Fatty alcohol synthesis from fatty acids at mild temperature by subsequent enzymatic esterification and metal-catalyzed hydrogenation

Schlipkoeter KE, Betke T, Kleber J, Gröger H, Liese A (2020)
Organic and Biomolecular Chemistry 18(39): 7862-7867.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Schlipkoeter, Kim E.; Betke, TobiasUniBi; Kleber, Joscha; Gröger, HaraldUniBi; Liese, Andreas
Abstract / Bemerkung
Fatty alcohols are important products in chemical industry to be used in the formulation of surfactants and lubricants. This work describes a two step approach for the production of myristyl alcohol under neat conditions by combining a lipase catalyzed esterification of myristic acid and myristyl alcohol with a ruthenium catalyzed hydrogenation of the intermediate myristyl myristate. The esterification was carried out in a bubble column reactor with the commercial immobilized lipase B fromCandida antarcticaas a biocatalyst, while the hydrogenation was conducted under pressurized conditions being catalyzed by the homogeneous chemocatalyst Ru-Macho-BH. By investigating the reaction steps separately, comparable reaction rates were found for the esterification of short chain and long chain alcohols. Additionally, the hydrogen pressure could be reduced to 35 bar compared to the current industrial Lurgi process. Characterization of cross interactions by the reactants myristic acid and sodium myristate in the hydrogenation demonstrates that the metal catalyst was completely deactivated, even at a low amount of 0.5 mol% of myristic acid. Complete conversion of myristic acid in the esterification with equal amounts of myristic acid and myristyl alcohol was obtained, overcoming any limitation in the hydrogenation. In comparison to the Lurgi process starting also from fatty acid and fatty alcohols, the chemoenzymatic two step reaction sequence could be realized at lower reaction temperatures of 60 and 100 degrees C as well as lower hydrogen pressures of 35 bar.
Erscheinungsjahr
2020
Zeitschriftentitel
Organic and Biomolecular Chemistry
Band
18
Ausgabe
39
Seite(n)
7862-7867
ISSN
1477-0520
eISSN
1477-0539
Page URI
https://pub.uni-bielefeld.de/record/2948631

Zitieren

Schlipkoeter KE, Betke T, Kleber J, Gröger H, Liese A. Fatty alcohol synthesis from fatty acids at mild temperature by subsequent enzymatic esterification and metal-catalyzed hydrogenation. Organic and Biomolecular Chemistry . 2020;18(39):7862-7867.
Schlipkoeter, K. E., Betke, T., Kleber, J., Gröger, H., & Liese, A. (2020). Fatty alcohol synthesis from fatty acids at mild temperature by subsequent enzymatic esterification and metal-catalyzed hydrogenation. Organic and Biomolecular Chemistry , 18(39), 7862-7867. doi:10.1039/d0ob01561j
Schlipkoeter, K. E., Betke, T., Kleber, J., Gröger, H., and Liese, A. (2020). Fatty alcohol synthesis from fatty acids at mild temperature by subsequent enzymatic esterification and metal-catalyzed hydrogenation. Organic and Biomolecular Chemistry 18, 7862-7867.
Schlipkoeter, K.E., et al., 2020. Fatty alcohol synthesis from fatty acids at mild temperature by subsequent enzymatic esterification and metal-catalyzed hydrogenation. Organic and Biomolecular Chemistry , 18(39), p 7862-7867.
K.E. Schlipkoeter, et al., “Fatty alcohol synthesis from fatty acids at mild temperature by subsequent enzymatic esterification and metal-catalyzed hydrogenation”, Organic and Biomolecular Chemistry , vol. 18, 2020, pp. 7862-7867.
Schlipkoeter, K.E., Betke, T., Kleber, J., Gröger, H., Liese, A.: Fatty alcohol synthesis from fatty acids at mild temperature by subsequent enzymatic esterification and metal-catalyzed hydrogenation. Organic and Biomolecular Chemistry . 18, 7862-7867 (2020).
Schlipkoeter, Kim E., Betke, Tobias, Kleber, Joscha, Gröger, Harald, and Liese, Andreas. “Fatty alcohol synthesis from fatty acids at mild temperature by subsequent enzymatic esterification and metal-catalyzed hydrogenation”. Organic and Biomolecular Chemistry 18.39 (2020): 7862-7867.

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