175 Publications

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[175]
2017 | Journal Article | PUB-ID: 2912737
Taking control over microbial populations: Current approaches for exploiting biological noise in bioprocesses
Delvigne F, Baert J, Sassi H, Fickers P, Grünberger A, Dusny C (2017)
Biotechnology Journal 12(7): 1600549.
PUB | DOI | WoS | PubMed | Europe PMC
 
[174]
2017 | Conference Abstract | PUB-ID: 2912771
Microfluidic single-cell (co-)cultivation: Exploring the next dimension
Rudat A, Noack S, Wiechert W, Kohlheyer D, Grünberger A (2017)
Presented at the Data-driven Biotechnology - bench, bioreactor and bedside, Copenhagen, Denmark.
PUB
 
[173]
2017 | Conference Abstract | PUB-ID: 2912759
Microfluidic Single-Cell Cultivation: A key for next generation bioprocess development?
Grünberger A (2017)
Presented at the FFBiotech Symposium - Innovative approaches in bioreactors design and operation, Lille, France.
PUB
 
[172]
2017 | Journal Article | PUB-ID: 2912738
Coarse-graining bacteria colonies for modelling critical solute distributions in picolitre bioreactors for bacterial studies on single-cell level
Westerwalbesloh C, Grünberger A, Wiechert W, Kohlheyer D, von Lieres E (2017)
Microbial Biotechnology 10(4): 845-857.
PUB | DOI | PubMed | Europe PMC
 
[171]
2017 | Journal Article | PUB-ID: 2912521
Real-time monitoring of fungal growth and morphogenesis at single-cell resolution
Grünberger A, Schöler K, Probst C, Kornfeld G, Hardiman T, Wiechert W, Kohlheyer D, Noack S (2017)
Engineering in life sciences 17(1): 86–92.
PUB | DOI
 
[170]
2017 | Book Chapter | PUB-ID: 2912520
Application of Mini- and Micro-Bioreactors for Microbial Bioprocesses
Ladner T, Grünberger A, Probst C, Kohlheyer D, Büchs J, Delvigne F (2017)
In: Current Developments in Biotechnology and Bioengineering. Larroche C, Sanromán MÁ, Du G, Pandey A (Eds); Amsterdam: Elsevier: 433-461.
PUB | DOI
 
[169]
2017 | Conference Paper | PUB-ID: 2912518
Microfluidic device for control and sensing of dynamic oxygen levels during cell cultivation
Kaganovitch E, Krischer M, Probst C, Grünberger A, Zunic E, Freier C, Wiechert W, Kohlheyer D (2017)
In: 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016). Red Hook, NY: Curran Associates, Inc.: 355-356.
PUB
 
[168]
2017 | Conference Abstract | PUB-ID: 2912509
Microfluidic cultivation chamber for the investigation of synthetic microbial co-cultures on single-cell level: From the development to first application
Rudat A, Wiechert W, Kohlheyer D, Grünberger A (2017)
Presented at the BioProcessing Days 2017, Recklinghausen, Germany.
PUB
 
[167]
2017 | Conference Abstract | PUB-ID: 2912508
Microfluidic heterogeneity analysis of fluorescence-based gene expression of industrially relevant production strains on single-cell level
Burmeister A, Bitzenhofer NL, Grünberger A, Binder D, Drepper T, Wiechert W, Kohlheyer D (2017)
Presented at the BioProcessing Days 2017, Recklinghausen, Germany.
PUB
 
[166]
2017 | Conference Abstract | PUB-ID: 2912507
Spatiotemporal analysis of synthetic microbial communities at the single-cell level in microfluidic interaction compartments
Rudat A, Wiechert W, Kohlheyer D, Grünberger A (2017)
Presented at the 6th International Conference on Microbial Communication for Young Scientists, Jena, Germany.
PUB
 
[165]
2017 | Conference Abstract | PUB-ID: 2912506
Integrated High-Throughput Platform for Microfluidic Live-Cell Analysis with Feed-Back Eyperimentation
Sachs CC, Grünberger A, Probst C, Wiechert W, Kohlheyer D, Nöh K (2017)
Presented at the DECHEMA-Tagung "Systems Biology meets Synthetic Biology", Frankfurt, Germany.
PUB
 
[164]
2017 | Conference Abstract | PUB-ID: 2912505
Microfluidic single-cell cultivation of S. lividans: Uncovering heterogeneity in filamentous growth
Sachs CC, Koepff J, Kohlheyer D, Wiechert W, Oldiges M, Nöh K, Grünberger A (2017)
Presented at the DECHEMA-Tagung "Systems Biology meets Synthetic Biology", Frankfurt, Germany.
PUB
 
[163]
2017 | Conference Abstract | PUB-ID: 2912504
Models for Developing and Optimizing Microscale Bacteria Cultivation
Westerwalbesloh C, Grünberger A, Wiechert W, Kohlheyer D, von Lieres E (2017)
Presented at the Himmelfahrtstagung 2017: Models for Developing and Optimising Biotech Production, Neu-Ulm, Germany.
PUB
 
[162]
2017 | Conference Abstract | PUB-ID: 2912503
Picoliter bioreactors for microbial consortia: From proof of concept to first application
Rudat A, Wiechert W, Kohlheyer D, Grünberger A (2017)
Presented at the Himmelfahrtstagung 2017: Models for Developing and Optimising Biotech Production, Neu-Ulm, Germany.
PUB
 
[161]
2017 | Conference Abstract | PUB-ID: 2912502
Functionally-active protein aggregates - towards the realization of an enzyme cascade in catalytically-active inclusion bodies
Jäger VD, Longerich S, Dietrich M, Kloss R, Grünberger A, Pohl M, Jaeger K-E, Krauss U (2017)
Presented at the BioTrans 2017, Budapest, Hungary.
PUB
 
[160]
2017 | Conference Abstract | PUB-ID: 2912501
Catalytically active inclusion bodies: A novel carrier-free Enzyme Immobilisation method
Kloss R, Limberg M, Jäger VD, Mackfeld U, Karmainski T, Grünberger A, Krauss U, Pohl M (2017)
Presented at the BioTrans 2017, Budapest, Hungary.
PUB
 
[159]
2016 | Conference Abstract | PUB-ID: 2912820
Combinatorial antibiotic effects of natural biocide cocktails
Hage-Hülsmann J, Grünberger A, Thies S, Domröse A, Klein A, Binder D, Hilgers F, Kohlheyer D, Pietruszka J, Jaeger KE, Drepper T, et al. (2016)
Presented at the IV International Conference on Antimicrobial Research, Malaga, Spain.
PUB
 
[158]
2016 | Conference Abstract | PUB-ID: 2912532
Characterizing substrate availability within microfluidic tools employed for the analysis of genetically modified single cells
Westerwalbesloh C, Grünberger A, Stute B, Weber S, Kohlheyer D, von Lieres E (2016)
Presented at the 1. International Conference on Molecular Interaction Engineering (MIE), Karlsruhe, Germany.
PUB
 
[157]
2016 | Conference Abstract | PUB-ID: 2912803
Employing photocaged carbohydrates in light-controlled cell factories for synthetic bio(techno)logy and single cell applications
Binder D, Bier C, Grünberger A, Hilgers F, Loeschcke A, Kohlheyer D, Pietruszka J, Jaeger KE, Drepper T (2016)
Presented at the Annual Conference of the Association for General and Applied Microbiology (VAAM),, Jena, Germany.
PUB
 
[156]
2016 | Conference Abstract | PUB-ID: 2912772
Spatio-temporal analysis of bacterial populations at single-cell level
Grünberger A, Sachs C, Kohlheyer D, Wiechert W, Nöh K (2016)
Presented at the IBG Modelling Workshop, Jülich, Germany.
PUB
 
[155]
2016 | Conference Abstract | PUB-ID: 2912540
Bacterial phase diagrams – Using engineering concepts to predict cell-to-cell heterogeneity of microbial gene expression
Grünberger A, Steffens I, Binder D, Drepper T, Wiechert W, Kohlheyer D (2016)
Presented at the Jahrestagung 2016 der Vereinigung für Allgemeine und Angewandte Mikrobiologie, Jena, Germany.
PUB
 
[154]
2016 | Conference Abstract | PUB-ID: 2912761
Microfluidic single-cell bioreactors: Introduction, application and future perspectives
Grünberger A (2016)
Presented at the LCSB Biannual Minisymposia in Modelling/Automation/Microfluidics at the University of Luxembourg, Esch-sur-Alzette, Luxembourg.
PUB
 
[153]
2016 | Conference Abstract | PUB-ID: 2912760
Picoliter bioreactors for microbial consortia: A novel concept to investigate microbial interactions at the single-cell level
Grünberger A (2016)
Presented at the SynComBio Workshop “Applications of synthetic microbial communities in bioeconomy", Düsseldorf, Germany.
PUB
 
[152]
2016 | Conference Abstract | PUB-ID: 2912526
Comparison of different cultivation chamber designs for microfluidic bioreactors
Westerwalbesloh C, Grünberger A, Wiechert W, Kohlheyer D, von Lieres E (2016)
Chemie Ingenieur Technik 88(9): 1390.
PUB | DOI
 
[151]
2016 | Journal Article | PUB-ID: 2912739
Enhanced protein and biochemical production using CRISPRi-based growth switches
Li S, Jendresen CB, Grünberger A, Ronda C, Jensen SI, Noack S, Nielsen AT (2016)
Metabolic Engineering 38: 274-284.
PUB | DOI | PubMed | Europe PMC
 
[150]
2016 | Journal Article | PUB-ID: 2912514
Comparative Single-Cell Analysis of Different E. coli Expression Systems during Microfluidic Cultivation
Binder D, Probst C, Grünberger A, Hilgers F, Loeschcke A, Jaeger K-E, Kohlheyer D, Drepper T (2016)
PLoS one 11(8): e0160711.
PUB | PDF | DOI | WoS | PubMed | Europe PMC
 
[149]
2016 | Journal Article | PUB-ID: 2912522
Image-Based Single Cell Profiling: High-Throughput Processing of Mother Machine Experiments
Sachs CC, Grünberger A, Helfrich S, Probst C, Wiechert W, Kohlheyer D, Nöh K (2016)
PLoS one 11(9): e0163453 -.
PUB | PDF | DOI | WoS | PubMed | Europe PMC
 
[148]
2016 | Conference Abstract | PUB-ID: 2912539
Nutrient distribution in perfusion based picoliter bioreactors
Westerwalbesloh C, Grünberger A, Stute B, Weber S, Wiechert W, Kohlheyer D, von Lieres E (2016)
Presented at the 4th BioProScale Symposium "Bioprocess intensification through process analytical technology (PAT) and quality by design (QbD)", Berlin, Germany.
PUB
 
[147]
2016 | Conference Abstract | PUB-ID: 2912538
Bacterial phase diagrams: Analyzing and predicting cell-to-cell heterogeneity of microbial gene expression
Steffens I, Grünberger A, Binder D, Drepper T, Wiechert W, Kohlheyer D (2016)
Presented at the 4th BioProScale Symposium "Bioprocess intensification through process analytical technology (PAT) and quality by design (QbD)", Berlin (Germany.
PUB
 
[146]
2016 | Conference Abstract | PUB-ID: 2912537
Bioprocesses under magnification: Learning from single cells about large-scale processes
Grünberger A, Wiechert W, Kohlheyer D (2016)
Presented at the 4th BioProScale Symposium "Bioprocess intensification through process analytical technology (PAT) and quality by design (QbD)", Berlin, Germany.
PUB
 
[145]
2016 | Journal Article | PUB-ID: 2912544
Photocaged Arabinose - A Novel Optogenetic Switch for Rapid and Gradual Control of Microbial Gene Expression
Binder D, Bier C, Grünberger A, Drobietz D, Hage-Hülsmann J, rey G, Büchs J, Kohlheyer D, Loeschcke A, Wiechert W, Jaeger K-E, et al. (2016)
ChemBioChem 17(4): 296-299.
PUB | DOI | WoS | PubMed | Europe PMC
 
[144]
2016 | Conference Paper | PUB-ID: 2912552
Closing the gap between microfluidic single-cell analysis and bioprocess development for microbial organisms
Probst C, Freier C, Mahr R, Grünberger A, Helfrich S, Wiechert W, Nöh K, Frunzke J, Kohlheyer D (2016)
In: 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2015). Red Hook, NY: Curran Associates, Inc.: 537-539.
PUB
 
[143]
2016 | Conference Abstract | PUB-ID: 2912536
An integrated platform for dynamic microfluidic experimentation with single-cell resolution
Sachs CC, Probst C, Grünberger A, Wiechert W, Frunzke J, Kohlheyer D, Nöh K (2016)
Presented at the DECHEMA-Tagung 'Single Cell Technologies 2016', Frankfurt, Germany.
PUB
 
[142]
2016 | Conference Abstract | PUB-ID: 2912535
Bacterial phase diagrams: A novel concept to predict and control bacterial gene expression
Grünberger A, Steffens I, Binder D, Drepper T, Wiechert W, Kohlheyer D (2016)
Presented at the DECHEMA-Himmelfahrtstagung: New Frontiers for Biotech Processes, Koblenz, Germany.
PUB
 
[141]
2016 | Conference Abstract | PUB-ID: 2912534
Single-cell microfluidics for bioprocess development
Grünberger A (2016)
Presented at the GreenWin Conferences “Green Chemistry and White Biotechnology", Gembloux, Belgium.
PUB
 
[140]
2016 | Conference Abstract | PUB-ID: 2912531
Modeling inhomogeneities across cultivation chamber arrays in single-cell cultivation devices
Westerwalbesloh C, Grünberger A, Kohlheyer D, von Lieres E (2016)
Presented at the EMBL Conference Microfluidics, Heidelberg (Germany.
PUB
 
[139]
2016 | Conference Abstract | PUB-ID: 2912530
Single-cell analysis of E. coli in microfluidic batch reactors
Kaganovitch E, Probst C, Westerwalbesloh C, Grünberger A, Wiechert W, Kohlheyer D (2016)
Presented at the EMBL Conference Microfluidics, Heidelberg (Germany.
PUB
 
[138]
2016 | Conference Abstract | PUB-ID: 2912529
Microbial metabolic state diagrams: Using microfluidic single-cell cultivation to predict bacterial gene expresssion
Grünberger A, Steffens I, Binder D, Drepper T, Wiechert W, Kohlheyer D (2016)
Presented at the EMBL Conference Microfluidics, Heidelberg, Germany.
PUB
 
[137]
2016 | Conference Abstract | PUB-ID: 2912527
Microfluidic single-cell cultivation: Is small the new beautiful?
Grünberger A (2016)
Presented at the 6th International Bielefeld-CeBiTec Research Conference: Advances in Industrial Biotechnology: New Techniques, Substrates and Products for Bioprocesses, Bielefeld, Germany.
PUB
 
[136]
2016 | Conference Abstract | PUB-ID: 2912525
Microfluidic heterogeneity analysis of fluorescence-based gene expression of industrially relevant production strains on single-cell level
Burmeister A, Bitzenhofer NL, Grünberger A, Binder D, Drepper T, Wiechert W (2016)
Presented at the 18. Heiligenstädter Kolloquium „Technische Systeme für die Lebenswissenschaften, Heiligenstadt, Germany.
PUB
 
[135]
2016 | Conference Abstract | PUB-ID: 2912524
Microfluidic cultivation of the microalgae Chlorella sorokiniana on single-cell level at defined environments
Brehl C, Grünberger A, Probst C, Pfaff C, Wiechert W, Behrendt D, Kohlheyer D (2016)
Presented at the 9. DECHEMA Bundesalgenstammtisch, Jülich, Germany.
PUB
 
[134]
2016 | Conference Abstract | PUB-ID: 2912523
Microfluidic cultivation of the microalgae Chlorella sorokiniana on single-cell level at defined environments
Brehl C, Grünberger A, Probst C, Pfaff C, Wiechert W, Behrendt D, Kohlheyer D (2016)
Presented at the ProcessNet 2016, Aachen, Germany.
PUB
 
[133]
2016 | Journal Article | PUB-ID: 2904866
Light-controlled cell factories – Employing photocaged IPTG for light-mediated optimization of lac-based gene expression and (+)-valencene biosynthesis in Corynebacterium glutamicum
Binder D, Frohwitter J, Mahr R, Bier C, Grünberger A, Loeschcke A, Peters-Wendisch P, Kohlheyer D, Pietruszka J, Frunzke J, Jaeger K-E, et al. (2016)
Appl Environ Microbiol 82: 6141-6149.
PUB | DOI | WoS | PubMed | Europe PMC
 
