An Asymmetric Organocatalytic Aldol Reaction of a Hydrophobic Aldehyde in Aqueous Medium Running in Flow Mode
Schober L, Ratnam S, Yamashita Y, Adebar N, Pieper M, Berkessel A, Hessel V, Gröger H (2019)
Synthesis 51(5): 1178-1184.
Zeitschriftenaufsatz
| Veröffentlicht | Englisch
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s-0037-1610404.pdf
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Autor*in
Schober, LukasUniBi;
Ratnam, Shahilan;
Yamashita, YasunobuUniBi;
Adebar, NiklasUniBi;
Pieper, MatthiasUniBi;
Berkessel, Albrecht;
Hessel, Volker;
Gröger, HaraldUniBi
Abstract / Bemerkung
Reaction conditions have been identified to conduct a one-pot asymmetric organocatalytic aldol reaction with a hydrophobic substrate in aqueous medium via a process running in flow mode. By employing a mixture of water and 2-propanol, a hydrophobic aldehyde and 3.6 mol% of an organocatalyst, this microreactor process affords the desired aldol adduct with a conversion of 74% and an enantioselectivity of 89% after a reaction time of 60 minutes.
Stichworte
aldol reaction;
asymmetric catalysis;
continuously running processes;
flow chemistry;
organocatalysis;
water
Erscheinungsjahr
2019
Zeitschriftentitel
Synthesis
Band
51
Ausgabe
5
Seite(n)
1178-1184
Urheberrecht / Lizenzen
ISSN
0039-7881
eISSN
1437-210X
Page URI
https://pub.uni-bielefeld.de/record/2934376
Zitieren
Schober L, Ratnam S, Yamashita Y, et al. An Asymmetric Organocatalytic Aldol Reaction of a Hydrophobic Aldehyde in Aqueous Medium Running in Flow Mode. Synthesis. 2019;51(5):1178-1184.
Schober, L., Ratnam, S., Yamashita, Y., Adebar, N., Pieper, M., Berkessel, A., Hessel, V., et al. (2019). An Asymmetric Organocatalytic Aldol Reaction of a Hydrophobic Aldehyde in Aqueous Medium Running in Flow Mode. Synthesis, 51(5), 1178-1184. doi:10.1055/s-0037-1610404
Schober, Lukas, Ratnam, Shahilan, Yamashita, Yasunobu, Adebar, Niklas, Pieper, Matthias, Berkessel, Albrecht, Hessel, Volker, and Gröger, Harald. 2019. “An Asymmetric Organocatalytic Aldol Reaction of a Hydrophobic Aldehyde in Aqueous Medium Running in Flow Mode”. Synthesis 51 (5): 1178-1184.
Schober, L., Ratnam, S., Yamashita, Y., Adebar, N., Pieper, M., Berkessel, A., Hessel, V., and Gröger, H. (2019). An Asymmetric Organocatalytic Aldol Reaction of a Hydrophobic Aldehyde in Aqueous Medium Running in Flow Mode. Synthesis 51, 1178-1184.
Schober, L., et al., 2019. An Asymmetric Organocatalytic Aldol Reaction of a Hydrophobic Aldehyde in Aqueous Medium Running in Flow Mode. Synthesis, 51(5), p 1178-1184.
L. Schober, et al., “An Asymmetric Organocatalytic Aldol Reaction of a Hydrophobic Aldehyde in Aqueous Medium Running in Flow Mode”, Synthesis, vol. 51, 2019, pp. 1178-1184.
Schober, L., Ratnam, S., Yamashita, Y., Adebar, N., Pieper, M., Berkessel, A., Hessel, V., Gröger, H.: An Asymmetric Organocatalytic Aldol Reaction of a Hydrophobic Aldehyde in Aqueous Medium Running in Flow Mode. Synthesis. 51, 1178-1184 (2019).
Schober, Lukas, Ratnam, Shahilan, Yamashita, Yasunobu, Adebar, Niklas, Pieper, Matthias, Berkessel, Albrecht, Hessel, Volker, and Gröger, Harald. “An Asymmetric Organocatalytic Aldol Reaction of a Hydrophobic Aldehyde in Aqueous Medium Running in Flow Mode”. Synthesis 51.5 (2019): 1178-1184.
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