Practical asymmetric enzymatic reduction through discovery of a dehydrogenase-compatible biphasic reaction media
Gröger H, Hummel W, Buchholz S, Drauz K, Nguyen TV, Rollmann C, Husken H, Abokitse K (2003)
Organic Letters 5(2): 173-176.
Zeitschriftenaufsatz
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Autor*in
Gröger, HaraldUniBi;
Hummel, Werner;
Buchholz, Stefan;
Drauz, Karlheinz;
Nguyen, Tien Van;
Rollmann, Claudia;
Husken, Hendrik;
Abokitse, Kofi
Abstract / Bemerkung
[reaction: see text] An enzyme-compatible biphasic reaction media for the asymmetric biocatalytic reduction of ketones with in situ cofactor regeneration has been developed. In this biphasic reaction media, which is advantageous for reactions at higher substrate concentrations, both enzymes (alcohol dehydrogenase and FDH from Candida boidinii) remain stable. The reductions with poorly water-soluble ketones were carried out at substrate concentrations of 10-200 mM, and the optically active (S)-alcohols were formed with moderate to good conversions and with up to >99% ee.
Erscheinungsjahr
2003
Zeitschriftentitel
Organic Letters
Band
5
Ausgabe
2
Seite(n)
173-176
ISSN
1523-7060
eISSN
1523-7052
Page URI
https://pub.uni-bielefeld.de/record/2347176
Zitieren
Gröger H, Hummel W, Buchholz S, et al. Practical asymmetric enzymatic reduction through discovery of a dehydrogenase-compatible biphasic reaction media. Organic Letters. 2003;5(2):173-176.
Gröger, H., Hummel, W., Buchholz, S., Drauz, K., Nguyen, T. V., Rollmann, C., Husken, H., et al. (2003). Practical asymmetric enzymatic reduction through discovery of a dehydrogenase-compatible biphasic reaction media. Organic Letters, 5(2), 173-176. https://doi.org/10.1021/ol0272139
Gröger, Harald, Hummel, Werner, Buchholz, Stefan, Drauz, Karlheinz, Nguyen, Tien Van, Rollmann, Claudia, Husken, Hendrik, and Abokitse, Kofi. 2003. “Practical asymmetric enzymatic reduction through discovery of a dehydrogenase-compatible biphasic reaction media”. Organic Letters 5 (2): 173-176.
Gröger, H., Hummel, W., Buchholz, S., Drauz, K., Nguyen, T. V., Rollmann, C., Husken, H., and Abokitse, K. (2003). Practical asymmetric enzymatic reduction through discovery of a dehydrogenase-compatible biphasic reaction media. Organic Letters 5, 173-176.
Gröger, H., et al., 2003. Practical asymmetric enzymatic reduction through discovery of a dehydrogenase-compatible biphasic reaction media. Organic Letters, 5(2), p 173-176.
H. Gröger, et al., “Practical asymmetric enzymatic reduction through discovery of a dehydrogenase-compatible biphasic reaction media”, Organic Letters, vol. 5, 2003, pp. 173-176.
Gröger, H., Hummel, W., Buchholz, S., Drauz, K., Nguyen, T.V., Rollmann, C., Husken, H., Abokitse, K.: Practical asymmetric enzymatic reduction through discovery of a dehydrogenase-compatible biphasic reaction media. Organic Letters. 5, 173-176 (2003).
Gröger, Harald, Hummel, Werner, Buchholz, Stefan, Drauz, Karlheinz, Nguyen, Tien Van, Rollmann, Claudia, Husken, Hendrik, and Abokitse, Kofi. “Practical asymmetric enzymatic reduction through discovery of a dehydrogenase-compatible biphasic reaction media”. Organic Letters 5.2 (2003): 173-176.
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Rao J, Zhang R, Liang H, Gao XD, Nakanishi H, Xu Y., Microb Cell Fact 18(1), 2019
PMID: 31109314
Rao J, Zhang R, Liang H, Gao XD, Nakanishi H, Xu Y., Microb Cell Fact 18(1), 2019
PMID: 31109314
Potent oxazoline analog of apratoxin C: Synthesis, biological evaluation, and conformational analysis.
Yoshida M, Onda Y, Masuda Y, Doi T., Biopolymers 106(4), 2016
PMID: 26584466
Yoshida M, Onda Y, Masuda Y, Doi T., Biopolymers 106(4), 2016
PMID: 26584466
Whole-cell double oxidation of n-heptane.
Müller CA, Dennig A, Welters T, Winkler T, Ruff AJ, Hummel W, Gröger H, Schwaneberg U., J Biotechnol 191(), 2014
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Müller CA, Dennig A, Welters T, Winkler T, Ruff AJ, Hummel W, Gröger H, Schwaneberg U., J Biotechnol 191(), 2014
PMID: 24925696
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Temme H, Dethloff O, Pitner WR, Fischer S, Scheurich R, Schulte M, Niemeyer B., Appl Microbiol Biotechnol 93(6), 2012
PMID: 22159609
Temme H, Dethloff O, Pitner WR, Fischer S, Scheurich R, Schulte M, Niemeyer B., Appl Microbiol Biotechnol 93(6), 2012
PMID: 22159609
Designing organometallic compounds for catalysis and therapy.