[132]
2016 | Journal Article | PUB-ID: 2912513
Optogenetic Regulation of Tunable Gene Expression in Yeast Using Photo-Labile Caged Methionine
Kusen PM, Wandrey G, Probst C, Grünberger A, Holz M, Meyer zu Berstenhorst S, Kohlheyer D, Büchs J, Pietruszka J (2016)
ACS chemical biology 11(10): 2915-2922.
PUB | DOI | WoS | PubMed | Europe PMC
 
[131]
2016 | Conference Abstract | PUB-ID: 2912512
Sugar Based Caged Compounds for Biotechnological Synthetic Biological Applications
Bier C, Binder D, Grünberger A, Drobietz D, Hage-Hülsmann J, Kohlheyer D, Löschcke A, Jaeger K-E, Drepper T, Pietruszka J (2016)
Presented at the 26th IUPAC Symposium on Photochemistry, Osaka, Japan.
PUB
 
[130]
2016 | Conference Abstract | PUB-ID: 2912511
Photocaged Carbohydrates: Versatile Tools for Biotechnological Applications
Bier C, Binder D, Grünberger A, Drobietz D, Kohlheyer D, Löschcke A, Jaeger K-E, Drepper T, Pietruszka J (2016)
Presented at the 18th International Conference on Photochemistry, Paris, France.
PUB
 
[129]
2015 | Conference Abstract | PUB-ID: 2912549
Metabolite biosensors for single cell Analysis and the Evolution of production strains
Mahr R, Mustafi N, Grünberger A, Helfrich S, Nöh K, Kohlheyer D, Frunzke J (2015)
Presented at the 30. Jahrestagung der Vereinigung für Allgemeine und Angewandte Mikrobiologie, Marburg, Germany.
PUB
 
[128]
2015 | Conference Abstract | PUB-ID: 2912804
Instantaneous microfluidic metabolic activity sensing for non-invasive single cell physiology analysis of a prokaryote and its descendants
Krämer C, Helfrich S, Singh A, Grünberger A, Wiechert W, Nöh K, Kohlheyer D (2015)
Presented at the 3nd International Conference IMPLEMENTATION OF MICROREACTOR TECHNOLOGY INTO BIOTECHNOLOGY (IMTB 2015), Opatija, Croatia.
PUB
 
[127]
2015 | Conference Abstract | PUB-ID: 2912773
Single-cell microfluidics meets applied biotechnology: From expectation to application
Grünberger A, Probst C, Frunzke J, Noack S, Wiechert W, Kohlheyer D (2015)
Presented at the Jahreskongress Biotechnologie 2020+, Berlin, Germany.
PUB
 
[126]
2015 | Conference Abstract | PUB-ID: 2912763
Microfluidic Single-Cell Cultivation: The key for next generation bioprocess development?
Grünberger A (2015)
Presented at the Colloquium Biotechnology, Technical Faculty - Bielefeld University, Bielefeld.
PUB
 
[125]
2015 | Conference Abstract | PUB-ID: 2912566
Single-Cell Bioreactors: Cutting Edge Cultivation Devices for the Ultimate Scale-Down of Bioprocesses
Grünberger A, Probst C, Wiechert W, Kohlheyer D (2015)
Presented at the DECHEMA-Himmelfahrtstagung "Scale-up and scale-down of bioprocesses", Hamburg-Bergedorf, Germany.
PUB
 
[124]
2015 | Dissertation | PUB-ID: 2912574
Single-Cell Analysis of Microbial Production Strains in Microfluidic Bioreactors
Grünberger A (2015) Schriften des Forschungszentrums Jülich Reihe Schlüsseltechnologien / Key Technologies; 114.
Jülich: RWTH Aachen.
PUB | PDF
 
[123]
2015 | Journal Article | PUB-ID: 2912562
Einzelzell-Bioreaktoren - fast unsichtbar, aber nicht unscheinbar
Grünberger A (2015)
Biospektrum 21(3): 353-353.
PUB | DOI
 
[122]
2015 | Journal Article | PUB-ID: 2912556
Lichtgesteuerte Genexpression auf Einzelzellebene
Binder D, Probst C, Bier C, Loeschcke A, Grünberger A (2015)
Biospektrum 21(6): 612-615.
PUB | DOI
 
[121]
2015 | Journal Article | PUB-ID: 2912554
Non-Invasive Microbial Metabolic Activity Sensing at Single Cell Level by Perfusion of Calcein Acetoxymethyl Ester
Krämer CEM, Singh A, Helfrich S, Grünberger A, Wiechert W, Nöh K, Kohlheyer D (2015)
PLoS one 10(10): e0141768.
PUB | PDF | DOI | WoS | PubMed | Europe PMC
 
[120]
2015 | Journal Article | PUB-ID: 2912557
Modeling and CFD Simulation of nutrient Distribution in picoliter bioreactors for bacterial growth studies on single-cell level
Westerwalbesloh C, Grünberger A, Stute B, Weber S, Wiechert W, Kohlheyer D, von Lieres E (2015)
Lab on a chip 15(21): 4177-4186.
PUB | PDF | DOI | WoS | PubMed | Europe PMC
 
[119]
2015 | Journal Article | PUB-ID: 2912584
Rapid inoculation of single bacteria into parallel picoliter fermentation chambers
Probst C, Grünberger A, Braun N, Helfrich S, Nöh K, Wiechert W, Kohlheyer D (2015)
Analytical methods 7(1): 91-98.
PUB | DOI | WoS
 
[118]
2015 | Conference Abstract | PUB-ID: 2912558
Single-cell microfluidics meets applied biotechnology: From expectation to application
Grünberger A, Probst C, Frunzke J, Noack S, Wiechert W, Kohlheyer D (2015)
Presented at the Jahreskongress der Forschungsorganisationen zum Strategieprozess Biotechnologie 2020+, Berlin, Germany.
PUB
 
[117]
2015 | Conference Abstract | PUB-ID: 2912559
High-throughput long-term growth characterization of C. glutamicum on single cell using the Mother Machine
Sachs CC, Helfrich S, Grünberger A, Probst C, Wiechert W, Kohlheyer D, Nöh K (2015)
Presented at the Colloquium Synthetic Biology - Opportunities for Interdisciplinary Research from Biology to Engineering, Aachen, Germany.
PUB
 
[116]
2015 | Conference Abstract | PUB-ID: 2912560
Dynamic environmental control in microfluidic devices for single-cell Analysis of biological production processes
Zunic E, Schechtel A, Probst C, Grünberger A, Freier C, Seibold G, Wiechert W, Kohlheyer D (2015)
Presented at the Kolloquium Synthetic Biology - Opportunities for Interdisciplinary Research from Biology to Engineering, Aachen, Germany.
PUB
 
[115]
2015 | Conference Abstract | PUB-ID: 2912563
High-throughput, long-term growth characterization of C. glutamicum on single cell level using the Mother Machine
Sachs CC, Helfrich S, Grünberger A, Probst C, Wiechert W, Kohlheyer D, Nöh K (2015)
Presented at the 3rd International Conference of the Cluster of Excellence Tailor-Made Fuels from Biomass, Aachen, Germany.
PUB
 
[114]
2015 | Conference Abstract | PUB-ID: 2912565
Single-cell microfluidics meets applied biotechnology: From expectation to application
Grünberger A, Probst C, Frunzke J, Noack S, Wiechert W, Kohlheyer D (2015)
Presented at the Conference "Cell Factories and Biosustainability - Technologies for Cell Factory Construction", Hillerod, Denmark.
PUB
 
[113]
2015 | Conference Abstract | PUB-ID: 2912567
Single-cell bioreactors: Improving the understanding of microbial metabolism
Grünberger A (2015)
Presented at the 30. Jahrestagung der Vereinigung für Allgemeine und Angewandte Mikrobiologie, Marburg (Germany.
PUB
 
[112]
2015 | Journal Article | PUB-ID: 2912568
Technical bias of microcultivation environments on single cell physiology
Dusny C, Grünberger A, Probst C, Wiechert W, Kohlheyer D, Schmid A (2015)
Lab on a chip 15(8): 1822-1834.
PUB | DOI | WoS | PubMed | Europe PMC
 
[111]
2015 | Conference Abstract | PUB-ID: 2912541
Light-controlled cell factories - Employing optogenetic plug-and-play expression modules based on photocaged carbohydrates for synthetic bio(techno)logy and single cell applications
Binder D, Bier C, Grünberger A, Loeschcke A, Kohlheyer D, Pietruszka J, Jaeger K-E, Drepper T (2015)
Presented at the ESP Photobiology conference, Aveiro, Portugal.
PUB
 
[110]
2015 | Conference Abstract | PUB-ID: 2912542
Optical control of gene expression in bacteria on the single-cell level by caged compounds
Probst C, Grünberger A, Binder D, Steffen I, Wiechert W, Kohlheyer D (2015)
Presented at the Synthetic Biology: Opportunities for Interdisciplinary Research from Biology to Engineering, Aachen, Germany.
PUB
 
[109]
2015 | Conference Abstract | PUB-ID: 2912545
Heterologous production of antibacterial secondary metabolites from Serratia marcescens in Pseudomonas putida
Loeschcke A, Thies S, Hage-Hülsmann J, Grünberger A, Binder D, Domröse A, Klein A, Kohlheyer D, Pietruszka J, Jaeger K-E, Drepper T (2015)
Presented at the 6th Congress of European Microbiologists (FEMS 2015), Maastricht, Netherlands.
PUB
 
[108]
2015 | Conference Abstract | PUB-ID: 2912546
Single-cell microfluidics: A key technology to understand life at environmental defined conditions
Grünberger A, Wiechert W, Kohlheyer D (2015)
Presented at the Kick-off Konferenz: Leben? - Eine neue Förderinitiative stellt sich vor, Hannover, Germany.
PUB
 
[107]
2015 | Conference Abstract | PUB-ID: 2912548
Caged Compounds for Biotechnological and Synthetic Biological Applications
Bier C, Binder D, Grünberger A, Drobietz D, Hage-Hülsmann J, Kohlheyer D, Loeschke A, Jaeger K-E, Drepper T, Pietruszka J (2015)
Presented at the European Society for Photobiology 2015 Congress, Aveiro, Portugal.
PUB
 
[106]
2015 | Journal Article | PUB-ID: 2912550
Spatiotemporal microbial single-cell analysis using a high-throughput microfluidics cultivation platform
Grünberger A, Probst C, Helfrich S, a A, Stute B, Wiechert W, von Lieres E, Nöh K, Frunzke J, Kohlheyer D (2015)
Cytometry / A 87(12): 1101–1115.
PUB | DOI | WoS | PubMed | Europe PMC
 
[105]
2015 | Conference Abstract | PUB-ID: 2912551
Genetically encoded sensor analysis with spatial and temporal Resolution by time-lapse imaging
Probst C, Grünberger A, Krämer C, Sachs CC, Wiechert W, Baumgart M, Kohlheyer D (2015)
Presented at the 1st Evaluation Symposium, Molecular Interaction Engineering, MIE-Project, Karlsruhe, Germany.
PUB
 
[104]
2015 | Journal Article | PUB-ID: 2912555
Vizardous: interactive analysis of microbial populations with single cell resolution
Helfrich S, Azzouzi CE, Probst C, Seiffarth J, Grünberger A, Wiechert W, Kohlheyer D, Nöh K (2015)
Bioinformatics 31(23): 3875-3877.
PUB | DOI | WoS | PubMed | Europe PMC
 
[103]
2014 | Journal Article | PUB-ID: 2912730
Analysis of SOS-Induced Spontaneous Prophage Induction in Corynebacterium glutamicum at the Single-Cell Level
Nanda AM, Heyer A, Kramer C, Grünberger A, Kohlheyer D, Frunzke J (2014)
Journal of Bacteriology 196(1): 180-188.
PUB | PDF | DOI | WoS | PubMed | Europe PMC
 
[102]
2014 | Conference Abstract | PUB-ID: 2912823
Application of a genetically-encoded metabolite sensor for single cell analysis and development of production strains
Mahr R, Mustafi N, Grünberger A, Helfrich S, Nöh K, Kohlheyer D, Frunzke J (2014)
Presented at the Metabolic engineering X, Vancouver, Canada.
PUB
 
[101]
2014 | Conference Abstract | PUB-ID: 2912814
Introduction into Microfluidic Single-Cell Analysis
Grünberger A, Probst C (2014)
Presented at the Biology feat, Engineering – SYNBIO – Single Cell Analysis in Microfluidic Devices (Workshop), Jülich, Germany.
PUB
 
[100]
2014 | Conference Abstract | PUB-ID: 2912808
Metabolite biosensors for single cell analysis and the development of production strains
Mahr R, Mustafi N, Grünberger A, Helfrich S, Nöh K, Kohlheyer D, Frunzke J (2014)
Presented at the 30th Symposium „Mechanisms of gene regulation”, Düsseldorf, Germany.
PUB
 
[99]
2014 | Conference Abstract | PUB-ID: 2912806
Cage me if you can! Optogenetic bacterial gene regulation using photocaged inducers
Binder D, Grünberger A, Loeschcke A, Probst C, Bier C, Pietruszka J, Wiechert W, Kohlheyer D, Jäger KE, Drepper T (2014)
Presented at the 30th Symposium „Mechanisms of gene regulation”, Düsseldorf, Germany.
PUB
 
[98]
2014 | Conference Abstract | PUB-ID: 2912805
Microfluidic Single-Cell Analysis – Potential for Microalgae Research?
Kohlheyer D, Grünberger A, Weber S, Nedbal L, Wiechert W (2014)
Presented at the BioSC Workshop | Exploration "Perspectives of Algal Technologies", Jülich, Germany.
PUB
 
[97]
2014 | Conference Abstract | PUB-ID: 2912766
Picoliter Bioreactors: Learning from Single Cells about Large Scale Processes
Grünberger A (2014)
Presented at the iGEM Meetup, Aachen, Germany.
PUB
 
[96]
2014 | Conference Paper | PUB-ID: 2912601
Simple microfluidics for complex organisms: A microfluidic chip System for growth and Morphogenesis studies of filamentous fungi
Grünberger A, Schmitz K, Probst C, Noack S, Wiechert W, Kohlheyer D (2014)
In: 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2013). Red Hook, NY: Curran.
PUB
 
[95]
2014 | Conference Abstract | PUB-ID: 2912592
Optimizing growth performance of Corynebacterium glutamicum at the single-cell level
Weber S, Grünberger A, Probst C, Wiechert W, Kohlheyer D (2014)
Chemie Ingenieur Technik 88(9): 1414.
PUB | DOI
 
[94]
2014 | Conference Abstract | PUB-ID: 2912593
Systematic screening of single-cell growth and production in a picoliter cultivation platform
Grünberger A, Unthan S, Mahr R, Frunzke J, Noack S, Wiechert W, Kohlheyer D (2014)
Chemie Ingenieur Technik 86(9): 1408.
PUB | DOI
 
[93]
2014 | Journal Article | PUB-ID: 2912573
Application of a Genetically Encoded Biosensor for Live Cell Imaging of L-Valine Production in Pyruvate Dehydrogenase Complex-Deficient Corynebacterium glutamicum Strains
Mustafi N, Grünberger A, Mahr R, Helfrich S, Nöh K, Blombach B, Kohlheyer D, Frunzke J (2014)
PLoS one 9(1): e85731.
PUB | PDF | DOI | WoS | PubMed | Europe PMC
 
[92]
2014 | Journal Article | PUB-ID: 2912594
Light-responsive control of bacterial gene Expression: precise triggering of the lac promoter activity using photocaged IPTG
Binder D, Grünberger A, Loeschcke A, Probst C, Bier C, Pietruszka J, Wiechert W, Kohlheyer D, Jaeger K-E, Drepper T (2014)
Integrative biology 6(8): 755-765.
PUB | PDF | DOI | WoS | PubMed | Europe PMC
 
[91]
2014 | Conference Abstract | PUB-ID: 2912580
Quantitative Physiology of Single Cells for Linking Phenotype and Environment
Dusny C, Grünberger A, Rosenthal K, Wiechert W, Schmid A (2014)
Presented at the 24th Annual Conference of the German Society for Flow Cytometry, Dresden, Germany.
PUB
 
[90]
2014 | Conference Abstract | PUB-ID: 2912582
Microfluidic Single-Cell Cultivation Systems: Versatile Tools for Microbiology
Grünberger A, Probst C, Nanda A, Frunzke J, Wiechert W, Kohlheyer D (2014)
Presented at the 4th Annual Conference of the Association for General and Applied Microbiology, Dresden, Germany.
PUB
 
