Segmented flow processes as an efficient tool to overcome hurdles of whole-cell biocatalysis in organic solvents

Gröger H, Adenbar N, Nastke A, Löwe J (2021)
Angewandte Chemie International Edition.

Zeitschriftenaufsatz | E-Veröff. vor dem Druck | Englisch
 
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Abstract / Bemerkung
In modern process development, it is imperative to consider biocatalysis, and whole-cell catalysts often represent a favored form of such catalysts. However, the application of whole-cell catalysis in typical organic batch two-phase synthesis often struggles due to mass transfer limitations, emulsion formation, tedious work-up and, thus, low yields. Herein, we demonstrate that utilizing segmented flow tools enables the conduction of whole-cell biocatalysis efficiently in biphasic media. Exemplified for three different biotransformations, the power of such segmented flow processes is shown. For example, a 3-fold increase of conversion from 34% to >99% and a dramatic simplified work-up leading to a 1.5-fold higher yield from 44% to 65% compared to the analogous batch process was achieved in such a flow process. © 2021 Wiley-VCH GmbH.
Erscheinungsjahr
2021
Zeitschriftentitel
Angewandte Chemie International Edition
eISSN
1521-3773
Page URI
https://pub.uni-bielefeld.de/record/2953003

Zitieren

Gröger H, Adenbar N, Nastke A, Löwe J. Segmented flow processes as an efficient tool to overcome hurdles of whole-cell biocatalysis in organic solvents. Angewandte Chemie International Edition. 2021.
Gröger, H., Adenbar, N., Nastke, A., & Löwe, J. (2021). Segmented flow processes as an efficient tool to overcome hurdles of whole-cell biocatalysis in organic solvents. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.202015887
Gröger, H., Adenbar, N., Nastke, A., and Löwe, J. (2021). Segmented flow processes as an efficient tool to overcome hurdles of whole-cell biocatalysis in organic solvents. Angewandte Chemie International Edition.
Gröger, H., et al., 2021. Segmented flow processes as an efficient tool to overcome hurdles of whole-cell biocatalysis in organic solvents. Angewandte Chemie International Edition.
H. Gröger, et al., “Segmented flow processes as an efficient tool to overcome hurdles of whole-cell biocatalysis in organic solvents”, Angewandte Chemie International Edition, 2021.
Gröger, H., Adenbar, N., Nastke, A., Löwe, J.: Segmented flow processes as an efficient tool to overcome hurdles of whole-cell biocatalysis in organic solvents. Angewandte Chemie International Edition. (2021).
Gröger, Harald, Adenbar, Niklas, Nastke, Alina, and Löwe, Jana. “Segmented flow processes as an efficient tool to overcome hurdles of whole-cell biocatalysis in organic solvents”. Angewandte Chemie International Edition (2021).

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