PUB - Publikationen an der Universität Bielefeld

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• [32]
  

  2023 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2981179

  Tromsdorf N, Ullrich F, Rethmeier M, Sommerhoff C, Schaschke N. E-64c-hydrazide based cathepsin C inhibitors: Optimizing the interactions with the S1'-S2' area. ChemMedChem. 2023: e202300218.

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• [31]
  

  2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2703442

  Mikhaylov G, Klimpel D, Schaschke N, et al. Selective Targeting of Tumor and Stromal Cells By a Nanocarrier System Displaying Lipidated Cathepsin B Inhibitor. Angewandte Chemie International Edition. 2014;53(38):10077-10081.

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• [30]
  

  2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2699425

  Tamhane T, Arampatzidou M, Gerganova V, et al. The activity and localization patterns of cathepsins B and X in cells of the mouse gastrointestinal tract differ along its length. Biological Chemistry. 2014;395(10):1201-1219.

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• [29]
  

  2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2622177

  Radzey H, Rethmeier M, Klimpel D, Grundhuber M, Sommerhoff CP, Schaschke N. E-64c-Hydrazide: A Lead Structure for the Development of Irreversible CathepsinC Inhibitors. Chemmedchem. 2013;8(8):1314-1321.

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• [28]
  

  2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2489346

  Kalinska M, Kantyka T, Greenbaum DC, et al. Substrate specificity of Staphylococcus aureus cysteine proteases - Staphopains A, B and C. Biochimie. 2012;94(2):318-327.

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• [27]
  

  2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2489135

  Diederich S, Sauerhering L, Weis M, et al. Activation of the Nipah Virus Fusion Protein in MDCK Cells Is Mediated by Cathepsin B within the Endosome-Recycling Compartment. Journal of Virology. 2012;86(7):3736-3745.

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• [26]
  

  2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2454769

  Janke D, Sommerhoff CP, Schaschke N. The arginine mimicking beta-amino acid beta(3)hPhe(3-H(2)N-CH(2)) as S1 ligand in cyclotheonamide-based beta-tryptase inhibitors. Bioorganic & Medicinal Chemistry. 2011;19(23):7236-7243.

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• [25]
  

  2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403684

  Schurigt U, Schad C, Glowa C, et al. Aziridine-2,3-Dicarboxylate-Based Cysteine Cathepsin Inhibitors Induce Cell Death in Leishmania major Associated with Accumulation of Debris in Autophagy-Related Lysosome-Like Vacuoles. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2010;54(12):5028-5041.

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• [24]
  

  2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403708

  Schaschke N, Sommerhoff CP. Upgrading a Natural Product: Inhibition of Human beta-Tryptase by Cyclotheonamide Analogues. CHEMMEDCHEM. 2010;5(3):367-370.

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• [23]
  

  2008 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403720

  Pfizer J, Assfalg-Machleidt I, Machleidt W, Schaschke N. Inhibition of human mu-calpain by conformationally constrained calpastatin peptides. BIOLOGICAL CHEMISTRY. 2008;389(1):83-90.

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• [22]
  

  2008 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403715

  Schaschke N, Assfalg-Machleidt I, Machleidt W. Inhibition of cathepsin L by epoxysuccinyl peptides simultaneously addressing active-site and remote-site regions. CHEMBIOCHEM. 2008;9(11):1721-1724.

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• [21]
  

  2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403726

  Bueth H, Buttigieg PL, Ostafe R, et al. Cathepsin B is essential for regeneration of scratch-wounded normal human epidermal keratinocytes. EUROPEAN JOURNAL OF CELL BIOLOGY. 2007;86(11-12):747-761.

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• [20]
  

  2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403747

  Sommerhoff CP, Schaschke N. Mast cell tryptase beta as a target in allergic inflammation: An evolving story. CURRENT PHARMACEUTICAL DESIGN. 2007;13(3):313-332.

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• [19]
  

  2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403737

  Pfizer JM, Assfalg-Machleidt I, Machleidt W, Moroder L, Schaschke N. Primed-site probing of papain-like cysteine proteases. INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS. 2007;13(1-2):93-104.

  PUB | DOI | WoS
   
• [18]
  

  2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403744

  Schaschke N. (2S,3S)-Oxirane-2,3-dicarboxylic acid: A privileged platform for probing human cysteine cathepsins. JOURNAL OF BIOTECHNOLOGY. 2007;129(2):308-315.

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• [17]
  

  2005 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403754

  Schaschke N, Gabrijelcic-Geiger D, Dominik A, Sommerhoff CP. Affinity chromatography of tryptases: Design, synthesis and characterization of a novel matrix-bound bivalent inhibitor. CHEMBIOCHEM. 2005;6(1):95-103.

