundu, Dhiman, Adebar, Niklas, Plass, Carmen, Kühn, Franziska, Gröger, Harald, and Akai, Shuji. 2020. “Continuous-Flow Dynamic Kinetic Resolution of Racemic Alcohols by Lipase-Oxovanadium Cocatalysis”. European journal of organic chemistry 2020 (13): 1961-1967.
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2020 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2941492Kühn, Franziska, Katsuragi, Satoko, Oki, Yasuhiro, Scholz, Cedric, Akai, Shuji, and Gröger, Harald. 2020. “Dynamic kinetic resolution of a tertiary alcohol.”. Chemical communications (Cambridge, England) 56 (19): 2885-2888.
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2020 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2940695Zhang, Chenyue, Song, Zhen, Jin, Can, Nijhuis, Job, Zhou, Teng, Noel, Timothy, Gröger, Harald, Sundmacher, Kai, van Hest, Jan, and Hessel, Volker. 2020. “Screening of functional solvent system for automatic aldehyde and ketone separation in aldol reaction: A combined COSMO-RS and experimental approach”. CHEMICAL ENGINEERING JOURNAL 385: 123399.
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2019 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2938558Adebar, Niklas, and Gröger, Harald. 2019. “Flow Process for Ketone Reduction Using a Superabsorber-Immobilized Alcohol Dehydrogenase from Lactobacillus brevis in a Packed-Bed Reactor.”. Bioengineering (Basel, Switzerland) 6 (4): 99.
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2019 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2938420Hyseni, Mentor, Zumbrägel, Nadine, Offermanns, Heribert, and Gröger, Harald. 2019. “Expanding the Scope of Asinger Chemistry towards Enantiomerically Pure Secondary Amines and β-Aminothiols through Chemoenzymatic Derivatization of 3-Thiazolines”. Chemistry 2019 (1): 180-191.
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2019 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2937856Adebar, Niklas, Choi, Ji-Eun, Schober, Lukas, Miyake, Ryoma, Iura, Takanobu, Kawabata, Hiroshi, and Gröger, Harald. 2019. “Overcoming Work-Up Limitations of Biphasic Biocatalytic Reaction Mixtures Through Liquid-Liquid Segmented Flow Processes”. ChemCatChem 11 (23): 5788-5793.
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2019 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2937513Hinzmann, Alessa, Adebar, Niklas, Betke, Tobias, Leppin, Monja, and Gröger, Harald. 2019. “Biotransformations in pure organic medium: organic solvent-labile enzymes in batch and flow exemplified for nitrile synthesis”. European Journal of Organic Chemistry 2019 (41): 6911-6916.
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2019 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2936335Plass, Carmen, Hinzmann, Alessa, Terhors, Michael, Brauer, Waldemar, Oike, Keiko, Yavuzer, Hilmi, Asano, Yasuhisa, Vorholt, Andreas J., Berke, Tobias, and Gröger, Harald. 2019. “Approaching Bulk Chemical Nitriles from Alkenes: A Hydrogen Cyanide-Free Approach through a Combination of Hydroformylation and Biocatalysis”. ACS CATALYSIS 9 (6): 5198-5203.
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2019 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2937299Hinzmann, Alessa, Glinski, Sylvia, Worm, Marion, and Gröger, Harald. 2019. “Enzymatic Synthesis of Aliphatic Nitriles at a Substrate Loading of up to 1.4 kg/L: A Biocatalytic Record Achieved with a Heme Protein”. The Journal of Organic Chemistry 84 (8): 4867-4872.
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2019 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2934122Telzerow, Aline, Paris, Juraj, Hakansson, Maria, Gonzalez-Sabin, Javier, Rios-Lombardia, Nicolas, Schurmann, Martin, Gröger, Harald, et al. 2019. “Amine Transaminase from Exophiala Xenobiotica-Crystal Structure and Engineering of a Fold IV Transaminase that Naturally Converts Biaryl Ketones”. ACS CATALYSIS 9 (2): 1140-1148.
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2019 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2934607Paris, Juraj, Telzerow, Aline, Rios-Lombardia, Nicolas, Steiner, Kerstin, Schwab, Helmut, Moris, Francisco, Gröger, Harald, and Gonzalez-Sabin, Javier. 2019. “Enantioselective One-Pot Synthesis of Biaryl-Substituted Amines by Combining Palladium and Enzyme Catalysis in Deep Eutectic Solvents”. ACS SUSTAINABLE CHEMISTRY & ENGINEERING 7 (5): 5486-5493.
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2019 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2934545Sproß, Jens, Muck, Alexander, and Gröger, Harald. 2019. “Detection and fragmentation of doubly charged peptide ions in MALDI-Q-TOF-MS by ion mobility spectrometry for improved protein identification.”. Analytical and bioanalytical chemistry 411 (24): 1-11.
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2019 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2934540Gröger, Harald, Schallmey, Anett, Schwab, Helmut, and Kourist, Robert. 2019. “Multi-enzyme cascades as synthetic tool for biocatalysis.”. Journal of Biotechnology 294: 88.
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2019 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2935493Kono, Masato, Harada, Shingo, Nozaki, Tomoyuki, Hashimoto, Yoshinori, Murata, Shun-Ichi, Gröger, Harald, Kuroda, Yusuke, et al. 2019. “Asymmetric Formal Synthesis of (+)-Catharanthine via Desymmetrization of Isoquinuclidine.”. Organic letters 21 (10): 3750-3754.
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2019 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2935205Uthoff, Florian, Löwe, Jana, Harms, Christina, Donsbach, Kai, and Gröger, Harald. 2019. “Chemoenzymatic Synthesis of a Chiral Ozanimod Key Intermediate Starting from Naphthalene as Cheap Petrochemical Feedstock.”. The Journal of organic chemistry 84 (8): 4856–4866.
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2019 | Konferenzbeitrag | PUB-ID: 2940489S. Epping, Miriam, Grundmann, Armin, Gröger, Harald, and Viefhues, Martina. 2019. “Dielectrophoretic analysis: a tool for studying the impact of organic solvents on whole-cell biocatalysts”. In 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS2019), 1014-1015.
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2019 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2934376Schober, Lukas, Ratnam, Shahilan, Yamashita, Yasunobu, Adebar, Niklas, Pieper, Matthias, Berkessel, Albrecht, Hessel, Volker, and Gröger, Harald. 2019. “An Asymmetric Organocatalytic Aldol Reaction of a Hydrophobic Aldehyde in Aqueous Medium Running in Flow Mode”. Synthesis 51 (5): 1178-1184.
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2019 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2936330Pieper, Matthias, Schleich, Herbert, and Gröger, Harald. 2019. “General Synthesis of Industrial Cephalosporin-Based Antibiotics Through Amidation with Tosyl Chloride as a Coupling Reagent”. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2019 (20): 3259-3263.
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2019 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2936145Choi, Ji-Eun, Gröger, Harald, Shinoda, Suguru, Inoue, Risa, Zheng, Daijun, and Asano, Yasuhisa. 2019. “Cyanide-free synthesis of an aromatic nitrile from a biorenewable-based aldoxime: Development and application of a recombinant aldoxime dehydratase as a biocatalyst”. Biocatalysis and Biotransformation 37 (6): 414-420.
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2019 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2936254Pieper, Matthias, Schleich, Herbert, and Gröger, Harald. 2019. “Isolation and characterization of side-products formed through ∆2-isomerization in the synthesis of cefpodoxime proxetil.”. The Journal of antibiotics 72 (9): 702-708.
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2019 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2933300Gröger, Harald. 2019. “Biocatalytic concepts for synthesizing amine bulk chemicals: recent approaches towards linear and cyclic aliphatic primary amines and substituted derivatives thereof”. Applied Microbiology and Biotechnology 103 (1): 83-95.
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2019 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2933685Löwe, Jana, Blifernez-Klassen, Olga, Baier, Thomas, Wobbe, Lutz, Kruse, Olaf, and Gröger, Harald. 2019. “Type II flavoprotein monooxygenase PsFMO_A from the bacterium Pimelobacter sp. Bb-B catalyzes enantioselective Baeyer-Villiger oxidations with a relaxed cofactor specificity.”. Journal of biotechnology 294: 81-87.
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2018 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2933928Maynard, Daniel, Gröger, Harald, Dierks, Thomas, and Dietz, Karl-Josef. 2018. “The function of the oxylipin 12-oxophytodienoic acid in cell signaling, stress acclimation, and development”. Journal of Experimental Botany 69 (22): 5341-5354.
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2018 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2913715Maynard, Daniel, Müller, Sara, Hahmeier, Monika, Löwe, Jana, Feussner, Ivo, Gröger, Harald, Viehhauser, Andrea, and Dietz, Karl-Josef. 2018. “One-pot synthesis of bioactive cyclopentenones from α-linolenic acid and docosahexaenoic acid”. Bioorganic & Medicinal Chemistry 26 (7): 1356-1364.
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2018 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2920724Pauly, Jan, Gröger, Harald, and Patel, Anant. 2018. “Design, characterisation and application of alginate-based encapsulated pig liver esterase”. Journal of Biotechnology 280: 42-48.
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2018 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2919867Zumbrägel, Nadine, Merten, Christian, Huber, Stefan M., and Gröger, Harald. 2018. “Enantioselective reduction of sulfur-containing cyclic imines through biocatalysis”. Nature Communications 9 (1): 1949.
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2018 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2931977Paris, Juraj, Rios-Lombardia, Nicolas, Moris, Francisco, Gröger, Harald, and Gonzalez-Sabin, Javier. 2018. “Novel Insights into the Combination of Metal- and Biocatalysis: Cascade One-Pot Synthesis of Enantiomerically Pure Biaryl Alcohols in Deep Eutectic Solvents”. CHEMCATCHEM 10 (19): 4417-4423.
