Dynamic Environmental Control in Microfluidic Single‐Cell Cultivations: From Concepts to Applications

Täuber S, Lieres E, Grünberger A (2020)
Small 16(16): 1906670.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Abstract / Bemerkung
Microfluidic single‐cell cultivation (MSCC) is an emerging field within fundamental as well as applied biology. During the last years, most MSCCs were performed at constant environmental conditions. Recently, MSCC at oscillating and dynamic environmental conditions has started to gain significant interest in the research community for the investigation of cellular behavior. Herein, an overview of this topic is given and microfluidic concepts that enable oscillating and dynamic control of environmental conditions with a focus on medium conditions are discussed, and their application in single‐cell research for the cultivation of both mammalian and microbial cell systems is demonstrated. Furthermore, perspectives for performing MSCC at complex dynamic environmental profiles of single parameters and multiparameters (e.g., pH and O2) in amplitude and time are discussed. The technical progress in this field provides completely new experimental approaches and lays the foundation for systematic analysis of cellular metabolism at fluctuating environments.
Stichworte
Biotechnology; Engineering (miscellaneous); Biomaterials
Erscheinungsjahr
2020
Zeitschriftentitel
Small
Band
16
Ausgabe
16
Art.-Nr.
1906670
ISSN
1613-6810
eISSN
1613-6829
Page URI
https://pub.uni-bielefeld.de/record/2941821

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Täuber S, Lieres E, Grünberger A. Dynamic Environmental Control in Microfluidic Single‐Cell Cultivations: From Concepts to Applications. Small. 2020;16(16): 1906670.
Täuber, S., Lieres, E., & Grünberger, A. (2020). Dynamic Environmental Control in Microfluidic Single‐Cell Cultivations: From Concepts to Applications. Small, 16(16), 1906670. doi:10.1002/smll.201906670
Täuber, S., Lieres, E., and Grünberger, A. (2020). Dynamic Environmental Control in Microfluidic Single‐Cell Cultivations: From Concepts to Applications. Small 16:1906670.
Täuber, S., Lieres, E., & Grünberger, A., 2020. Dynamic Environmental Control in Microfluidic Single‐Cell Cultivations: From Concepts to Applications. Small, 16(16): 1906670.
S. Täuber, E. Lieres, and A. Grünberger, “Dynamic Environmental Control in Microfluidic Single‐Cell Cultivations: From Concepts to Applications”, Small, vol. 16, 2020, : 1906670.
Täuber, S., Lieres, E., Grünberger, A.: Dynamic Environmental Control in Microfluidic Single‐Cell Cultivations: From Concepts to Applications. Small. 16, : 1906670 (2020).
Täuber, Sarah, Lieres, Eric, and Grünberger, Alexander. “Dynamic Environmental Control in Microfluidic Single‐Cell Cultivations: From Concepts to Applications”. Small 16.16 (2020): 1906670.
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