Continuous-Flow Dynamic Kinetic Resolution of Racemic Alcohols by Lipase-Oxovanadium Cocatalysis

Higashio K, Katsuragi S, Kundu D, Adebar N, Plass C, Kühn F, Gröger H, Akai S (2020)
European journal of organic chemistry 2020(13): 1961-1967.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Higashio, Koichi; Katsuragi, Satoko; Kundu, Dhiman; Adebar, NiklasUniBi; Plass, CarmenUniBi; Kühn, FranziskaUniBi; Gröger, HaraldUniBi; Akai, Shuji
Abstract / Bemerkung
A continuous-flow dynamic kinetic resolution of racemic secondary alcohols was carried out using a single column reactor packed with a mixture of immobilized lipase and an immobilized oxovanadium species, VMPS4. As a result, optically pure esters were produced in 88-92 % yields. Problems encountered in this study were overcome by using fillers that efficiently maintained the initial distribution of the catalysts in the reactor and by using a packing method in which the mixing ratio of the two catalysts was varied in a stepwise fashion. The flow process led to an increased turnover number of each catalyst compared to those of batch reactions.
Stichworte
Lipase; Oxovanadium; Dynamic kinetic resolution; Flow reaction; Alcohols
Erscheinungsjahr
2020
Zeitschriftentitel
European journal of organic chemistry
Band
2020
Ausgabe
13
Seite(n)
1961-1967
ISSN
1434-193X
eISSN
1099-0690
Page URI
https://pub.uni-bielefeld.de/record/2942890

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Higashio K, Katsuragi S, Kundu D, et al. Continuous-Flow Dynamic Kinetic Resolution of Racemic Alcohols by Lipase-Oxovanadium Cocatalysis. European journal of organic chemistry. 2020;2020(13):1961-1967.
Higashio, K., Katsuragi, S., Kundu, D., Adebar, N., Plass, C., Kühn, F., Gröger, H., et al. (2020). Continuous-Flow Dynamic Kinetic Resolution of Racemic Alcohols by Lipase-Oxovanadium Cocatalysis. European journal of organic chemistry, 2020(13), 1961-1967. doi:10.1002/ejoc.202000186
Higashio, K., Katsuragi, S., Kundu, D., Adebar, N., Plass, C., Kühn, F., Gröger, H., and Akai, S. (2020). Continuous-Flow Dynamic Kinetic Resolution of Racemic Alcohols by Lipase-Oxovanadium Cocatalysis. European journal of organic chemistry 2020, 1961-1967.
Higashio, K., et al., 2020. Continuous-Flow Dynamic Kinetic Resolution of Racemic Alcohols by Lipase-Oxovanadium Cocatalysis. European journal of organic chemistry, 2020(13), p 1961-1967.
K. Higashio, et al., “Continuous-Flow Dynamic Kinetic Resolution of Racemic Alcohols by Lipase-Oxovanadium Cocatalysis”, European journal of organic chemistry, vol. 2020, 2020, pp. 1961-1967.
Higashio, K., Katsuragi, S., Kundu, D., Adebar, N., Plass, C., Kühn, F., Gröger, H., Akai, S.: Continuous-Flow Dynamic Kinetic Resolution of Racemic Alcohols by Lipase-Oxovanadium Cocatalysis. European journal of organic chemistry. 2020, 1961-1967 (2020).
Higashio, Koichi, Katsuragi, Satoko, Kundu, Dhiman, Adebar, Niklas, Plass, Carmen, Kühn, Franziska, Gröger, Harald, and Akai, Shuji. “Continuous-Flow Dynamic Kinetic Resolution of Racemic Alcohols by Lipase-Oxovanadium Cocatalysis”. European journal of organic chemistry 2020.13 (2020): 1961-1967.
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