Efficient Enzymatic Amine Resolution at High Substrate Input Using Diethyl Malonate as an Acyl Donor of Low Hazard Potential
Simon S, Osswald S, Roos J, Gröger H (2012)
Zeitschrift für Naturforschung Section B-A Journal Of Chemical Sciences 67b(10): 1123-1126.
Zeitschriftenaufsatz
| Veröffentlicht | Englisch
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Autor*in
Simon, Sabine;
Osswald, Steffen;
Roos, Juergen;
Gröger, HaraldUniBi
Abstract / Bemerkung
Diethyl malonate turned out to be both a "green" and highly efficient acyl donor in the lipase-catalyzed resolution of amines, thus representing an attractive alternative to currently applied acyl donors. By means of this acyl donor a highly efficient enzymatic process for the resolution of amines, running at high substrate input of up to 200 g/L in an organic solvent classified as "usable" according to the Pfizer Solvent Selection Guide, is presented.
Stichworte
Biocatalysis;
Enantioselective Synthesis;
Amines;
Amides;
Enzymatic;
Resolution
Erscheinungsjahr
2012
Zeitschriftentitel
Zeitschrift für Naturforschung Section B-A Journal Of Chemical Sciences
Band
67b
Ausgabe
10
Seite(n)
1123-1126
ISSN
0932-0776
Page URI
https://pub.uni-bielefeld.de/record/2553547
Zitieren
Simon S, Osswald S, Roos J, Gröger H. Efficient Enzymatic Amine Resolution at High Substrate Input Using Diethyl Malonate as an Acyl Donor of Low Hazard Potential. Zeitschrift für Naturforschung Section B-A Journal Of Chemical Sciences. 2012;67b(10):1123-1126.
Simon, S., Osswald, S., Roos, J., & Gröger, H. (2012). Efficient Enzymatic Amine Resolution at High Substrate Input Using Diethyl Malonate as an Acyl Donor of Low Hazard Potential. Zeitschrift für Naturforschung Section B-A Journal Of Chemical Sciences, 67b(10), 1123-1126. doi:10.5560/ZNB.2012-0127
Simon, Sabine, Osswald, Steffen, Roos, Juergen, and Gröger, Harald. 2012. “Efficient Enzymatic Amine Resolution at High Substrate Input Using Diethyl Malonate as an Acyl Donor of Low Hazard Potential”. Zeitschrift für Naturforschung Section B-A Journal Of Chemical Sciences 67b (10): 1123-1126.
Simon, S., Osswald, S., Roos, J., and Gröger, H. (2012). Efficient Enzymatic Amine Resolution at High Substrate Input Using Diethyl Malonate as an Acyl Donor of Low Hazard Potential. Zeitschrift für Naturforschung Section B-A Journal Of Chemical Sciences 67b, 1123-1126.
Simon, S., et al., 2012. Efficient Enzymatic Amine Resolution at High Substrate Input Using Diethyl Malonate as an Acyl Donor of Low Hazard Potential. Zeitschrift für Naturforschung Section B-A Journal Of Chemical Sciences, 67b(10), p 1123-1126.
S. Simon, et al., “Efficient Enzymatic Amine Resolution at High Substrate Input Using Diethyl Malonate as an Acyl Donor of Low Hazard Potential”, Zeitschrift für Naturforschung Section B-A Journal Of Chemical Sciences, vol. 67b, 2012, pp. 1123-1126.
Simon, S., Osswald, S., Roos, J., Gröger, H.: Efficient Enzymatic Amine Resolution at High Substrate Input Using Diethyl Malonate as an Acyl Donor of Low Hazard Potential. Zeitschrift für Naturforschung Section B-A Journal Of Chemical Sciences. 67b, 1123-1126 (2012).
Simon, Sabine, Osswald, Steffen, Roos, Juergen, and Gröger, Harald. “Efficient Enzymatic Amine Resolution at High Substrate Input Using Diethyl Malonate as an Acyl Donor of Low Hazard Potential”. Zeitschrift für Naturforschung Section B-A Journal Of Chemical Sciences 67b.10 (2012): 1123-1126.
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