[89]
2014 | Conference Abstract | PUB-ID: 2912583
Picoliter Bioreactors: Learning from Single Cells about Large-Scale Bioprocesses
Grünberger A, Probst C, Wiechert W, Kohlheyer D (2014)
Presented at the 24th Annual conference of the German Society for Cytometry, Dresden, Germany.
PUB
 
[88]
2014 | Journal Article | PUB-ID: 2912597
Single-cell microfluidics: opportunity for bioprocess development
Grünberger A, Wiechert W, Kohlheyer D (2014)
Current opinion in biotechnology 29: 15-23.
PUB | DOI | WoS | PubMed | Europe PMC
 
[87]
2014 | Journal Article | PUB-ID: 2912605
Taking Control over Control: Use of Product Sensing in Single Cells to Remove Flux Control at Key Enzymes in Biosynthesis Pathways
Schendzielorz G, Dippong M, Grünberger A, Kohlheyer D, Yoshida A, Binder S, Nishiyama C, Nishiyama M, Bott M, Eggeling L (2014)
ACS Synthetic Biology 3(1): 21–29.
PUB | DOI | WoS | PubMed | Europe PMC
 
[86]
2014 | Conference Abstract | PUB-ID: 2912586
Microbial Populations on the Microfluidic Analyst's Couch: Approaching Cellular Heterogeneity
Helfrich S, Azzouzi CE, Krämer C, Pfeifer E, Grünberger A, Mustafi N, Wiechert W, Frunzke J, Kohlheyer D, Nöh K (2014)
Presented at the BioImage Informatics 2014, Leuven, Belgium.
PUB
 
[85]
2014 | Conference Abstract | PUB-ID: 2912585
Robust Automated Image Analysis of Mother Machine Microfluidic Growth Devices
Sachs CC, Grünberger A, Wiechert W, Nöh K, Kohlheyer D (2014)
Presented at the BioImage Informatics 2014, Leuven, Belgium.
PUB
 
[84]
2014 | Conference Abstract | PUB-ID: 2912587
Metabolite biosensors for single cell analysis and the development of production strains
Mahr R, Mustafi N, Grünberger A, Helfrich S, Nöh K, Kohlheyer D, Frunzke J (2014)
Presented at the Gemeinsame Jahrestagung der Deutschen Gesellschaft für Hygiene und Mikrobiologie und der Vereinigung für Allgemeine und Angewandte Mikrobiologie, Dresden, Germany.
PUB
 
[83]
2014 | Conference Abstract | PUB-ID: 2912588
Investigating single-cell growth of microbial cell factories: is counting cells enough?
Helfrich S, Grünberger A, Kohlheyer D, Wiechert W, Nöh K (2014)
Presented at the 2nd International Workshop on Image-based Systems Biology, Jena (Germany.
PUB
 
[82]
2014 | Conference Abstract | PUB-ID: 2912590
Transcription factor-based biosensor for microbial strain development
Mahr R, Mustafi N, Grünberger A, Helfrich S, Nöh K, Kohlheyer D, Frunzke J (2014)
Presented at the 30th Symposium "Mechanisms of Gene Regulation" of the VAAM study group "Regulation & Signal Transduction in Prokaryotes", Düsseldorf, Germany.
PUB
 
[81]
2014 | Conference Abstract | PUB-ID: 2912589
Microfluids as platform for the spatiotemporal analysis of bacterial populations at single-cell level
Helfrich S, Krämer C, Grünberger A, Azzouzi CE, Pfeifer E, Frunzke J, Wiechert W, Kohlheyer D, Nöh K (2014)
Presented at the 30th Symposium "Mechanisms of Gene Regulation" of the VAAM study group "Regulation & Signal Transduction in Prokaryotes", Düsseldorf, Germany.
PUB
 
[80]
2014 | Conference Abstract | PUB-ID: 2912591
Microfluidic Single-Cell Cultivation: Opportunity for Industrial Bioprocess Development
Grünberger A, Probst C, Frunzke J, Noack S, Wiechert W, Kohlheyer D (2014)
Presented at the EMBL Conference – Microfluidics 2014, Heidelberg, Germany.
PUB
 
[79]
2014 | Conference Abstract | PUB-ID: 2912595
Single-cell Bioreactors boost Bioprocess Development: New Insights into Cellular Metabolism
Kohlheyer D, Grünberger A, Probst C, Helfrich S, Frunzke J, Eggeling L, Nöh K, Noack S, Wiechert W (2014)
Presented at the Metabolic Engineering X, Vancouver, Canada.
PUB
 
[78]
2014 | Conference Abstract | PUB-ID: 2912596
Single-cell cultivation in picoliter scale: Opportunity for bioprocess development
Grünberger A, Probst C, Unthan S, Mustafi N, Frunzke J, Noack S, Wiechert W, Kohlheyer D (2014)
Presented at the 3rd BioProScale Symposium, Berlin, Germany.
PUB
 
[77]
2014 | Conference Abstract | PUB-ID: 2912569
Cage me if you can! Optogenetic bacterial gene regulation using photocaged inducers
Binder D, Grünberger A, Loeschcke A, Probst C, Bier C, Pietruszka J, Wiechert W, Kohlheyer D, Jaeger K-E, Drepper T (2014)
Presented at the VAAM Jahrestagung, Dresden, Germany.
PUB
 
[76]
2014 | Conference Paper | PUB-ID: 2912571
Microfluidic Single-Cell Analysis Platform for Biotechnological Process Development
Grünberger A, Probst C, Helfrich S, Frunzke J, Noack S, Nöh K, Wiechert W, Kohlheyer D (2014)
In: MicroTAS 2014. San Diego, California: CBM Society: 3 p.
PUB
 
[75]
2014 | Conference Abstract | PUB-ID: 2912575
Microfluidics as platform for the spatio-temporal analysis of bacterial populations at single-cell level
Krämer C, Helfrich S, Azzouzi CE, Grünberger A, Pfeifer E, Frunzke J, Wiechert W, Nöh K, Kohlheyer D (2014)
Presented at the International Meeting, Phenotypic heterogeneity and sociobiology of bacterial populations, Irsee, Germany.
PUB
 
[74]
2014 | Conference Abstract | PUB-ID: 2912576
From extracellular Environment to functional phenotype: Quantitative comparison of single cell physiology in static and steady environments
Dusny C, Grünberger A, Wiechert W, Kohlheyer D, Schmid A (2014)
Presented at the 3rd BioProScale Symposium "Inhomogeneities in large-scale bioprocesses. System biology and process dynamics", Berlin, Germany.
PUB
 
[73]
2014 | Journal Article | PUB-ID: 2912616
Beyond growth rate 0.6: What drives Corynebacterium glutamicum to higher growth rates in defined medium
Unthan S, Grünberger A, van Ooyen J, Gätgens J, Heinrich J, Paczia N, Wiechert W, Kohlheyer D, Noack S (2014)
Biotechnology and bioengineering 111(2): 359–371.
PUB | DOI | WoS | PubMed | Europe PMC
 
[72]
2013 | Conference Abstract | PUB-ID: 2912836
Characterization of light-triggered gene expression in E. coli with respect to population and single cell response
Binder D, Grünberger A, Loeschcke A, Probst C, Pietruszka J, Wiechert W, Kohlheyer D, Jaeger KE, Drepper T (2013)
Presented at the New Approaches and Concepts in Microbiology, Heidelberg, Germany.
PUB
 
[71]
2013 | Conference Abstract | PUB-ID: 2912835
Application of a genetically- encoded metabolite sensor for single cell analysis and the development of production strains
Mahr R, Mustafi N, Grünberger A, Helfrich S, Nöh K, Kohlheyer D, Frunzke J (2013)
Presented at the Advanced Imaging in Cell- and Microbiology: Technology and Applications (AICMB), Jülich, Germany.
PUB
 
[70]
2013 | Conference Abstract | PUB-ID: 2912834
Characterization of light-triggered gene expression in E. coli with respect to population and single cell response
Binder D, Grünberger A, Loeschcke A, Probst C, Pietruszka J, Wiechert W, Kohlheyer D, Jaeger KE, Drepper T (2013)
Presented at the Advanced Imaging in Cell- and Microbiology: Technology and Applications (AICMB), Jülich, Germany.
PUB
 
[69]
2013 | Conference Abstract | PUB-ID: 2912833
Single-cell dynamics of the SOS response in Corynebacterium glutamicum
Nanda AM, Heyer A, Grünberger A, Helfrich S, Kohlheyer D, Nöh K, Frunzke J (2013)
Presented at the Advanced Imaging in Cell- and Microbiology: Technology and Applications (AICMB), Jülich, Germany.
PUB
 
[68]
2013 | Conference Abstract | PUB-ID: 2912830
Microfluidic single-cell analysis in dynamic environments
Probst C, Grünberger A, Krämer C, Wiechert W, Kohlheyer D (2013)
Presented at the Advanced Imaging in Cell- and Microbiology: Technology and Applications (AICMB), Jülich, Germany.
PUB
 
[67]
2013 | Conference Abstract | PUB-ID: 2912829
Automated image analysis pipeline for single cell bacterial growth studies
Sachs C, Grünberger A, Probst C, Wiechert W, Kohlheyer D (2013)
Presented at the Advanced Imaging in Cell- and Microbiology: Technology and Applications (AICMB), Jülich, Germany.
PUB
 
[66]
2013 | Conference Abstract | PUB-ID: 2912828
Continuous Non-Invasive Real-Time Viability Measurement of Bacteria on Single Cell Level in Microfluidic Chip Cultures?
Krämer C, Grünberger A, Probst C, Wiechert W, Kohlheyer D (2013)
Presented at the Advanced Imaging in Cell- and Microbiology: Technology and Applications (AICMB), Jülich, Germany.
PUB
 
[65]
2013 | Conference Abstract | PUB-ID: 2912827
Application of a genetically- encoded metabolite sensor for single cell analysis and the development of production strains
Mahr R, Mustafi N, Grünberger A, Helfrich S, Nöh K, Kohlheyer D, Frunzke J (2013)
Presented at the Jülich Biotech Day, Jülich, Germany.
PUB
 
[64]
2013 | Conference Abstract | PUB-ID: 2912826
Exploration and Analysis of cell population development: Customisable interactive lineage trees
Helfrich S, Azzouzi CE, Grünberger A, Wiechert W, Nöh K (2013)
Presented at the Jülich Biotech Day, Jülich, Germany.
PUB
 
[63]
2013 | Conference Abstract | PUB-ID: 2912825
Characterization of light-triggered gene expression in E. coli with respect to population and single cell response
Binder D, Grünberger A, Loeschcke A, Probst C, Pietruszka J, Wiechert W, Kohlheyer D, Jaeger KE, Drepper T (2013)
Presented at the Jülich Biotech Day, Jülich, Germany.
PUB
 
[62]
2013 | Conference Abstract | PUB-ID: 2912824
Single-cell dynamics of the SOS response in Corynebacterium glutamicum
Nanda AM, Heyer A, Grünberger A, Helfrich S, Kohlheyer D, Nöh K, Frunzke J (2013)
Presented at the Jülich Biotech Day, Jülich, Germany.
PUB
 
[61]
2013 | Conference Abstract | PUB-ID: 2912810
Analysis of microbial observables on single cell level: Challenges of Cell Clusters for Microscopy-based Image Processing
Helfrich S, Grünberger A, Kohlheyer D, Wiechert W, Nöh K (2013)
Presented at the 9th European Congress of Chemical Engineering (ECCE9)/ 2nd European Congress of Applied Biotechnology (ECAB2), The Hague, Netherlands.
PUB
 
[60]
2013 | Conference Abstract | PUB-ID: 2912809
Microbial Metabolite Production – Live in Concert
Frunzke J, Mahr R, Grünberger A, Mustafi N, Kohlheyer D (2013)
Presented at the Advanced Imaging in Cell- and Microbiology: Technology and Applications (AICMB), Jülich, Germany.
PUB
 
[59]
2013 | Journal Article | PUB-ID: 2912745
Coarse-Grained Modeling of Protein Second Osmotic Virial Coefficients: Sterics and Short-Ranged Attractions
Grünberger A, Lai P-K, Blanco MA, Roberts CJ (2013)
The Journal of Physical Chemistry B 117(3): 763-770.
PUB | DOI
 
[58]
2013 | Journal Article | PUB-ID: 2912606
Visualization of Imbalances in Sulfur Assimilation and Synthesis of Sulfur-Containing Amino Acids at the Single-Cell Level
Hoffmann K, Grünberger A, Lausberg F, Bott M, Eggeling L (2013)
Applied and environmental microbiology 79(21): 6730-6736.
PUB | DOI | WoS | PubMed | Europe PMC
 
[57]
2013 | Journal Article | PUB-ID: 2912611
Polydimethylsiloxane (PDMS) Sub-Micron Traps for Single-Cell Analysis of Bacteria
Probst C, Grünberger A, Wiechert W, Kohlheyer D (2013)
Micromachines 4(4): 357-369.
PUB | PDF | DOI | WoS
 
[56]
2013 | Journal Article | PUB-ID: 2912599
Microfluidic Picoliter Bioreactor for Microbial Single-cell Analysis: Fabrication, System Setup, and Operation
Grünberger A, Probst C, Heyer A, Wiechert W, Frunzke J, Kohlheyer D (2013)
Journal of visualized experiments 82: UNSP e50560.
PUB | PDF | DOI | WoS
 
[55]
2013 | Journal Article | PUB-ID: 2912600
Microfluidic growth chambers with optical tweezers for full spatial single-cell control and analysis of evolving microbes
Probst C, Grünberger A, Wiechert W, Kohlheyer D (2013)
Journal of microbiological methods 95(3): 470-476.
PUB | DOI | WoS | PubMed | Europe PMC
 
[54]
2013 | Conference Abstract | PUB-ID: 2912602
Automated High-Throughput Time-Lapse Microscopy of Bacteria Microcolonies in Parallelized Monolayer Growth Chambers
Grünberger A, Helfrich S, Mustafi N, Probst C, Frunzke J, Nöh K, Wiechert W, Kohlheyer D (2013)
Presented at the Advanced Imaging in Cell- and Microbiology: Technology and Applications, Jülich, Germany.
PUB
 
[53]
2013 | Conference Abstract | PUB-ID: 2912603
Single Cell Bioreactors for Bioprocess Optimization
Grünberger A, Probst C, Unthan S, Krämer C, Paczia N, Noack S, Wiechert W, Kohlheyer D (2013)
Presented at the Jülich Biotech Day 2013, Jülich,Germany.
PUB
 
[52]
2013 | Conference Abstract | PUB-ID: 2912604
Application of a genetically encoded biosensor for single cell analysis and strain development of production strains
Mahr R, Mustafi N, Grünberger A, Helfrich S, Nöh K, Kohlheyer D, Frunzke J (2013)
Presented at the New concepts and approaches in microbiology, Heidelberg, Germany.
PUB
 
[51]
2013 | Conference Abstract | PUB-ID: 2912607
SOS-induced spontaneous prophage induction in Corynebacterium glutamicum
Nanda A, Heyer A, Krämer C, Grünberger A, Kohlheyer D, Frunzke J (2013)
Presented at the Nikon Symposium on Advanced Imaging in Cell- and Microbiology Technology and Applications, Jülich, Germany.
PUB
 
[50]
2013 | Conference Abstract | PUB-ID: 2912609
Single-cell Dynamics of the SOS Response in Corynebacterium glutamicum
Nanda A, Heyer A, Grünberger A, Helfrich S, Kohlheyer D, Nöh K, Frunzke J (2013)
Presented at the Bacterial Networks, Pultusk, Poland.
PUB
 
[49]
2013 | Conference Abstract | PUB-ID: 2912612
SOS-induced spontaneous prophage induction in Corynebacterium glutamicum
Nanda A, Heyer A, Krämer C, Grünberger A, Kohlheyer D, Frunzke J (2013)
Presented at the EMBL Heidelberg "New Approaches and Concepts in Microbiology", Heidelberg, Germany.
PUB
 
[48]
2013 | Conference Abstract | PUB-ID: 2912608
SOS-induced spontaneous prophage induction in Corynebacterium glutamicum
Nanda A, Heyer A, Krämer C, Grünberger A, Kohlheyer D, Frunzke J (2013)
Presented at the Jülich Biotech Day 2013, Jülich, Germany.
PUB
 
[47]
2013 | Journal Article | PUB-ID: 2614036
Construction of a prophage-free variant of Corynebacterium glutamicum ATCC 13032 - a platform strain for basic research and industrial biotechnology
Baumgart M, Unthan S, Rückert C, Sivalingam J, Grünberger A, Kalinowski J, Bott M, Noack S, Frunzke J (2013)
Applied and environmental microbiology 79(19): 6006-6015.
PUB | DOI | WoS | PubMed | Europe PMC
 