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2018 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2930227Zumbrägel, Nadine, and Gröger, Harald. 2018. “Merging Heterocyclic Chemistry and Biocatalysis in One-Pot Processes through Compartmentalization of the Reaction Steps”. Bioengineering 5 (3): 60.
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2018 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2921159Löwe, Jana, Siewert, Arthur, Scholpp, Anna-Catharina, Wobbe, Lutz, and Gröger, Harald. 2018. “Providing reducing power by microalgal photosynthesis: a novel perspective towards sustainable biocatalytic production of bulk chemicals exemplified for aliphatic amines”. Scientific Reports 8 (1): 10436.
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2018 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2932504Betke, Tobias, Maier, Manuel, Gruber-Wölfler, Heidrun, and Gröger, Harald. 2018. “Biocatalytic production of adiponitrile and related aliphatic linear α,ω-dinitriles”. Nature Communications 9 (1): 5112.
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2018 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2931119Pieper, Matthias, Kumpert, Mario, König, Burghard, Schleich, Herbert, Bayer, Thomas, and Gröger, Harald. 2018. “Process Development for Synthesizing the Cephalosporin Antibiotic Cefotaxime in Batch and Flow Mode”. Organic Process Research & Development 22 (8): 947-954.
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2018 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2931113Uthoff, Florian, and Gröger, Harald. 2018. “Asymmetric Synthesis of 1-Phenylethylamine from Styrene via Combined Wacker Oxidation and Enzymatic Reductive Amination”. JOURNAL OF ORGANIC CHEMISTRY 83 (16): 9517-9521.
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2018 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2933180Sako, Makoto, Aoki, Takanori, Zumbrägel, Nadine, Schober, Lukas, Gröger, Harald, Takizawa, Shinobu, and Sasai, Hiroaki. 2018. “Chiral Dinuclear Vanadium Complex-Mediated Oxidative Coupling of Resorcinols”. The Journal of Organic Chemistry 84 (3): 1580-1587.
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2018 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2933177Zumbrägel, Nadine, Machui, Paul, Nonnhoff, Jannis, and Gröger, Harald. 2018. “Enantioselective Biocatalytic Reduction of 2H-1,4-Benzoxazines Using Imine Reductases”. The Journal of Organic Chemistry 84 (3): 1440-1447.
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2018 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2933179Zumbrägel, Nadine, and Gröger, Harald. 2018. “One-pot synthesis of a 3-thiazolidine through combination of an Asinger-type multi-component-condensation reaction with an enzymatic imine reduction”. Journal of Biotechnology 291: 35-40.
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2018 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2931244Rommelmann, Philipp, Nachtigall, Beate, Guntelmann, Tim, Gröger, Harald, and Kuck, Dietmar. 2018. “Stereoselective synthesis of enantiomerically pure bowl-shaped hydroxytribenzotriquinacenes”. ORGANIC & BIOMOLECULAR CHEMISTRY 16 (31): 5635-5642.
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2018 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2930305Zumbrägel, Nadine, Sako, Makoto, Takizawa, Shinobu, Sasai, Hiroaki, and Gröger, Harald. 2018. “Vanadium-Catalyzed Dehydrogenation of N-Heterocycles in Water”. Organic Letters 20 (16): 4723-4727.
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2018 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2920277Löwe, Jana, Ingram, Aaron A., and Gröger, Harald. 2018. “Enantioselective synthesis of amines via reductive amination with a dehydrogenase mutant from Exigobacterium sibiricum: Substrate scope, co-solvent tolerance and biocatalyst immobilization”. BIOORGANIC & MEDICINAL CHEMISTRY 26 (7): 1387-1392.
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2018 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2916923Betke, Tobias, Higuchi, Jun, Rommelmann, Philipp, Oike, Keiko, Nomura, Taiji, Kato, Yasuo, Asano, Yasuhisa, and Gröger, Harald. 2018. “Biocatalytic Synthesis of Nitriles through Dehydration of Aldoximes: The Substrate Scope of Aldoxime Dehydratases”. ChemBioChem 19 (8): 768-779.
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2908777Scherkus, Christian, Schmidt, Sandy, Bornscheuer, Uwe T., Gröger, Harald, Kara, Selin, and Liese, Andreas. 2017. “Kinetic insights into ϵ-caprolactone synthesis: Improvement of an enzymatic cascade reaction”. Biotechnology and Bioengineering 114 (6): 1215-1221.
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2017 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2908647Viefhues, Martina, Schlüter, Laura, Wedde, Severin, Gröger, Harald, and Anselmetti, Dario. 2017. “Nano/Microfluidic Devices for Whole-Cell Biocatalyst Analysis by UV/VIS-Spectroscopy”. In Proceedings of the 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2016 (µTAS 2016), 3:1635-1636. Dublin, Irland: The Chemical and Biological Microsystems Society (CBMS).
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2908557Hahn, Katharina, Neumeister, Katrin, Mix, Andreas, Kottke, Tilman, Gröger, Harald, and Fischer von Mollard, Gabriele. 2017. “Recombinant expression and characterization of a l-amino acid oxidase from the fungus Rhizoctonia solani”. Applied Microbiology and Biotechnology 101 (7): 2853–2864.
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2913114Betke, Tobias, Rommelmann, Philipp, Oike, Keiko, Asano, Yasuhisa, and Gröger, Harald. 2017. “Cyanide-Free and Broadly Applicable Enantioselective Synthetic Platform for Chiral Nitriles through a Biocatalytic Approach”. Angewandte Chemie (International ed. in English) 46 (40): 12361-12366.
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2916530Gröger, Harald, Pieper, Matthias, Koenig, Burghard, Bayer, Thomas, and Schleich, Herbert. 2017. “Industrial landmarksinthedevelopmentofsustainableproduction processesforthe beta-lactam antibiotickeyintermediate 7-aminocephalosporanic acid (7-ACA)”. SUSTAINABLE CHEMISTRY AND PHARMACY 5: 72-79.
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2910386Reimer, Anna, Wedde, Severin, Staudt, Svenja, Schmidt, Sandy, Hoeffer, Diana, Hummel, Werner, Kragl, Udo, Bornscheuer, Uwe T., and Gröger, Harald. 2017. “Process Development through Solvent Engineering in the Biocatalytic Synthesis of the Heterocyclic Bulk Chemical epsilon-Caprolactone”. JOURNAL OF HETEROCYCLIC CHEMISTRY 54 (1): 391-396.
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2909081Rulli, Giuseppe, Duangdee, Nongnaphat, Hummel, Werner, Berkessel, Albrecht, and Gröger, Harald. 2017. “First Tandem-Type One-Pot Process Combining Asymmetric Organo- and Biocatalytic Reactions in Aqueous Media Exemplified for the Enantioselective and Diastereoselective Synthesis of 1,3-Diols”. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2017 (4): 812-817.
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2911773Heidlindemann, Marcel, Berkessel, Albrecht, and Gröger, Harald. 2017. “"Side-Product Catalysis": Substrate Autoxidation as an Overlooked Side Reaction Generating a Co-Catalyst for Enhancing Asymmetric Aldol Reactions”. CHEMCATCHEM 9 (8): 1383-1388.
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2910338Wedde, Severin, Rommelmann, Philipp, Scherkus, Christian, Schmidt, Sandy, Bornscheuer, Uwe T., Liese, Andreas, and Gröger, Harald. 2017. “An alternative approach towards poly-epsilon-caprolactone through a chemoenzymatic synthesis: combined hydrogenation, bio-oxidations and polymerization without the isolation of intermediates”. GREEN CHEMISTRY 19 (5): 1286-1290.
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2910354Uthoff, Florian, Sato, Hirofumi, and Gröger, Harald. 2017. “Formal Enantioselective Hydroamination of Non-Activated Alkenes: Transformation of Styrenes into Enantiomerically Pure 1-Phenylethylamines in Chemoenzymatic One-Pot Synthesis”. CHEMCATCHEM 9 (4): 555-558.
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2916529Uthoff, Florian, Reimer, Anna, Liese, Andreas, and Gröger, Harald. 2017. “Enzymatic resolution of an amine under solvent-free conditions with diethyl malonate as reagent for acylation”. SUSTAINABLE CHEMISTRY AND PHARMACY 5: 42-45.
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2914659Wedde, Severin, Kleusch, Christian, Bakonyi, Daniel, and Gröger, Harald. 2017. “High-throughput-feasible screening tool for determining enzyme stabilities against organic solvents directly from crude extracts”. Chembiochem : a European journal of chemical biology 18 (24): 2399-2403.
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2916457Rommelmann, Philipp, Betke, Tobias, and Gröger, Harald. 2017. “Synthesis of Enantiomerically Pure N-Acyl Amino Nitriles via Catalytic Dehydration of Oximes and Application in a de Novo Synthesis of Vildagliptin”. Organic Process Research & Development 21 (10): 1521-1527.
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2909084Biermann, Marc, Bakonyi, Daniel, Hummel, Werner, and Gröger, Harald. 2017. “Design of recombinant whole-cell catalysts for double reduction of C=C and C=O bonds in enals and application in the synthesis of Guerbet alcohols as industrial bulk chemicals for lubricants”. GREEN CHEMISTRY 19 (2): 405-410.
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2907316Müller, C. A., Weingartner, A. M., Dennig, A., Ruff, A. J., Gröger, Harald, and Schwaneberg, Ulrich. 2016. “A whole cell biocatalyst for double oxidation of cyclooctane”. Journal of Industrial Microbiology & Biotechnology 43 (12): 1641-1646.
