PUB - Publikationen an der Universität Bielefeld

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• [32]
  

  2023 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2981179

  E-64c-hydrazide based cathepsin C inhibitors: Optimizing the interactions with the S1'-S2' area
  Tromsdorf N, Ullrich F, Rethmeier M, Sommerhoff C, Schaschke N (2023)
  ChemMedChem: e202300218.

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• [31]
  

  2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2703442

  Selective Targeting of Tumor and Stromal Cells By a Nanocarrier System Displaying Lipidated Cathepsin B Inhibitor
  Mikhaylov G, Klimpel D, Schaschke N, Mikac U, Vizovisek M, Fonovic M, Turk V, Turk B, Vasiljeva O (2014)
  Angewandte Chemie International Edition 53(38): 10077-10081.

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• [30]
  

  2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2699425

  The activity and localization patterns of cathepsins B and X in cells of the mouse gastrointestinal tract differ along its length
  Tamhane T, Arampatzidou M, Gerganova V, Tacke M, Illukkumbura R, Dauth S, Schaschke N, Peters C, Reinheckel T, Brix K (2014)
  Biological Chemistry 395(10): 1201-1219.

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• [29]
  

  2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2622177

  E-64c-Hydrazide: A Lead Structure for the Development of Irreversible CathepsinC Inhibitors
  Radzey H, Rethmeier M, Klimpel D, Grundhuber M, Sommerhoff CP, Schaschke N (2013)
  Chemmedchem 8(8): 1314-1321.

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• [28]
  

  2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2489346

  Substrate specificity of Staphylococcus aureus cysteine proteases - Staphopains A, B and C
  Kalinska M, Kantyka T, Greenbaum DC, Larsen KS, Wladyka B, Jabaiah A, Bogyo M, Daugherty PS, Wysocka M, Jaros M, Lesner A, et al. (2012)
  Biochimie 94(2): 318-327.

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• [27]
  

  2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2489135

  Activation of the Nipah Virus Fusion Protein in MDCK Cells Is Mediated by Cathepsin B within the Endosome-Recycling Compartment
  Diederich S, Sauerhering L, Weis M, Altmeppen H, Schaschke N, Reinheckel T, Erbar S, Maisner A (2012)
  Journal of Virology 86(7): 3736-3745.

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• [26]
  

  2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2454769

  The arginine mimicking beta-amino acid beta(3)hPhe(3-H(2)N-CH(2)) as S1 ligand in cyclotheonamide-based beta-tryptase inhibitors
  Janke D, Sommerhoff CP, Schaschke N (2011)
  Bioorganic & Medicinal Chemistry 19(23): 7236-7243.

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• [25]
  

  2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403684

  Aziridine-2,3-Dicarboxylate-Based Cysteine Cathepsin Inhibitors Induce Cell Death in Leishmania major Associated with Accumulation of Debris in Autophagy-Related Lysosome-Like Vacuoles
  Schurigt U, Schad C, Glowa C, Baum U, Thomale K, Schnitzer JK, Schultheis M, Schaschke N, Schirmeister T, Moll H (2010)
  ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 54(12): 5028-5041.

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• [24]
  

  2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403708

  Upgrading a Natural Product: Inhibition of Human beta-Tryptase by Cyclotheonamide Analogues
  Schaschke N, Sommerhoff CP (2010)
  CHEMMEDCHEM 5(3): 367-370.

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• [23]
  

  2008 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403720

  Inhibition of human mu-calpain by conformationally constrained calpastatin peptides
  Pfizer J, Assfalg-Machleidt I, Machleidt W, Schaschke N (2008)
  BIOLOGICAL CHEMISTRY 389(1): 83-90.

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• [22]
  

  2008 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403715

  Inhibition of cathepsin L by epoxysuccinyl peptides simultaneously addressing active-site and remote-site regions
  Schaschke N, Assfalg-Machleidt I, Machleidt W (2008)
  CHEMBIOCHEM 9(11): 1721-1724.

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• [21]
  

  2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403726

  Cathepsin B is essential for regeneration of scratch-wounded normal human epidermal keratinocytes
  Bueth H, Buttigieg PL, Ostafe R, Rehders M, Dannenmann SR, Schaschke N, Stark H-J, Boukamp P, Brix K (2007)
  EUROPEAN JOURNAL OF CELL BIOLOGY 86(11-12): 747-761.

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• [20]
  

  2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403747

  Mast cell tryptase beta as a target in allergic inflammation: An evolving story
  Sommerhoff CP, Schaschke N (2007)
  CURRENT PHARMACEUTICAL DESIGN 13(3): 313-332.

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• [19]
  

  2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403737

  Primed-site probing of papain-like cysteine proteases
  Pfizer JM, Assfalg-Machleidt I, Machleidt W, Moroder L, Schaschke N (2007)
  INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS 13(1-2): 93-104.

  PUB | DOI | WoS
   
• [18]
  

  2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403744

  (2S,3S)-Oxirane-2,3-dicarboxylic acid: A privileged platform for probing human cysteine cathepsins
  Schaschke N (2007)
  JOURNAL OF BIOTECHNOLOGY 129(2): 308-315.

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• [17]
  

  2005 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403754

  Affinity chromatography of tryptases: Design, synthesis and characterization of a novel matrix-bound bivalent inhibitor
  Schaschke N, Gabrijelcic-Geiger D, Dominik A, Sommerhoff CP (2005)
  CHEMBIOCHEM 6(1): 95-103.

