61 Publikationen
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2025 | Datenpublikation | PUB-ID: 2994643Holtgräwe, D., Ashraf, S., Weisshaar, B., & Viehöver, P. (2025). Transcriptomic analysis of Pinot Noir and Pinot Noir Precoce updated to PN40024.v5 reference datasets. Bielefeld University. https://doi.org/10.4119/unibi/2994643
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2024 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2994723Schmidt, N., Maiwald, S., Mann, L., Weber, B., Seibt, K. M., Breitenbach, S., Liedtke, S., et al. (2024). BeetRepeats: reference sequences for genome and polymorphism annotation in sugar beet and wild relatives. BMC Research Notes, 17(1), 351. https://doi.org/10.1186/s13104-024-06993-4
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2023 | Datenpublikation | PUB-ID: 2966927Sielemann, K., Pucker, B., Orsini, E., Elashry, A., Schulte, L., Viehöver, P., Müller, A. E., et al. (2023). Genome assembly, structural and functional annotation, and mRNA coverage/length files for KWS2320ONT_v1.0 and Strube U2BvONT_v1.0. Bielefeld University. https://doi.org/10.4119/unibi/2966927
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2023 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2980215Sielemann, K., Pucker, B., Orsini, E., Elashry, A., Schulte, L., Viehöver, P., Müller, A., et al. (2023). Genomic characterization of a nematode tolerance locus in sugar beet. BMC Genomics, 24, 748. https://doi.org/10.1186/s12864-023-09823-2
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2023 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2969571Schilbert, H., Holzenkamp, K., Viehöver, P., Holtgräwe, D., & Möllers, C. (2023). Homoeologous non-reciprocal translocation explains a major QTL for seed lignin content in oilseed rape (Brassica napus L.). Theoretical and Applied Genetics, 136, 172. https://doi.org/10.1007/s00122-023-04407-w
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2023 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2985152Schmidt, N., Sielemann, K., Breitenbach, S., Fuchs, J., Pucker, B., Weisshaar, B., Holtgräwe, D., et al. (2023). Repeat turnover meets stable chromosomes: repetitive DNA sequences mark speciation and gene pool boundaries in sugar beet and wild beets. The Plant Journal, 118(1), 171-190. https://doi.org/10.1111/tpj.16599
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2023 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2985993Müllner, S., Frommer, B., Holtgräwe, D., Viehöver, P., Hüttel, B., Töpfer, R., Weisshaar, B., et al. (2023). Analysis of the Rpv12 locus in a haplotype‑separated grapevine genome sequence. Vitis: Journal of Grapevine Research , 62(Special Issue), 77-80. https://doi.org/10.5073/VITIS.2023.62.SPECIAL-ISSUE.77-80
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2023 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2964982Frommer, B., Muellner, S., Holtgräwe, D., Viehöver, P., Huettel, B., Toepfer, R., Weisshaar, B., et al. (2023). Phased grapevine genome sequence assembly of an Rpv12 carrier for exploration of Rpv12 associated positional and functional Plasmopara viticola resistance genes. Frontiers in Plant Science, 14, 1180982. https://doi.org/10.3389/fpls.2023.1180982
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2023 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2978044Shi, X., Cao, S., Wang, X., Huang, S., Wang, Y., Liu, Z., Liu, W., et al. (2023). The complete reference genome for grapevine (Vitis vinifera L.) genetics and breeding. Horticulture Research, 10(5), uhad061. https://doi.org/10.1093/hr/uhad061
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2023 | Datenpublikation | PUB-ID: 2966932Sielemann, K., Schmidt, N., Guzik, J., Kalina, N., Pucker, B., Viehöver, P., Breitenbach, S., et al. (2023). Genome assembly and structural and functional annotation files for crop wild relatives of sugar beet. Bielefeld University. https://doi.org/10.4119/unibi/2966932
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2023 | Preprint | Veröffentlicht | PUB-ID: 2980439Sielemann, K., Schmidt, N., Guzik, J., Kalina, N., Pucker, B., Viehöver, P., Breitenbach, S., et al. (2023). Pangenome of cultivated beet and crop wild relatives reveals parental relationships of a tetraploid wild beet. bioRxiv. https://doi.org/10.1101/2023.06.28.546919
