Threonine aldolases-screening, properties and applications in the synthesis of non-proteinogenic beta-hydroxy-alpha-amino acids

Dückers N, Baer K, Simon S, Gröger H, Hummel W (2010)
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 88(2): 409-424.

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DOI
Autor*in
Dückers, Nina; Baer, Katrin; Simon, Sabine; Gröger, HaraldUniBi; Hummel, WernerUniBi
Einrichtung
Fakultät für Chemie > Industrielle Organische Chemie und Biotechnologie
Abstract / Bemerkung
Threonine aldolases (TAs) constitute a powerful tool for catalyzing carbon-carbon bond formations in synthetic organic chemistry, thus enabling an enantio- and diastereoselective synthesis of beta-hydroxy-alpha-amino acids. Starting from the achiral precursors glycine and an aldehyde, two new stereogenic centres are formed in this catalytic step. The resulting chiral beta-hydroxy-alpha-amino acid products are important precursors for pharmaceuticals such as thiamphenicol, a l-threo-phenylserine derivative or l-threo-3,4-dihydroxyphenylserine. TAs are pyridoxal-5-phosphate-dependent enzymes, which, in nature, catalyze the cleavage of l-threonine or l-allo-threonine to glycine and acetaldehyde in a glycine biosynthetic pathway. TAs from a broad number of species of bacteria and fungi have been isolated and characterised as biocatalysts for the synthesis of beta-hydroxy-alpha-amino acids. In this review, screening methods to obtain novel TAs, their biological function, biochemical characterisation and preparative biotransformations with TAs are described.
Erscheinungsjahr
2010
Zeitschriftentitel
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
Band
88
Ausgabe
2
Seite(n)
409-424
ISSN
0175-7598
eISSN
1432-0614
Page URI
https://pub.uni-bielefeld.de/record/2344737

Zitieren

Dückers N, Baer K, Simon S, Gröger H, Hummel W. Threonine aldolases-screening, properties and applications in the synthesis of non-proteinogenic beta-hydroxy-alpha-amino acids. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY. 2010;88(2):409-424.
Dückers, N., Baer, K., Simon, S., Gröger, H., & Hummel, W. (2010). Threonine aldolases-screening, properties and applications in the synthesis of non-proteinogenic beta-hydroxy-alpha-amino acids. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 88(2), 409-424. https://doi.org/10.1007/s00253-010-2751-8
Dückers, Nina, Baer, Katrin, Simon, Sabine, Gröger, Harald, and Hummel, Werner. 2010. “Threonine aldolases-screening, properties and applications in the synthesis of non-proteinogenic beta-hydroxy-alpha-amino acids”. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 88 (2): 409-424.
Dückers, N., Baer, K., Simon, S., Gröger, H., and Hummel, W. (2010). Threonine aldolases-screening, properties and applications in the synthesis of non-proteinogenic beta-hydroxy-alpha-amino acids. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 88, 409-424.
Dückers, N., et al., 2010. Threonine aldolases-screening, properties and applications in the synthesis of non-proteinogenic beta-hydroxy-alpha-amino acids. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 88(2), p 409-424.
N. Dückers, et al., “Threonine aldolases-screening, properties and applications in the synthesis of non-proteinogenic beta-hydroxy-alpha-amino acids”, APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, vol. 88, 2010, pp. 409-424.
Dückers, N., Baer, K., Simon, S., Gröger, H., Hummel, W.: Threonine aldolases-screening, properties and applications in the synthesis of non-proteinogenic beta-hydroxy-alpha-amino acids. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY. 88, 409-424 (2010).
Dückers, Nina, Baer, Katrin, Simon, Sabine, Gröger, Harald, and Hummel, Werner. “Threonine aldolases-screening, properties and applications in the synthesis of non-proteinogenic beta-hydroxy-alpha-amino acids”. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 88.2 (2010): 409-424.

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