Noffke AL, Habtemariam A, Pizarro AM, Sadler PJ., Chem Commun (Camb) 48(43), 2012
PMID: 22517189
Noffke AL, Habtemariam A, Pizarro AM, Sadler PJ., Chem Commun (Camb) 48(43), 2012
PMID: 22517189
Investigation of asymmetric alcohol dehydrogenase (ADH) reduction of acetophenone derivatives: effect of charge density.
Naik HG, Yeniad B, Koning CE, Heise A., Org Biomol Chem 10(25), 2012
PMID: 22609978
Naik HG, Yeniad B, Koning CE, Heise A., Org Biomol Chem 10(25), 2012
PMID: 22609978
A photocatalyst/enzyme couple that uses solar energy in the asymmetric reduction of acetophenones.
Choudhury S, Baeg JO, Park NJ, Yadav RK., Angew Chem Int Ed Engl 51(46), 2012
PMID: 23065709
Choudhury S, Baeg JO, Park NJ, Yadav RK., Angew Chem Int Ed Engl 51(46), 2012
PMID: 23065709
Candida spp. redox machineries: an ample biocatalytic platform for practical applications and academic insights.
Gamenara D, Domínguez de María P., Biotechnol Adv 27(3), 2009
PMID: 19500548
Gamenara D, Domínguez de María P., Biotechnol Adv 27(3), 2009
PMID: 19500548
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Lavandera I, Kern A, Schaffenberger M, Gross J, Glieder A, de Wildeman S, Kroutil W., ChemSusChem 1(5), 2008
PMID: 18702138
Lavandera I, Kern A, Schaffenberger M, Gross J, Glieder A, de Wildeman S, Kroutil W., ChemSusChem 1(5), 2008
PMID: 18702138
Activity and selectivity of W110A secondary alcohol dehydrogenase from Thermoanaerobacter ethanolicus in organic solvents and ionic liquids: mono- and biphasic media.
Musa MM, Ziegelmann-Fjeld KI, Vieille C, Phillips RS., Org Biomol Chem 6(5), 2008
PMID: 18292880
Musa MM, Ziegelmann-Fjeld KI, Vieille C, Phillips RS., Org Biomol Chem 6(5), 2008
PMID: 18292880
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PMID: 18436317
Woodley JM., Trends Biotechnol 26(6), 2008
PMID: 18436317
Xerogel-encapsulated W110A secondary alcohol dehydrogenase from Thermoanaerobacter ethanolicus performs asymmetric reduction of hydrophobic ketones in organic solvents.
Musa MM, Ziegelmann-Fjeld KI, Vieille C, Zeikus JG, Phillips RS., Angew Chem Int Ed Engl 46(17), 2007
PMID: 17361973
Musa MM, Ziegelmann-Fjeld KI, Vieille C, Zeikus JG, Phillips RS., Angew Chem Int Ed Engl 46(17), 2007
PMID: 17361973
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Sariaslani FS., Annu Rev Microbiol 61(), 2007
PMID: 17456010
Sariaslani FS., Annu Rev Microbiol 61(), 2007
PMID: 17456010
The potential of cloud point system as a novel two-phase partitioning system for biotransformation.
Wang Z., Appl Microbiol Biotechnol 75(1), 2007
PMID: 17318534
Wang Z., Appl Microbiol Biotechnol 75(1), 2007
PMID: 17318534
High-resolution structures of formate dehydrogenase from Candida boidinii.
Schirwitz K, Schmidt A, Lamzin VS., Protein Sci 16(6), 2007
PMID: 17525463
Schirwitz K, Schmidt A, Lamzin VS., Protein Sci 16(6), 2007
PMID: 17525463
Our senior editors. Stefan Buchholz: industrial biotechnology.
Buchholz S., Biotechnol J 1(2), 2006
PMID: 16892243
Buchholz S., Biotechnol J 1(2), 2006
PMID: 16892243
Operational concept for the improved synthesis of (R)-3,3'-furoin and related hydrophobic compounds with benzaldehyde lyase.
Ansorge-Schumacher MB, Greiner L, Schroeper F, Mirtschin S, Hischer T., Biotechnol J 1(5), 2006
PMID: 16892292
Ansorge-Schumacher MB, Greiner L, Schroeper F, Mirtschin S, Hischer T., Biotechnol J 1(5), 2006
PMID: 16892292
Engineered phenylalanine dehydrogenase in organic solvents: homogeneous and biphasic enzymatic reactions.
Cainelli G, Engel PC, Galletti P, Giacomini D, Gualandi A, Paradisi F., Org Biomol Chem 3(24), 2005
PMID: 16327891
Cainelli G, Engel PC, Galletti P, Giacomini D, Gualandi A, Paradisi F., Org Biomol Chem 3(24), 2005
PMID: 16327891
Recent advances in the biocatalytic reduction of ketones and oxidation of sec-alcohols.
Kroutil W, Mang H, Edegger K, Faber K., Curr Opin Chem Biol 8(2), 2004
PMID: 15062771
Kroutil W, Mang H, Edegger K, Faber K., Curr Opin Chem Biol 8(2), 2004
PMID: 15062771
Recent developments in pyridine nucleotide regeneration.
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PMID: 12943852
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