[46]
2013 | Conference Abstract | PUB-ID: 2912613
Microfluidic cultivation technology and application: analysing single-microbes under perfect environmental control
Probst C, Grünberger A, Frunzke J, Wiechert W, Kohlheyer D (2013)
Presented at the EMBL Heidelberg "New Approaches and Concepts in Microbiology", Heidelberg, Germany.
PUB
 
[45]
2013 | Conference Abstract | PUB-ID: 2912614
Continuous Non-Invasive Real-Time Viability Measurement of Bacteria on Single Cell Level in Microfluidic Chip Cultures
Krämer C, Grünberger A, Probst C, Wiechert W, Kohlheyer D (2013)
Presented at the EMBL Heidelberg "New Approaches and Concepts in Microbiology", Heidelberg, Germany.
PUB
 
[44]
2013 | Conference Abstract | PUB-ID: 2912615
Explorative Analysis of Cell Population Development: Customizable Interactive Lineage Trees
Helfrich S, Azzouzi CE, Grünberger A, Wiechert W, Nöh K (2013)
Presented at the EMBL Heidelberg "New Approaches and Concepts in Microbiology", Heidelberg, Germany.
PUB
 
[43]
2013 | Conference Abstract | PUB-ID: 2912617
Continuous viability fluorescent staining of growing Corynebacterium glutamicum colonies without sample preparation in an automated microfluidic measurement system
Krämer C, Grünberger A, Probst C, Wiechert W, Kohlheyer D (2013)
Presented at the How Deas Is Dead III Conference, Berlin, Germany.
PUB
 
[42]
2013 | Conference Abstract | PUB-ID: 2912618
Picoliter fermentation with single bacteria: Learning from the one to unravel the crowd
Kohlheyer D, Grünberger A, Probst C, Frunzke J, Wiechert W (2013)
Presented at the 2nd International Congress Implementation of Microreactor Technology in Biotechnology, Cavtat, Croatia.
PUB
 
[41]
2013 | Conference Abstract | PUB-ID: 2912619
Femtoliter chemostat for long-term bacteria growth and production analysis on single cell level
Grünberger A, Probst C, Wiechert W, Kohlheyer D (2013)
Presented at the 2nd International Conference Implementation of Microreactor Technology in Biotechnology, Cavtat, Croatia.
PUB
 
[40]
2013 | Conference Abstract | PUB-ID: 2912620
Increasing biomass productivity of C. glutamicum - new insights from microscale cultivations
Noack S, Grünberger A, van Ooyen J, Kohlheyer D, Wiechert W (2013)
Presented at the 9th European Congress of Chemical Engineering, Den Haag, The Netherlands.
PUB
 
[39]
2013 | Conference Abstract | PUB-ID: 2912621
Towards High-Throughput Microbial Single Cell Analysis In Picoliter Bioreactors
Grünberger A, Mustafi N, Probst C, Frunzke J, Wiechert W, Kohlheyer D (2013)
Presented at the 9th European Congress of Chemical Engineering, Den Haag, The Netherlands.
PUB
 
[38]
2013 | Conference Abstract | PUB-ID: 2912622
Picoliter Bioreactors: Learning from Single Cells about Large Scale Processes
Wiechert W, Kohlheyer D, Noack S, Frunzke J, Mustafi N, Grünberger A (2013)
Presented at the Copenhagen Bioscience Conferences, Cell Factories and Biosustainability, Favrholm, Denmark.
PUB
 
[37]
2013 | Conference Abstract | PUB-ID: 2912623
Spontaneous prophage induction in Corynebacterium glutamicum
Heyer A, Nanda A, Grünberger A, Kohlheyer D, Frunzke J (2013)
Presented at the VAAM-Tagung 2013, Bremen, Germany.
PUB
 
[36]
2013 | Conference Abstract | PUB-ID: 2912624
High-throughput Microbial Single Cell analysis in Picoliter Bioreactors
Grünberger A, Mustafi N, Probst C, Frunzke J, Wiechert W, Kohlheyer D (2013)
Presented at the VAAM-Tagung 2013, Bremen, Germany.
PUB
 
[35]
2013 | Conference Abstract | PUB-ID: 2912625
Single cell growth under constant environmental conditions and defined C sources: A case study for Corynebacterium glutamicum
Heinrich J, Grünberger A, Probst C, Wiechert W, Kohlheyer D (2013)
Presented at the VAAM-Tagung 2013, Bremen, Germany.
PUB
 
[34]
2013 | Conference Abstract | PUB-ID: 2912626
Femtoliter chemostat for long-term bacteria growth and production analysis on single cell level
Grünberger A, Probst C, Wiechert W, Kohlheyer D (2013)
Presented at the Single Cell Analysis Europe 2013, Barcelona, Spain.
PUB
 
[33]
2013 | Conference Abstract | PUB-ID: 2912627
Time lapse microbial single cell analysis in a micro fabricated batch reactor
Probst C, Frank P, Grünberger A, Wiechert W, Kohlheyer D (2013)
Presented at the Single Cell Analysis Europe 2013, Barcelona, Spain.
PUB
 
[32]
2013 | Conference Abstract | PUB-ID: 2912630
Microbial single cell analysis of production strains in microfabricated habitats
Kohlheyer D, Grünberger A, Probst C, Krämer C, Eggeling L, Frunzke J, Wiechert W (2013)
Presented at the DECHEMA-Workshop Microfluidics for Systems Biology and Bioprocess Development, Frankfurt, Germany.
PUB
 
[31]
2013 | Journal Article | PUB-ID: 2912631
Beyond growth rate 0.6: Corynebacterium glutamicum cultivated in highly diluted environments
Grünberger A, van Ooyen J, Paczia N, Rohe P, Schendzielorz G, Eggeling L, Wiechert W, Kohlheyer D, Noack S (2013)
Biotechnology and bioengineering 110(1): 220-228.
PUB | DOI | WoS | PubMed | Europe PMC
 
[30]
2012 | Conference Abstract | PUB-ID: 2912841
Dynamics of the SOS response in single cells of Corynebacterium glutamicum
Nanda AM, Grünberger A, Heyer A, Helfrich S, Kohlheyer D, Nöh K, Frunzke J (2012)
Presented at the 2nd Molecular Microbiology Meeting Würzburg, Würzburg, Germany.
PUB
 
[29]
2012 | Conference Abstract | PUB-ID: 2912840
Dynamics of the SOS response in single cells of Corynebacterium glutamicum
Nanda AM, Grünberger A, Heyer A, Helfrich S, Kohlheyer D, Nöh K, Frunzke J (2012)
Presented at the Microbial Stress: from Molecules to System, Belgirate (VB)/Maggiore Lake, Italy.
PUB
 
[28]
2012 | Conference Abstract | PUB-ID: 2912839
Phenotypic Sorting and Analysis of Bacteria Production Strains using Optical Tweezers and Microfluidics
Probst C, Grünberger A, Wiechert W, Kohlheyer D (2012)
Presented at the EMBL Conference – Microfluidics 2012, Heidelberg, Germany.
PUB
 
[27]
2012 | Conference Abstract | PUB-ID: 2912838
“Catch it and Batch it”- Microfluidics single cell batch cultivation utilizing picoliter bioreactors
Frank P, Probst C, Grünberger A, Wiechert W, Kohlheyer D (2012)
Presented at the ProcessNet- Jahrestagung 2012 und 30. DECHEMA Jahrestagung der Biotechnologen, Karlsruhe, Germany.
PUB
 
[26]
2012 | Conference Abstract | PUB-ID: 2912837
Screening of Escherichia coli on single-cell level by hyphenating microfluidic picoliter fermentation and optical tweezers
Probst C, Grünberger A, Wiechert W, Kohlheyer D (2012)
Presented at the 3rd European Conference on Microfluidics, Heidelberg, Germany.
PUB
 
[25]
2012 | Conference Abstract | PUB-ID: 2912777
Towards high-throughput single cell growth optimization and production analysis using picoliter bioreactors
Grünberger A, Probst C, Wiechert W, Kohlheyer D (2012)
Presented at the Metabolic Engineering IX 2012, Biarritz, France.
PUB
 
[24]
2012 | Conference Abstract | PUB-ID: 2912776
Single Cell Analysis of Industrially Relevant Bacterial Strains in Picoliter Environments
Grünberger A, Probst. C, Frank P, Wiechert W, Kohlheyer D (2012)
Presented at the EMBL Conference – Microfluidics 2012, Heidelberg, Germany.
PUB
 
[23]
2012 | Conference Abstract | PUB-ID: 2912767
Fermentation at Picoliter Scale: Microfluidics for single cell analysis of prokaryotic production strains
Grünberger A, Probst C, Wiechert W, Kohlheyer D (2012)
Presented at the Achema 2012, Frankfurt, Germany.
PUB
 
[22]
2012 | Conference Paper | PUB-ID: 2912758
Single Cell Trapping and Analysis for Prokaryotic Production Strains in Sub-µm Fluidic Structures
Grünberger A, Probst C, Binder S, Ziaee R, Eggeling L, Wiechert W, Kohlheyer D (2012)
In: 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011 (MiroTAS 2011). Red Hook, NY: Curran.
PUB
 
[21]
2012 | Conference Paper | PUB-ID: 2912643
High-Throughput lineage tree investigations of bacteria microcolonies using arrays of monolayer growth chambers
Grünberger A, Helfrich S, Probst C, Wiechert W, Nöh K, Kohlheyer D (2012)
In: Proceedings of The Sixteenth International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2012). San Diego, California: CBMS.
PUB
 
[20]
2012 | Conference Paper | PUB-ID: 2912646
Industrial Biotechnology meets Microfluidics - Disposable high-throughput single cell analysis device for industrially relevant bacterial strains
Grünberger A, Helfrich S, Probst C, Nöh K, Wiechert W, Kohlheyer D (2012)
In: Proceedings - µFLU-12. Paris: SHF.
PUB
 
[19]
2012 | Journal Article | PUB-ID: 2912746
The development and application of a single-cell biosensor for the detection of l-methionine and branched-chain amino acids
Mustafi N, Grünberger A, Kohlheyer D, Bott M, Frunzke J (2012)
Metabolic Engineering 14(4): 449-457.
PUB | DOI | PubMed | Europe PMC
 
[18]
2012 | Journal Article | PUB-ID: 2912747
Synthesis of Chiral Cyanohydrins by Recombinant Escherichia coli Cells in a Micro-Aqueous Reaction System
Scholz KE, Okrob D, Kopka B, Grünberger A, Pohl M, Jaeger K-E, Krauss U (2012)
Applied and Environmental Microbiology 78(14): 5025-5027.
PUB | DOI | PubMed | Europe PMC
 
[17]
2012 | Journal Article | PUB-ID: 2912728
A disposable picolitre bioreactor for cultivation and investigation of industrially relevant bacteria on the single cell level
Grünberger A, Paczia N, Probst C, Schendzielorz G, Eggeling L, Noack S, Wiechert W, Kohlheyer D (2012)
Lab on a Chip 12(11): 2060-2068.
PUB | PDF | DOI
 
[16]
2012 | Conference Abstract | PUB-ID: 2912645
Catch it and batch it: picoliter fermentation at the single cell level
Kohlheyer D, Grünberger A, Probst C, Frank P, Wiechert W (2012)
Presented at the International Workshop on New and Synthetic Bioproduction Systems, Hamburg-Harburg, Germany.
PUB
 
[15]
2012 | Conference Abstract | PUB-ID: 2912635
Metabolite sensors for single-cell isolation of producing bacteria
Binder S, Schendzielorz G, Kohlheyer D, Grünberger A, Wiechert W, Bott M, Eggeling L (2012)
Presented at the Metabolic Engineering IX, Biarritz, France.
PUB
 
[14]
2012 | Conference Abstract | PUB-ID: 2912638
A biosensor for the intracellular detection of L-methionine and branched-chain amino acids - Monitoring of amino acid production at the single cell level
Mustafi N, Grünberger A, Helfrich S, Kohlheyer D, Nöh K, Bott M, Frunzke J (2012)
Presented at the 15th International Conference on Biotechnology, Istanbul, Turkey.
PUB
 
[13]
2012 | Conference Abstract | PUB-ID: 2912633
Picoliter bioreactors for growth heterogeneity studies of industrially relevant bacteria on single cell level
Grünberger A, Probst C, Wiechert W, Kohlheyer D (2012)
Presented at the 2nd BioProScale Symposium: Inhomogeneities in large-scale bioprocesses: System biology and process dynamics, Berlin, Germany.
PUB
 
[12]
2012 | Conference Paper | PUB-ID: 2912639
Phenotypic Sorting and Analysis of Bacteria ProductionStrains Using Optical Tweezers and Microfluidics
Probst C, Grünberger A, Kohlheyer D, Wiechert W (2012)
Chemie - Ingenieur - Technik: CIT 84(8): 1344.
PUB | DOI
 
[11]
2012 | Conference Paper | PUB-ID: 2912640
High-Throughput Growth Rate Determination of Bacteria Micro colonies on Single Cell Level
Grünberger A, Probst C, Wiechert W, Kohlheyer D (2012)
Chemie - Ingenieur - Technik: CIT 84(8): 1336-1337.
PUB | DOI
 
[10]
2012 | Conference Paper | PUB-ID: 2912641
Femtoliter Growth Channels: Bacteria Long-Term Growth Patterns Analysis on Singel Cell Level
Grünberger A, Probst C, Wiechert W, Kohlheyer D (2012)
Chemie - Ingenieur - Technik: CIT 84(8): 1407.
PUB | DOI
 
[9]
2012 | Conference Abstract | PUB-ID: 2912642
Single Cell Microfluidics: From Fabrication to Application
Grünberger A, Frank P, Probst C, Wiechert W, Kohlheyer D (2012)
Presented at the Jülich Biotech Day, Jülich, Germany.
PUB
 
[8]
2012 | Conference Abstract | PUB-ID: 2912647
Semi-Automated Evaluation of Microbial Observables from High-Throughput Time-lapse Microscopy
Helfrich S, Grünberger A, Kohlheyer D, Wiechert W, Nöh K (2012)
Presented at the German Conference on Bioinformatics 2012, Jena (Germany).
PUB
 
[7]
2011 | Conference Abstract | PUB-ID: 2912843
Fluorescence reporters for the analysis of whole cell biocatalysts in non-conventional media
Scholz KE, Okrob D, Kopka B, Grünberger A, Pohl M, Jaeger KE, Krauss U (2011)
Presented at the , Biotrans 2011, Giardini Naxos (Messina), Italy.
PUB
 
[6]
2011 | Conference Abstract | PUB-ID: 2912842
A biosensor for the intracellular detection of L-methionine and branched-chain amino acids
Mustafi N, Grünberger A, Kohlheyer D, Bott M, Frunzke J (2011)
Presented at the 5th International Conference on Analysis of Microbial Cells at the Single Cell Level, Caryy-Le-Rouet, France.
PUB
 
[5]
2011 | Conference Abstract | PUB-ID: 2912811
Sub-µm Fluidic Structures for Single Cell Trapping and Analysis of Prokaryotic Production Strains
Kohlheyer D, Grünberger A, Probst C, Wiechert W (2011)
Presented at the 21st Annual conference of the German Society for Cytometry, Bonn, Germany.
PUB
 
[4]
2011 | Conference Abstract | PUB-ID: 2912778
Single Cell Trapping and Analysis for Prokaryotic Production Strains in Sub -µm Fluidic Structures
Grünberger A, Probst C, Wiechert W, Kohlheyer D (2011)
Presented at the NanoBioTech-Montreux 2011, Montreux, Switzerland.
PUB
 
[3]
2011 | Conference Abstract | PUB-ID: 2912768
A continuous picoliter bioreactor for heterogeneity studies of bacteria microcolonies
Grünberger A, Probst C, Wiechert W, Kohlheyer D (2011)
Presented at the NanoBioTech-Montreux 2011, Montreux, Switzerland.
PUB
 
[2]
2010 | Conference Abstract | PUB-ID: 2912812
Protein Interactions from Kirwood-Buff Analysis of Light Scattering and Coarse-Grained Molecular Models
Blanko MA, Grünberger A, Sahin E, Roberts CJ (2010)
Presented at the AIChE, Salt Lake City (UT), USA.
PUB
 
