Synthetic Processes toward Nitriles without the Use of Cyanide: A Biocatalytic Concept Based on Dehydration of Aldoximes in Water

Hinzmann A, Betke T, Asano Y, Gröger H (2021)
Chemistry – A European Journal 27(17): 5313-5321.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Abstract / Bemerkung
While belonging to the most fundamental functional groups, nitriles represent a class of compound that still raises challenges in terms of an efficient, cost‐effective, general and, at the same time, sustainable way for their synthesis. Complementing existing chemical routes, recently a cyanide‐free enzymatic process technology based on the use of an aldoxime dehydratase (Oxd) as a biocatalyst component has been developed and successfully applied for the synthesis of a range of nitrile products. In these biotransformations, the Oxd enzymes catalyze the dehydration of aldoximes as readily available substrates to the nitrile products. Herein, these developments with such enzymes are summarized, with a strong focus on synthetic applications. It is demonstrated that this biocatalytic technology has the potential to “cross the bridge” between the production of fine chemicals and pharmaceuticals, on one hand, and bulk and commodity chemicals, on the other.
Erscheinungsjahr
2021
Zeitschriftentitel
Chemistry – A European Journal
Band
27
Ausgabe
17
Seite(n)
5313-5321
ISSN
0947-6539
eISSN
1521-3765
Finanzierungs-Informationen
Open-Access-Publikationskosten wurden durch die Universität Bielefeld im Rahmen des DEAL-Vertrags gefördert.
Page URI
https://pub.uni-bielefeld.de/record/2953112

Zitieren

Hinzmann A, Betke T, Asano Y, Gröger H. Synthetic Processes toward Nitriles without the Use of Cyanide: A Biocatalytic Concept Based on Dehydration of Aldoximes in Water. Chemistry – A European Journal. 2021;27(17):5313-5321.
Hinzmann, A., Betke, T., Asano, Y., & Gröger, H. (2021). Synthetic Processes toward Nitriles without the Use of Cyanide: A Biocatalytic Concept Based on Dehydration of Aldoximes in Water. Chemistry – A European Journal, 27(17), 5313-5321. https://doi.org/10.1002/chem.202001647
Hinzmann, A., Betke, T., Asano, Y., and Gröger, H. (2021). Synthetic Processes toward Nitriles without the Use of Cyanide: A Biocatalytic Concept Based on Dehydration of Aldoximes in Water. Chemistry – A European Journal 27, 5313-5321.
Hinzmann, A., et al., 2021. Synthetic Processes toward Nitriles without the Use of Cyanide: A Biocatalytic Concept Based on Dehydration of Aldoximes in Water. Chemistry – A European Journal, 27(17), p 5313-5321.
A. Hinzmann, et al., “Synthetic Processes toward Nitriles without the Use of Cyanide: A Biocatalytic Concept Based on Dehydration of Aldoximes in Water”, Chemistry – A European Journal, vol. 27, 2021, pp. 5313-5321.
Hinzmann, A., Betke, T., Asano, Y., Gröger, H.: Synthetic Processes toward Nitriles without the Use of Cyanide: A Biocatalytic Concept Based on Dehydration of Aldoximes in Water. Chemistry – A European Journal. 27, 5313-5321 (2021).
Hinzmann, Alessa, Betke, Tobias, Asano, Yasuhisa, and Gröger, Harald. “Synthetic Processes toward Nitriles without the Use of Cyanide: A Biocatalytic Concept Based on Dehydration of Aldoximes in Water”. Chemistry – A European Journal 27.17 (2021): 5313-5321.
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2021-03-23T10:17:42Z
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