Norbert Schaschke

norbert.schaschke@uni-bielefeld.de
PEVZ-ID
175702

32 Publikationen

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  • [32]
    2023 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2981179 OA
    Tromsdorf N, Ullrich F, Rethmeier M, Sommerhoff C, Schaschke N (2023)
    E-64c-hydrazide based cathepsin C inhibitors: Optimizing the interactions with the S1'-S2' area.
    ChemMedChem: e202300218.
    PUB | PDF | DOI | WoS | PubMed | Europe PMC
     
  • [31]
    2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2703442
    Mikhaylov G, Klimpel D, Schaschke N, Mikac U, Vizovisek M, Fonovic M, Turk V, Turk B, Vasiljeva O (2014)
    Selective Targeting of Tumor and Stromal Cells By a Nanocarrier System Displaying Lipidated Cathepsin B Inhibitor.
    Angewandte Chemie International Edition 53(38): 10077-10081.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [30]
    2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2699425
    Tamhane T, Arampatzidou M, Gerganova V, Tacke M, Illukkumbura R, Dauth S, Schaschke N, Peters C, Reinheckel T, Brix K (2014)
    The activity and localization patterns of cathepsins B and X in cells of the mouse gastrointestinal tract differ along its length.
    Biological Chemistry 395(10): 1201-1219.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [29]
    2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2622177
    Radzey H, Rethmeier M, Klimpel D, Grundhuber M, Sommerhoff CP, Schaschke N (2013)
    E-64c-Hydrazide: A Lead Structure for the Development of Irreversible CathepsinC Inhibitors.
    Chemmedchem 8(8): 1314-1321.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [28]
    2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2489346
    Kalinska M, Kantyka T, Greenbaum DC, Larsen KS, Wladyka B, Jabaiah A, Bogyo M, Daugherty PS, Wysocka M, Jaros M, Lesner A, Rolka K, Schaschke N, Stennicke H, Dubin A, Potempa J, Dubin G (2012)
    Substrate specificity of Staphylococcus aureus cysteine proteases - Staphopains A, B and C.
    Biochimie 94(2): 318-327.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [27]
    2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2489135
    Diederich S, Sauerhering L, Weis M, Altmeppen H, Schaschke N, Reinheckel T, Erbar S, Maisner A (2012)
    Activation of the Nipah Virus Fusion Protein in MDCK Cells Is Mediated by Cathepsin B within the Endosome-Recycling Compartment.
    Journal of Virology 86(7): 3736-3745.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [26]
    2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2454769
    Janke D, Sommerhoff CP, Schaschke N (2011)
    The arginine mimicking beta-amino acid beta(3)hPhe(3-H(2)N-CH(2)) as S1 ligand in cyclotheonamide-based beta-tryptase inhibitors.
    Bioorganic & Medicinal Chemistry 19(23): 7236-7243.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [25]
    2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403684
    Schurigt U, Schad C, Glowa C, Baum U, Thomale K, Schnitzer JK, Schultheis M, Schaschke N, Schirmeister T, Moll H (2010)
    Aziridine-2,3-Dicarboxylate-Based Cysteine Cathepsin Inhibitors Induce Cell Death in Leishmania major Associated with Accumulation of Debris in Autophagy-Related Lysosome-Like Vacuoles.
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 54(12): 5028-5041.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [24]
    2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403708
    Schaschke N, Sommerhoff CP (2010)
    Upgrading a Natural Product: Inhibition of Human beta-Tryptase by Cyclotheonamide Analogues.
    CHEMMEDCHEM 5(3): 367-370.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [23]
    2008 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403720
    Pfizer J, Assfalg-Machleidt I, Machleidt W, Schaschke N (2008)
    Inhibition of human mu-calpain by conformationally constrained calpastatin peptides.
    BIOLOGICAL CHEMISTRY 389(1): 83-90.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [22]
    2008 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403715
    Schaschke N, Assfalg-Machleidt I, Machleidt W (2008)
    Inhibition of cathepsin L by epoxysuccinyl peptides simultaneously addressing active-site and remote-site regions.
    CHEMBIOCHEM 9(11): 1721-1724.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [21]
    2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403726
    Bueth H, Buttigieg PL, Ostafe R, Rehders M, Dannenmann SR, Schaschke N, Stark H-J, Boukamp P, Brix K (2007)
    Cathepsin B is essential for regeneration of scratch-wounded normal human epidermal keratinocytes.
    EUROPEAN JOURNAL OF CELL BIOLOGY 86(11-12): 747-761.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [20]
    2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403747
    Sommerhoff CP, Schaschke N (2007)
    Mast cell tryptase beta as a target in allergic inflammation: An evolving story.
    CURRENT PHARMACEUTICAL DESIGN 13(3): 313-332.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [19]
    2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403737
    Pfizer JM, Assfalg-Machleidt I, Machleidt W, Moroder L, Schaschke N (2007)
    Primed-site probing of papain-like cysteine proteases.
    INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS 13(1-2): 93-104.
    PUB | DOI | WoS
     
