Biocatalytic production of adiponitrile and related aliphatic linear α,ω-dinitriles

Betke T, Maier M, Gruber-Wölfler H, Gröger H (2018)
Nature Communications 9: 5112.

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Abstract / Bemerkung
Linear α,ω-dinitriles are important precursors for the polymer industry. Most prominently, adiponitrile is produced on an annual scale of ca. 1 million tons. However, a drawback of today’s dominating process is the need for large amounts of highly toxic hydrogen cyanide. In this contribution, an alternative approach towards such linear dinitriles is presented based on dehydration of readily available α,ω-dialdoximes at ambient conditions by means of aldoxime dehydratases. In contrast to existing production routes this biocatalytic route enables a highly regio- and chemoselective approach towards dinitriles without the use of hydrogen cyanide or harsh reaction conditions. In addition, a selective synthesis of adiponitrile with substrate loadings of up to 100 g/L and high yields of up to 80% was achieved. Furthermore, a lab scale process on liter scale leading to > 99% conversion at 50 g/L underlines the potential and robustness of this method for technical applicability.
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Zeitschriftentitel
Nature Communications
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9
Artikelnummer
5112
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Article Processing Charge funded by the Deutsche Forschungsgemeinschaft and the Open Access Publication Fund of Bielefeld University.
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Betke T, Maier M, Gruber-Wölfler H, Gröger H. Biocatalytic production of adiponitrile and related aliphatic linear α,ω-dinitriles. Nature Communications. 2018;9: 5112.
Betke, T., Maier, M., Gruber-Wölfler, H., & Gröger, H. (2018). Biocatalytic production of adiponitrile and related aliphatic linear α,ω-dinitriles. Nature Communications, 9, 5112. doi:10.1038/s41467-018-07434-0
Betke, T., Maier, M., Gruber-Wölfler, H., and Gröger, H. (2018). Biocatalytic production of adiponitrile and related aliphatic linear α,ω-dinitriles. Nature Communications 9:5112.
Betke, T., et al., 2018. Biocatalytic production of adiponitrile and related aliphatic linear α,ω-dinitriles. Nature Communications, 9: 5112.
T. Betke, et al., “Biocatalytic production of adiponitrile and related aliphatic linear α,ω-dinitriles”, Nature Communications, vol. 9, 2018, : 5112.
Betke, T., Maier, M., Gruber-Wölfler, H., Gröger, H.: Biocatalytic production of adiponitrile and related aliphatic linear α,ω-dinitriles. Nature Communications. 9, : 5112 (2018).
Betke, Tobias, Maier, Manuel, Gruber-Wölfler, Heidrun, and Gröger, Harald. “Biocatalytic production of adiponitrile and related aliphatic linear α,ω-dinitriles”. Nature Communications 9 (2018): 5112.
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2018-12-03T06:54:03Z

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