Asymmetric synthesis of an (R)-cyanohydrin using enzymes entrapped in lens-shaped gels

Gröger H, Capan E, Barthuber A, Vorlop KD (2001)
Organic Letters 3(13): 1969-1972.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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DOI
Autor*in
Gröger, HaraldUniBi; Capan, E; Barthuber, A; Vorlop, K D
Einrichtung
Fakultät für Chemie > Industrielle Organische Chemie und Biotechnologie
Abstract / Bemerkung
[structure: see text] A novel synthesis of (R)-cyanohydrins is described which is based on the use of cross-linked and subsequently poly(vinyl alcohol)-entrapped (R)-oxynitrilases. These immobilized lens-shaped biocatalysts have a well-defined macroscopic size in the mm range, show no catalyst leaching, and can be recycled efficiently. Furthermore, this immobilization method is cheap and the entrapped (R)-oxynitrilases gave similar good results compared with those of free enzymes. The (R)-cyanohydrin was obtained in good yields and with high enantioselectivities of up to >99% ee.
Erscheinungsjahr
2001
Zeitschriftentitel
Organic Letters
Band
3
Ausgabe
13
Seite(n)
1969-1972
ISSN
1523-7060
eISSN
1523-7052
Page URI
https://pub.uni-bielefeld.de/record/2347191

Zitieren

Gröger H, Capan E, Barthuber A, Vorlop KD. Asymmetric synthesis of an (R)-cyanohydrin using enzymes entrapped in lens-shaped gels. Organic Letters. 2001;3(13):1969-1972.
Gröger, H., Capan, E., Barthuber, A., & Vorlop, K. D. (2001). Asymmetric synthesis of an (R)-cyanohydrin using enzymes entrapped in lens-shaped gels. Organic Letters, 3(13), 1969-1972. https://doi.org/10.1021/ol015920g
Gröger, Harald, Capan, E, Barthuber, A, and Vorlop, K D. 2001. “Asymmetric synthesis of an (R)-cyanohydrin using enzymes entrapped in lens-shaped gels”. Organic Letters 3 (13): 1969-1972.
Gröger, H., Capan, E., Barthuber, A., and Vorlop, K. D. (2001). Asymmetric synthesis of an (R)-cyanohydrin using enzymes entrapped in lens-shaped gels. Organic Letters 3, 1969-1972.
Gröger, H., et al., 2001. Asymmetric synthesis of an (R)-cyanohydrin using enzymes entrapped in lens-shaped gels. Organic Letters, 3(13), p 1969-1972.
H. Gröger, et al., “Asymmetric synthesis of an (R)-cyanohydrin using enzymes entrapped in lens-shaped gels”, Organic Letters, vol. 3, 2001, pp. 1969-1972.
Gröger, H., Capan, E., Barthuber, A., Vorlop, K.D.: Asymmetric synthesis of an (R)-cyanohydrin using enzymes entrapped in lens-shaped gels. Organic Letters. 3, 1969-1972 (2001).
Gröger, Harald, Capan, E, Barthuber, A, and Vorlop, K D. “Asymmetric synthesis of an (R)-cyanohydrin using enzymes entrapped in lens-shaped gels”. Organic Letters 3.13 (2001): 1969-1972.

9 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

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