Segmented flow processes as an efficient tool to overcome hurdles of whole-cell biocatalysis in organic solvents

Gröger H, Adenbar N, Nastke A, Löwe J (2021)
Angewandte Chemie International Edition 60(29): 15863-15869.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Abstract / Bemerkung
In modern process development, it is imperative to consider biocatalysis, and whole-cell catalysts often represent a favored form of such catalysts. However, the application of whole-cell catalysis in typical organic batch two-phase synthesis often struggles due to mass transfer limitations, emulsion formation, tedious work-up and, thus, low yields. Herein, we demonstrate that utilizing segmented flow tools enables the conduction of whole-cell biocatalysis efficiently in biphasic media. Exemplified for three different biotransformations, the power of such segmented flow processes is shown. For example, a 3-fold increase of conversion from 34% to >99% and a dramatic simplified work-up leading to a 1.5-fold higher yield from 44% to 65% compared to the analogous batch process was achieved in such a flow process. © 2021 Wiley-VCH GmbH.
Erscheinungsjahr
2021
Zeitschriftentitel
Angewandte Chemie International Edition
Band
60
Ausgabe
29
Seite(n)
15863-15869
eISSN
1521-3773
Finanzierungs-Informationen
Open-Access-Publikationskosten wurden durch die Universität Bielefeld im Rahmen des DEAL-Vertrags gefördert.
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https://pub.uni-bielefeld.de/record/2953003

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Gröger H, Adenbar N, Nastke A, Löwe J. Segmented flow processes as an efficient tool to overcome hurdles of whole-cell biocatalysis in organic solvents. Angewandte Chemie International Edition. 2021;60(29):15863-15869.
Gröger, H., Adenbar, N., Nastke, A., & Löwe, J. (2021). Segmented flow processes as an efficient tool to overcome hurdles of whole-cell biocatalysis in organic solvents. Angewandte Chemie International Edition, 60(29), 15863-15869. https://doi.org/10.1002/anie.202015887
Gröger, Harald, Adenbar, Niklas, Nastke, Alina, and Löwe, Jana. 2021. “Segmented flow processes as an efficient tool to overcome hurdles of whole-cell biocatalysis in organic solvents”. Angewandte Chemie International Edition 60 (29): 15863-15869.
Gröger, H., Adenbar, N., Nastke, A., and Löwe, J. (2021). Segmented flow processes as an efficient tool to overcome hurdles of whole-cell biocatalysis in organic solvents. Angewandte Chemie International Edition 60, 15863-15869.
Gröger, H., et al., 2021. Segmented flow processes as an efficient tool to overcome hurdles of whole-cell biocatalysis in organic solvents. Angewandte Chemie International Edition, 60(29), p 15863-15869.
H. Gröger, et al., “Segmented flow processes as an efficient tool to overcome hurdles of whole-cell biocatalysis in organic solvents”, Angewandte Chemie International Edition, vol. 60, 2021, pp. 15863-15869.
Gröger, H., Adenbar, N., Nastke, A., Löwe, J.: Segmented flow processes as an efficient tool to overcome hurdles of whole-cell biocatalysis in organic solvents. Angewandte Chemie International Edition. 60, 15863-15869 (2021).
Gröger, Harald, Adenbar, Niklas, Nastke, Alina, and Löwe, Jana. “Segmented flow processes as an efficient tool to overcome hurdles of whole-cell biocatalysis in organic solvents”. Angewandte Chemie International Edition 60.29 (2021): 15863-15869.
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2022-07-08T07:59:05Z
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