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• [16]
  

  2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403774

  Stern I, Schaschke N, Moroder L, Turk D. Crystal structure of NS-134 in complex with bovine cathepsin B: a two-headed epoxysuccinyl inhibitor extends along the entire active-site cleft. BIOCHEMICAL JOURNAL. 2004;381(2):511-517.

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• [15]
  

  2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403779

  Giragossian C, Schaschke N, Moroder L, Mierke DF. Conformational and molecular modeling studies of beta-cyclodextrin-heptagastrin and the third extracellular loop of the cholecystokinin 2 receptor. BIOCHEMISTRY. 2004;43(10):2724-2731.

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• [14]
  

  2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403785

  Schaschke N. Miraziridine A: natures blueprint towards protease class-spanning inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2004;14(4):855-857.

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• [13]
  

  2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403760

  Buth H, Wolters B, Hartwig B, et al. HaCaT keratinocytes secrete lysosomal cysteine proteinases during migration. EUROPEAN JOURNAL OF CELL BIOLOGY. 2004;83(11-12):781-795.

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• [12]
  

  2003 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403798

  Gil-Parrado S, Assfalg-Machleidt I, Fiorino F, et al. Calpastatin exon 1B-derived peptide, a selective inhibitor of calpain: Enhancing cell permeability by conjugation with penetratin. BIOLOGICAL CHEMISTRY. 2003;384(3):395-402.

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• [11]
  

  2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403813

  Balaji KN, Schaschke N, Machleidt W, Catalfamo M, Henkart PA. Surface cathepsin B protects cytotoxic lymphocytes from self-destruction after degranulation. JOURNAL OF EXPERIMENTAL MEDICINE. 2002;196(4):493-503.

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• [10]
  

  2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403820

  Schaschke N, Deluca D, Assfalg-Machleidt I, Hohneke C, Sommerhoff CP, Machleidt W. Epoxysuccinyl peptide-derived cathepsin B inhibitors: Modulating membrane permeability by conjugation with the C-terminal heptapeptide segment of penetratin. BIOLOGICAL CHEMISTRY. 2002;383(5):849-852.

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• [9]
  

  2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403828

  Schaschke N, Dominik A, Matschiner G, Sommerhoff CP. Bivalent inhibition of beta-tryptase: Distance scan of neighboring subunits by dibasic inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2002;12(6):985-988.

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• [8]
  

  2001 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403834

  Schaschke N, Matschiner G, Zettl F, et al. Bivalent inhibition of human beta-tryptase. CHEMISTRY & BIOLOGY. 2001;8(4):313-327.

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• [7]
  

  2000 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403844

  Schaschke N, Assfalg-Machleidt I, Lassleben T, Sommerhoff CP, Moroder L, Machleidt W. Epoxysuccinyl peptide-derived affinity labels for cathepsin B. FEBS LETTERS. 2000;482(1-2):91-96.

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• [6]
  

  2000 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403852

  Schaschke N, Assfalg-Machleidt I, Machleidt W, Lassleben T, Sommerhoff CP, Moroder L. beta-cyclodextrin/epoxysuccinyl peptide conjugates: new drug targeting system for tumor cells. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2000;10(7):677-680.

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• [5]
  

  1998 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403860

  Schaschke N, Fiori S, Weyher E, et al. Cyclodextrin as carrier of peptide hormones. Conformational and biological properties of beta-cyclodextrin/gastrin constructs. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 1998;120(28):7030-7038.

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• [4]
  

  1998 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403869

  Schaschke N, Assfalg-Machleidt I, Machleidt W, Moroder L. Substrate/propeptide-derived endo-epoxysuccinyl peptides as highly potent and selective cathepsin B inhibitors. FEBS LETTERS. 1998;421(1):80-82.

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• [3]
  

  1997 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403875

  Schaschke N, Musiol HJ, AssfalgMachleidt I, Machleidt W, Moroder L. Oligopresentation of protease inhibitors with beta-cyclodextrin as template. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 1997;7(19):2507-2512.

  PUB | DOI | WoS
   
• [2]
  

  1997 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403882

  Schaschke N, AssfalgMachleidt I, Machleidt W, Turk D, Moroder L. E-64 analogues as inhibitors of cathepsin B. On the role of the absolute configuration of the epoxysuccinyl group. BIOORGANIC & MEDICINAL CHEMISTRY. 1997;5(9):1789-1797.

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• [1]
  

  1996 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403889

  Schaschke N, Musiol HJ, AssfalgMachleidt I, Machleidt W, RudolphBohner S, Moroder L. Cyclodextrins as templates for the presentation of protease inhibitors. FEBS LETTERS. 1996;391(3):297-301.

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