A disposable picolitre bioreactor for cultivation and investigation of industrially relevant bacteria on the single cell level

Grünberger A, Paczia N, Probst C, Schendzielorz G, Eggeling L, Noack S, Wiechert W, Kohlheyer D (2012)
Lab on a Chip 12(11): 2060-2068.

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Grünberger A, Paczia N, Probst C, et al. A disposable picolitre bioreactor for cultivation and investigation of industrially relevant bacteria on the single cell level. Lab on a Chip. 2012;12(11):2060-2068.
Grünberger, A., Paczia, N., Probst, C., Schendzielorz, G., Eggeling, L., Noack, S., Wiechert, W., et al. (2012). A disposable picolitre bioreactor for cultivation and investigation of industrially relevant bacteria on the single cell level. Lab on a Chip, 12(11), 2060-2068. doi:10.1039/c2lc40156h
Grünberger, A., Paczia, N., Probst, C., Schendzielorz, G., Eggeling, L., Noack, S., Wiechert, W., and Kohlheyer, D. (2012). A disposable picolitre bioreactor for cultivation and investigation of industrially relevant bacteria on the single cell level. Lab on a Chip 12, 2060-2068.
Grünberger, A., et al., 2012. A disposable picolitre bioreactor for cultivation and investigation of industrially relevant bacteria on the single cell level. Lab on a Chip, 12(11), p 2060-2068.
A. Grünberger, et al., “A disposable picolitre bioreactor for cultivation and investigation of industrially relevant bacteria on the single cell level”, Lab on a Chip, vol. 12, 2012, pp. 2060-2068.
Grünberger, A., Paczia, N., Probst, C., Schendzielorz, G., Eggeling, L., Noack, S., Wiechert, W., Kohlheyer, D.: A disposable picolitre bioreactor for cultivation and investigation of industrially relevant bacteria on the single cell level. Lab on a Chip. 12, 2060-2068 (2012).
Grünberger, Alexander, Paczia, Nicole, Probst, Christopher, Schendzielorz, Georg, Eggeling, Lothar, Noack, Stephan, Wiechert, Wolfgang, and Kohlheyer, Dietrich. “A disposable picolitre bioreactor for cultivation and investigation of industrially relevant bacteria on the single cell level”. Lab on a Chip 12.11 (2012): 2060-2068.
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51 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

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Enhanced protein and biochemical production using CRISPRi-based growth switches.
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Technical bias of microcultivation environments on single-cell physiology.
Dusny C, Grünberger A, Probst C, Wiechert W, Kohlheyer D, Schmid A., Lab Chip 15(8), 2015
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Life under extreme energy limitation: a synthesis of laboratory- and field-based investigations.
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Modeling and CFD simulation of nutrient distribution in picoliter bioreactors for bacterial growth studies on single-cell level.
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Spatiotemporal microbial single-cell analysis using a high-throughput microfluidics cultivation platform.
Grünberger A, Probst C, Helfrich S, Nanda A, Stute B, Wiechert W, von Lieres E, Nöh K, Frunzke J, Kohlheyer D., Cytometry A 87(12), 2015
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Beyond growth rate 0.6: What drives Corynebacterium glutamicum to higher growth rates in defined medium.
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Analysis of SOS-induced spontaneous prophage induction in Corynebacterium glutamicum at the single-cell level.
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Application of a genetically encoded biosensor for live cell imaging of L-valine production in pyruvate dehydrogenase complex-deficient Corynebacterium glutamicum strains.
Mustafi N, Grünberger A, Mahr R, Helfrich S, Nöh K, Blombach B, Kohlheyer D, Frunzke J., PLoS One 9(1), 2014
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Looking for the pick of the bunch: high-throughput screening of producing microorganisms with biosensors.
Schallmey M, Frunzke J, Eggeling L, Marienhagen J., Curr Opin Biotechnol 26(), 2014
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Single-cell microfluidics: opportunity for bioprocess development.
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Frontier microfluidic techniques for short and long-term single cell analysis.
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Light-responsive control of bacterial gene expression: precise triggering of the lac promoter activity using photocaged IPTG.
Binder D, Grünberger A, Loeschcke A, Probst C, Bier C, Pietruszka J, Wiechert W, Kohlheyer D, Jaeger KE, Drepper T., Integr Biol (Camb) 6(8), 2014
PMID: 24894989
Measuring bacterial adaptation dynamics at the single-cell level using a microfluidic chemostat and time-lapse fluorescence microscopy.
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Beyond growth rate 0.6: Corynebacterium glutamicum cultivated in highly diluted environments.
Grünberger A, van Ooyen J, Paczia N, Rohe P, Schiendzielorz G, Eggeling L, Wiechert W, Kohlheyer D, Noack S., Biotechnol Bioeng 110(1), 2013
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Monitoring of population dynamics of Corynebacterium glutamicum by multiparameter flow cytometry.
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Microfluidic chemostat for measuring single cell dynamics in bacteria.
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Microtools for single-cell analysis in biopharmaceutical development and manufacturing.
Love KR, Bagh S, Choi J, Love JC., Trends Biotechnol 31(5), 2013
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Construction of a prophage-free variant of Corynebacterium glutamicum ATCC 13032 for use as a platform strain for basic research and industrial biotechnology.
Baumgart M, Unthan S, Rückert C, Sivalingam J, Grünberger A, Kalinowski J, Bott M, Noack S, Frunzke J., Appl Environ Microbiol 79(19), 2013
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Microfluidic growth chambers with optical tweezers for full spatial single-cell control and analysis of evolving microbes.
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Microfluidic picoliter bioreactor for microbial single-cell analysis: fabrication, system setup, and operation.
Gruenberger A, Probst C, Heyer A, Wiechert W, Frunzke J, Kohlheyer D., J Vis Exp (82), 2013
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Paczia N, Nilgen A, Lehmann T, Gätgens J, Wiechert W, Noack S., Microb Cell Fact 11(), 2012
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