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2906851Gómez Baraibar, Álvaro, Reichert, Dennis, Mügge, Carolin, Seger, Svenja, Gröger, Harald, and Kourist, Robert. 2016. “A One-Pot Cascade Reaction Combining an Encapsulated Decarboxylase with a Metathesis Catalyst for the Synthesis of Bio-Based Antioxidants”. Angewandte Chemie International Edition 55 (47): 14823-14827.
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2904890Bulut, Dalia, Duangdee, Nongnaphat, Gröger, Harald, Berkessel, Albrecht, and Hummel, Werner. 2016. “Screening, Molecular Cloning, and Biochemical Characterization of an Alcohol Dehydrogenase from Pichia pastoris Useful for the Kinetic Resolution of a Racemic β-Hydroxy-β-trifluoromethyl Ketone”. Chembiochem 17 (14): 1349-1358.
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2907726Scherkus, Christian, Schmidt, Sandy, Bornscheuer, Uwe T., Gröger, Harald, Kara, Selin, and Liese, Andreas. 2016. “A Fed-Batch Synthetic Strategy for a Three-Step Enzymatic Synthesis of Poly-epsilon-caprolactone”. CHEMCATCHEM 8 (22): 3446-3452.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2785615Tomasek, Jasmine, Seßler, Miriam, Gröger, Harald, and Schatz, Jürgen. 2015. “Olefin Metathesis Reaction in Water and in Air Improved by Supramolecular Additives”. Molecules 20 (10): 19130-19141.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2786832Greschner, Wilko, Neumann, Beate, Stammler, Hans-Georg, Gröger, Harald, and Kuck, Dietmar. 2015. “Enantiomerically Pure Tribenzotriquinacenes through Stereoselective Synthesis”. Angewandte Chemie (International ed. in English) 54 (46): 13764-13768.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2719049Böhm, Philipp, and Gröger, Harald. 2015. “Iron(III)-porphyrin Complex FeTSPP: A Versatile Water-soluble Catalyst for Oxidations in Organic Syntheses, Biorenewables Degradation and Environmental Applications”. ChemCatChem 7 (1): 22-28.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2901254Schmidt, Sandy, Buechsenschuetz, Hanna C., Scherkus, Christian, Liese, Andreas, Gröger, Harald, and Bornscheuer, Uwe T. 2015. “Biocatalytic access to chiral polyesters by an artificial enzyme cascade synthesis”. ChemCatChem 7 (23): 3951-3955.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2764353Metzner, Richard, Hummel, Werner, Wetterich, Frank, Koenig, Burghard, and Gröger, Harald. 2015. “Integrated Biocatalysis in Multistep Drug Synthesis without Intermediate Isolation: A de Novo Approach toward a Rosuvastatin Key Building Block”. Organic Process Research & Development 19 (6): 635-638.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2757961Takizawa, Shinobu, Gröger, Harald, and Sasai, Hiroaki. 2015. “Vanadium in asymmetric synthesis: emerging concepts in catalyst design and applications”. Chemistry 21 (25): 8992-8997.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2721884Schmidt, Sandy, Scherkus, Christian, Muschiol, Jan, Menyes, Ulf, Winkler, Till, Hummel, Werner, Gröger, Harald, Liese, Andreas, Herz, Hans-Georg, and Bornscheuer, Uwe T. 2015. “An Enzyme Cascade Synthesis of ε-Caprolactone and its Oligomers”. Angewandte Chemie (International ed. in English) 54 (9): 2784-2787.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2729781Sato, Hirofumi, Hummel, Werner, and Gröger, Harald. 2015. “Cooperative Catalysis of Noncompatible Catalysts through Compartmentalization: Wacker Oxidation and Enzymatic Reduction in a One-Pot Process in Aqueous Media”. Angewandte Chemie (International ed. in English) 54 (15): 4488-4492.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2758474Reß, Tina, Hummel, Werner, Hanlon, Steven P., Iding, Hans, and Gröger, Harald. 2015. “The Organic-Synthetic Potential of Recombinant Ene Reductases: Substrate-Scope Evaluation and Process Optimization”. ChemCatChem 7 (8): 1302-1311.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2761249Bulut, Dalia, Gröger, Harald, and Hummel, Werner. 2015. “Development of a growth-dependent selection system for identification of L-threonine aldolases”. Applied Microbiology and Biotechnology 99 (14): 5875-5883.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2729792Heidlindemann, Marcel, Hammel, Matthias, Scheffler, Ulf, Mahrwald, Rainer, Hummel, Werner, Berkessel, Albrecht, and Gröger, Harald. 2015. “Chemoenzymatic Synthesis of Vitamin B5-Intermediate (R)-Pantolactone via Combined Asymmetric Organo- and Biocatalysis”. The Journal of Organic Chemistry 80 (7): 3387-3396.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2677387Winkler, Till, Gröger, Harald, and Hummel, Werner. 2014. “Enantioselective Rearrangement Coupled with Water Addition: Direct Synthesis of Enantiomerically Pure Saturated Carboxylic Acids from a, b- Unsaturated Aldehydes”. ChemCatChem 6 (4): 961-964.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2708863Müller, Christina A., Dennig, Alexander, Welters, Tim, Winkler, Till, Ruff, Anna Joelle, Hummel, Werner, Gröger, Harald, and Schwaneberg, Ulrich. 2014. “Whole-cell double oxidation of n-heptane”. Journal of biotechnology 191: 196-204.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2708851Hummel, Werner, and Gröger, Harald. 2014. “Strategies for regeneration of nicotinamide coenzymes emphasizing self-sufficient closed-loop recycling systems”. Journal of biotechnology 191: 22-31.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2690890Heidlindemann, Marcel, Rulli, Giuseppe, Berkessel, Albrecht, Hummel, Werner, and Gröger, Harald. 2014. “Combination of Asymmetric Organo- and Biocatalytic Reactions in Organic Media Using Immobilized Catalysts in Different Compartments”. ACS Catalysis 4 (4): 1099-1103.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2707682Metzner, Richard, Okazaki, Seiji, Asano, Yasuhisa, and Gröger, Harald. 2014. “Cyanide-free Enantioselective Synthesis of Nitriles: Synthetic Proof of a Biocatalytic Concept and Mechanistic Insights”. ChemCatChem 6 (11): 3105-3109.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2699267Alfaro Blasco, Maria, and Gröger, Harald. 2014. “Enzymatic resolution of racemates with a 'remote' stereogenic center as an efficient tool in drug, flavor and vitamin synthesis”. Bioorganic & medicinal chemistry 22 (20): 5539-5546.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2681761Greschner, Wilko, Lanzerath, Carsten, Reß, Tina, Tenbrink, Katharina, Borchert, Sonja, Mix, Andreas, Hummel, Werner, and Gröger, Harald. 2014. “Artificial cofactor regeneration with an iron(III)porphyrin as NADH-oxidase mimic in the enzymatic oxidation of L-glutamate to alpha-ketoglutarate”. Journal of Molecular Catalysis B Enzymatic 103: 10-15.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2682298Gröger, Harald, and Hummel, Werner. 2014. “Combining the 'two worlds' of chemocatalysis and biocatalysis towards multi-step one-pot processes in aqueous media”. Current opinion in chemical biology 19: 171-179.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2672840Gröger, Harald. 2014. “Hydroxy Functionalization of Non-Activated C-H and C=C Bonds: New Perspectives for the Synthesis of Alcohols through Biocatalytic Processes”. Angewandte Chemie. International edition 53 (12): 3067-3069.
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2634611Gröger, Harald, Sewald, Norbert, and Wendisch, Volker F. 2013. “Bio-integrated organic synthesis in industry: Biocatalytic breakthroughs, industrial processes, emerging fields”. Journal of Biotechnology 168 (3): 241-242.
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2612864Mueller, Christina A., Akkapurathu, Beneeta, Winkler, Till, Staudt, Svenja, Hummel, Werner, Gröger, Harald, and Schwaneberg, Ulrich. 2013. “In Vitro Double Oxidation of n-Heptane with Direct Cofactor Regeneration”. Advanced Synthesis & Catalysis 355 (9): 1787-1798.
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2560792Staudt, Svenja, Burda, Edyta, Giese, Carolin, Müller, Christina A., Marienhagen, Jan, Schwaneberg, Ulrich, Hummel, Werner, Drauz, Karlheinz, and Gröger, Harald. 2013. “Direct Oxidation of Cycloalkanes to Cycloalkanones with Oxygen in Water”. Angewandte Chemie International Edition 52 (8): 2359-2363.
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2637130Rulli, Giuseppe, Heidlindemann, Marcel, Berkessel, Albrecht, Hummel, Werner, and Gröger, Harald. 2013. “Towards catalyst compartimentation in combined chemo- and biocatalytic processes: Immobilization of alcohol dehydrogenases for the diastereoselective reduction of a β-hydroxy ketone obtained from an organocatalytic aldol reaction”. Journal of biotechnology 168 (3): 271-276.
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2621189Burda, Edyta, Reß, Tina, Winkler, Till, Giese, Carolin, Kostrov, Xenia, Huber, Tobias, Hummel, Werner, and Gröger, Harald. 2013. “Highly Enantioselective Reduction of α-Methylated Nitroalkenes”. Angewandte Chemie (International ed. in English) 52 (35): 9323-9326.
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2621177Staudt, Svenja, Bornscheuer, Uwe T, Menyes, Ulf, Hummel, Werner, and Gröger, Harald. 2013. “Direct biocatalytic one-pot-transformation of cyclohexanol with molecular oxygen into ɛ-caprolactone”. Enzyme and microbial technology 53 (4): 288-292.