[1]
2009 | Conference Abstract | PUB-ID: 2912813
Media optimization for the microalgae Chamydomonas reinhardtii Stm6 using statistical design
Grünberger A, Stephens E, Hankamer B (2009)
Presented at the , IMB Summer Symposium: A systems Biology approach to biofuel production: From light capture to biodiesel production, Brisbane, Australia.
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[175]
2017 | Journal Article | PUB-ID: 2912737
Taking control over microbial populations: Current approaches for exploiting biological noise in bioprocesses
Delvigne F, Baert J, Sassi H, Fickers P, Grünberger A, Dusny C (2017)
Biotechnology Journal 12(7): 1600549.
PUB | DOI | WoS | PubMed | Europe PMC
 
[174]
2017 | Conference Abstract | PUB-ID: 2912771
Microfluidic single-cell (co-)cultivation: Exploring the next dimension
Rudat A, Noack S, Wiechert W, Kohlheyer D, Grünberger A (2017)
Presented at the Data-driven Biotechnology - bench, bioreactor and bedside, Copenhagen, Denmark.
PUB
 
[173]
2017 | Conference Abstract | PUB-ID: 2912759
Microfluidic Single-Cell Cultivation: A key for next generation bioprocess development?
Grünberger A (2017)
Presented at the FFBiotech Symposium - Innovative approaches in bioreactors design and operation, Lille, France.
PUB
 
[172]
2017 | Journal Article | PUB-ID: 2912738
Coarse-graining bacteria colonies for modelling critical solute distributions in picolitre bioreactors for bacterial studies on single-cell level
Westerwalbesloh C, Grünberger A, Wiechert W, Kohlheyer D, von Lieres E (2017)
Microbial Biotechnology 10(4): 845-857.
PUB | DOI | PubMed | Europe PMC
 
[171]
2017 | Journal Article | PUB-ID: 2912521
Real-time monitoring of fungal growth and morphogenesis at single-cell resolution
Grünberger A, Schöler K, Probst C, Kornfeld G, Hardiman T, Wiechert W, Kohlheyer D, Noack S (2017)
Engineering in life sciences 17(1): 86–92.
PUB | DOI
 
[170]
2017 | Book Chapter | PUB-ID: 2912520
Application of Mini- and Micro-Bioreactors for Microbial Bioprocesses
Ladner T, Grünberger A, Probst C, Kohlheyer D, Büchs J, Delvigne F (2017)
In: Current Developments in Biotechnology and Bioengineering. Larroche C, Sanromán MÁ, Du G, Pandey A (Eds); Amsterdam: Elsevier: 433-461.
PUB | DOI
 
[169]
2017 | Conference Paper | PUB-ID: 2912518
Microfluidic device for control and sensing of dynamic oxygen levels during cell cultivation
Kaganovitch E, Krischer M, Probst C, Grünberger A, Zunic E, Freier C, Wiechert W, Kohlheyer D (2017)
In: 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016). Red Hook, NY: Curran Associates, Inc.: 355-356.
PUB
 
[168]
2017 | Conference Abstract | PUB-ID: 2912509
Microfluidic cultivation chamber for the investigation of synthetic microbial co-cultures on single-cell level: From the development to first application
Rudat A, Wiechert W, Kohlheyer D, Grünberger A (2017)
Presented at the BioProcessing Days 2017, Recklinghausen, Germany.
PUB
 
[167]
2017 | Conference Abstract | PUB-ID: 2912508
Microfluidic heterogeneity analysis of fluorescence-based gene expression of industrially relevant production strains on single-cell level
Burmeister A, Bitzenhofer NL, Grünberger A, Binder D, Drepper T, Wiechert W, Kohlheyer D (2017)
Presented at the BioProcessing Days 2017, Recklinghausen, Germany.
PUB
 
[166]
2017 | Conference Abstract | PUB-ID: 2912507
Spatiotemporal analysis of synthetic microbial communities at the single-cell level in microfluidic interaction compartments
Rudat A, Wiechert W, Kohlheyer D, Grünberger A (2017)
Presented at the 6th International Conference on Microbial Communication for Young Scientists, Jena, Germany.
PUB
 
[165]
2017 | Conference Abstract | PUB-ID: 2912506
Integrated High-Throughput Platform for Microfluidic Live-Cell Analysis with Feed-Back Eyperimentation
Sachs CC, Grünberger A, Probst C, Wiechert W, Kohlheyer D, Nöh K (2017)
Presented at the DECHEMA-Tagung "Systems Biology meets Synthetic Biology", Frankfurt, Germany.
PUB
 
[164]
2017 | Conference Abstract | PUB-ID: 2912505
Microfluidic single-cell cultivation of S. lividans: Uncovering heterogeneity in filamentous growth
Sachs CC, Koepff J, Kohlheyer D, Wiechert W, Oldiges M, Nöh K, Grünberger A (2017)
Presented at the DECHEMA-Tagung "Systems Biology meets Synthetic Biology", Frankfurt, Germany.
PUB
 
[163]
2017 | Conference Abstract | PUB-ID: 2912504
Models for Developing and Optimizing Microscale Bacteria Cultivation
Westerwalbesloh C, Grünberger A, Wiechert W, Kohlheyer D, von Lieres E (2017)
Presented at the Himmelfahrtstagung 2017: Models for Developing and Optimising Biotech Production, Neu-Ulm, Germany.
PUB
 
[162]
2017 | Conference Abstract | PUB-ID: 2912503
Picoliter bioreactors for microbial consortia: From proof of concept to first application
Rudat A, Wiechert W, Kohlheyer D, Grünberger A (2017)
Presented at the Himmelfahrtstagung 2017: Models for Developing and Optimising Biotech Production, Neu-Ulm, Germany.
PUB
 
[161]
2017 | Conference Abstract | PUB-ID: 2912502
Functionally-active protein aggregates - towards the realization of an enzyme cascade in catalytically-active inclusion bodies
Jäger VD, Longerich S, Dietrich M, Kloss R, Grünberger A, Pohl M, Jaeger K-E, Krauss U (2017)
Presented at the BioTrans 2017, Budapest, Hungary.
PUB
 
[160]
2017 | Conference Abstract | PUB-ID: 2912501
Catalytically active inclusion bodies: A novel carrier-free Enzyme Immobilisation method
Kloss R, Limberg M, Jäger VD, Mackfeld U, Karmainski T, Grünberger A, Krauss U, Pohl M (2017)
Presented at the BioTrans 2017, Budapest, Hungary.
PUB
 
[159]
2016 | Conference Abstract | PUB-ID: 2912820
Combinatorial antibiotic effects of natural biocide cocktails
Hage-Hülsmann J, Grünberger A, Thies S, Domröse A, Klein A, Binder D, Hilgers F, Kohlheyer D, Pietruszka J, Jaeger KE, Drepper T, et al. (2016)
Presented at the IV International Conference on Antimicrobial Research, Malaga, Spain.
PUB
 
[158]
2016 | Conference Abstract | PUB-ID: 2912532
Characterizing substrate availability within microfluidic tools employed for the analysis of genetically modified single cells
Westerwalbesloh C, Grünberger A, Stute B, Weber S, Kohlheyer D, von Lieres E (2016)
Presented at the 1. International Conference on Molecular Interaction Engineering (MIE), Karlsruhe, Germany.
PUB
 
[157]
2016 | Conference Abstract | PUB-ID: 2912803
Employing photocaged carbohydrates in light-controlled cell factories for synthetic bio(techno)logy and single cell applications
Binder D, Bier C, Grünberger A, Hilgers F, Loeschcke A, Kohlheyer D, Pietruszka J, Jaeger KE, Drepper T (2016)
Presented at the Annual Conference of the Association for General and Applied Microbiology (VAAM),, Jena, Germany.
PUB
 
[156]
2016 | Conference Abstract | PUB-ID: 2912772
Spatio-temporal analysis of bacterial populations at single-cell level
Grünberger A, Sachs C, Kohlheyer D, Wiechert W, Nöh K (2016)
Presented at the IBG Modelling Workshop, Jülich, Germany.
PUB
 
[155]
2016 | Conference Abstract | PUB-ID: 2912540
Bacterial phase diagrams – Using engineering concepts to predict cell-to-cell heterogeneity of microbial gene expression
Grünberger A, Steffens I, Binder D, Drepper T, Wiechert W, Kohlheyer D (2016)
Presented at the Jahrestagung 2016 der Vereinigung für Allgemeine und Angewandte Mikrobiologie, Jena, Germany.
PUB
 
[154]
2016 | Conference Abstract | PUB-ID: 2912761
Microfluidic single-cell bioreactors: Introduction, application and future perspectives
Grünberger A (2016)
Presented at the LCSB Biannual Minisymposia in Modelling/Automation/Microfluidics at the University of Luxembourg, Esch-sur-Alzette, Luxembourg.
PUB
 
[153]
2016 | Conference Abstract | PUB-ID: 2912760
Picoliter bioreactors for microbial consortia: A novel concept to investigate microbial interactions at the single-cell level
Grünberger A (2016)
Presented at the SynComBio Workshop “Applications of synthetic microbial communities in bioeconomy", Düsseldorf, Germany.
PUB
 
[152]
2016 | Conference Abstract | PUB-ID: 2912526
Comparison of different cultivation chamber designs for microfluidic bioreactors
Westerwalbesloh C, Grünberger A, Wiechert W, Kohlheyer D, von Lieres E (2016)
Chemie Ingenieur Technik 88(9): 1390.
PUB | DOI
 
[151]
2016 | Journal Article | PUB-ID: 2912739
Enhanced protein and biochemical production using CRISPRi-based growth switches
Li S, Jendresen CB, Grünberger A, Ronda C, Jensen SI, Noack S, Nielsen AT (2016)
Metabolic Engineering 38: 274-284.
PUB | DOI | PubMed | Europe PMC
 
[150]
2016 | Journal Article | PUB-ID: 2912514
Comparative Single-Cell Analysis of Different E. coli Expression Systems during Microfluidic Cultivation
Binder D, Probst C, Grünberger A, Hilgers F, Loeschcke A, Jaeger K-E, Kohlheyer D, Drepper T (2016)
PLoS one 11(8): e0160711.
PUB | PDF | DOI | WoS | PubMed | Europe PMC
 
[149]
2016 | Journal Article | PUB-ID: 2912522
Image-Based Single Cell Profiling: High-Throughput Processing of Mother Machine Experiments
Sachs CC, Grünberger A, Helfrich S, Probst C, Wiechert W, Kohlheyer D, Nöh K (2016)
PLoS one 11(9): e0163453 -.
PUB | PDF | DOI | WoS | PubMed | Europe PMC
 
[148]
2016 | Conference Abstract | PUB-ID: 2912539
Nutrient distribution in perfusion based picoliter bioreactors
Westerwalbesloh C, Grünberger A, Stute B, Weber S, Wiechert W, Kohlheyer D, von Lieres E (2016)
Presented at the 4th BioProScale Symposium "Bioprocess intensification through process analytical technology (PAT) and quality by design (QbD)", Berlin, Germany.
PUB
 
[147]
2016 | Conference Abstract | PUB-ID: 2912538
Bacterial phase diagrams: Analyzing and predicting cell-to-cell heterogeneity of microbial gene expression
Steffens I, Grünberger A, Binder D, Drepper T, Wiechert W, Kohlheyer D (2016)
Presented at the 4th BioProScale Symposium "Bioprocess intensification through process analytical technology (PAT) and quality by design (QbD)", Berlin (Germany.
PUB
 
[146]
2016 | Conference Abstract | PUB-ID: 2912537
Bioprocesses under magnification: Learning from single cells about large-scale processes
Grünberger A, Wiechert W, Kohlheyer D (2016)
Presented at the 4th BioProScale Symposium "Bioprocess intensification through process analytical technology (PAT) and quality by design (QbD)", Berlin, Germany.
PUB
 
[145]
2016 | Journal Article | PUB-ID: 2912544
Photocaged Arabinose - A Novel Optogenetic Switch for Rapid and Gradual Control of Microbial Gene Expression
Binder D, Bier C, Grünberger A, Drobietz D, Hage-Hülsmann J, rey G, Büchs J, Kohlheyer D, Loeschcke A, Wiechert W, Jaeger K-E, et al. (2016)
ChemBioChem 17(4): 296-299.
PUB | DOI | WoS | PubMed | Europe PMC
 
[144]
2016 | Conference Paper | PUB-ID: 2912552
Closing the gap between microfluidic single-cell analysis and bioprocess development for microbial organisms
Probst C, Freier C, Mahr R, Grünberger A, Helfrich S, Wiechert W, Nöh K, Frunzke J, Kohlheyer D (2016)
In: 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2015). Red Hook, NY: Curran Associates, Inc.: 537-539.
PUB
 
[143]
2016 | Conference Abstract | PUB-ID: 2912536
An integrated platform for dynamic microfluidic experimentation with single-cell resolution
Sachs CC, Probst C, Grünberger A, Wiechert W, Frunzke J, Kohlheyer D, Nöh K (2016)
Presented at the DECHEMA-Tagung 'Single Cell Technologies 2016', Frankfurt, Germany.
PUB
 
[142]
2016 | Conference Abstract | PUB-ID: 2912535
Bacterial phase diagrams: A novel concept to predict and control bacterial gene expression
Grünberger A, Steffens I, Binder D, Drepper T, Wiechert W, Kohlheyer D (2016)
Presented at the DECHEMA-Himmelfahrtstagung: New Frontiers for Biotech Processes, Koblenz, Germany.
PUB
 
[141]
2016 | Conference Abstract | PUB-ID: 2912534
Single-cell microfluidics for bioprocess development
Grünberger A (2016)
Presented at the GreenWin Conferences “Green Chemistry and White Biotechnology", Gembloux, Belgium.
PUB
 
[140]
2016 | Conference Abstract | PUB-ID: 2912531
Modeling inhomogeneities across cultivation chamber arrays in single-cell cultivation devices
Westerwalbesloh C, Grünberger A, Kohlheyer D, von Lieres E (2016)
Presented at the EMBL Conference Microfluidics, Heidelberg (Germany.
PUB
 
[139]
2016 | Conference Abstract | PUB-ID: 2912530
Single-cell analysis of E. coli in microfluidic batch reactors
Kaganovitch E, Probst C, Westerwalbesloh C, Grünberger A, Wiechert W, Kohlheyer D (2016)
Presented at the EMBL Conference Microfluidics, Heidelberg (Germany.
PUB
 
[138]
2016 | Conference Abstract | PUB-ID: 2912529
Microbial metabolic state diagrams: Using microfluidic single-cell cultivation to predict bacterial gene expresssion
Grünberger A, Steffens I, Binder D, Drepper T, Wiechert W, Kohlheyer D (2016)
Presented at the EMBL Conference Microfluidics, Heidelberg, Germany.
PUB
 
[137]
2016 | Conference Abstract | PUB-ID: 2912527
Microfluidic single-cell cultivation: Is small the new beautiful?
Grünberger A (2016)
Presented at the 6th International Bielefeld-CeBiTec Research Conference: Advances in Industrial Biotechnology: New Techniques, Substrates and Products for Bioprocesses, Bielefeld, Germany.
PUB
 
[136]
2016 | Conference Abstract | PUB-ID: 2912525
Microfluidic heterogeneity analysis of fluorescence-based gene expression of industrially relevant production strains on single-cell level
Burmeister A, Bitzenhofer NL, Grünberger A, Binder D, Drepper T, Wiechert W (2016)
Presented at the 18. Heiligenstädter Kolloquium „Technische Systeme für die Lebenswissenschaften, Heiligenstadt, Germany.
PUB
 
[135]
2016 | Conference Abstract | PUB-ID: 2912524
Microfluidic cultivation of the microalgae Chlorella sorokiniana on single-cell level at defined environments
Brehl C, Grünberger A, Probst C, Pfaff C, Wiechert W, Behrendt D, Kohlheyer D (2016)
Presented at the 9. DECHEMA Bundesalgenstammtisch, Jülich, Germany.
PUB
 
[134]
2016 | Conference Abstract | PUB-ID: 2912523
Microfluidic cultivation of the microalgae Chlorella sorokiniana on single-cell level at defined environments
Brehl C, Grünberger A, Probst C, Pfaff C, Wiechert W, Behrendt D, Kohlheyer D (2016)
Presented at the ProcessNet 2016, Aachen, Germany.
PUB
 
[133]
2016 | Journal Article | PUB-ID: 2904866
Light-controlled cell factories – Employing photocaged IPTG for light-mediated optimization of lac-based gene expression and (+)-valencene biosynthesis in Corynebacterium glutamicum
Binder D, Frohwitter J, Mahr R, Bier C, Grünberger A, Loeschcke A, Peters-Wendisch P, Kohlheyer D, Pietruszka J, Frunzke J, Jaeger K-E, et al. (2016)
Appl Environ Microbiol 82: 6141-6149.
PUB | DOI | WoS | PubMed | Europe PMC
 