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2023 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2967809Velt, A., Frommer, B., Blanc, S., Holtgräwe, D., Duchêne, É., Dumas, V., Grimplet, J., et al. (2023). An improved reference of the grapevine genome reasserts the origin of the PN40024 highly-homozygous genotype. G3 Genes|Genomes|Genetics, 13(5), jkad067. https://doi.org/10.1093/g3journal/jkad067
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2022 | Datenpublikation | PUB-ID: 2962793Frommer, B., Weisshaar, B., & Holtgräwe, D. (2022). Chromosome-scale haplotype genome sequence assemblies of ‘Börner’ and corresponding genome sequence annotations. Bielefeld University. https://doi.org/10.4119/unibi/2962793
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2022 | Preprint | PUB-ID: 2964291Frommer, B., Hausmann, L., Holtgräwe, D., Viehöver, P., Hüttel, B., Reinhard, R., Töpfer, R., et al. (2022). A fully phased interspecific grapevine rootstock genome sequence representing *V. riparia* and *V. cinerea* and allele-aware annotation of the phylloxera resistance locus *Rdv1*. bioRxiv. https://doi.org/10.1101/2022.07.07.499180
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2022 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2963558Schilbert, H., Pucker, B., Ries, D., Viehöver, P., Micic, Z., Dreyer, F., Beckmann, K., et al. (2022). Mapping-by-sequencing reveals genomic regions associated with seed quality parameters in <em>Brassica napus</em>. Genes, 13(7), 1131. https://doi.org/10.3390/genes13071131
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2022 | Datenpublikation | PUB-ID: 2963492Pucker, B., Schilbert, H., Viehöver, P., Weisshaar, B., & Holtgräwe, D. (2022). Supplementary material related to MBS analysis of seed quality parameters in Brassica napus. Bielefeld University. https://doi.org/10.4119/unibi/2963492
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2022 | Datenpublikation | PUB-ID: 2962800Frommer, B., Müllner, S., Weisshaar, B., & Holtgräwe, D. (2022). Phase-separated genome sequence assembly of the grapevine cultivar Gf.99-03 and its annotation. Bielefeld University. https://doi.org/10.4119/unibi/2962800
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2022 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2958188Sielemann, K., Pucker, B., Schmidt, N., Viehöver, P., Weisshaar, B., Heitkam, T., & Holtgräwe, D. (2022). Complete pan-plastome sequences enable high resolution phylogenetic classification of sugar beet and closely related crop wild relatives. BMC Genomics, 23, 113. https://doi.org/10.1186/s12864-022-08336-8
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2022 | Datenpublikation | PUB-ID: 2962639Rosleff Sörensen, T., Frommer, B., Viehöver, P., Weisshaar, B., & Holtgräwe, D. (2022). Contig sequences derived from selected ‘Börner’ BACs assigned to either of the two parental haplotypes *V. riparia* or *V. cinerea* of the *Vitis* rootstock ‘Börner’. Bielefeld University. https://doi.org/10.4119/unibi/2962639
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2021 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2952955Theine, J., Holtgräwe, D., Herzog, K., Schwander, F., Kicherer, A., Hausmann, L., Viehöver, P., et al. (2021). Transcriptomic analysis of temporal shifts in berry development between two grapevine cultivars of the Pinot family reveals potential genes controlling ripening time. BMC Plant Biology, 21, 327. https://doi.org/10.1186/s12870-021-03110-6
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2021 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2956071Schilbert, H., Schöne, M., Baier, T., Busche, M., Viehöver, P., Weisshaar, B., & Holtgräwe, D. (2021). Characterization of the Brassica napus flavonol synthase gene family reveals bifunctional flavonol synthases. Frontiers in Plant Science, 12, 733762. https://doi.org/10.3389/fpls.2021.733762
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2021 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2948771Matar, S., Kumar, A., Holtgräwe, D., Weisshaar, B., & Melzer, S. (2021). The transition to flowering in winter rapeseed during vernalization. Plant, Cell & Environment, 44(2), 506-518. https://doi.org/10.1111/pce.13946
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2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2948720Pucker, B., Schwandner, A., Becker, S., Hausmann, L., Viehöver, P., Töpfer, R., Weisshaar, B., et al. (2020). RNA-Seq Time Series of Vitis vinifera Bud Development Reveals Correlation of Expression Patterns with the Local Temperature Profile. Plants, 9(11), 1548. https://doi.org/10.3390/plants9111548