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2647580Strompen, Simon, Weiss, Markus, Gröger, Harald, Hilterhaus, Lutz, and Liese, Andreas. 2013. “Development of a Continuously Operating Process for the Enantioselective Synthesis of a beta-Amino Acid Ester via a Solvent-Free Chemoenzymatic Reaction Sequence”. Advanced Synthesis & Catalysis 355 (11-12): 2391-2399.
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2635953Rulli, Giuseppe, Fredriksen, Kim A., Duangdee, Nongnaphat, Bonge-Hansen, Tore, Berkessel, Albrecht, and Gröger, Harald. 2013. “Asymmetric Organocatalytic Aldol Reaction in Water: Mechanistic Insights and Development of a Semi-Continuously Operating Process”. Synthesis 45 (18): 2512-2519.
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2471821Schnapperelle, Ingo, Hummel, Werner, and Gröger, Harald. 2012. “Formal Asymmetric Hydration of Non-Activated Alkenes in Aqueous Medium through a "Chemoenzymatic Catalytic System"”. Chemistry - A European Journal 18 (4): 1073-1076.
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2445201Strompen, S., Weiß, M., Ingram, T., Smirnova, I., Gröger, Harald, Hilterhaus, L., and Liese, A. 2012. “Kinetic investigation of a solvent-free, chemoenzymatic reaction sequence towards enantioselective synthesis of a ß-amino acid ester”. Biotechnology and Bioengineering 109 (6): 1479-1489.
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2474296Staudt, Svenja, Mueller, Christina A., Marienhagen, Jan, Boeing, Christian, Buchholz, Stefan, Schwaneberg, Ulrich, and Gröger, Harald. 2012. “Biocatalytic hydroxylation of n-butane with in situ cofactor regeneration at low temperature and under normal pressure”. Beilstein Journal of Organic Chemistry 8: 186-191.
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2012 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 2397781Hummel, Werner, and Gröger, Harald. 2012. “Reductive Amination of Keto Acids”. In Enzyme Catalysis in Organic Synthesis, ed. Karlheinz Drauz, Harald Gröger, and Oliver May, 3rd ed., 3:1165-1221. Weinheim: Wiley-VCH.
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2012 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 2397744Paravidino, Monica, Böhm, Philipp, Gröger, Harald, and Hanefeld, Ulf. 2012. “Hydrolysis and Formation of Carboxylic Acid Esters”. In Enzyme Catalysis in Organic Synthesis, ed. Karlheinz Drauz, Harald Gröger, and Oliver May, 3rd ed., 1:251-362. Weinheim: Wiley-VCH.
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2012 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 2397699Gröger, Harald, Hummel, Werner, Borchert, Sonja, and Kraußer, Marina. 2012. “Reduction of Ketones and Aldehydes to Alcohols”. In Enzyme Catalysis in Organic Synthesis, ed. Karlheinz Drauz, Harald Gröger, and Oliver May, 3rd ed. Vol. 2. Weinheim: Wiley-VCH.
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2012 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 2445173Gröger, Harald, and Asano, Yasuhisa. 2012. “Introduction - Principles and Historical Landmark of Enzyme Catalysis in Organic Synthesis ”. In Enzyme Catalysis in Organic Synthesis, ed. Karlheinz Drauz, Harald Gröger, and Oliver May, 3rd ed., 1:3-42. Weinheim: Wiley-VCH.
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2553547Simon, Sabine, Osswald, Steffen, Roos, Juergen, and Gröger, Harald. 2012. “Efficient Enzymatic Amine Resolution at High Substrate Input Using Diethyl Malonate as an Acyl Donor of Low Hazard Potential”. Zeitschrift für Naturforschung Section B-A Journal Of Chemical Sciences 67b (10): 1123-1126.
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2445196Borchert, Sonja, Burda, Edyta, Schatz, Jürgen, Hummel, Werner, and Gröger, Harald. 2012. “Combination of a Suzuki cross-coupling reaction using a water-soluble palladium catalyst with an asymmetric enzymatic reduction towards a one-pot reaction in aqueous medium at room temperature”. J. Mol. Catal. B: Enzym. 84 (SI): 89-93.
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2012 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 2398903Gröger, Harald, Hummel, Werner, and Metzner, Richard. 2012. “Asymmetric Biocatalytic Reduction of Ketones”. In Synthetic Methods VI – Enzymatic and Semi-Enzymatic, ed. Erick M. Carreira and Hisashi Yamamoto, 7:181-215. Comprehensive Chirality. Oxford: Elsevier.
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2517832Duangdee, Nongnaphat, Harnying, Wacharee, Rulli, Giuseppe, Neudoerfl, Joerg-M., Gröger, Harald, and Berkessel, Albrecht. 2012. “Highly Enantioselective Organocatalytic Trifluoromethyl Carbinol Synthesis-A Caveat on Reaction Times and Product Isolation”. Journal of the American Chemical Society 134 (27): 11196-11205.
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2474508Berkessel, Albrecht, Harnying, Wacharee, Duangdee, Nongnaphat, Neudoerfl, Joerg-M., and Gröger, Harald. 2012. “Large-Scale Synthesis of Singh's Catalyst in a One-Pot Procedure Starting from Proline”. Organic Process Research & Development 16 (1): 123-128.
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2509926Gröger, Harald, Asano, Yasuhisa, Bornscheuer, Uwe T., and Ogawa, Jun. 2012. “Development of Biocatalytic Processes in Japan and Germany: From Research Synergies to Industrial Applications”. Chemistry - An Asian Journal 7 (6): 1138-1153.
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2493243Weiss, Markus, Borchert, Sonja, Remond, Emmanuelle, Juge, Sylvain, and Gröger, Harald. 2012. “Asymmetric addition of a nitrogen nucleophile to an enoate in the presence of a chiral phase-transfer catalyst: A novel approach toward enantiomerically enriched protected beta-amino acids”. Heteroatom Chemistry 23 (2): 202-209.
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2490875Prechter, Agnes, Gröger, Harald, and Heinrich, Markus R. 2012. “Synthesis of (S)-(+)-cericlamine through lipase-catalyzed aminolysis of azo acetates”. Organic & Biomolecular Chemistry 10 (17): 3384.
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2407538Maid, H., Böhm, P., Huber, S.M., Bauer, W., Hummel, Werner, Jux, N., and Gröger, Harald. 2011. “Eisenkatalyse zur In-situ-Regenerierung oxidierter Cofaktoren durch Aktivierung und Reduktion von O2: ein synthetisches Metallporphyrin als biomimetische NAD(P)H-Oxidase”. Angewandte Chemie 123 (10): 2445-2448.
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2344721Maid, Harald, Boehm, Philipp, Huber, Stefan M., Bauer, Walter, Hummel, Werner, Jux, Norbert, and Gröger, Harald. 2011. “Iron Catalysis for In Situ Regeneration of Oxidized Cofactors by Activation and Reduction of Molecular Oxygen: A Synthetic Metalloporphyrin as a Biomimetic NAD(P)H Oxidase”. Angewandte Chemie International Edition 50 (10): 2397-2400.
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2407610Rulli, Giuseppe, Duangdee, Nongnaphat, Baer, Katrin, Hummel, Werner, Berkessel, Albrecht, and Gröger, Harald. 2011. “Gesteuerte kinetisch oder thermodynamisch kontrollierte Organokatalyse und Anwendung in der chemoenzymatischen Synthese”. Angew. Chem. 123 (34): 8092-8095.
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2344713Rulli, Giuseppe, Duangdee, Nongnaphat, Baer, Katrin, Hummel, Werner, Berkessel, Albrecht, and Gröger, Harald. 2011. “Direction of Kinetically versus Thermodynamically Controlled Organocatalysis and Its Application in Chemoenzymatic Synthesis”. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 50 (34): 7944-7947.
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2344730Richter, Nina, Gröger, Harald, and Hummel, Werner. 2011. “Asymmetric reduction of activated alkenes using an enoate reductase from Gluconobacter oxydans”. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 89 (1): 79-89.
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2344704Krausser, Marina, Winkler, Till, Richter, Nina, Dommer, Sabine, Fingerhut, Anja, Hummel, Werner, and Gröger, Harald. 2011. “Combination of C=C Bond Formation by Wittig Reaction and Enzymatic C=C Bond Reduction in a One-Pot Process in Water”. ChemCatChem 3 (2): 293-296.
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2398890Tenbrink, Katharina, Seßler, Miriam, Schatz, Jürgen, and Gröger, Harald. 2011. “Combination of Olefin Metathesis and Enzymatic Ester Hydrolysis in Aqueous Media in a One-Pot Synthesis”. Adv. Synth. & Catal. 353 (13): 2363-2367.
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2344695Dietz, Friedrich R., Prechter, Agnes, Gröger, Harald, and Heinrich, Markus R. 2011. “Chiral azo compounds: enantioselective synthesis and transformations into beta-amino alcohols and alpha-amino acids with a quaternary stereocenter”. TETRAHEDRON LETTERS 52 (6): 655-657.
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2394651Baer, Katrin, Dückers, Nina, Rosenbaum, Thorsten, Leggewie, Christian, Simon, Sabine, Krausser, Marina, Osswald, Steffen, Hummel, Werner, and Gröger, Harald. 2011. “A study towards efficient L-threonine aldolase-catalyzed enantio- and diastereoselective aldol reactions of glycine with substituted benzaldehydes: biocatalyst production and process development”. Tetrahedron Asymmetry 22 (9): 925-928.