  • [18]
    2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403744
    Schaschke N (2007)
    (2S,3S)-Oxirane-2,3-dicarboxylic acid: A privileged platform for probing human cysteine cathepsins.
    JOURNAL OF BIOTECHNOLOGY 129(2): 308-315.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [17]
    2005 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403754
    Schaschke N, Gabrijelcic-Geiger D, Dominik A, Sommerhoff CP (2005)
    Affinity chromatography of tryptases: Design, synthesis and characterization of a novel matrix-bound bivalent inhibitor.
    CHEMBIOCHEM 6(1): 95-103.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [16]
    2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403774
    Stern I, Schaschke N, Moroder L, Turk D (2004)
    Crystal structure of NS-134 in complex with bovine cathepsin B: a two-headed epoxysuccinyl inhibitor extends along the entire active-site cleft.
    BIOCHEMICAL JOURNAL 381(2): 511-517.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [15]
    2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403779
    Giragossian C, Schaschke N, Moroder L, Mierke DF (2004)
    Conformational and molecular modeling studies of beta-cyclodextrin-heptagastrin and the third extracellular loop of the cholecystokinin 2 receptor.
    BIOCHEMISTRY 43(10): 2724-2731.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [14]
    2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403785
    Schaschke N (2004)
    Miraziridine A: natures blueprint towards protease class-spanning inhibitors.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 14(4): 855-857.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [13]
    2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403760
    Buth H, Wolters B, Hartwig B, Meier-Bornheim R, Veith H, Hansen M, Sommerhoff CP, Schaschke N, Machleidt N, Fusenig NE, Boukamp P, Brix K (2004)
    HaCaT keratinocytes secrete lysosomal cysteine proteinases during migration.
    EUROPEAN JOURNAL OF CELL BIOLOGY 83(11-12): 781-795.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [12]
    2003 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403798
    Gil-Parrado S, Assfalg-Machleidt I, Fiorino F, Deluca D, Pfeiler D, Schaschke N, Moroder L, Machleidt W (2003)
    Calpastatin exon 1B-derived peptide, a selective inhibitor of calpain: Enhancing cell permeability by conjugation with penetratin.
    BIOLOGICAL CHEMISTRY 384(3): 395-402.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [11]
    2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403813
    Balaji KN, Schaschke N, Machleidt W, Catalfamo M, Henkart PA (2002)
    Surface cathepsin B protects cytotoxic lymphocytes from self-destruction after degranulation.
    JOURNAL OF EXPERIMENTAL MEDICINE 196(4): 493-503.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [10]
    2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403820
    Schaschke N, Deluca D, Assfalg-Machleidt I, Hohneke C, Sommerhoff CP, Machleidt W (2002)
    Epoxysuccinyl peptide-derived cathepsin B inhibitors: Modulating membrane permeability by conjugation with the C-terminal heptapeptide segment of penetratin.
    BIOLOGICAL CHEMISTRY 383(5): 849-852.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [9]
    2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403828
    Schaschke N, Dominik A, Matschiner G, Sommerhoff CP (2002)
    Bivalent inhibition of beta-tryptase: Distance scan of neighboring subunits by dibasic inhibitors.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 12(6): 985-988.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [8]
    2001 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403834
    Schaschke N, Matschiner G, Zettl F, Marquardt U, Bergner A, Bode W, Sommerhoff CP, Moroder L (2001)
    Bivalent inhibition of human beta-tryptase.
    CHEMISTRY & BIOLOGY 8(4): 313-327.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [7]
    2000 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403844
    Schaschke N, Assfalg-Machleidt I, Lassleben T, Sommerhoff CP, Moroder L, Machleidt W (2000)
    Epoxysuccinyl peptide-derived affinity labels for cathepsin B.
    FEBS LETTERS 482(1-2): 91-96.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [6]
    2000 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403852
    Schaschke N, Assfalg-Machleidt I, Machleidt W, Lassleben T, Sommerhoff CP, Moroder L (2000)
    beta-cyclodextrin/epoxysuccinyl peptide conjugates: new drug targeting system for tumor cells.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 10(7): 677-680.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [5]
    1998 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403860
    Schaschke N, Fiori S, Weyher E, Escrieut C, Fourmy D, Muller G, Moroder L (1998)
    Cyclodextrin as carrier of peptide hormones. Conformational and biological properties of beta-cyclodextrin/gastrin constructs.
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 120(28): 7030-7038.
    PUB | DOI | WoS
     
  • [4]
    1998 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403869
    Schaschke N, Assfalg-Machleidt I, Machleidt W, Moroder L (1998)
    Substrate/propeptide-derived endo-epoxysuccinyl peptides as highly potent and selective cathepsin B inhibitors.
    FEBS LETTERS 421(1): 80-82.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [3]
    1997 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403875
    Schaschke N, Musiol HJ, AssfalgMachleidt I, Machleidt W, Moroder L (1997)
    Oligopresentation of protease inhibitors with beta-cyclodextrin as template.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 7(19): 2507-2512.
    PUB | DOI | WoS
     
  • [2]
    1997 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403882
    Schaschke N, AssfalgMachleidt I, Machleidt W, Turk D, Moroder L (1997)
    E-64 analogues as inhibitors of cathepsin B. On the role of the absolute configuration of the epoxysuccinyl group.
    BIOORGANIC & MEDICINAL CHEMISTRY 5(9): 1789-1797.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [1]
    1996 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403889
    Schaschke N, Musiol HJ, AssfalgMachleidt I, Machleidt W, RudolphBohner S, Moroder L (1996)
    Cyclodextrins as templates for the presentation of protease inhibitors.
    FEBS LETTERS 391(3): 297-301.
    PUB | DOI | WoS | PubMed | Europe PMC
     
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