[132]
2016 | Journal Article | PUB-ID: 2912513
Optogenetic Regulation of Tunable Gene Expression in Yeast Using Photo-Labile Caged Methionine
Kusen PM, Wandrey G, Probst C, Grünberger A, Holz M, Meyer zu Berstenhorst S, Kohlheyer D, Büchs J, Pietruszka J (2016)
ACS chemical biology 11(10): 2915-2922.
PUB | DOI | WoS | PubMed | Europe PMC
 
[131]
2016 | Conference Abstract | PUB-ID: 2912512
Sugar Based Caged Compounds for Biotechnological Synthetic Biological Applications
Bier C, Binder D, Grünberger A, Drobietz D, Hage-Hülsmann J, Kohlheyer D, Löschcke A, Jaeger K-E, Drepper T, Pietruszka J (2016)
Presented at the 26th IUPAC Symposium on Photochemistry, Osaka, Japan.
PUB
 
[130]
2016 | Conference Abstract | PUB-ID: 2912511
Photocaged Carbohydrates: Versatile Tools for Biotechnological Applications
Bier C, Binder D, Grünberger A, Drobietz D, Kohlheyer D, Löschcke A, Jaeger K-E, Drepper T, Pietruszka J (2016)
Presented at the 18th International Conference on Photochemistry, Paris, France.
PUB
 
[129]
2015 | Conference Abstract | PUB-ID: 2912549
Metabolite biosensors for single cell Analysis and the Evolution of production strains
Mahr R, Mustafi N, Grünberger A, Helfrich S, Nöh K, Kohlheyer D, Frunzke J (2015)
Presented at the 30. Jahrestagung der Vereinigung für Allgemeine und Angewandte Mikrobiologie, Marburg, Germany.
PUB
 
[128]
2015 | Conference Abstract | PUB-ID: 2912804
Instantaneous microfluidic metabolic activity sensing for non-invasive single cell physiology analysis of a prokaryote and its descendants
Krämer C, Helfrich S, Singh A, Grünberger A, Wiechert W, Nöh K, Kohlheyer D (2015)
Presented at the 3nd International Conference IMPLEMENTATION OF MICROREACTOR TECHNOLOGY INTO BIOTECHNOLOGY (IMTB 2015), Opatija, Croatia.
PUB
 
[127]
2015 | Conference Abstract | PUB-ID: 2912773
Single-cell microfluidics meets applied biotechnology: From expectation to application
Grünberger A, Probst C, Frunzke J, Noack S, Wiechert W, Kohlheyer D (2015)
Presented at the Jahreskongress Biotechnologie 2020+, Berlin, Germany.
PUB
 
[126]
2015 | Conference Abstract | PUB-ID: 2912763
Microfluidic Single-Cell Cultivation: The key for next generation bioprocess development?
Grünberger A (2015)
Presented at the Colloquium Biotechnology, Technical Faculty - Bielefeld University, Bielefeld.
PUB
 
[125]
2015 | Conference Abstract | PUB-ID: 2912566
Single-Cell Bioreactors: Cutting Edge Cultivation Devices for the Ultimate Scale-Down of Bioprocesses
Grünberger A, Probst C, Wiechert W, Kohlheyer D (2015)
Presented at the DECHEMA-Himmelfahrtstagung "Scale-up and scale-down of bioprocesses", Hamburg-Bergedorf, Germany.
PUB
 
[124]
2015 | Dissertation | PUB-ID: 2912574
Single-Cell Analysis of Microbial Production Strains in Microfluidic Bioreactors
Grünberger A (2015) Schriften des Forschungszentrums Jülich Reihe Schlüsseltechnologien / Key Technologies; 114.
Jülich: RWTH Aachen.
PUB | PDF
 
[123]
2015 | Journal Article | PUB-ID: 2912562
Einzelzell-Bioreaktoren - fast unsichtbar, aber nicht unscheinbar
Grünberger A (2015)
Biospektrum 21(3): 353-353.
PUB | DOI
 
[122]
2015 | Journal Article | PUB-ID: 2912556
Lichtgesteuerte Genexpression auf Einzelzellebene
Binder D, Probst C, Bier C, Loeschcke A, Grünberger A (2015)
Biospektrum 21(6): 612-615.
PUB | DOI
 
[121]
2015 | Journal Article | PUB-ID: 2912554
Non-Invasive Microbial Metabolic Activity Sensing at Single Cell Level by Perfusion of Calcein Acetoxymethyl Ester
Krämer CEM, Singh A, Helfrich S, Grünberger A, Wiechert W, Nöh K, Kohlheyer D (2015)
PLoS one 10(10): e0141768.
PUB | PDF | DOI | WoS | PubMed | Europe PMC
 
[120]
2015 | Journal Article | PUB-ID: 2912557
Modeling and CFD Simulation of nutrient Distribution in picoliter bioreactors for bacterial growth studies on single-cell level
Westerwalbesloh C, Grünberger A, Stute B, Weber S, Wiechert W, Kohlheyer D, von Lieres E (2015)
Lab on a chip 15(21): 4177-4186.
PUB | PDF | DOI | WoS | PubMed | Europe PMC
 
[119]
2015 | Journal Article | PUB-ID: 2912584
Rapid inoculation of single bacteria into parallel picoliter fermentation chambers
Probst C, Grünberger A, Braun N, Helfrich S, Nöh K, Wiechert W, Kohlheyer D (2015)
Analytical methods 7(1): 91-98.
PUB | DOI | WoS
 
[118]
2015 | Conference Abstract | PUB-ID: 2912558
Single-cell microfluidics meets applied biotechnology: From expectation to application
Grünberger A, Probst C, Frunzke J, Noack S, Wiechert W, Kohlheyer D (2015)
Presented at the Jahreskongress der Forschungsorganisationen zum Strategieprozess Biotechnologie 2020+, Berlin, Germany.
PUB
 
[117]
2015 | Conference Abstract | PUB-ID: 2912559
High-throughput long-term growth characterization of C. glutamicum on single cell using the Mother Machine
Sachs CC, Helfrich S, Grünberger A, Probst C, Wiechert W, Kohlheyer D, Nöh K (2015)
Presented at the Colloquium Synthetic Biology - Opportunities for Interdisciplinary Research from Biology to Engineering, Aachen, Germany.
PUB
 
[116]
2015 | Conference Abstract | PUB-ID: 2912560
Dynamic environmental control in microfluidic devices for single-cell Analysis of biological production processes
Zunic E, Schechtel A, Probst C, Grünberger A, Freier C, Seibold G, Wiechert W, Kohlheyer D (2015)
Presented at the Kolloquium Synthetic Biology - Opportunities for Interdisciplinary Research from Biology to Engineering, Aachen, Germany.
PUB
 
[115]
2015 | Conference Abstract | PUB-ID: 2912563
High-throughput, long-term growth characterization of C. glutamicum on single cell level using the Mother Machine
Sachs CC, Helfrich S, Grünberger A, Probst C, Wiechert W, Kohlheyer D, Nöh K (2015)
Presented at the 3rd International Conference of the Cluster of Excellence Tailor-Made Fuels from Biomass, Aachen, Germany.
PUB
 
[114]
2015 | Conference Abstract | PUB-ID: 2912565
Single-cell microfluidics meets applied biotechnology: From expectation to application
Grünberger A, Probst C, Frunzke J, Noack S, Wiechert W, Kohlheyer D (2015)
Presented at the Conference "Cell Factories and Biosustainability - Technologies for Cell Factory Construction", Hillerod, Denmark.
PUB
 
[113]
2015 | Conference Abstract | PUB-ID: 2912567
Single-cell bioreactors: Improving the understanding of microbial metabolism
Grünberger A (2015)
Presented at the 30. Jahrestagung der Vereinigung für Allgemeine und Angewandte Mikrobiologie, Marburg (Germany.
PUB
 
[112]
2015 | Journal Article | PUB-ID: 2912568
Technical bias of microcultivation environments on single cell physiology
Dusny C, Grünberger A, Probst C, Wiechert W, Kohlheyer D, Schmid A (2015)
Lab on a chip 15(8): 1822-1834.
PUB | DOI | WoS | PubMed | Europe PMC
 
[111]
2015 | Conference Abstract | PUB-ID: 2912541
Light-controlled cell factories - Employing optogenetic plug-and-play expression modules based on photocaged carbohydrates for synthetic bio(techno)logy and single cell applications
Binder D, Bier C, Grünberger A, Loeschcke A, Kohlheyer D, Pietruszka J, Jaeger K-E, Drepper T (2015)
Presented at the ESP Photobiology conference, Aveiro, Portugal.
PUB
 
[110]
2015 | Conference Abstract | PUB-ID: 2912542
Optical control of gene expression in bacteria on the single-cell level by caged compounds
Probst C, Grünberger A, Binder D, Steffen I, Wiechert W, Kohlheyer D (2015)
Presented at the Synthetic Biology: Opportunities for Interdisciplinary Research from Biology to Engineering, Aachen, Germany.
PUB
 
[109]
2015 | Conference Abstract | PUB-ID: 2912545
Heterologous production of antibacterial secondary metabolites from Serratia marcescens in Pseudomonas putida
Loeschcke A, Thies S, Hage-Hülsmann J, Grünberger A, Binder D, Domröse A, Klein A, Kohlheyer D, Pietruszka J, Jaeger K-E, Drepper T (2015)
Presented at the 6th Congress of European Microbiologists (FEMS 2015), Maastricht, Netherlands.
PUB
 
[108]
2015 | Conference Abstract | PUB-ID: 2912546
Single-cell microfluidics: A key technology to understand life at environmental defined conditions
Grünberger A, Wiechert W, Kohlheyer D (2015)
Presented at the Kick-off Konferenz: Leben? - Eine neue Förderinitiative stellt sich vor, Hannover, Germany.
PUB
 
[107]
2015 | Conference Abstract | PUB-ID: 2912548
Caged Compounds for Biotechnological and Synthetic Biological Applications
Bier C, Binder D, Grünberger A, Drobietz D, Hage-Hülsmann J, Kohlheyer D, Loeschke A, Jaeger K-E, Drepper T, Pietruszka J (2015)
Presented at the European Society for Photobiology 2015 Congress, Aveiro, Portugal.
PUB
 
[106]
2015 | Journal Article | PUB-ID: 2912550
Spatiotemporal microbial single-cell analysis using a high-throughput microfluidics cultivation platform
Grünberger A, Probst C, Helfrich S, a A, Stute B, Wiechert W, von Lieres E, Nöh K, Frunzke J, Kohlheyer D (2015)
Cytometry / A 87(12): 1101–1115.
PUB | DOI | WoS | PubMed | Europe PMC
 
[105]
2015 | Conference Abstract | PUB-ID: 2912551
Genetically encoded sensor analysis with spatial and temporal Resolution by time-lapse imaging
Probst C, Grünberger A, Krämer C, Sachs CC, Wiechert W, Baumgart M, Kohlheyer D (2015)
Presented at the 1st Evaluation Symposium, Molecular Interaction Engineering, MIE-Project, Karlsruhe, Germany.
PUB
 
[104]
2015 | Journal Article | PUB-ID: 2912555
Vizardous: interactive analysis of microbial populations with single cell resolution
Helfrich S, Azzouzi CE, Probst C, Seiffarth J, Grünberger A, Wiechert W, Kohlheyer D, Nöh K (2015)
Bioinformatics 31(23): 3875-3877.
PUB | DOI | WoS | PubMed | Europe PMC
 
[103]
2014 | Journal Article | PUB-ID: 2912730
Analysis of SOS-Induced Spontaneous Prophage Induction in Corynebacterium glutamicum at the Single-Cell Level
Nanda AM, Heyer A, Kramer C, Grünberger A, Kohlheyer D, Frunzke J (2014)
Journal of Bacteriology 196(1): 180-188.
PUB | PDF | DOI | WoS | PubMed | Europe PMC
 
[102]
2014 | Conference Abstract | PUB-ID: 2912823
Application of a genetically-encoded metabolite sensor for single cell analysis and development of production strains
Mahr R, Mustafi N, Grünberger A, Helfrich S, Nöh K, Kohlheyer D, Frunzke J (2014)
Presented at the Metabolic engineering X, Vancouver, Canada.
PUB
 
[101]
2014 | Conference Abstract | PUB-ID: 2912814
Introduction into Microfluidic Single-Cell Analysis
Grünberger A, Probst C (2014)
Presented at the Biology feat, Engineering – SYNBIO – Single Cell Analysis in Microfluidic Devices (Workshop), Jülich, Germany.
PUB
 
[100]
2014 | Conference Abstract | PUB-ID: 2912808
Metabolite biosensors for single cell analysis and the development of production strains
Mahr R, Mustafi N, Grünberger A, Helfrich S, Nöh K, Kohlheyer D, Frunzke J (2014)
Presented at the 30th Symposium „Mechanisms of gene regulation”, Düsseldorf, Germany.
PUB
 
[99]
2014 | Conference Abstract | PUB-ID: 2912806
Cage me if you can! Optogenetic bacterial gene regulation using photocaged inducers
Binder D, Grünberger A, Loeschcke A, Probst C, Bier C, Pietruszka J, Wiechert W, Kohlheyer D, Jäger KE, Drepper T (2014)
Presented at the 30th Symposium „Mechanisms of gene regulation”, Düsseldorf, Germany.
PUB
 
[98]
2014 | Conference Abstract | PUB-ID: 2912805
Microfluidic Single-Cell Analysis – Potential for Microalgae Research?
Kohlheyer D, Grünberger A, Weber S, Nedbal L, Wiechert W (2014)
Presented at the BioSC Workshop | Exploration "Perspectives of Algal Technologies", Jülich, Germany.
PUB
 
[97]
2014 | Conference Abstract | PUB-ID: 2912766
Picoliter Bioreactors: Learning from Single Cells about Large Scale Processes
Grünberger A (2014)
Presented at the iGEM Meetup, Aachen, Germany.
PUB
 
[96]
2014 | Conference Paper | PUB-ID: 2912601
Simple microfluidics for complex organisms: A microfluidic chip System for growth and Morphogenesis studies of filamentous fungi
Grünberger A, Schmitz K, Probst C, Noack S, Wiechert W, Kohlheyer D (2014)
In: 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2013). Red Hook, NY: Curran.
PUB
 
[95]
2014 | Conference Abstract | PUB-ID: 2912592
Optimizing growth performance of Corynebacterium glutamicum at the single-cell level
Weber S, Grünberger A, Probst C, Wiechert W, Kohlheyer D (2014)
Chemie Ingenieur Technik 88(9): 1414.
PUB | DOI
 
[94]
2014 | Conference Abstract | PUB-ID: 2912593
Systematic screening of single-cell growth and production in a picoliter cultivation platform
Grünberger A, Unthan S, Mahr R, Frunzke J, Noack S, Wiechert W, Kohlheyer D (2014)
Chemie Ingenieur Technik 86(9): 1408.
PUB | DOI
 
[93]
2014 | Journal Article | PUB-ID: 2912573
Application of a Genetically Encoded Biosensor for Live Cell Imaging of L-Valine Production in Pyruvate Dehydrogenase Complex-Deficient Corynebacterium glutamicum Strains
Mustafi N, Grünberger A, Mahr R, Helfrich S, Nöh K, Blombach B, Kohlheyer D, Frunzke J (2014)
PLoS one 9(1): e85731.
PUB | PDF | DOI | WoS | PubMed | Europe PMC
 
[92]
2014 | Journal Article | PUB-ID: 2912594
Light-responsive control of bacterial gene Expression: precise triggering of the lac promoter activity using photocaged IPTG
Binder D, Grünberger A, Loeschcke A, Probst C, Bier C, Pietruszka J, Wiechert W, Kohlheyer D, Jaeger K-E, Drepper T (2014)
Integrative biology 6(8): 755-765.
PUB | PDF | DOI | WoS | PubMed | Europe PMC
 
[91]
2014 | Conference Abstract | PUB-ID: 2912580
Quantitative Physiology of Single Cells for Linking Phenotype and Environment
Dusny C, Grünberger A, Rosenthal K, Wiechert W, Schmid A (2014)
Presented at the 24th Annual Conference of the German Society for Flow Cytometry, Dresden, Germany.
PUB
 
[90]
2014 | Conference Abstract | PUB-ID: 2912582
Microfluidic Single-Cell Cultivation Systems: Versatile Tools for Microbiology
Grünberger A, Probst C, Nanda A, Frunzke J, Wiechert W, Kohlheyer D (2014)
Presented at the 4th Annual Conference of the Association for General and Applied Microbiology, Dresden, Germany.
PUB
 