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2011 | Patent | PUB-ID: 2453495Gröger, Harald, Hüsken, H., Drauz, K., and Landfester, K. 2011. “Enzymreaktionen in Miniemulsionen”.
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2011 | Patent | Veröffentlicht | PUB-ID: 2458477Heinrich, M., Gröger, Harald, Prechter, A., and Dietz, F. 2011. “Verfahren zur Herstellung von enantiomerenangereicherten Azoverbindungen, Aminoalkoholen und Aminosäuren mit einem quartären Kohlenstoffzentrum”.
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2010 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 2344784Weckbecker, Andrea, Gröger, Harald, and Hummel, Werner. 2010. “Regeneration of Nicotinamide Coenzymes: Principles and Applications for the Synthesis of Chiral Compounds”. In BIOSYSTEMS ENGINEERING I: CREATING SUPERIOR BIOCATALYSTS, ed. C. Wittmann and W. R. Krull, 120:195-242. Advances in Biochemical Engineering-Biotechnology. Berlin, Heidelberg: Springer Berlin Heidelberg.
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2344737Dückers, Nina, Baer, Katrin, Simon, Sabine, Gröger, Harald, and Hummel, Werner. 2010. “Threonine aldolases-screening, properties and applications in the synthesis of non-proteinogenic beta-hydroxy-alpha-amino acids”. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 88 (2): 409-424.
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2344761Baer, Katrin, Dueckers, Nina, Hummel, Werner, and Gröger, Harald. 2010. “Expanding the Application Range of Aldolases: Novel Asymmetric Syntheses of alpha-Methylated beta-Hydroxy alpha-Amino Acids and beta-Amino Alcohols”. ChemCatChem 2 (8): 939-942.
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2344754Alfaro Blasco, Maria, Thumann, Silvia, Wittmann, Juergen, Athanassios, Giannis, and Gröger, Harald. 2010. “Enantioselective biocatalytic synthesis of (S)-monastrol”. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 20 (15): 4679-4682.
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2344744Bauer, Peter, Munkert, Jennifer, Brydziun, Margareta, Burda, Edyta, Mueller-Uri, Frieder, Gröger, Harald, Muller, Yves A., and Kreis, Wolfgang. 2010. “Highly conserved progesterone 5 beta-reductase genes (P5 beta R) from 5 beta-cardenolide-free and 5 beta-cardenolide-producing angiosperms”. PHYTOCHEMISTRY 71 (13): 1495-1505.
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2344772Neupert, Adrian, Ress, Tina, Wittmann, Jürgen, Hummel, Werner, and Gröger, Harald. 2010. “Enantioselective Biocatalytic Reduction of Non-protected Hydroxyacetophenones”. Zeitschrift für Naturforschung. Section B, a journal of chemical sciences 65 (3): 337-340.
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2010 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 2396569Gröger, Harald. 2010. “Enzyme-Catalyzed Asymmetric Synthesis”. In Catalytic Asymmetric Synthesis, ed. I. Ojima, 6:269-341. Hoboken, New Jersey: John Wiley & Sons.
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2010 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 2396563Gröger, Harald, Borchert, S., Kraußer, M., and Hummel, W. 2010. “Enzyme-Catalyzed Asymmetric Reduction of Ketones”. In Encyclopedia of Industrial Biotechnology, Bioprocess, Bioseparation, and Cell Technology, ed. M. Flickinger, 3:2094-2110. New York: John Wiley Sons.
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2010 | Patent | PUB-ID: 2453130Altenbuchner, J., Menzel, A., Gröger, Harald, Werner, H., and Hummel, W. 2010. “Verfahren zur Herstellung von optisch aktiven Aminosäuren mittels eines Ganzzellkatalysators”.
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2010 | Patent | PUB-ID: 2453301Gröger, Harald, Burda, E., Schwaneberg, U., Marienhagen, J., and Drauz, K. 2010. “Verfahren zur enzymatischen Umsetzung von Alkanen”.
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2010 | Patent | Veröffentlicht | PUB-ID: 2399883Doderer, K., Gröger, Harald, and May, O. 2010. “Verfahren zur Herstellung von überwiegend ein Enantiomer enthaltendem 1,1,1-Trifluorpropanol”.
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2344767Parkot, Julia, Gröger, Harald, and Hummel, Werner. 2010. “Purification, cloning, and overexpression of an alcohol dehydrogenase from Nocardia globerula reducing aliphatic ketones and bulky ketoesters”. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 86 (6): 1813-1820.
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2010 | Patent | PUB-ID: 2453169Gröger, Harald, May, O., Rollmann, C., Chamouleau, F., Orologas, N., and Drauz, K. 2010. “Herstellung optisch aktiver Alkohole mit Hilfe von Ganzzellkatalsatoren”.
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2009 | Patent | PUB-ID: 2453000Hummel, W., Abokitse, K., and Gröger, Harald. 2009. “ADH aus Rhodococcus erythropolis”.
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2009 | Patent | PUB-ID: 2453012Gröger, Harald, and Werner, H. 2009. “Verfahren zur enzymatischen Herstellung enantiomerenangereicherter ß-Aminosäuren”.
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2009 | Patent | PUB-ID: 2453151Schulze, R., Lorenz, P., Eck, J., May, O., Gröger, Harald, and Trauthwein, H. 2009. “Neue Alkoholdehydrogenasen”.
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2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2344799Burda, Edyta, Krausser, Marina, Fischer, Gabriele, Hummel, Werner, Mueller-Uri, Frieder, Kreis, Wolfgang, and Gröger, Harald. 2009. “Recombinant Delta(4,5)-Steroid 5 beta-Reductases as Biocatalysts for the Reduction of Activated C=C-Double Bonds in Monocyclic and Acyclic Molecules”. ADVANCED SYNTHESIS & CATALYSIS 351 (17): 2787-2790.
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2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2344823Baer, Katrin, Krausser, Marina, Burda, Edyta, Hummel, Werner, Berkessel, Albrecht, and Gröger, Harald. 2009. “Sequential and Modular Synthesis of Chiral 1,3-Diols with Two Stereogenic Centers: Access to All Four Stereoisomers by Combination of Organo- and Biocatalysis”. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 48 (49): 9355-9358.
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2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2346641Burda, Edyta, Hummel, Werner, and Gröger, Harald. 2009. “Multistep one-pot processes in aqueous media by combination of palladium-catalyzed cross-coupling reactions and biotransformations”. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 238.
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2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2344795Dietz, Friedrich R., and Gröger, Harald. 2009. “Asymmetric Synthesis of All Stereoisomers of alpha-Methylthreonine Using an Organocatalytic Steglich Rearrangement Reaction as a Key Step”. SYNTHESIS-STUTTGART, no. 24: 4208-4218.
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2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2407531Baer, K., Kraußer, M., Burda, E., Hummel, W., Berkessel, A., and Gröger, Harald. 2009. “Sequenzielle und modulare Synthese von chiralen 1,3-Diolen mit zwei Stereozentren: Zugang zu allen vier Stereoisomeren durch Kombination von Organo- und Biokatalyse”. Angew. Chem. 121 (49): 9519-9522.
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2009 | Patent | PUB-ID: 2453286Doderer, K., Wienand, W., Gröger, Harald, and Rollmann, C. 2009. “Verfahren zur Herstellung von enantimerenangereicherten Aminen”.
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2009 | Patent | Veröffentlicht | PUB-ID: 2400139Gröger, Harald, Rollmann, C., Werner, H., Chamouleau, F.-C., and Orzewski, D. 2009. “Aufarbeitung von Reaktionslösungen aus Ganzzell-Biotransformationen”.
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2009 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 2396636Gröger, Harald, and Dietz, F.R. 2009. “Biocatalytic Synthesis of Natural and Non-Natural alpha-Amino Acids”. In Wiley Encyclopedia of Chemical Biology, ed. T.P. Begley, 1:191-204. Hoboken: John Wiley & Sons,.
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2009 | Patent | PUB-ID: 2453051Gröger, Harald, Hüsken, H., Rollmann, C., Chamouleau, F., Drauz, K., Hummel, W., and Hagedorn, C. 2009. “Gekoppeltes cofaktorabhängiges enzymatisches Reaktionssystem”.
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2008 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2344831Dietz, Friedrich R., and Gröger, Harald. 2008. “Novel catalytic synthetic route to protected alpha-methyl threonine and the first asymmetric acetyl migration in a Steglich rearrangement reaction”. SYNLETT 2008 (5): 663-666.
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2008 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2347145Gröger, Harald. 2008. “Asymmetric organocatalysis on a technical scale: current status and future challenges”. In Organocatalysis, ed. M.T. Reetz, B. List, S. Jaroch, H. Weinmann, and Schering Stiftung, 2007,2:227-258. Ernst Schering Foundation Symposium Proceedings, 2007-2. Berlin u.a.: Springer.
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2008 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 2396697Gröger, Harald. 2008. “Asymmetric Organocatalysis on a Technical Scale: Current Status and Future Challenges”. In Ernst Schering Foundation Symposium Proceedings 2007-2: Organocatalysis, ed. M.T. Reetz, B. List, S. Jaroch, and H. Weinheim, 141-158. Berlin, Heidelberg: Springer-Verlag.
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2008 | Patent | PUB-ID: 2453245Gröger, Harald, Wienand, W., Rollmann, C., Werner, H., and Reichert, D. 2008. “Verfahren zur Herstellung von enantiomerenangereicherten Alkylencarbonaten”.
