Recombinant Delta(4,5)-Steroid 5 beta-Reductases as Biocatalysts for the Reduction of Activated C=C-Double Bonds in Monocyclic and Acyclic Molecules

Burda E, Krausser M, Fischer G, Hummel W, Mueller-Uri F, Kreis W, Gröger H (2009)
ADVANCED SYNTHESIS & CATALYSIS 351(17): 2787-2790.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Burda, Edyta; Krausser, Marina; Fischer, Gabriele; Hummel, Werner; Mueller-Uri, Frieder; Kreis, Wolfgang; Gröger, HaraldUniBi
Abstract / Bemerkung
It was found that Delta(4,5)-steroid 5 beta-reductases are capable of reducing also small molecules bearing an activated C=C double bond such as monocyclic enones and acyclic enoate esters. As preferred Delta(4,5)-steroid 5 beta-reductase (5 beta-StR) for this purpose, 5 beta-StR from Arabidopsis thaliana was used. In part. enzyme activities are even higher than that for progesterone. Successful preliminary biotransformations with enzymatic in situ cofactor recycling were also carried out. When using the prochiral compound isophorone as a substrate, a high enantioselective reaction course (>99% ee) was observed.
Erscheinungsjahr
2009
Zeitschriftentitel
ADVANCED SYNTHESIS & CATALYSIS
Band
351
Ausgabe
17
Seite(n)
2787-2790
ISSN
1615-4150
eISSN
1615-4169
Page URI
https://pub.uni-bielefeld.de/record/2344799

Zitieren

Burda E, Krausser M, Fischer G, et al. Recombinant Delta(4,5)-Steroid 5 beta-Reductases as Biocatalysts for the Reduction of Activated C=C-Double Bonds in Monocyclic and Acyclic Molecules. ADVANCED SYNTHESIS & CATALYSIS. 2009;351(17):2787-2790.
Burda, E., Krausser, M., Fischer, G., Hummel, W., Mueller-Uri, F., Kreis, W., & Gröger, H. (2009). Recombinant Delta(4,5)-Steroid 5 beta-Reductases as Biocatalysts for the Reduction of Activated C=C-Double Bonds in Monocyclic and Acyclic Molecules. ADVANCED SYNTHESIS & CATALYSIS, 351(17), 2787-2790. https://doi.org/10.1002/adsc.200900024
Burda, E., Krausser, M., Fischer, G., Hummel, W., Mueller-Uri, F., Kreis, W., and Gröger, H. (2009). Recombinant Delta(4,5)-Steroid 5 beta-Reductases as Biocatalysts for the Reduction of Activated C=C-Double Bonds in Monocyclic and Acyclic Molecules. ADVANCED SYNTHESIS & CATALYSIS 351, 2787-2790.
Burda, E., et al., 2009. Recombinant Delta(4,5)-Steroid 5 beta-Reductases as Biocatalysts for the Reduction of Activated C=C-Double Bonds in Monocyclic and Acyclic Molecules. ADVANCED SYNTHESIS & CATALYSIS, 351(17), p 2787-2790.
E. Burda, et al., “Recombinant Delta(4,5)-Steroid 5 beta-Reductases as Biocatalysts for the Reduction of Activated C=C-Double Bonds in Monocyclic and Acyclic Molecules”, ADVANCED SYNTHESIS & CATALYSIS, vol. 351, 2009, pp. 2787-2790.
Burda, E., Krausser, M., Fischer, G., Hummel, W., Mueller-Uri, F., Kreis, W., Gröger, H.: Recombinant Delta(4,5)-Steroid 5 beta-Reductases as Biocatalysts for the Reduction of Activated C=C-Double Bonds in Monocyclic and Acyclic Molecules. ADVANCED SYNTHESIS & CATALYSIS. 351, 2787-2790 (2009).
Burda, Edyta, Krausser, Marina, Fischer, Gabriele, Hummel, Werner, Mueller-Uri, Frieder, Kreis, Wolfgang, and Gröger, Harald. “Recombinant Delta(4,5)-Steroid 5 beta-Reductases as Biocatalysts for the Reduction of Activated C=C-Double Bonds in Monocyclic and Acyclic Molecules”. ADVANCED SYNTHESIS & CATALYSIS 351.17 (2009): 2787-2790.

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