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2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2941655Holtgräwe, D., Rosleff Soerensen, T., Hausmann, L., Pucker, B., Viehöver, P., Töpfer, R., & Weisshaar, B. (2020). A Partially Phase-Separated Genome Sequence Assembly of the Vitis Rootstock ‘Börner’ (Vitis riparia × Vitis cinerea) and Its Exploitation for Marker Development and Targeted Mapping. Frontiers in Plant Science, 11, 156. https://doi.org/10.3389/fpls.2020.00156
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2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2942459Frommer, B., Holtgräwe, D., Hausmann, L., Viehöver, P., Huettel, B., Töpfer, R., & Weisshaar, B. (2020). Genome Sequences of Both Organelles of the Grapevine Rootstock Cultivar ‘Börner’. Microbiology Resource Announcements, 9(15), e01471-19. https://doi.org/10.1128/mra.01471-19
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2020 | Datenpublikation | PUB-ID: 2941430Frommer, B., Holtgräwe, D., & Weisshaar, B. (2020). Dataset describing RNA editing sites in the chloroplast genome of 'Boerner' (Vitis riparia x Vitis cinerea). Bielefeld University. doi:10.4119/unibi/2941430
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2020 | Datenpublikation | PUB-ID: 2941437Frommer, B., Holtgräwe, D., & Weisshaar, B. (2020). Dataset describing RNA editing sites in the mitochondrial genome of 'Boerner' (Vitis riparia x Vitis cinerea). Bielefeld University. doi:10.4119/unibi/2941437
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2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2943420Vu, D. P., Martins Rodrigues, C., Jung, B., Meissner, G., Klemens, P. A. W., Holtgräwe, D., Fürtauer, L., et al. (2020). Vacuolar sucrose homeostasis is critical for plant development, seed properties, and night-time survival in Arabidopsis. Journal of Experimental Botany, 71(16), 4930-4943. doi:10.1093/jxb/eraa205
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2019 | Datenpublikation | PUB-ID: 2938180Holtgräwe, D., Pucker, B., Rosleff Sörensen, T., & Weisshaar, B. (2019). Heterozygous SNVs between BoeWGS1.0 and PN40024. Bielefeld University. https://doi.org/10.4119/unibi/2938180
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2019 | Datenpublikation | PUB-ID: 2938178Holtgräwe, D., Pucker, B., Rosleff Sörensen, T., & Weisshaar, B. (2019). Homozygous SNVs between BoeWGS1.0 and PN40024. Bielefeld University. https://doi.org/10.4119/unibi/2938178
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2019 | Datenpublikation | PUB-ID: 2938185Holtgräwe, D., Pucker, B., Rosleff Sörensen, T., & Weisshaar, B. (2019). Description and mapping positions of BoeWGS1.0 contigs. Bielefeld University. doi:10.4119/unibi/2938185
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2019 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2935698Pucker, B., Holtgräwe, D., Stadermann, K. B., Frey, K., Huettel, B., Reinhardt, R., & Weisshaar, B. (2019). Chromosome-level sequence assembly reveals the structure of the Arabidopsis thaliana Nd-1 genome and its gene set. PLoS One, 14(5), e0216233. doi:10.1371/journal.pone.0216233
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2019 | Datenpublikation | PUB-ID: 2949309Pucker, B., Holtgräwe, D., Stadermann, K. B., & Weisshaar, B. (2019). Chromosome-level Assembly Reveals the Niederzenz (Nd-1) Genome Structure and Gene Set. Leibniz Institute of Plant Genetics and Crop Plant Research (IPK), Seeland OT Gatersleben. doi:10.5447/IPK/2019/4
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2019 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2936315Kamal, N., Ochßner, I., Schwandner, A., Viehöver, P., Hausmann, L., Töpfer, R., Weisshaar, B., et al. (2019). Characterization of genes and alleles involved in the control of flowering time in grapevine. PLoS One, 14(7), e0214703. doi:10.1371/journal.pone.0214703
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2911903Capistrano-Gossmann, G. G., Ries, D., Holtgräwe, D., Minoche, A., Kraft, T., Frerichmann, S. L. M., Rosleff Sörensen, T., et al. (2017). Crop wild relative populations of Beta vulgaris allow direct mapping of agronomically important genes. Nature Communications, 8(1), 15708. doi:10.1038/ncomms15708