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• [16]
  

  2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403774

  Crystal structure of NS-134 in complex with bovine cathepsin B: a two-headed epoxysuccinyl inhibitor extends along the entire active-site cleft
  Stern I, Schaschke N, Moroder L, Turk D (2004)
  BIOCHEMICAL JOURNAL 381(2): 511-517.

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• [15]
  

  2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403779

  Conformational and molecular modeling studies of beta-cyclodextrin-heptagastrin and the third extracellular loop of the cholecystokinin 2 receptor
  Giragossian C, Schaschke N, Moroder L, Mierke DF (2004)
  BIOCHEMISTRY 43(10): 2724-2731.

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• [14]
  

  2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403785

  Miraziridine A: natures blueprint towards protease class-spanning inhibitors
  Schaschke N (2004)
  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 14(4): 855-857.

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• [13]
  

  2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403760

  HaCaT keratinocytes secrete lysosomal cysteine proteinases during migration
  Buth H, Wolters B, Hartwig B, Meier-Bornheim R, Veith H, Hansen M, Sommerhoff CP, Schaschke N, Machleidt N, Fusenig NE, Boukamp P, et al. (2004)
  EUROPEAN JOURNAL OF CELL BIOLOGY 83(11-12): 781-795.

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• [12]
  

  2003 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403798

  Calpastatin exon 1B-derived peptide, a selective inhibitor of calpain: Enhancing cell permeability by conjugation with penetratin
  Gil-Parrado S, Assfalg-Machleidt I, Fiorino F, Deluca D, Pfeiler D, Schaschke N, Moroder L, Machleidt W (2003)
  BIOLOGICAL CHEMISTRY 384(3): 395-402.

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• [11]
  

  2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403813

  Surface cathepsin B protects cytotoxic lymphocytes from self-destruction after degranulation
  Balaji KN, Schaschke N, Machleidt W, Catalfamo M, Henkart PA (2002)
  JOURNAL OF EXPERIMENTAL MEDICINE 196(4): 493-503.

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• [10]
  

  2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403820

  Epoxysuccinyl peptide-derived cathepsin B inhibitors: Modulating membrane permeability by conjugation with the C-terminal heptapeptide segment of penetratin
  Schaschke N, Deluca D, Assfalg-Machleidt I, Hohneke C, Sommerhoff CP, Machleidt W (2002)
  BIOLOGICAL CHEMISTRY 383(5): 849-852.

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• [9]
  

  2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403828

  Bivalent inhibition of beta-tryptase: Distance scan of neighboring subunits by dibasic inhibitors
  Schaschke N, Dominik A, Matschiner G, Sommerhoff CP (2002)
  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 12(6): 985-988.

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• [8]
  

  2001 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403834

  Bivalent inhibition of human beta-tryptase
  Schaschke N, Matschiner G, Zettl F, Marquardt U, Bergner A, Bode W, Sommerhoff CP, Moroder L (2001)
  CHEMISTRY & BIOLOGY 8(4): 313-327.

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• [7]
  

  2000 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403844

  Epoxysuccinyl peptide-derived affinity labels for cathepsin B
  Schaschke N, Assfalg-Machleidt I, Lassleben T, Sommerhoff CP, Moroder L, Machleidt W (2000)
  FEBS LETTERS 482(1-2): 91-96.

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• [6]
  

  2000 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403852

  beta-cyclodextrin/epoxysuccinyl peptide conjugates: new drug targeting system for tumor cells
  Schaschke N, Assfalg-Machleidt I, Machleidt W, Lassleben T, Sommerhoff CP, Moroder L (2000)
  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 10(7): 677-680.

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• [5]
  

  1998 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403860

  Cyclodextrin as carrier of peptide hormones. Conformational and biological properties of beta-cyclodextrin/gastrin constructs
  Schaschke N, Fiori S, Weyher E, Escrieut C, Fourmy D, Muller G, Moroder L (1998)
  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 120(28): 7030-7038.

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• [4]
  

  1998 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403869

  Substrate/propeptide-derived endo-epoxysuccinyl peptides as highly potent and selective cathepsin B inhibitors
  Schaschke N, Assfalg-Machleidt I, Machleidt W, Moroder L (1998)
  FEBS LETTERS 421(1): 80-82.

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• [3]
  

  1997 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403875

  Oligopresentation of protease inhibitors with beta-cyclodextrin as template
  Schaschke N, Musiol HJ, AssfalgMachleidt I, Machleidt W, Moroder L (1997)
  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 7(19): 2507-2512.

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• [2]
  

  1997 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403882

  E-64 analogues as inhibitors of cathepsin B. On the role of the absolute configuration of the epoxysuccinyl group
  Schaschke N, AssfalgMachleidt I, Machleidt W, Turk D, Moroder L (1997)
  BIOORGANIC & MEDICINAL CHEMISTRY 5(9): 1789-1797.

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• [1]
  

  1996 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403889

  Cyclodextrins as templates for the presentation of protease inhibitors
  Schaschke N, Musiol HJ, AssfalgMachleidt I, Machleidt W, RudolphBohner S, Moroder L (1996)
  FEBS LETTERS 391(3): 297-301.

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