Practical asymmetric enzymatic reduction through discovery of a dehydrogenase-compatible biphasic reaction media
Gröger H, Hummel W, Buchholz S, Drauz K, Nguyen TV, Rollmann C, Husken H, Abokitse K (2003)
Organic Letters 5(2): 173-176.
Zeitschriftenaufsatz
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Autor*in
Gröger, HaraldUniBi;
Hummel, Werner;
Buchholz, Stefan;
Drauz, Karlheinz;
Nguyen, Tien Van;
Rollmann, Claudia;
Husken, Hendrik;
Abokitse, Kofi
Abstract / Bemerkung
[reaction: see text] An enzyme-compatible biphasic reaction media for the asymmetric biocatalytic reduction of ketones with in situ cofactor regeneration has been developed. In this biphasic reaction media, which is advantageous for reactions at higher substrate concentrations, both enzymes (alcohol dehydrogenase and FDH from Candida boidinii) remain stable. The reductions with poorly water-soluble ketones were carried out at substrate concentrations of 10-200 mM, and the optically active (S)-alcohols were formed with moderate to good conversions and with up to >99% ee.
Erscheinungsjahr
2003
Zeitschriftentitel
Organic Letters
Band
5
Ausgabe
2
Seite(n)
173-176
ISSN
1523-7060
eISSN
1523-7052
Page URI
https://pub.uni-bielefeld.de/record/2347176
Zitieren
Gröger H, Hummel W, Buchholz S, et al. Practical asymmetric enzymatic reduction through discovery of a dehydrogenase-compatible biphasic reaction media. Organic Letters. 2003;5(2):173-176.
Gröger, H., Hummel, W., Buchholz, S., Drauz, K., Nguyen, T. V., Rollmann, C., Husken, H., et al. (2003). Practical asymmetric enzymatic reduction through discovery of a dehydrogenase-compatible biphasic reaction media. Organic Letters, 5(2), 173-176. https://doi.org/10.1021/ol0272139
Gröger, Harald, Hummel, Werner, Buchholz, Stefan, Drauz, Karlheinz, Nguyen, Tien Van, Rollmann, Claudia, Husken, Hendrik, and Abokitse, Kofi. 2003. “Practical asymmetric enzymatic reduction through discovery of a dehydrogenase-compatible biphasic reaction media”. Organic Letters 5 (2): 173-176.
Gröger, H., Hummel, W., Buchholz, S., Drauz, K., Nguyen, T. V., Rollmann, C., Husken, H., and Abokitse, K. (2003). Practical asymmetric enzymatic reduction through discovery of a dehydrogenase-compatible biphasic reaction media. Organic Letters 5, 173-176.
Gröger, H., et al., 2003. Practical asymmetric enzymatic reduction through discovery of a dehydrogenase-compatible biphasic reaction media. Organic Letters, 5(2), p 173-176.
H. Gröger, et al., “Practical asymmetric enzymatic reduction through discovery of a dehydrogenase-compatible biphasic reaction media”, Organic Letters, vol. 5, 2003, pp. 173-176.
Gröger, H., Hummel, W., Buchholz, S., Drauz, K., Nguyen, T.V., Rollmann, C., Husken, H., Abokitse, K.: Practical asymmetric enzymatic reduction through discovery of a dehydrogenase-compatible biphasic reaction media. Organic Letters. 5, 173-176 (2003).
Gröger, Harald, Hummel, Werner, Buchholz, Stefan, Drauz, Karlheinz, Nguyen, Tien Van, Rollmann, Claudia, Husken, Hendrik, and Abokitse, Kofi. “Practical asymmetric enzymatic reduction through discovery of a dehydrogenase-compatible biphasic reaction media”. Organic Letters 5.2 (2003): 173-176.
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