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2017 | Datenpublikation | PUB-ID: 2949668Dohm, J. C., Gonzalez, I., Holtgräwe, D., Minoche, A., Rosleff Sörensen, T., Weisshaar, B., & Himmelbauer, H. (2017). Beta vulgaris spp. maritima draft genome sequence assembly and structural prediction of protein coding genes. Leibniz Institute of Plant Genetics and Crop Plant Research (IPK), Seeland OT Gatersleben. doi:10.5447/IPK/2017/3
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2915524Pucker, B., Holtgräwe, D., & Weisshaar, B. (2017). Consideration of non-canonical splice sites improves gene prediction on the Arabidopsis thaliana Niederzenz-1 genome sequence. BMC Research Notes, 10(1), 667. doi:10.1186/s13104-017-2985-y
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2905844Pucker, B., Holtgräwe, D., Rosleff Sörensen, T., Stracke, R., Viehöver, P., & Weisshaar, B. (2016). A de novo Genome Sequence Assembly of the Arabidopsis thaliana Accession Niederzenz-1 Displays Presence/Absence Variation and Strong Synteny. PLoS One, 11(10), e0164321. doi:10.1371/journal.pone.0164321
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2905177Stadermann, K. B., Holtgräwe, D., & Weisshaar, B. (2016). Chloroplast genome sequence of Arabidopsis thaliana accession Landsberg erecta assembled from Single-Molecule, Real-Time sequencing data. Genome Announcements, 4(5), e00975-16. doi:10.1128/genomeA.00975-16
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2901603Ries, D., Holtgräwe, D., Viehöver, P., & Weisshaar, B. (2016). Rapid gene identification in sugar beet using deep sequencing of DNA from phenotypic pools selected from breeding panels. BMC Genomics, 17(1), 236. doi:10.1186/s12864-016-2566-9
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2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2905827Weisshaar, B., Himmelbauer, H., Schmidt, T., Holtgräwe, D., Minoche, A. E., Dohm, J., Stracke, R., et al. (2016). Sugar Beet BeetMap-3, and Steps to Improve the Genome Assembly and Genome Sequence Annotation (W875). Presented at the Plant and Animal Genome XXIV Conference, San Diego, USA.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2775617Stadermann, K. B., Weisshaar, B., & Holtgräwe, D. (2015). SMRT sequencing only de novo assembly of the sugar beet (Beta vulgaris) chloroplast genome. BMC Bioinformatics, 16(1), 295. doi:10.1186/s12859-015-0726-6
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2764063Minoche, A. E., Dohm, J. C., Schneider, J., Holtgräwe, D., Viehöver, P., Montfort, M., Rosleff Sörensen, T., et al. (2015). Exploiting single-molecule transcript sequencing for eukaryotic gene prediction. Genome Biology, 16(1), 184. doi:10.1186/s13059-015-0729-7
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2689802Fechter, I., Hausmann, L., Zyprian, E., Daum, M., Holtgräwe, D., Weisshaar, B., & Töpfer, R. (2014). QTL analysis of flowering time and ripening traits suggests an impact of a genomic region on linkage group 1 in Vitis. Theoretical and Applied Genetics, 127(9), 1857-1872. doi:10.1007/s00122-014-2310-2
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2643946Dohm, J. C., Minoche, A. E., Holtgräwe, D., Capella-Gutiérrez, S., Zakrzewski, F., Tafer, H., Rupp, O., et al. (2014). The genome of the recently domesticated crop plant sugar beet (Beta vulgaris). Nature, 505(7484), 546-549. https://doi.org/10.1038/nature12817
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2699085Holtgräwe, D., Rosleff Sörensen, T., Viehöver, P., Schneider, J., Schulz, B., Borchardt, D., Kraft, T., et al. (2014). Reliable In Silico Identification of Sequence Polymorphisms and Their Application for Extending the Genetic Map of Sugar Beet (Beta vulgaris). PLoS ONE, 9(10), e110113. doi:10.1371/journal.pone.0110113
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2696778Stracke, R., Holtgräwe, D., Schneider, J., Pucker, B., Rosleff Sörensen, T., & Weisshaar, B. (2014). Genome-wide identification and characterisation of R2R3-MYB genes in sugar beet ( Beta vulgaris ). BMC Plant Biology, 14(1), 249. doi:10.1186/s12870-014-0249-8
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2678005Heitkam, T., Holtgräwe, D., Dohm, J. C., Minoche, A. E., Himmelbauer, H., Weisshaar, B., & Schmidt, T. (2014). Profiling of extensively diversified plant LINEs reveals distinct plant-specific subclades. The Plant Journal, 79(3), 385-397. doi:10.1111/tpj.12565
