Threonine aldolases-screening, properties and applications in the synthesis of non-proteinogenic beta-hydroxy-alpha-amino acids

Dückers N, Baer K, Simon S, Gröger H, Hummel W (2010)
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 88(2): 409-424.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
Threonine aldolases (TAs) constitute a powerful tool for catalyzing carbon-carbon bond formations in synthetic organic chemistry, thus enabling an enantio- and diastereoselective synthesis of beta-hydroxy-alpha-amino acids. Starting from the achiral precursors glycine and an aldehyde, two new stereogenic centres are formed in this catalytic step. The resulting chiral beta-hydroxy-alpha-amino acid products are important precursors for pharmaceuticals such as thiamphenicol, a l-threo-phenylserine derivative or l-threo-3,4-dihydroxyphenylserine. TAs are pyridoxal-5-phosphate-dependent enzymes, which, in nature, catalyze the cleavage of l-threonine or l-allo-threonine to glycine and acetaldehyde in a glycine biosynthetic pathway. TAs from a broad number of species of bacteria and fungi have been isolated and characterised as biocatalysts for the synthesis of beta-hydroxy-alpha-amino acids. In this review, screening methods to obtain novel TAs, their biological function, biochemical characterisation and preparative biotransformations with TAs are described.
Erscheinungsjahr
Zeitschriftentitel
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
Band
88
Ausgabe
2
Seite(n)
409-424
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eISSN
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Dückers N, Baer K, Simon S, Gröger H, Hummel W. Threonine aldolases-screening, properties and applications in the synthesis of non-proteinogenic beta-hydroxy-alpha-amino acids. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY. 2010;88(2):409-424.
Dückers, N., Baer, K., Simon, S., Gröger, H., & Hummel, W. (2010). Threonine aldolases-screening, properties and applications in the synthesis of non-proteinogenic beta-hydroxy-alpha-amino acids. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 88(2), 409-424. doi:10.1007/s00253-010-2751-8
Dückers, N., Baer, K., Simon, S., Gröger, H., and Hummel, W. (2010). Threonine aldolases-screening, properties and applications in the synthesis of non-proteinogenic beta-hydroxy-alpha-amino acids. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 88, 409-424.
Dückers, N., et al., 2010. Threonine aldolases-screening, properties and applications in the synthesis of non-proteinogenic beta-hydroxy-alpha-amino acids. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 88(2), p 409-424.
N. Dückers, et al., “Threonine aldolases-screening, properties and applications in the synthesis of non-proteinogenic beta-hydroxy-alpha-amino acids”, APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, vol. 88, 2010, pp. 409-424.
Dückers, N., Baer, K., Simon, S., Gröger, H., Hummel, W.: Threonine aldolases-screening, properties and applications in the synthesis of non-proteinogenic beta-hydroxy-alpha-amino acids. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY. 88, 409-424 (2010).
Dückers, Nina, Baer, Katrin, Simon, Sabine, Gröger, Harald, and Hummel, Werner. “Threonine aldolases-screening, properties and applications in the synthesis of non-proteinogenic beta-hydroxy-alpha-amino acids”. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 88.2 (2010): 409-424.

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