A disposable picolitre bioreactor for cultivation and investigation of industrially relevant bacteria on the single cell level

Grünberger A, Paczia N, Probst C, Schendzielorz G, Eggeling L, Noack S, Wiechert W, Kohlheyer D (2012)
Lab on a Chip 12(11): 2060-2068.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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URN
urn:nbn:de:0070-pub-29127288
Autor*in
Grünberger, AlexanderUniBi; Paczia, Nicole; Probst, Christopher; Schendzielorz, Georg; Eggeling, Lothar; Noack, Stephan; Wiechert, Wolfgang; Kohlheyer, Dietrich
Einrichtung
Technische Fakultät > AG Multiscale Bioengineering
Erscheinungsjahr
2012
Zeitschriftentitel
Lab on a Chip
Band
12
Ausgabe
11
Seite(n)
2060-2068
ISSN
1473-0197
eISSN
1473-0189
Page URI
https://pub.uni-bielefeld.de/record/2912728

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Grünberger A, Paczia N, Probst C, et al. A disposable picolitre bioreactor for cultivation and investigation of industrially relevant bacteria on the single cell level. Lab on a Chip. 2012;12(11):2060-2068.
Grünberger, A., Paczia, N., Probst, C., Schendzielorz, G., Eggeling, L., Noack, S., Wiechert, W., et al. (2012). A disposable picolitre bioreactor for cultivation and investigation of industrially relevant bacteria on the single cell level. Lab on a Chip, 12(11), 2060-2068. doi:10.1039/c2lc40156h
Grünberger, Alexander, Paczia, Nicole, Probst, Christopher, Schendzielorz, Georg, Eggeling, Lothar, Noack, Stephan, Wiechert, Wolfgang, and Kohlheyer, Dietrich. 2012. “A disposable picolitre bioreactor for cultivation and investigation of industrially relevant bacteria on the single cell level”. Lab on a Chip 12 (11): 2060-2068.
Grünberger, A., Paczia, N., Probst, C., Schendzielorz, G., Eggeling, L., Noack, S., Wiechert, W., and Kohlheyer, D. (2012). A disposable picolitre bioreactor for cultivation and investigation of industrially relevant bacteria on the single cell level. Lab on a Chip 12, 2060-2068.
Grünberger, A., et al., 2012. A disposable picolitre bioreactor for cultivation and investigation of industrially relevant bacteria on the single cell level. Lab on a Chip, 12(11), p 2060-2068.
A. Grünberger, et al., “A disposable picolitre bioreactor for cultivation and investigation of industrially relevant bacteria on the single cell level”, Lab on a Chip, vol. 12, 2012, pp. 2060-2068.
Grünberger, A., Paczia, N., Probst, C., Schendzielorz, G., Eggeling, L., Noack, S., Wiechert, W., Kohlheyer, D.: A disposable picolitre bioreactor for cultivation and investigation of industrially relevant bacteria on the single cell level. Lab on a Chip. 12, 2060-2068 (2012).
Grünberger, Alexander, Paczia, Nicole, Probst, Christopher, Schendzielorz, Georg, Eggeling, Lothar, Noack, Stephan, Wiechert, Wolfgang, and Kohlheyer, Dietrich. “A disposable picolitre bioreactor for cultivation and investigation of industrially relevant bacteria on the single cell level”. Lab on a Chip 12.11 (2012): 2060-2068.
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52 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Importance of Pyruvate Sensing and Transport for the Resuscitation of Viable but Nonculturable Escherichia coli K-12.
Vilhena C, Kaganovitch E, Grünberger A, Motz M, Forné I, Kohlheyer D, Jung K., J Bacteriol 201(3), 2019
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Reproduction of Large-Scale Bioreactor Conditions on Microfluidic Chips.
Ho P, Westerwalbesloh C, Kaganovitch E, Grünberger A, Neubauer P, Kohlheyer D, Lieres EV., Microorganisms 7(4), 2019
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Quantitative modelling of nutrient-limited growth of bacterial colonies in microfluidic cultivation.
Hornung R, Grünberger A, Westerwalbesloh C, Kohlheyer D, Gompper G, Elgeti J., J R Soc Interface 15(139), 2018
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Population heterogeneity in microbial bioprocesses: origin, analysis, mechanisms, and future perspectives.
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Natural biocide cocktails: Combinatorial antibiotic effects of prodigiosin and biosurfactants.
Hage-Hülsmann J, Grünberger A, Thies S, Santiago-Schübel B, Klein AS, Pietruszka J, Binder D, Hilgers F, Domröse A, Drepper T, Kohlheyer D, Jaeger KE, Loeschcke A., PLoS One 13(7), 2018
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Cytometry meets next-generation sequencing - RNA-Seq of sorted subpopulations reveals regional replication and iron-triggered prophage induction in Corynebacterium glutamicum.