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2684495Dally, N., Xiao, K., Holtgräwe, D., & Jung, C. (2014). The B2 flowering time locus of beet encodes a zinc finger transcription factor. Proceedings of the National Academy of Sciences, 111(28), 10365-10370. doi:10.1073/pnas.1404829111
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2562610Weber, B., Heitkam, T., Holtgräwe, D., Weisshaar, B., Minoche, A. E., Dohm, J. C., Himmelbauer, H., et al. (2013). Highly diverse chromoviruses of Beta vulgaris are classified by chromodomains and chromosomal integration. Mobile DNA, 4(1), 8. doi:10.1186/1759-8753-4-8
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2454417Dohm, J. C., Lange, C., Holtgräwe, D., Rosleff Sörensen, T., Borchardt, D., Schulz, B., Lehrach, H., et al. (2012). Palaeohexaploid Ancestry for Caryophyllales Inferred from Extensive Gene-Based Physical and Genetic Mapping of the Sugar Beet Genome (Beta vulgaris). The Plant Journal, 70(3), 528-540. doi:10.1111/j.1365-313X.2011.04898.x
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2532965Wollrab, C., Heitkam, T., Holtgräwe, D., Weisshaar, B., Minoche, A. E., Dohm, J. C., Himmelbauer, H., et al. (2012). Evolutionary reshuffling in the Errantivirus lineage Elbe within the Beta vulgaris genome. The Plant Journal, 72(4), 636-651. doi:10.1111/j.1365-313X.2012.05107.x
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2457584Menzel, G., Krebs, C., Diez, M., Holtgräwe, D., Weisshaar, B., Minoche, A. E., Dohm, J. C., et al. (2012). Survey of sugar beet (Beta vulgaris L.) hAT transposons and MITE-like hATpin derivatives. Plant Molecular Biology, 78(4-5), 393-405. doi:10.1007/s11103-011-9872-z
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2318497Holtgräwe, D., Weisshaar, B., & Himmelbauer, H. (2011). Die Entschlüsselung der Süßen: GABI-Future-Projekt erstellt Referenzsequenz des Genoms der Zuckerrübe. GenomXPress, 2011(2), 4-6.
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1665020Zakrzewski, F., Wenke, T., Holtgräwe, D., Weisshaar, B., & Schmidt, T. (2010). Analysis of a c0t-1 library enables the targeted identification of minisatellite and satellite families in Beta vulgaris. BMC Plant Biology, 10(1), 8. https://doi.org/10.1186/1471-2229-10-8
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1794548Lange, C., Mittermayr, L., Dohm, J. C., Holtgräwe, D., Weisshaar, B., & Himmelbauer, H. (2010). High-throughput identification of genetic markers using representational oligonucleotide microarray analysis. Theoretical and Applied Genetics, 121(3), 549-565. https://doi.org/10.1007/s00122-010-1329-2
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2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1589556Wenke, T., Holtgräwe, D., Horn, A. V., Weisshaar, B., & Schmidt, T. (2009). An abundant and heavily truncated non-LTR retrotransposon (LINE) family in Beta vulgaris. Plant Molecular Biology, 71(6), 585-597. https://doi.org/10.1007/s11103-009-9542-6
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2008 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1586335Menzel, G., Dechyeva, D., Wenke, T., Holtgräwe, D., Weisshaar, B., & Schmidt, T. (2008). Diversity of a complex centromeric satellite and molecular characterization of dispersed sequence families in sugar beet (Beta vulgaris). Annals of Botany, 102(4), 521-530. https://doi.org/10.1093/aob/mcn131
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2008 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1635969Lange, C., Holtgräwe, D., Schulz, B., Weisshaar, B., & Himmelbauer, H. (2008). Construction and characterization of a sugar beet (Beta vulgaris) fosmid library. Genome, 51(11), 948-951. https://doi.org/10.1139/G08-071
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2005 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1996233Holtgräwe, D., Scholz, A., Altmann, B., & Scheibe, R. (2005). Cytoskeleton-associated, carbohydrate-metabolizing enzymes in maize identified by yeast two-hybrid screening. Physiologia Plantarum, 125(2), 141-156. https://doi.org/10.1111/j.1399-3054.2005.00548.x
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2003 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1864372Hardin, S. C., Tang, G. - Q., Scholz, A., Holtgräwe, D., Winter, H., & Huber, S. C. (2003). Phosphorylation of sucrose synthase at serine 170: occurrence and possible role as a signal for proteolysis. Plant J, 35(5), 588-603. https://doi.org/10.1046/j.1365-313X.2003.01831.x