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2008 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2344840Dominguez de Maria, Pablo, Stillger, Thomas, Pohl, Martina, Kiesel, Michael, Liese, Andreas, Gröger, Harald, and Trauthwein, Harald. 2008. “Enantioselective C-C bond ligation using recombinant Escherichia coli-whole-cell biocatalysts”. ADVANCED SYNTHESIS & CATALYSIS 350 (1): 165-173.
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2008 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2344835Burda, Edyta, Hummel, Werner, and Gröger, Harald. 2008. “Modular Chemoenzymatic One-Pot Syntheses in Aqueous Media: Combination of a Palladium-Catalyzed Cross-Coupling with an Asymmetric Biotransformation”. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 47 (49): 9551-9554.
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2008 | Patent | PUB-ID: 2453216Gröger, Harald, May, O., Rossen, K., and Drauz, K. 2008. “Verfahren zur Herstellung von enantiomerenangereicherten Aminen und Amiden durch enzymatische Racematspaltung”.
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2008 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 2396674Gröger, Harald, and Burda, E. 2008. “Chiral Trivalent Phosphorus Compounds as Organocatalysts in Asymmetric Synthesis”. In Phosphorous Ligands in Asymmetric Catalysis - Synthesis and Applications, ed. A. Börner, 3:1175-1197. Weinheim: Wiley-VCH.
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2008 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2407518Burda, E., Hummel, W., and Gröger, Harald. 2008. “Modulare chemoenzymatische Eintopfsynthesen im wässrigen Medium: Kombination einer Palladium-katalysierten Kreuzkupplung mit einer asymmetrischen Biotransformation”. Angew. Chem. 120 (49): 9693-9696.
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2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2346666Berkessel, Albrecht, Rollmann, Claudia, Chamouleau, Francoise, Labs, Stefanie, May, Oliver, and Gröger, Harald. 2007. “Practical two-step synthesis of an enantiopure aliphatic terminal (S)-epoxide based on reduction of haloalkanones with ``Designer Cells''”. ADVANCED SYNTHESIS & CATALYSIS 349 (17-18): 2697-2704.
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2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2346685Gröger, Harald, Rollmann, Claudia, Chamouleau, Francoise, Sebastien, Isabelle, May, Oliver, Wienand, Wolfgang, and Drauz, Karlheinz. 2007. “Enantioselective reduction of 4-fluoroacetophenone at high substrate concentration using a tailor-made recombinant whole-cell catalyst”. ADVANCED SYNTHESIS & CATALYSIS 349 (4-5): 709-712.
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2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2344854Osswald, S., Doderer, K., Gröger, Harald, and Wienand, W. 2007. “Alcohol dehydrogenase whole-cell catalysts - A broad technology platform for life science applications”. CHIMICA OGGI-CHEMISTRY TODAY 25 (5, S): 16-18.
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2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2344865Dominguez de Maria, Pablo, Pohl, Martina, Gocke, Doerte, Gröger, Harald, Trauthwein, Harald, Stillger, Thomas, Walter, Lydia, and Mueller, Michael. 2007. “Asymmetric synthesis of aliphatic 2-hydroxy ketones by enzymatic carboligation of aldehydes”. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2007 (18): 2940-2944.
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2007 | Patent | PUB-ID: 2453180Gröger, Harald, Chamouleau, F., and Hagedorn, C. 2007. “Verfahren zur Herstellung primärer Alkohole”.
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2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2346674Krausser, Marina, Hummel, Werner, and Gröger, Harald. 2007. “Enantioselective one-pot two-step synthesis of hydrophobic allylic alcohols in aqueous medium through the combination of a wittig reaction and an enzymatic ketone reduction”. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2007 (31): 5175-5179.
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2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2346679Chamouleau, Francoise, Hagedorn, Chad, May, Oliver, and Gröger, Harald. 2007. “Biocatalytic alclehyde reduction using tailor-made whole-cell catalysts: a novel synthesis of the aroma chemical cinnamyl alcohol”. FLAVOUR AND FRAGRANCE JOURNAL 22 (3): 169-172.
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2007 | Patent | PUB-ID: 2399880Hummel, W., Schümers, J., and Gröger, Harald. 2007. “Alkoholdehydrogenase aus Nocardia globulera und deren Verwendung”.
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2006 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2396781Gröger, Harald, May, O., Hüsken, H., Georgeon, S., Drauz, K., and Landfester, K. 2006. “Enantioselektive Enzymreaktionen in Miniemulsionen als effiziente "Nanoreaktoren"”. Angew. Chem. Int. Ed., no. 45: 1645-1648.
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2006 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2407494Gröger, Harald, Chamouleau, F., Orologas, N., Rollmann, C., Drauz, K., Hummel, W., Weckbecker, A., and May, O. 2006. “Enantioselektive Ketonreduktion mit "Designerzellen" bei hohen Substratkonzentrationen: Hocheffizienter Zugang zu funktionalisierten optisch aktiven Alkoholen”. Angew. Chem. 118 (34): 5806-5809.
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2006 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2347147Gröger, Harald, Chamouleau, Francoise, Orologas, Nicolas, Rollmann, Claudia, Drauz, Karlheinz, Hummel, Werner, Weckbecker, Andrea, and May, Oliver. 2006. “Enantioselective reduction of ketones with "designer cells" at high substrate concentrations: highly efficient access to functionalized optically active alcohols”. Angewandte Chemie International Edition 45 (34): 5677-5681.
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2006 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2396830Dominguez de Maria, P., Stillger, T., Pohl, M., Wallert, S., Drauz, K., Gröger, Harald, Trauthwein, H., and Liese, A. 2006. “Preparative Enantioselective Synthesis of Benzoins and (R)-2-Hydroxy-1-phenyl-propanone Using Benzaldehyde Lyase”. J. Mol. Catal. B: Enzym. 38 (1): 43-47.
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2006 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 2396733Buchholz, S., and Gröger, Harald. 2006. “Biocatalytic Concepts for the Synthesis of Optically Active Amines”. In Biocatalysis in the Pharmaceutical and Biotechnology Industries, ed. R.N. Patel, 829-847. New York: CRC Press.
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2006 | Patent | PUB-ID: 2399875Dominguez de Maria, P., Trauthwein, H., May, O., Gröger, Harald, and Drauz, K. 2006. “Verfahren zur Herstellung von enantiomer angereicherten alpha-Hydroxyketonen”.
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2006 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 2396749Buchholz, S., and Gröger, Harald. 2006. “Enationselective Biocatalytic Reduction of Ketones for the Synthesis of Optically Active Alcohols”. In Biocatalysis in the Pharmaceutical and Biotechnology Industries, ed. R.N. Patel, Chapter 32:757-790. New York: CRC Press.
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2006 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2396819Gröger, Harald, May, O., Werner, H., Menzel, A., and Altenbuchner, J. 2006. “A "Second Generation-Process" for the Synthesis of L-Neopentylglycine: Asymmetric Reductive Amination Using a Recombinant Whole Cell Catalyst”. Org. Proc. Res. Developm. 10 (3): 666-669.
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2006 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2407476Gröger, Harald, May, O., Hüsken, H., Georgeon, S., Drauz, K., and Landfester, K. 2006. “Enantioselektive Enzymreaktionen in Miniemulsionen als effiziente "Nanoreaktoren"”. Angew. Chem., no. 118: 1678-1679.
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2005 | Patent | PUB-ID: 2399843Wallert, S., Grayson, J.I., Drauz, K., Gröger, Harald, Bolm, C., Dominguez de Maria, P., and Chamouleau, F. 2005. “Enzymatische Reaktionen in Gegenwart ionischer Additive”.
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2005 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 2396902Buchholz, S., and Gröger, Harald. 2005. “Ganzzellbiokatalyse”. In Angewandte Mikrobiologie, ed. G. Antranikian, Chapter 8:161-172. Heidelberg: Springer-Verlag.
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2005 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2396930Dominguez de Maria, P., Kossmann, B., Potgrave, N., Buchholz, S., Trauthwein, H., May, O., and Gröger, Harald. 2005. “Improved Process for the Enantioselective Hydrolysis of Prochiral Diethyl Malonates Catalyzed by Pig Liver Esterase”. Synlett, no. 11: 1746-1748.
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2005 | Patent | PUB-ID: 2399762Hummel, H., Geueke, B., Kuzu, M., and Gröger, Harald. 2005. “Verfahren zur Herstellung von D-Aminosäuren”.
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2005 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2396908Wallert, S., Drauz, K., Grayson, I., Gröger, Harald, Dominguez de Maria, P., and Bolm, C. 2005. “Ionic liquids as Additives in the Pig Liver Esterase (PLE) Catalyzed Synthesis of Chiral Disubstituted Malonates”. Green Chem. 7 (8): 602-605.
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2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2347164Gröger, Harald, Trauthwein, Harald, Buchholz, Stefan, Drauz, Karlheinz, Sacherer, Christiane, Godfrin, Sylvie, and Werner, Helge. 2004. “The first aminoacylase-catalyzed enantioselective synthesis of aromatic beta-amino acids”. Org. Biomol. Chemistry 2 (14): 1977-1978.
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2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2397106Menzel, A., Werner, H., Altenbuchner, J., and Gröger, Harald. 2004. “From Enzymes to "Designer Bugs" in Reductive Amination: A New Process for the Synthesis of L-tert-Leucine Using a Whole Cell-Catalyst”. Eng. Life Sciences 4: 573-576.
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2004 | Patent | PUB-ID: 2399668Gröger, Harald, and Hummel, W. 2004. “Gekoppeltes enzymatisches Reaktionssystem”.
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2004 | Patent | PUB-ID: 2399670Gröger, Harald, and Hummel, W. 2004. “Gekoppeltes enzymatisches Reaktionssystem unter Einsatz einer Formiatdehydrogenase aus Candida boidinii”.