[89]
2014 | Conference Abstract | PUB-ID: 2912583
Picoliter Bioreactors: Learning from Single Cells about Large-Scale Bioprocesses
Grünberger A, Probst C, Wiechert W, Kohlheyer D (2014)
Presented at the 24th Annual conference of the German Society for Cytometry, Dresden, Germany.
PUB
 
[88]
2014 | Journal Article | PUB-ID: 2912597
Single-cell microfluidics: opportunity for bioprocess development
Grünberger A, Wiechert W, Kohlheyer D (2014)
Current opinion in biotechnology 29: 15-23.
PUB | DOI | WoS | PubMed | Europe PMC
 
[87]
2014 | Journal Article | PUB-ID: 2912605
Taking Control over Control: Use of Product Sensing in Single Cells to Remove Flux Control at Key Enzymes in Biosynthesis Pathways
Schendzielorz G, Dippong M, Grünberger A, Kohlheyer D, Yoshida A, Binder S, Nishiyama C, Nishiyama M, Bott M, Eggeling L (2014)
ACS Synthetic Biology 3(1): 21–29.
PUB | DOI | WoS | PubMed | Europe PMC
 
[86]
2014 | Conference Abstract | PUB-ID: 2912586
Microbial Populations on the Microfluidic Analyst's Couch: Approaching Cellular Heterogeneity
Helfrich S, Azzouzi CE, Krämer C, Pfeifer E, Grünberger A, Mustafi N, Wiechert W, Frunzke J, Kohlheyer D, Nöh K (2014)
Presented at the BioImage Informatics 2014, Leuven, Belgium.
PUB
 
[85]
2014 | Conference Abstract | PUB-ID: 2912585
Robust Automated Image Analysis of Mother Machine Microfluidic Growth Devices
Sachs CC, Grünberger A, Wiechert W, Nöh K, Kohlheyer D (2014)
Presented at the BioImage Informatics 2014, Leuven, Belgium.
PUB
 
[84]
2014 | Conference Abstract | PUB-ID: 2912587
Metabolite biosensors for single cell analysis and the development of production strains
Mahr R, Mustafi N, Grünberger A, Helfrich S, Nöh K, Kohlheyer D, Frunzke J (2014)
Presented at the Gemeinsame Jahrestagung der Deutschen Gesellschaft für Hygiene und Mikrobiologie und der Vereinigung für Allgemeine und Angewandte Mikrobiologie, Dresden, Germany.
PUB
 
[83]
2014 | Conference Abstract | PUB-ID: 2912588
Investigating single-cell growth of microbial cell factories: is counting cells enough?
Helfrich S, Grünberger A, Kohlheyer D, Wiechert W, Nöh K (2014)
Presented at the 2nd International Workshop on Image-based Systems Biology, Jena (Germany.
PUB
 
[82]
2014 | Conference Abstract | PUB-ID: 2912590
Transcription factor-based biosensor for microbial strain development
Mahr R, Mustafi N, Grünberger A, Helfrich S, Nöh K, Kohlheyer D, Frunzke J (2014)
Presented at the 30th Symposium "Mechanisms of Gene Regulation" of the VAAM study group "Regulation & Signal Transduction in Prokaryotes", Düsseldorf, Germany.
PUB
 
[81]
2014 | Conference Abstract | PUB-ID: 2912589
Microfluids as platform for the spatiotemporal analysis of bacterial populations at single-cell level
Helfrich S, Krämer C, Grünberger A, Azzouzi CE, Pfeifer E, Frunzke J, Wiechert W, Kohlheyer D, Nöh K (2014)
Presented at the 30th Symposium "Mechanisms of Gene Regulation" of the VAAM study group "Regulation & Signal Transduction in Prokaryotes", Düsseldorf, Germany.
PUB
 
[80]
2014 | Conference Abstract | PUB-ID: 2912591
Microfluidic Single-Cell Cultivation: Opportunity for Industrial Bioprocess Development
Grünberger A, Probst C, Frunzke J, Noack S, Wiechert W, Kohlheyer D (2014)
Presented at the EMBL Conference – Microfluidics 2014, Heidelberg, Germany.
PUB
 
[79]
2014 | Conference Abstract | PUB-ID: 2912595
Single-cell Bioreactors boost Bioprocess Development: New Insights into Cellular Metabolism
Kohlheyer D, Grünberger A, Probst C, Helfrich S, Frunzke J, Eggeling L, Nöh K, Noack S, Wiechert W (2014)
Presented at the Metabolic Engineering X, Vancouver, Canada.
PUB
 
[78]
2014 | Conference Abstract | PUB-ID: 2912596
Single-cell cultivation in picoliter scale: Opportunity for bioprocess development
Grünberger A, Probst C, Unthan S, Mustafi N, Frunzke J, Noack S, Wiechert W, Kohlheyer D (2014)
Presented at the 3rd BioProScale Symposium, Berlin, Germany.
PUB
 
[77]
2014 | Conference Abstract | PUB-ID: 2912569
Cage me if you can! Optogenetic bacterial gene regulation using photocaged inducers
Binder D, Grünberger A, Loeschcke A, Probst C, Bier C, Pietruszka J, Wiechert W, Kohlheyer D, Jaeger K-E, Drepper T (2014)
Presented at the VAAM Jahrestagung, Dresden, Germany.
PUB
 
[76]
2014 | Conference Paper | PUB-ID: 2912571
Microfluidic Single-Cell Analysis Platform for Biotechnological Process Development
Grünberger A, Probst C, Helfrich S, Frunzke J, Noack S, Nöh K, Wiechert W, Kohlheyer D (2014)
In: MicroTAS 2014. San Diego, California: CBM Society: 3 p.
PUB
 
[75]
2014 | Conference Abstract | PUB-ID: 2912575
Microfluidics as platform for the spatio-temporal analysis of bacterial populations at single-cell level
Krämer C, Helfrich S, Azzouzi CE, Grünberger A, Pfeifer E, Frunzke J, Wiechert W, Nöh K, Kohlheyer D (2014)
Presented at the International Meeting, Phenotypic heterogeneity and sociobiology of bacterial populations, Irsee, Germany.
PUB
 
[74]
2014 | Conference Abstract | PUB-ID: 2912576
From extracellular Environment to functional phenotype: Quantitative comparison of single cell physiology in static and steady environments
Dusny C, Grünberger A, Wiechert W, Kohlheyer D, Schmid A (2014)
Presented at the 3rd BioProScale Symposium "Inhomogeneities in large-scale bioprocesses. System biology and process dynamics", Berlin, Germany.
PUB
 
[73]
2014 | Journal Article | PUB-ID: 2912616
Beyond growth rate 0.6: What drives Corynebacterium glutamicum to higher growth rates in defined medium
Unthan S, Grünberger A, van Ooyen J, Gätgens J, Heinrich J, Paczia N, Wiechert W, Kohlheyer D, Noack S (2014)
Biotechnology and bioengineering 111(2): 359–371.
PUB | DOI | WoS | PubMed | Europe PMC
 
[72]
2013 | Conference Abstract | PUB-ID: 2912836
Characterization of light-triggered gene expression in E. coli with respect to population and single cell response
Binder D, Grünberger A, Loeschcke A, Probst C, Pietruszka J, Wiechert W, Kohlheyer D, Jaeger KE, Drepper T (2013)
Presented at the New Approaches and Concepts in Microbiology, Heidelberg, Germany.
PUB
 
[71]
2013 | Conference Abstract | PUB-ID: 2912835
Application of a genetically- encoded metabolite sensor for single cell analysis and the development of production strains
Mahr R, Mustafi N, Grünberger A, Helfrich S, Nöh K, Kohlheyer D, Frunzke J (2013)
Presented at the Advanced Imaging in Cell- and Microbiology: Technology and Applications (AICMB), Jülich, Germany.
PUB
 
[70]
2013 | Conference Abstract | PUB-ID: 2912834
Characterization of light-triggered gene expression in E. coli with respect to population and single cell response
Binder D, Grünberger A, Loeschcke A, Probst C, Pietruszka J, Wiechert W, Kohlheyer D, Jaeger KE, Drepper T (2013)
Presented at the Advanced Imaging in Cell- and Microbiology: Technology and Applications (AICMB), Jülich, Germany.
PUB
 
[69]
2013 | Conference Abstract | PUB-ID: 2912833
Single-cell dynamics of the SOS response in Corynebacterium glutamicum
Nanda AM, Heyer A, Grünberger A, Helfrich S, Kohlheyer D, Nöh K, Frunzke J (2013)
Presented at the Advanced Imaging in Cell- and Microbiology: Technology and Applications (AICMB), Jülich, Germany.
PUB
 
[68]
2013 | Conference Abstract | PUB-ID: 2912830
Microfluidic single-cell analysis in dynamic environments
Probst C, Grünberger A, Krämer C, Wiechert W, Kohlheyer D (2013)
Presented at the Advanced Imaging in Cell- and Microbiology: Technology and Applications (AICMB), Jülich, Germany.
PUB
 
[67]
2013 | Conference Abstract | PUB-ID: 2912829
Automated image analysis pipeline for single cell bacterial growth studies
Sachs C, Grünberger A, Probst C, Wiechert W, Kohlheyer D (2013)
Presented at the Advanced Imaging in Cell- and Microbiology: Technology and Applications (AICMB), Jülich, Germany.
PUB
 
[66]
2013 | Conference Abstract | PUB-ID: 2912828
Continuous Non-Invasive Real-Time Viability Measurement of Bacteria on Single Cell Level in Microfluidic Chip Cultures?
Krämer C, Grünberger A, Probst C, Wiechert W, Kohlheyer D (2013)
Presented at the Advanced Imaging in Cell- and Microbiology: Technology and Applications (AICMB), Jülich, Germany.
PUB
 
[65]
2013 | Conference Abstract | PUB-ID: 2912827
Application of a genetically- encoded metabolite sensor for single cell analysis and the development of production strains
Mahr R, Mustafi N, Grünberger A, Helfrich S, Nöh K, Kohlheyer D, Frunzke J (2013)
Presented at the Jülich Biotech Day, Jülich, Germany.
PUB
 
[64]
2013 | Conference Abstract | PUB-ID: 2912826
Exploration and Analysis of cell population development: Customisable interactive lineage trees
Helfrich S, Azzouzi CE, Grünberger A, Wiechert W, Nöh K (2013)
Presented at the Jülich Biotech Day, Jülich, Germany.
PUB
 
[63]
2013 | Conference Abstract | PUB-ID: 2912825
Characterization of light-triggered gene expression in E. coli with respect to population and single cell response
Binder D, Grünberger A, Loeschcke A, Probst C, Pietruszka J, Wiechert W, Kohlheyer D, Jaeger KE, Drepper T (2013)
Presented at the Jülich Biotech Day, Jülich, Germany.
PUB
 
[62]
2013 | Conference Abstract | PUB-ID: 2912824
Single-cell dynamics of the SOS response in Corynebacterium glutamicum
Nanda AM, Heyer A, Grünberger A, Helfrich S, Kohlheyer D, Nöh K, Frunzke J (2013)
Presented at the Jülich Biotech Day, Jülich, Germany.
PUB
 
[61]
2013 | Conference Abstract | PUB-ID: 2912810
Analysis of microbial observables on single cell level: Challenges of Cell Clusters for Microscopy-based Image Processing
Helfrich S, Grünberger A, Kohlheyer D, Wiechert W, Nöh K (2013)
Presented at the 9th European Congress of Chemical Engineering (ECCE9)/ 2nd European Congress of Applied Biotechnology (ECAB2), The Hague, Netherlands.
PUB
 
[60]
2013 | Conference Abstract | PUB-ID: 2912809
Microbial Metabolite Production – Live in Concert
Frunzke J, Mahr R, Grünberger A, Mustafi N, Kohlheyer D (2013)
Presented at the Advanced Imaging in Cell- and Microbiology: Technology and Applications (AICMB), Jülich, Germany.
PUB
 
[59]
2013 | Journal Article | PUB-ID: 2912745
Coarse-Grained Modeling of Protein Second Osmotic Virial Coefficients: Sterics and Short-Ranged Attractions
Grünberger A, Lai P-K, Blanco MA, Roberts CJ (2013)
The Journal of Physical Chemistry B 117(3): 763-770.
PUB | DOI
 
[58]
2013 | Journal Article | PUB-ID: 2912606
Visualization of Imbalances in Sulfur Assimilation and Synthesis of Sulfur-Containing Amino Acids at the Single-Cell Level
Hoffmann K, Grünberger A, Lausberg F, Bott M, Eggeling L (2013)
Applied and environmental microbiology 79(21): 6730-6736.
PUB | DOI | WoS | PubMed | Europe PMC
 
[57]
2013 | Journal Article | PUB-ID: 2912611
Polydimethylsiloxane (PDMS) Sub-Micron Traps for Single-Cell Analysis of Bacteria
Probst C, Grünberger A, Wiechert W, Kohlheyer D (2013)
Micromachines 4(4): 357-369.
PUB | PDF | DOI | WoS
 
[56]
2013 | Journal Article | PUB-ID: 2912599
Microfluidic Picoliter Bioreactor for Microbial Single-cell Analysis: Fabrication, System Setup, and Operation
Grünberger A, Probst C, Heyer A, Wiechert W, Frunzke J, Kohlheyer D (2013)
Journal of visualized experiments 82: UNSP e50560.
PUB | PDF | DOI | WoS
 
[55]
2013 | Journal Article | PUB-ID: 2912600
Microfluidic growth chambers with optical tweezers for full spatial single-cell control and analysis of evolving microbes
Probst C, Grünberger A, Wiechert W, Kohlheyer D (2013)
Journal of microbiological methods 95(3): 470-476.
PUB | DOI | WoS | PubMed | Europe PMC
 
[54]
2013 | Conference Abstract | PUB-ID: 2912602
Automated High-Throughput Time-Lapse Microscopy of Bacteria Microcolonies in Parallelized Monolayer Growth Chambers
Grünberger A, Helfrich S, Mustafi N, Probst C, Frunzke J, Nöh K, Wiechert W, Kohlheyer D (2013)
Presented at the Advanced Imaging in Cell- and Microbiology: Technology and Applications, Jülich, Germany.
PUB
 
[53]
2013 | Conference Abstract | PUB-ID: 2912603
Single Cell Bioreactors for Bioprocess Optimization
Grünberger A, Probst C, Unthan S, Krämer C, Paczia N, Noack S, Wiechert W, Kohlheyer D (2013)
Presented at the Jülich Biotech Day 2013, Jülich,Germany.
PUB
 
[52]
2013 | Conference Abstract | PUB-ID: 2912604
Application of a genetically encoded biosensor for single cell analysis and strain development of production strains
Mahr R, Mustafi N, Grünberger A, Helfrich S, Nöh K, Kohlheyer D, Frunzke J (2013)
Presented at the New concepts and approaches in microbiology, Heidelberg, Germany.
PUB
 
[51]
2013 | Conference Abstract | PUB-ID: 2912607
SOS-induced spontaneous prophage induction in Corynebacterium glutamicum
Nanda A, Heyer A, Krämer C, Grünberger A, Kohlheyer D, Frunzke J (2013)
Presented at the Nikon Symposium on Advanced Imaging in Cell- and Microbiology Technology and Applications, Jülich, Germany.
PUB
 
[50]
2013 | Conference Abstract | PUB-ID: 2912609
Single-cell Dynamics of the SOS Response in Corynebacterium glutamicum
Nanda A, Heyer A, Grünberger A, Helfrich S, Kohlheyer D, Nöh K, Frunzke J (2013)
Presented at the Bacterial Networks, Pultusk, Poland.
PUB
 
[49]
2013 | Conference Abstract | PUB-ID: 2912612
SOS-induced spontaneous prophage induction in Corynebacterium glutamicum
Nanda A, Heyer A, Krämer C, Grünberger A, Kohlheyer D, Frunzke J (2013)
Presented at the EMBL Heidelberg "New Approaches and Concepts in Microbiology", Heidelberg, Germany.
PUB
 
[48]
2013 | Conference Abstract | PUB-ID: 2912608
SOS-induced spontaneous prophage induction in Corynebacterium glutamicum
Nanda A, Heyer A, Krämer C, Grünberger A, Kohlheyer D, Frunzke J (2013)
Presented at the Jülich Biotech Day 2013, Jülich, Germany.
PUB
 
[47]
2013 | Journal Article | PUB-ID: 2614036
Construction of a prophage-free variant of Corynebacterium glutamicum ATCC 13032 - a platform strain for basic research and industrial biotechnology
Baumgart M, Unthan S, Rückert C, Sivalingam J, Grünberger A, Kalinowski J, Bott M, Noack S, Frunzke J (2013)
Applied and environmental microbiology 79(19): 6006-6015.
PUB | DOI | WoS | PubMed | Europe PMC
 
