Enantioselective one-pot two-step synthesis of hydrophobic allylic alcohols in aqueous medium through the combination of a wittig reaction and an enzymatic ketone reduction

Krausser M, Hummel W, Gröger H (2007)
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2007(31): 5175-5179.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Krausser, Marina; Hummel, Werner; Gröger, HaraldUniBi
Abstract / Bemerkung
A one-pot two-step process for the enantioselective synthesis of hydrophobic allylic alcohols was developed, which comprises ketone formation by the Wittig reaction and their enzymatic in situ biotransformation into the desired target products. By means of this combined Wittig reaction and bioreduction, the allylic alcohols were prepared with conversions of up to 90 %, and with excellent enantio selectivities of >99 % ee. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007).
Stichworte
alcohols; chemoenzymatic synthesis; enzyme catalysis; wittig reactions; reduction
Erscheinungsjahr
2007
Zeitschriftentitel
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Band
2007
Ausgabe
31
Seite(n)
5175-5179
ISSN
1434-193X
eISSN
1099-0690
Page URI
https://pub.uni-bielefeld.de/record/2346674

Zitieren

Krausser M, Hummel W, Gröger H. Enantioselective one-pot two-step synthesis of hydrophobic allylic alcohols in aqueous medium through the combination of a wittig reaction and an enzymatic ketone reduction. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. 2007;2007(31):5175-5179.
Krausser, M., Hummel, W., & Gröger, H. (2007). Enantioselective one-pot two-step synthesis of hydrophobic allylic alcohols in aqueous medium through the combination of a wittig reaction and an enzymatic ketone reduction. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2007(31), 5175-5179. doi:10.1002/ejoc.200700647
Krausser, M., Hummel, W., and Gröger, H. (2007). Enantioselective one-pot two-step synthesis of hydrophobic allylic alcohols in aqueous medium through the combination of a wittig reaction and an enzymatic ketone reduction. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2007, 5175-5179.
Krausser, M., Hummel, W., & Gröger, H., 2007. Enantioselective one-pot two-step synthesis of hydrophobic allylic alcohols in aqueous medium through the combination of a wittig reaction and an enzymatic ketone reduction. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2007(31), p 5175-5179.
M. Krausser, W. Hummel, and H. Gröger, “Enantioselective one-pot two-step synthesis of hydrophobic allylic alcohols in aqueous medium through the combination of a wittig reaction and an enzymatic ketone reduction”, EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 2007, 2007, pp. 5175-5179.
Krausser, M., Hummel, W., Gröger, H.: Enantioselective one-pot two-step synthesis of hydrophobic allylic alcohols in aqueous medium through the combination of a wittig reaction and an enzymatic ketone reduction. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. 2007, 5175-5179 (2007).
Krausser, Marina, Hummel, Werner, and Gröger, Harald. “Enantioselective one-pot two-step synthesis of hydrophobic allylic alcohols in aqueous medium through the combination of a wittig reaction and an enzymatic ketone reduction”. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2007.31 (2007): 5175-5179.

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