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2004 | Patent | PUB-ID: 2399682Hummel, W., and Gröger, Harald. 2004. “Enzymatisches Reaktionssystem”.
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2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2397117Gröger, Harald, Hummel, W., Rollmann, C., Chamouleau, F., Hüsken, H, Werner, H., Wunderlich, C., Abokitse, K., Drauz, K., and Buchholz, S. 2004. “Preparative Asymmetric Reduction of Ketones in a Biphasic Medium with an (S)-AIcohol Dehydrogenase under in situ-Cofactor-Recycling with a Formate Dehydrogenase”. Tetrahedron 60 (3): 633-640.
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2004 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 2397155Shibasaki, M., Kanai, M., and Gröger, Harald. 2004. “Nitroaldol Reaction”. In Comprehensive Asymmetric Catalysis, Supplement, ed. E. Jacobsen, A. Pfaltz, and H. Yamamoto, 1:131-133. Heidelberg: Springer-Verlag.
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2004 | Patent | PUB-ID: 2399679Naamniek, S., Hummel, W., and Gröger, Harald. 2004. “Verwendung von Malatdehydrogenase zur NADH-Regenerierung”.
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2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2397147May, O., and Gröger, Harald. 2004. “Enzymatic Cofactor-Regeneration Technology Platforms for Chiral alpha-Amino Acids and Alcohols”. Speciality Chemicals Magazine 5: 24-25.
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2004 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 2397178Gröger, Harald, and Drauz, K. 2004. “Methods for the Biocatalytic Production of L-Amino Acids on Industrial Scale”. In Large-Scale Asymmetric Catalysis, ed. E. Schmidt and H.U. Blaser, 131-147. Weinheim: Wiley-VCH Verlag.
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2004 | Patent | PUB-ID: 2399703Rollmann, C., Gröger, Harald, Bommarius, A.B., and Hummel, W. 2004. “Gekoppeltes cofaktorabhängiges enzymatisches Reaktionssystem”.
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2003 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 2397232Gröger, Harald, Wilken, J., and Berkessel, A. 2003. “Simple Amino acids and Short-chain Peptides as Efficient Metal-free Catalysts in Asymmetric Synthesis”. In Organic Synthesis Highlights, ed. V. Schmalz and T. Wirth, 178-186. Weinheim: Wiley-VCH Verlag.
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2003 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2347176Gröger, Harald, Hummel, Werner, Buchholz, Stefan, Drauz, Karlheinz, Nguyen, Tien Van, Rollmann, Claudia, Husken, Hendrik, and Abokitse, Kofi. 2003. “Practical asymmetric enzymatic reduction through discovery of a dehydrogenase-compatible biphasic reaction media”. Organic Letters 5 (2): 173-176.
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2003 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2347173Gröger, Harald. 2003. “Catalytic enantioselective Strecker reactions and analogous syntheses”. Chemical Reviews 103 (8): 2795-2828.
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2003 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2397219Hummel, W., Abokitse, K., Drauz, K., Rollmann, C., and Gröger, Harald. 2003. “Towards a Large-Scale Asymmetric Reduction Process with Isolated Enzymes: Expression of an (S)-Alcohol Dehydrogenase in E. coli and Studies on the Synthetic Potential of this Biocatalyst”. Adv. Synth. Catal. 345: 153-159.
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2003 | Patent | PUB-ID: 2399663Gröger, Harald, and Werner, H. 2003. “Verfahren zur enzymatischen Herstellung enantiomerenangereicherter ß-Aminosäuren”.
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2003 | Patent | PUB-ID: 2399205Schwarm, M., Roos, J., Gröger, Harald, Werner, H., and Rippel, C. 2003. “Verfahren zur Kristallisation von Oxonorleucinacetal”.
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2003 | Patent | PUB-ID: 2399215Gröger, Harald, Trauthwein, H., Drauz, K., Buchholz, S., Sacherer, C., and Werner, H. 2003. “Verfahren zur Herstellung von optisch aktiven ß-Aminocarbonsäuren aus racemischen N-acetylierten ß-Aminocarbonsäuren”.
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2002 | Patent | PUB-ID: 2399141Sans, J., and Gröger, Harald. 2002. “Verfahren zur Herstellung von Amiden”.
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2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2397245Gröger, Harald, Capan, E., Barthuber, A., and Vorlop, K.-D. 2002. “Biocatalytic Asymmetric Hydrocyanation in the Presence of (R)-Oxynitrilases Entrapped in Lens-Shaped Gels”. Landbauforschung Völkenrode Sonderheft (Special Issue) 241: 87-91.
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2002 | Patent | PUB-ID: 2399100Gröger, Harald, Fleischer, F., Hammer, B., and Hitzler, M. 2002. “Verfahren zur Herstellung von N-Phosphonomethyliminodiessigsäure”.
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2002 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 2397254Schultz, C., Gröger, Harald, Dinkel, C., Drauz, K., and Waldmann, H. 2002. “Special Catalysts and Processes: Biocatalysis and Enzyme-Analogous Processes”. In Applied Homogeneous Catalysis with Organometallic Compounds, ed. B. Cornils and W.A. Herrmann, 2.nd ed., 2:872-911. Weinheim: Wiley-VCH-Verlag.
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2002 | Patent | PUB-ID: 2399176Shibasaki, M., Kanai, M., Manickam, G., Nogami, H., and Gröger, Harald. 2002. “Verfahren zur Herstellung von optisch aktiven Cyanhydrinen”.
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2001 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2397265Gröger, Harald. 2001. “The Development of New Monometallic Bifunctional Catalysts with Lewis Acid and Lewis Base properties, and their Applicationin Asymmetric Cyanation Reactions”. Chem. Eur. J. 7: 5246-5251.
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2001 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2347186Gröger, Harald. 2001. “The development of new monometallic bifunctional catalysts with Lewis acid and Lewis base properties, and their application in asymmetric cyanation reactions”. Chemistry 7 (24): 5246-5251.
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2001 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2397268Gröger, Harald. 2001. “Enzymatic Routes to Enantiomerically Pure Aromatic alpha-Hydroxy Carboxylic Acids: A Further Example for the Diversity of Biocatalysis”. Adv. Synth. Catal. 343: 547-558.
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2001 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2397279Gröger, Harald, and Wilken, J. 2001. “The Application of L-Proline as an Enzyme Mimic and Further New Asymmetric Syntheses Using Small Organic Molecules as Chiral Catalysis”. Angew. Chem. Int. Ed. 40: 529-532.
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2001 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2347191Gröger, Harald, Capan, E, Barthuber, A, and Vorlop, K D. 2001. “Asymmetric synthesis of an (R)-cyanohydrin using enzymes entrapped in lens-shaped gels”. Organic Letters 3 (13): 1969-1972.
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2001 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2397285Manickam, G., Nogami, H., Kanai, M., Gröger, Harald, and Shibasaki, M. 2001. “Anti- and Syn-Selective Cyanosilylation Reactions Promoted by a Sugar-Based Bifunctional Catalyst: Stereoselective Synthesis of Essential building Blocks for HIV Protease Inhibitors and Bestatin”. Synlett, 617-620.
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2001 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2407474Gröger, Harald, and Wilken, Jörg. 2001. “Die Anwendung von L-Prolin als Enzymmimetikum und weitere neue asymmetrische Synthesen mit kleinen organischen Molekülen als chiralen Katalysatoren”. Angewandte Chem., no. 113: 545-548.
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2001 | Patent | PUB-ID: 2399121Gröger, Harald, Vorlop, K.-D., and Capan, E. 2001. “Method for Producing Optically Active Cyanohydrins”.
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2001 | Patent | PUB-ID: 2399126Gröger, Harald, Sans, J., Barthuber, A., and Haindl, R. 2001. “Verfahren zur Herstellung von Amiden oder Estern”.
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2000 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2347215Gröger, Harald, and Hammer, B. 2000. “Catalytic concepts for the enantioselective synthesis of alpha-amino and alpha-hydroxy phosphonates”. Chemistry 6 (6): 943-948.
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2000 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2397396Gröger, Harald, Goerlich, J.R., Schmutzler, R., and Martens, J. 2000. “The First Synthesis of a 2H-1,4-Benzothiazine-based Phosphine Oxide and Sulfide”. Phosphorus, Sulfur, Silicon 166: 253-259.
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2000 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2397409Pennemann, H., Wassmann, S., Wilken, J., Gröger, Harald, Wallbaum, S., Kossenjans, M., Haase, D., Saak, W., Pohl, S., and Martens, J. 2000. “Preparation of an Enantiomerically Pure Helical Nickel(II) Complex Using a New Chiral Tetradentate Ligand Derived from an Industrial Waste Material”. J. Chem. Soc. Dalton Trans., 2467-2470.
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2000 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2397430Gröger, Harald, Sans, J., and Güthner, T. 2000. “1,3,5-Triazines, versatile industrial building blocks: Synthetic approaches and applications”. Chimica Oggi/Chemistry Today 18 (3/4): 12-15.
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2000 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2397352Schlemminger, I., Saida, Y., Gröger, Harald, Maison, W., Durot, N., Sasai, H., Shibasaki, M., and Martens, J. 2000. “Concept of Improved Rigidity: How to Make Enantioselective Hydrophosphonylation of Cyclic Imines Catalyzed by Chiral Heterobimetallic Lanthanoid Complexes Almost Perfect”. J. Org. Chem. 65: 4818-4825.