[46]
2013 | Conference Abstract | PUB-ID: 2912613
Microfluidic cultivation technology and application: analysing single-microbes under perfect environmental control
Probst C, Grünberger A, Frunzke J, Wiechert W, Kohlheyer D (2013)
Presented at the EMBL Heidelberg "New Approaches and Concepts in Microbiology", Heidelberg, Germany.
PUB
 
[45]
2013 | Conference Abstract | PUB-ID: 2912614
Continuous Non-Invasive Real-Time Viability Measurement of Bacteria on Single Cell Level in Microfluidic Chip Cultures
Krämer C, Grünberger A, Probst C, Wiechert W, Kohlheyer D (2013)
Presented at the EMBL Heidelberg "New Approaches and Concepts in Microbiology", Heidelberg, Germany.
PUB
 
[44]
2013 | Conference Abstract | PUB-ID: 2912615
Explorative Analysis of Cell Population Development: Customizable Interactive Lineage Trees
Helfrich S, Azzouzi CE, Grünberger A, Wiechert W, Nöh K (2013)
Presented at the EMBL Heidelberg "New Approaches and Concepts in Microbiology", Heidelberg, Germany.
PUB
 
[43]
2013 | Conference Abstract | PUB-ID: 2912617
Continuous viability fluorescent staining of growing Corynebacterium glutamicum colonies without sample preparation in an automated microfluidic measurement system
Krämer C, Grünberger A, Probst C, Wiechert W, Kohlheyer D (2013)
Presented at the How Deas Is Dead III Conference, Berlin, Germany.
PUB
 
[42]
2013 | Conference Abstract | PUB-ID: 2912618
Picoliter fermentation with single bacteria: Learning from the one to unravel the crowd
Kohlheyer D, Grünberger A, Probst C, Frunzke J, Wiechert W (2013)
Presented at the 2nd International Congress Implementation of Microreactor Technology in Biotechnology, Cavtat, Croatia.
PUB
 
[41]
2013 | Conference Abstract | PUB-ID: 2912619
Femtoliter chemostat for long-term bacteria growth and production analysis on single cell level
Grünberger A, Probst C, Wiechert W, Kohlheyer D (2013)
Presented at the 2nd International Conference Implementation of Microreactor Technology in Biotechnology, Cavtat, Croatia.
PUB
 
[40]
2013 | Conference Abstract | PUB-ID: 2912620
Increasing biomass productivity of C. glutamicum - new insights from microscale cultivations
Noack S, Grünberger A, van Ooyen J, Kohlheyer D, Wiechert W (2013)
Presented at the 9th European Congress of Chemical Engineering, Den Haag, The Netherlands.
PUB
 
[39]
2013 | Conference Abstract | PUB-ID: 2912621
Towards High-Throughput Microbial Single Cell Analysis In Picoliter Bioreactors
Grünberger A, Mustafi N, Probst C, Frunzke J, Wiechert W, Kohlheyer D (2013)
Presented at the 9th European Congress of Chemical Engineering, Den Haag, The Netherlands.
PUB
 
[38]
2013 | Conference Abstract | PUB-ID: 2912622
Picoliter Bioreactors: Learning from Single Cells about Large Scale Processes
Wiechert W, Kohlheyer D, Noack S, Frunzke J, Mustafi N, Grünberger A (2013)
Presented at the Copenhagen Bioscience Conferences, Cell Factories and Biosustainability, Favrholm, Denmark.
PUB
 
[37]
2013 | Conference Abstract | PUB-ID: 2912623
Spontaneous prophage induction in Corynebacterium glutamicum
Heyer A, Nanda A, Grünberger A, Kohlheyer D, Frunzke J (2013)
Presented at the VAAM-Tagung 2013, Bremen, Germany.
PUB
 
[36]
2013 | Conference Abstract | PUB-ID: 2912624
High-throughput Microbial Single Cell analysis in Picoliter Bioreactors
Grünberger A, Mustafi N, Probst C, Frunzke J, Wiechert W, Kohlheyer D (2013)
Presented at the VAAM-Tagung 2013, Bremen, Germany.
PUB
 
[35]
2013 | Conference Abstract | PUB-ID: 2912625
Single cell growth under constant environmental conditions and defined C sources: A case study for Corynebacterium glutamicum
Heinrich J, Grünberger A, Probst C, Wiechert W, Kohlheyer D (2013)
Presented at the VAAM-Tagung 2013, Bremen, Germany.
PUB
 
[34]
2013 | Conference Abstract | PUB-ID: 2912626
Femtoliter chemostat for long-term bacteria growth and production analysis on single cell level
Grünberger A, Probst C, Wiechert W, Kohlheyer D (2013)
Presented at the Single Cell Analysis Europe 2013, Barcelona, Spain.
PUB
 
[33]
2013 | Conference Abstract | PUB-ID: 2912627
Time lapse microbial single cell analysis in a micro fabricated batch reactor
Probst C, Frank P, Grünberger A, Wiechert W, Kohlheyer D (2013)
Presented at the Single Cell Analysis Europe 2013, Barcelona, Spain.
PUB
 
[32]
2013 | Conference Abstract | PUB-ID: 2912630
Microbial single cell analysis of production strains in microfabricated habitats
Kohlheyer D, Grünberger A, Probst C, Krämer C, Eggeling L, Frunzke J, Wiechert W (2013)
Presented at the DECHEMA-Workshop Microfluidics for Systems Biology and Bioprocess Development, Frankfurt, Germany.
PUB
 
[31]
2013 | Journal Article | PUB-ID: 2912631
Beyond growth rate 0.6: Corynebacterium glutamicum cultivated in highly diluted environments
Grünberger A, van Ooyen J, Paczia N, Rohe P, Schendzielorz G, Eggeling L, Wiechert W, Kohlheyer D, Noack S (2013)
Biotechnology and bioengineering 110(1): 220-228.
PUB | DOI | WoS | PubMed | Europe PMC
 
[30]
2012 | Conference Abstract | PUB-ID: 2912841
Dynamics of the SOS response in single cells of Corynebacterium glutamicum
Nanda AM, Grünberger A, Heyer A, Helfrich S, Kohlheyer D, Nöh K, Frunzke J (2012)
Presented at the 2nd Molecular Microbiology Meeting Würzburg, Würzburg, Germany.
PUB
 
[29]
2012 | Conference Abstract | PUB-ID: 2912840
Dynamics of the SOS response in single cells of Corynebacterium glutamicum
Nanda AM, Grünberger A, Heyer A, Helfrich S, Kohlheyer D, Nöh K, Frunzke J (2012)
Presented at the Microbial Stress: from Molecules to System, Belgirate (VB)/Maggiore Lake, Italy.
PUB
 
[28]
2012 | Conference Abstract | PUB-ID: 2912839
Phenotypic Sorting and Analysis of Bacteria Production Strains using Optical Tweezers and Microfluidics
Probst C, Grünberger A, Wiechert W, Kohlheyer D (2012)
Presented at the EMBL Conference – Microfluidics 2012, Heidelberg, Germany.
PUB
 
[27]
2012 | Conference Abstract | PUB-ID: 2912838
“Catch it and Batch it”- Microfluidics single cell batch cultivation utilizing picoliter bioreactors
Frank P, Probst C, Grünberger A, Wiechert W, Kohlheyer D (2012)
Presented at the ProcessNet- Jahrestagung 2012 und 30. DECHEMA Jahrestagung der Biotechnologen, Karlsruhe, Germany.
PUB
 
[26]
2012 | Conference Abstract | PUB-ID: 2912837
Screening of Escherichia coli on single-cell level by hyphenating microfluidic picoliter fermentation and optical tweezers
Probst C, Grünberger A, Wiechert W, Kohlheyer D (2012)
Presented at the 3rd European Conference on Microfluidics, Heidelberg, Germany.
PUB
 
[25]
2012 | Conference Abstract | PUB-ID: 2912777
Towards high-throughput single cell growth optimization and production analysis using picoliter bioreactors
Grünberger A, Probst C, Wiechert W, Kohlheyer D (2012)
Presented at the Metabolic Engineering IX 2012, Biarritz, France.
PUB
 
[24]
2012 | Conference Abstract | PUB-ID: 2912776
Single Cell Analysis of Industrially Relevant Bacterial Strains in Picoliter Environments
Grünberger A, Probst. C, Frank P, Wiechert W, Kohlheyer D (2012)
Presented at the EMBL Conference – Microfluidics 2012, Heidelberg, Germany.
PUB
 
[23]
2012 | Conference Abstract | PUB-ID: 2912767
Fermentation at Picoliter Scale: Microfluidics for single cell analysis of prokaryotic production strains
Grünberger A, Probst C, Wiechert W, Kohlheyer D (2012)
Presented at the Achema 2012, Frankfurt, Germany.
PUB
 
[22]
2012 | Conference Paper | PUB-ID: 2912758
Single Cell Trapping and Analysis for Prokaryotic Production Strains in Sub-µm Fluidic Structures
Grünberger A, Probst C, Binder S, Ziaee R, Eggeling L, Wiechert W, Kohlheyer D (2012)
In: 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011 (MiroTAS 2011). Red Hook, NY: Curran.
PUB
 
[21]
2012 | Conference Paper | PUB-ID: 2912643
High-Throughput lineage tree investigations of bacteria microcolonies using arrays of monolayer growth chambers
Grünberger A, Helfrich S, Probst C, Wiechert W, Nöh K, Kohlheyer D (2012)
In: Proceedings of The Sixteenth International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2012). San Diego, California: CBMS.
PUB
 
[20]
2012 | Conference Paper | PUB-ID: 2912646
Industrial Biotechnology meets Microfluidics - Disposable high-throughput single cell analysis device for industrially relevant bacterial strains
Grünberger A, Helfrich S, Probst C, Nöh K, Wiechert W, Kohlheyer D (2012)
In: Proceedings - µFLU-12. Paris: SHF.
PUB
 
[19]
2012 | Journal Article | PUB-ID: 2912746
The development and application of a single-cell biosensor for the detection of l-methionine and branched-chain amino acids
Mustafi N, Grünberger A, Kohlheyer D, Bott M, Frunzke J (2012)
Metabolic Engineering 14(4): 449-457.
PUB | DOI | PubMed | Europe PMC
 
[18]
2012 | Journal Article | PUB-ID: 2912747
Synthesis of Chiral Cyanohydrins by Recombinant Escherichia coli Cells in a Micro-Aqueous Reaction System
Scholz KE, Okrob D, Kopka B, Grünberger A, Pohl M, Jaeger K-E, Krauss U (2012)
Applied and Environmental Microbiology 78(14): 5025-5027.
PUB | DOI | PubMed | Europe PMC
 
[17]
2012 | Journal Article | PUB-ID: 2912728
A disposable picolitre bioreactor for cultivation and investigation of industrially relevant bacteria on the single cell level
Grünberger A, Paczia N, Probst C, Schendzielorz G, Eggeling L, Noack S, Wiechert W, Kohlheyer D (2012)
Lab on a Chip 12(11): 2060-2068.
PUB | PDF | DOI
 
[16]
2012 | Conference Abstract | PUB-ID: 2912645
Catch it and batch it: picoliter fermentation at the single cell level
Kohlheyer D, Grünberger A, Probst C, Frank P, Wiechert W (2012)
Presented at the International Workshop on New and Synthetic Bioproduction Systems, Hamburg-Harburg, Germany.
PUB
 
[15]
2012 | Conference Abstract | PUB-ID: 2912635
Metabolite sensors for single-cell isolation of producing bacteria
Binder S, Schendzielorz G, Kohlheyer D, Grünberger A, Wiechert W, Bott M, Eggeling L (2012)
Presented at the Metabolic Engineering IX, Biarritz, France.
PUB
 
[14]
2012 | Conference Abstract | PUB-ID: 2912638
A biosensor for the intracellular detection of L-methionine and branched-chain amino acids - Monitoring of amino acid production at the single cell level
Mustafi N, Grünberger A, Helfrich S, Kohlheyer D, Nöh K, Bott M, Frunzke J (2012)
Presented at the 15th International Conference on Biotechnology, Istanbul, Turkey.
PUB
 
[13]
2012 | Conference Abstract | PUB-ID: 2912633
Picoliter bioreactors for growth heterogeneity studies of industrially relevant bacteria on single cell level
Grünberger A, Probst C, Wiechert W, Kohlheyer D (2012)
Presented at the 2nd BioProScale Symposium: Inhomogeneities in large-scale bioprocesses: System biology and process dynamics, Berlin, Germany.
PUB
 
[12]
2012 | Conference Paper | PUB-ID: 2912639
Phenotypic Sorting and Analysis of Bacteria ProductionStrains Using Optical Tweezers and Microfluidics
Probst C, Grünberger A, Kohlheyer D, Wiechert W (2012)
Chemie - Ingenieur - Technik: CIT 84(8): 1344.
PUB | DOI
 
[11]
2012 | Conference Paper | PUB-ID: 2912640
High-Throughput Growth Rate Determination of Bacteria Micro colonies on Single Cell Level
Grünberger A, Probst C, Wiechert W, Kohlheyer D (2012)
Chemie - Ingenieur - Technik: CIT 84(8): 1336-1337.
PUB | DOI
 
[10]
2012 | Conference Paper | PUB-ID: 2912641
Femtoliter Growth Channels: Bacteria Long-Term Growth Patterns Analysis on Singel Cell Level
Grünberger A, Probst C, Wiechert W, Kohlheyer D (2012)
Chemie - Ingenieur - Technik: CIT 84(8): 1407.
PUB | DOI
 
[9]
2012 | Conference Abstract | PUB-ID: 2912642
Single Cell Microfluidics: From Fabrication to Application
Grünberger A, Frank P, Probst C, Wiechert W, Kohlheyer D (2012)
Presented at the Jülich Biotech Day, Jülich, Germany.
PUB
 
[8]
2012 | Conference Abstract | PUB-ID: 2912647
Semi-Automated Evaluation of Microbial Observables from High-Throughput Time-lapse Microscopy
Helfrich S, Grünberger A, Kohlheyer D, Wiechert W, Nöh K (2012)
Presented at the German Conference on Bioinformatics 2012, Jena (Germany).
PUB
 
[7]
2011 | Conference Abstract | PUB-ID: 2912843
Fluorescence reporters for the analysis of whole cell biocatalysts in non-conventional media
Scholz KE, Okrob D, Kopka B, Grünberger A, Pohl M, Jaeger KE, Krauss U (2011)
Presented at the , Biotrans 2011, Giardini Naxos (Messina), Italy.
PUB
 
[6]
2011 | Conference Abstract | PUB-ID: 2912842
A biosensor for the intracellular detection of L-methionine and branched-chain amino acids
Mustafi N, Grünberger A, Kohlheyer D, Bott M, Frunzke J (2011)
Presented at the 5th International Conference on Analysis of Microbial Cells at the Single Cell Level, Caryy-Le-Rouet, France.
PUB
 
[5]
2011 | Conference Abstract | PUB-ID: 2912811
Sub-µm Fluidic Structures for Single Cell Trapping and Analysis of Prokaryotic Production Strains
Kohlheyer D, Grünberger A, Probst C, Wiechert W (2011)
Presented at the 21st Annual conference of the German Society for Cytometry, Bonn, Germany.
PUB
 
[4]
2011 | Conference Abstract | PUB-ID: 2912778
Single Cell Trapping and Analysis for Prokaryotic Production Strains in Sub -µm Fluidic Structures
Grünberger A, Probst C, Wiechert W, Kohlheyer D (2011)
Presented at the NanoBioTech-Montreux 2011, Montreux, Switzerland.
PUB
 
[3]
2011 | Conference Abstract | PUB-ID: 2912768
A continuous picoliter bioreactor for heterogeneity studies of bacteria microcolonies
Grünberger A, Probst C, Wiechert W, Kohlheyer D (2011)
Presented at the NanoBioTech-Montreux 2011, Montreux, Switzerland.
PUB
 
[2]
2010 | Conference Abstract | PUB-ID: 2912812
Protein Interactions from Kirwood-Buff Analysis of Light Scattering and Coarse-Grained Molecular Models
Blanko MA, Grünberger A, Sahin E, Roberts CJ (2010)
Presented at the AIChE, Salt Lake City (UT), USA.
PUB
 
[1]
2009 | Conference Abstract | PUB-ID: 2912813
Media optimization for the microalgae Chamydomonas reinhardtii Stm6 using statistical design
Grünberger A, Stephens E, Hankamer B (2009)
Presented at the , IMB Summer Symposium: A systems Biology approach to biofuel production: From light capture to biodiesel production, Brisbane, Australia.
PUB
 

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