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Meander Designer: Automatically Generating Meander Channel Designs.
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New Technologies for Rapid Bacterial Identification and Antibiotic Resistance Profiling.
Kelley SO., SLAS Technol 22(2), 2017
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Homogenizing bacterial cell factories: Analysis and engineering of phenotypic heterogeneity.
Binder D, Drepper T, Jaeger KE, Delvigne F, Wiechert W, Kohlheyer D, Grünberger A., Metab Eng 42(), 2017
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Role of growth rate on the orientational alignment of Escherichia coli in a slit.
Sheats J, Sclavi B, Cosentino Lagomarsino M, Cicuta P, Dorfman KD., R Soc Open Sci 4(6), 2017
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Bioprocess scale-up/down as integrative enabling technology: from fluid mechanics to systems biology and beyond.
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Isoniazid Killing of Mycobacterium smegmatis NADH Pyrophosphatase Mutant at Single-Cell Level using Microfluidics and Time-Lapse Microscopy.
Elitas M., Sci Rep 7(1), 2017
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Heterogeneity in Pure Microbial Systems: Experimental Measurements and Modeling.
González-Cabaleiro R, Mitchell AM, Smith W, Wipat A, Ofiţeru ID., Front Microbiol 8(), 2017
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Beyond the bulk: disclosing the life of single microbial cells.
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Transcription factor-based biosensors in biotechnology: current state and future prospects.
Mahr R, Frunzke J., Appl Microbiol Biotechnol 100(1), 2016
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Programmable, Pneumatically Actuated Microfluidic Device with an Integrated Nanochannel Array To Track Development of Individual Bacteria.
Baker JD, Kysela DT, Zhou J, Madren SM, Wilkens AS, Brun YV, Jacobson SC., Anal Chem 88(17), 2016
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Silencing of cryptic prophages in Corynebacterium glutamicum.
Pfeifer E, Hünnefeld M, Popa O, Polen T, Kohlheyer D, Baumgart M, Frunzke J., Nucleic Acids Res 44(21), 2016
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Comparative Single-Cell Analysis of Different E. coli Expression Systems during Microfluidic Cultivation.
Binder D, Probst C, Grünberger A, Hilgers F, Loeschcke A, Jaeger KE, Kohlheyer D, Drepper T., PLoS One 11(8), 2016
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Enhanced protein and biochemical production using CRISPRi-based growth switches.
Li S, Jendresen CB, Grünberger A, Ronda C, Jensen SI, Noack S, Nielsen AT., Metab Eng 38(), 2016
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Measuring gene expression in single bacterial cells: recent advances in methods and micro-devices.
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Review of methods to probe single cell metabolism and bioenergetics.
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Impact of spontaneous prophage induction on the fitness of bacterial populations and host-microbe interactions.
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Microfluidic single-cell analysis links boundary environments and individual microbial phenotypes.
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Technical bias of microcultivation environments on single-cell physiology.
Dusny C, Grünberger A, Probst C, Wiechert W, Kohlheyer D, Schmid A., Lab Chip 15(8), 2015
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Life under extreme energy limitation: a synthesis of laboratory- and field-based investigations.
Lever MA, Rogers KL, Lloyd KG, Overmann J, Schink B, Thauer RK, Hoehler TM, Jørgensen BB., FEMS Microbiol Rev 39(5), 2015
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Live cell imaging of SOS and prophage dynamics in isogenic bacterial populations.
Helfrich S, Pfeifer E, Krämer C, Sachs CC, Wiechert W, Kohlheyer D, Nöh K, Frunzke J., Mol Microbiol 98(4), 2015
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Modeling and CFD simulation of nutrient distribution in picoliter bioreactors for bacterial growth studies on single-cell level.
Westerwalbesloh C, Grünberger A, Stute B, Weber S, Wiechert W, Kohlheyer D, von Lieres E., Lab Chip 15(21), 2015
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Spatiotemporal microbial single-cell analysis using a high-throughput microfluidics cultivation platform.
Grünberger A, Probst C, Helfrich S, Nanda A, Stute B, Wiechert W, von Lieres E, Nöh K, Frunzke J, Kohlheyer D., Cytometry A 87(12), 2015
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Fluorescent Reporter Libraries as Useful Tools for Optimizing Microbial Cell Factories: A Review of the Current Methods and Applications.
Delvigne F, Pêcheux H, Tarayre C., Front Bioeng Biotechnol 3(), 2015
PMID: 26442261
Beyond growth rate 0.6: What drives Corynebacterium glutamicum to higher growth rates in defined medium.