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2000 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2397440Gröger, Harald. 2000. “Moderne Methoden der Suzuki-Kreuzkupplung: Die langerwarteten universellen Synthesevarianten mit Arylchloriden”. J. Prakt. Chem. 342: 334-339.
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2000 | Patent | PUB-ID: 2399023Martens, J., Maison, W., Schlemminger, I., Westerhoff, O., and Gröger, Harald. 2000. “Precursors for PNA-Monomers”.
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2000 | Patent | PUB-ID: 2399111Gröger, Harald, Thalhammer, F., Fleischer, F., and Hammer, B. 2000. “Verfahren zur Herstellung von N-Phosphonomethyliminodiessigsäure”.
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1999 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 2347897Shibasaki, M., and Gröger, Harald. 1999. “The Asymmetric Nitroaldol Reaction: Addition of Nitroalkanes to Aldehydes in the Presence of Heterobimetallic Lanthanoid Catalysts”. In Comprehensive Asymmetric Catalysis, Vol 3, ed. E. Jacobsen, A. Pfaltz, and H. Yamamoto, 1075-1090. Heidelberg: Springer-Verlag.
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1999 | Zeitschriftenaufsatz | PUB-ID: 2347912Yamada, K.-i., Harwood, S.J., Gröger, Harald, and Shibasaki, M. 1999. “The First Catalytic Asymmetric Nitro-Mannich-type Reaction Promoted by a New Heterobimetallic Complex”. Angew. Chem. Int.Ed. 38: 3504-3506.
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1999 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2407545Vogl, E.M, Gröger, Harald, and Shibasaki, M. 1999. “Towards Perfect Asymmetric Catalysis: Additives and Co-catalysts”. Angew. Chem. Int. Ed. 38 (11): 1570-1577.
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1999 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 2347907Shibasaki, M., and Gröger, Harald. 1999. “Chiral Heterobimetallic Lanthanoid Complexes: A Highly Efficient Multifunctional Catalyst for the Asymmetric Formation of C-C,C-O, and C-P Bonds”. In Topics in Organometallic Chemistry: Lanthanides: Chemistry and Use in Organic Synthesis, ed. S. Kobayashi, 2:199-233. Heidelberg: Springer Verlag.
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1999 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2407465Yamada, Ken-ichi, Harwood, Simon J., Gröger, Harald, and Shibasaki, Masakatsu. 1999. “Erste katalytische asymmetrische Nitro-Mannich-Reaktion mit einem neuen Heterodimetallkomplex des Katalysators”. Angewandte Chem., no. 111: 3713-3715.
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1999 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2407462Vogl, Erasmus M., Gröger, Harald, and Shibasaki, Masakatsu. 1999. “Zur Perfektionierung der asymmetrischen Katalyse: Additive und Co-Katalysatoren”. Angew. Chem., no. 111: 1672-1680.
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1998 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2347854Gröger, Harald, Wilken, J., Martens, J., Neda, I., and Schmutzler, R. 1998. “The First Synthesis of Cyclic alpha-Amino Phosphonic Acid Amines Bearing the Benzodiazaphosphorinananone System”. Heteroatom Chem. 9: 679-686.
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1998 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2347865Gröger, Harald, Saida, Y., Sasai, H., Yamaguchi, K., Martens, J., and Shibasaki, M. 1998. “A New and Highly Efficient Route to Cyclic alpha-Amino Phosphonates: The First Catalytic Enantioselective Hydrophosphonylation of Cyclic Imines Catalyzed by Chiral Heterobimetallic Lanthanoid Complexes”. J. Am. Chem. Soc. 120: 3089-3103.
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1998 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2347881Gröger, Harald, Vogl, E.M., and Shibasaki, M. 1998. “New Catalytic Concepts for the Asymmetric Aldol Reaction”. Chem. Eur. J. 4: 1137-1141.
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1997 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2347828Gröger, Harald, Martens, J., Goerlich, J.R., and Schmutzler, R. 1997. “A Novel Synthetic Approach to alpha-Aminophosphine Sulfide Structures: The First Dimethylphosphine Sulfide Addition to 3-Thiazolines”. Phosphorus, Sulfur, Silicon 128: 153-163.
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1997 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2347743Wilken, J., Kossenjans, M., Gröger, Harald, and Martens, J. 1997. “Synthesis and Applilcation of New ß-Amino Alcohols Based on the Octahydrocyclopenta[b]pyrrol System in the Catalytic Enantioselective Addition of Diethylzinc to Benzaldehyde”. Tetrahedron: Asymmetry 8: 2007-2015.
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1997 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2347713Gröger, Harald, Tehranfar, D., Martens, J., Goerlich, J.R., Thönnessen, H., Jones, P.G., and Schmutzler, R. 1997. “Synthesis of Dimethyl 4-Thiazolidinylphosphine Oxides via Addition of Dimethylphosphine Oxide to 3-Thiazolines”. Heteroatom Chem. 8: 207-215.
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1997 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2347775Wilken, J., Gröger, Harald, Kossenjans, M., and Martens, J. 1997. “Synthesis and Application of New (threo)- and (erythro)-Amino Alcohols Based on the Octahydro-cyclopenta[b]pyrrol System in the Catalytic Enantioselective Addition of Diethylzinc to Benzaldehyde”. Tetrahedron Asymmetry 8: 2761-2771.
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1997 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2347821Reiners, I., Gröger, Harald, and Martens, J. 1997. “A New Enantioselective Synthetic Approach to ß-Aminothio-compounds via Enantioselective Reduction of N,S-Heterocyclic Imines”. J. Prakt. Chem. 339: 541-546.
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1997 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2347759Wilken, J., Thorey, C., Gröger, Harald, Haase, D., Saak, W., Pohl, S., Muzart, J., and Martens, J. 1997. “Synthesis of New, Chiral ß-sec-Amino Alcohols - Diastereodivergent Addition of Grignard-Reagents to a-Amno Aldehydes Based on the (all-R)-2-Azabicyclo[3.3.0]octane-System”. Liebigs Ann./Recuell, 2133-2146.
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1997 | Diskussionspapier | Veröffentlicht | PUB-ID: 2347850Gröger, Harald. 1997. Nukleophile Additionsreaktionen an die C=N-Doppelbindung schwefelhaltiger, cyclischer Imine unter Berücksichtigung stereoselektiver Aspekte. Universität Oldenburg.
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1996 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2347671Hatam, M., Goerlich, J.R., Schmutzler, R., Gröger, Harald, and Martens, J. 1996. “The Totally Protected Hydroxy Containing alpha-Amino Phosphonic Esters and alpha-Amino Phosphinoxides as well as their Carbamoyl Derivatives”. Synth. Commun. 26: 3685-3698.
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1996 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2344573Gröger, Harald, and Martens, J. 1996. “Synthese Totalgeschützter Thioanaloga der 1,2,3,4-Tetrahydrochinolin-2-carbonsäure aus 2H-1,4-Benzothiazinen via Ugi-Reaktion”. Sulfur Lett. 19: 197-206.
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1996 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2344556Gröger, Harald, and Martens, J. 1996. “Synthesis of New 4-Thiazolidinylphosphonates via Stereoselective Pudovik Reaction”. Synth. Commun. 26: 1903-1911.
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1996 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2344599Gröger, Harald, Manikowski, J., and Martens, J. 1996. “Synthetic Approach to New alpha-Aminophosphonates Derived from Six-Membered, Sulfur-Containing Heterocyclic Imines”. Phosphorus, Sulfur, Silicon 116: 123-132.
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1996 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2347651Neda, I., Kaukorat, T., Jones, P.G., Schmutzler, R., Gröger, Harald, and Martens, J. 1996. “Chemistry of the 1,3,5-Triaza-2-phosphorine-4,6-diones, Part XI. Base-Catalyzed Addition Reactions of 2-Oxo-2-hydro-1,3,5-trimethyl-1,3,5-triaza-2I4-phosphorine-4,6-dione to the C-N Double Bond of 3-Thiazoline Heterocycles”. Z. Naturforsch. 51b: 1486-1493.
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1996 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2347629Gröger, Harald, Wilken, J., Martens, J., Neda, I., Pinchuk, V., Thönnessen, H., Jones, P.G., and Schmutzler, R. 1996. “Stereoselektive Pudovik-Reaktion von 5,6-Benzo-2H-1-methyl-3-(2'-chlorethyl)-2-oxo-1,3,2I4-diazaphosphorin-4-on mit einem 3-Thiazolin und MPL-Chromatographische Isolierung des Überschußdiastereomers”. Z. Naturforsch. 51b: 1305-1312.
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1996 | Zeitschriftenaufsatz | PUB-ID: 2344586Gröger, Harald, Hatam, M., Kintscher, J., and Martens, J. 1996. “Synthesis of Glutathione Analogues, Peptide Nucleic Acids and Phosphono-oligopetides from Heterocyclic Imines”. Synth. Commun. 26: 3383-3394.
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1996 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2347696Gröger, Harald, Saida, Y., Arai, S., Martens, J., Sasai, H., and Shibasaki, M. 1996. “First Catalytic Asymmetric Hydrophosphonylation of Cyclilc Imines: Highly Efficient Enantioselective Approach to a 4-Thiazolidinylphosphonate via Chiral Titanium and Lanthanoid Catalysts”. Tetrahedron Lett. 37: 9291-9292.
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1995 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2344535Gröger, Harald, Hatam, M., and Martens, J. 1995. “Synthese Totalgeschützter, Nichtproteinogener alpha-Aminosäuren und Oligopeptide aus 2H-1,3-Oxazinen und 2H-1,3-Bezoxazinen via Ugi-Reaction”. Tetrahedron 51: 7173-7180.