Chemoenzymatic Cascades toward Aliphatic Nitriles Starting from Biorenewable Feedstocks

Hinzmann A, Stricker M, Gröger H (2020)
ACS SUSTAINABLE CHEMISTRY & ENGINEERING 8(46): 17088-17096.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Abstract / Bemerkung
A modern concept of producing nitriles involves aldoxime dehydratases, which are capable of dehydrating aldoximes to the corresponding nitriles without need of a cofactor. Aldoximes as the starting material for nitrile synthesis are easily prepared by condensation of hydroxylamine with the corresponding aldehydes. In this contribution we present chemoenzymatic cascade reactions toward nitriles consisting of an initial nitroxyl radical-catalyzed oxidation of aliphatic alcohols to aldehydes using sodium hypochlorite as the oxidation agent, subsequent condensation of the aldehyde with hydroxylamine, and a biocatalytic dehydration using aldoxime dehydratases to the corresponding nitriles without isolation of intermediates and using the product nitrile as a solvent. These formal "solvent-free" cascades open up the possibility to use biorenewable sources, namely fatty acids, as the starting material for a chemoenzymatic nitrile synthesis. We were also able to apply this cascade concept for the synthesis of aliphatic dinitriles, which are used as, e.g., a precursor for polymer building blocks. Overall yields without isolation of intermediates of up to 70% with very simple product isolation were achieved.
Stichworte
Aldoxime dehydratase; Nitriles; Cascade reactions; TEMPO-oxidation; Biorenewables
Erscheinungsjahr
2020
Zeitschriftentitel
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
Band
8
Ausgabe
46
Seite(n)
17088-17096
ISSN
2168-0485
Page URI
https://pub.uni-bielefeld.de/record/2950691

Zitieren

Hinzmann A, Stricker M, Gröger H. Chemoenzymatic Cascades toward Aliphatic Nitriles Starting from Biorenewable Feedstocks. ACS SUSTAINABLE CHEMISTRY & ENGINEERING. 2020;8(46):17088-17096.
Hinzmann, A., Stricker, M., & Gröger, H. (2020). Chemoenzymatic Cascades toward Aliphatic Nitriles Starting from Biorenewable Feedstocks. ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 8(46), 17088-17096. doi:10.1021/acssuschemeng.0c04981
Hinzmann, A., Stricker, M., and Gröger, H. (2020). Chemoenzymatic Cascades toward Aliphatic Nitriles Starting from Biorenewable Feedstocks. ACS SUSTAINABLE CHEMISTRY & ENGINEERING 8, 17088-17096.
Hinzmann, A., Stricker, M., & Gröger, H., 2020. Chemoenzymatic Cascades toward Aliphatic Nitriles Starting from Biorenewable Feedstocks. ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 8(46), p 17088-17096.
A. Hinzmann, M. Stricker, and H. Gröger, “Chemoenzymatic Cascades toward Aliphatic Nitriles Starting from Biorenewable Feedstocks”, ACS SUSTAINABLE CHEMISTRY & ENGINEERING, vol. 8, 2020, pp. 17088-17096.
Hinzmann, A., Stricker, M., Gröger, H.: Chemoenzymatic Cascades toward Aliphatic Nitriles Starting from Biorenewable Feedstocks. ACS SUSTAINABLE CHEMISTRY & ENGINEERING. 8, 17088-17096 (2020).
Hinzmann, Alessa, Stricker, Michael, and Gröger, Harald. “Chemoenzymatic Cascades toward Aliphatic Nitriles Starting from Biorenewable Feedstocks”. ACS SUSTAINABLE CHEMISTRY & ENGINEERING 8.46 (2020): 17088-17096.

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