Unthan S, Grünberger A, van Ooyen J, Gätgens J, Heinrich J, Paczia N, Wiechert W, Kohlheyer D, Noack S., Biotechnol Bioeng 111(2), 2014
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Analysis of SOS-induced spontaneous prophage induction in Corynebacterium glutamicum at the single-cell level.
Nanda AM, Heyer A, Krämer C, Grünberger A, Kohlheyer D, Frunzke J., J Bacteriol 196(1), 2014
PMID: 24163339
Application of a genetically encoded biosensor for live cell imaging of L-valine production in pyruvate dehydrogenase complex-deficient Corynebacterium glutamicum strains.
Mustafi N, Grünberger A, Mahr R, Helfrich S, Nöh K, Blombach B, Kohlheyer D, Frunzke J., PLoS One 9(1), 2014
PMID: 24465669
Looking for the pick of the bunch: high-throughput screening of producing microorganisms with biosensors.
Schallmey M, Frunzke J, Eggeling L, Marienhagen J., Curr Opin Biotechnol 26(), 2014
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Single-cell microfluidics: opportunity for bioprocess development.
Grünberger A, Wiechert W, Kohlheyer D., Curr Opin Biotechnol 29(), 2014
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Frontier microfluidic techniques for short and long-term single cell analysis.
Avesar J, Arye TB, Levenberg S., Lab Chip 14(13), 2014
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Kinetic models in industrial biotechnology - Improving cell factory performance.
Almquist J, Cvijovic M, Hatzimanikatis V, Nielsen J, Jirstrand M., Metab Eng 24(), 2014
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Application of metabolic engineering for the biotechnological production of L-valine.
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Light-responsive control of bacterial gene expression: precise triggering of the lac promoter activity using photocaged IPTG.
Binder D, Grünberger A, Loeschcke A, Probst C, Bier C, Pietruszka J, Wiechert W, Kohlheyer D, Jaeger KE, Drepper T., Integr Biol (Camb) 6(8), 2014
PMID: 24894989
Measuring bacterial adaptation dynamics at the single-cell level using a microfluidic chemostat and time-lapse fluorescence microscopy.
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Beyond growth rate 0.6: Corynebacterium glutamicum cultivated in highly diluted environments.
Grünberger A, van Ooyen J, Paczia N, Rohe P, Schiendzielorz G, Eggeling L, Wiechert W, Kohlheyer D, Noack S., Biotechnol Bioeng 110(1), 2013
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Monitoring of population dynamics of Corynebacterium glutamicum by multiparameter flow cytometry.
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Microfluidic chemostat for measuring single cell dynamics in bacteria.
Long Z, Nugent E, Javer A, Cicuta P, Sclavi B, Cosentino Lagomarsino M, Dorfman KD., Lab Chip 13(5), 2013
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Microtools for single-cell analysis in biopharmaceutical development and manufacturing.
Love KR, Bagh S, Choi J, Love JC., Trends Biotechnol 31(5), 2013
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Construction of a prophage-free variant of Corynebacterium glutamicum ATCC 13032 for use as a platform strain for basic research and industrial biotechnology.
Baumgart M, Unthan S, Rückert C, Sivalingam J, Grünberger A, Kalinowski J, Bott M, Noack S, Frunzke J., Appl Environ Microbiol 79(19), 2013
PMID: 23892752
Microfluidic growth chambers with optical tweezers for full spatial single-cell control and analysis of evolving microbes.
Probst C, Grünberger A, Wiechert W, Kohlheyer D., J Microbiol Methods 95(3), 2013
PMID: 24041615
An integrated microfluidic device for the high-throughput screening of microalgal cell culture conditions that induce high growth rate and lipid content.
Bae S, Kim CW, Choi JS, Yang JW, Seo TS., Anal Bioanal Chem 405(29), 2013
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Microfluidic picoliter bioreactor for microbial single-cell analysis: fabrication, system setup, and operation.
Gruenberger A, Probst C, Heyer A, Wiechert W, Frunzke J, Kohlheyer D., J Vis Exp (82), 2013
PMID: 24336165
A high-throughput approach to identify genomic variants of bacterial metabolite producers at the single-cell level.
Binder S, Schendzielorz G, Stäbler N, Krumbach K, Hoffmann K, Bott M, Eggeling L., Genome Biol 13(5), 2012
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Isolated microbial single cells and resulting micropopulations grow faster in controlled environments.
Dusny C, Fritzsch FS, Frick O, Schmid A., Appl Environ Microbiol 78(19), 2012
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Extensive exometabolome analysis reveals extended overflow metabolism in various microorganisms.
Paczia N, Nilgen A, Lehmann T, Gätgens J, Wiechert W, Noack S., Microb Cell Fact 11(), 2012
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