Merging Heterocyclic Chemistry and Biocatalysis in One-Pot Processes through Compartmentalization of the Reaction Steps
Zumbrägel N, Gröger H (2018)
Bioengineering 5(3): 60.
Zeitschriftenaufsatz
| Veröffentlicht | Englisch
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Abstract / Bemerkung
A proof of concept for a one-pot process merging a heterocycle formation by a classical chemical approach at basic conditions with a biocatalytic reduction, running at neutral pH conditions, is reported. A crucial component for this process is the compartmentalization of the single reactions by the use of polydimethylsiloxane thimbles. This process was applied successfully towards an asymmetric synthesis of (S)-2,2,3-trimethyl-1-thia-4-azaspiro[4.4]nonane, leading to excellent enantioselectivities of 99% enantiomeric excess (ee).
Stichworte
Asinger-type multi-component reaction;
asymmetric synthesis;
biocatalysis;
cascades;
compartmentalization;
heterocycles
Erscheinungsjahr
2018
Zeitschriftentitel
Bioengineering
Band
5
Ausgabe
3
Art.-Nr.
60
Urheberrecht / Lizenzen
ISSN
2306-5354
eISSN
2306-5354
Finanzierungs-Informationen
Open-Access-Publikationskosten wurden durch die Deutsche Forschungsgemeinschaft und die Universität Bielefeld gefördert.
Page URI
https://pub.uni-bielefeld.de/record/2930227
Zitieren
Zumbrägel N, Gröger H. Merging Heterocyclic Chemistry and Biocatalysis in One-Pot Processes through Compartmentalization of the Reaction Steps. Bioengineering. 2018;5(3): 60.
Zumbrägel, N., & Gröger, H. (2018). Merging Heterocyclic Chemistry and Biocatalysis in One-Pot Processes through Compartmentalization of the Reaction Steps. Bioengineering, 5(3), 60. doi:10.3390/bioengineering5030060
Zumbrägel, Nadine, and Gröger, Harald. 2018. “Merging Heterocyclic Chemistry and Biocatalysis in One-Pot Processes through Compartmentalization of the Reaction Steps”. Bioengineering 5 (3): 60.
Zumbrägel, N., and Gröger, H. (2018). Merging Heterocyclic Chemistry and Biocatalysis in One-Pot Processes through Compartmentalization of the Reaction Steps. Bioengineering 5:60.
Zumbrägel, N., & Gröger, H., 2018. Merging Heterocyclic Chemistry and Biocatalysis in One-Pot Processes through Compartmentalization of the Reaction Steps. Bioengineering, 5(3): 60.
N. Zumbrägel and H. Gröger, “Merging Heterocyclic Chemistry and Biocatalysis in One-Pot Processes through Compartmentalization of the Reaction Steps”, Bioengineering, vol. 5, 2018, : 60.
Zumbrägel, N., Gröger, H.: Merging Heterocyclic Chemistry and Biocatalysis in One-Pot Processes through Compartmentalization of the Reaction Steps. Bioengineering. 5, : 60 (2018).
Zumbrägel, Nadine, and Gröger, Harald. “Merging Heterocyclic Chemistry and Biocatalysis in One-Pot Processes through Compartmentalization of the Reaction Steps”. Bioengineering 5.3 (2018): 60.
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2019-09-06T09:19:00Z
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Daten bereitgestellt von European Bioinformatics Institute (EBI)
Zitationen in Europe PMC
Daten bereitgestellt von Europe PubMed Central.
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