32 Publikationen

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  • [32]
    2023 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2981179 OA
    Tromsdorf N, Ullrich F, Rethmeier M, Sommerhoff C, Schaschke N. E-64c-hydrazide based cathepsin C inhibitors: Optimizing the interactions with the S1'-S2' area. ChemMedChem. 2023: e202300218.
    PUB | PDF | DOI | WoS | PubMed | Europe PMC
     
  • [31]
    2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2703442
    Mikhaylov G, Klimpel D, Schaschke N, et al. Selective Targeting of Tumor and Stromal Cells By a Nanocarrier System Displaying Lipidated Cathepsin B Inhibitor. Angewandte Chemie International Edition. 2014;53(38):10077-10081.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [30]
    2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2699425
    Tamhane T, Arampatzidou M, Gerganova V, et al. The activity and localization patterns of cathepsins B and X in cells of the mouse gastrointestinal tract differ along its length. Biological Chemistry. 2014;395(10):1201-1219.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [29]
    2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2622177
    Radzey H, Rethmeier M, Klimpel D, Grundhuber M, Sommerhoff CP, Schaschke N. E-64c-Hydrazide: A Lead Structure for the Development of Irreversible CathepsinC Inhibitors. Chemmedchem. 2013;8(8):1314-1321.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [28]
    2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2489346
    Kalinska M, Kantyka T, Greenbaum DC, et al. Substrate specificity of Staphylococcus aureus cysteine proteases - Staphopains A, B and C. Biochimie. 2012;94(2):318-327.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [27]
    2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2489135
    Diederich S, Sauerhering L, Weis M, et al. Activation of the Nipah Virus Fusion Protein in MDCK Cells Is Mediated by Cathepsin B within the Endosome-Recycling Compartment. Journal of Virology. 2012;86(7):3736-3745.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [26]
    2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2454769
    Janke D, Sommerhoff CP, Schaschke N. The arginine mimicking beta-amino acid beta(3)hPhe(3-H(2)N-CH(2)) as S1 ligand in cyclotheonamide-based beta-tryptase inhibitors. Bioorganic & Medicinal Chemistry. 2011;19(23):7236-7243.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [25]
    2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403684
    Schurigt U, Schad C, Glowa C, et al. Aziridine-2,3-Dicarboxylate-Based Cysteine Cathepsin Inhibitors Induce Cell Death in Leishmania major Associated with Accumulation of Debris in Autophagy-Related Lysosome-Like Vacuoles. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2010;54(12):5028-5041.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [24]
    2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403708
    Schaschke N, Sommerhoff CP. Upgrading a Natural Product: Inhibition of Human beta-Tryptase by Cyclotheonamide Analogues. CHEMMEDCHEM. 2010;5(3):367-370.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [23]
    2008 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403720
    Pfizer J, Assfalg-Machleidt I, Machleidt W, Schaschke N. Inhibition of human mu-calpain by conformationally constrained calpastatin peptides. BIOLOGICAL CHEMISTRY. 2008;389(1):83-90.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [22]
    2008 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403715
    Schaschke N, Assfalg-Machleidt I, Machleidt W. Inhibition of cathepsin L by epoxysuccinyl peptides simultaneously addressing active-site and remote-site regions. CHEMBIOCHEM. 2008;9(11):1721-1724.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [21]
    2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403726
    Bueth H, Buttigieg PL, Ostafe R, et al. Cathepsin B is essential for regeneration of scratch-wounded normal human epidermal keratinocytes. EUROPEAN JOURNAL OF CELL BIOLOGY. 2007;86(11-12):747-761.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [20]
    2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403747
    Sommerhoff CP, Schaschke N. Mast cell tryptase beta as a target in allergic inflammation: An evolving story. CURRENT PHARMACEUTICAL DESIGN. 2007;13(3):313-332.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [19]
    2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403737
    Pfizer JM, Assfalg-Machleidt I, Machleidt W, Moroder L, Schaschke N. Primed-site probing of papain-like cysteine proteases. INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS. 2007;13(1-2):93-104.
    PUB | DOI | WoS
     
  • [18]
    2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403744
    Schaschke N. (2S,3S)-Oxirane-2,3-dicarboxylic acid: A privileged platform for probing human cysteine cathepsins. JOURNAL OF BIOTECHNOLOGY. 2007;129(2):308-315.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [17]
    2005 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403754
    Schaschke N, Gabrijelcic-Geiger D, Dominik A, Sommerhoff CP. Affinity chromatography of tryptases: Design, synthesis and characterization of a novel matrix-bound bivalent inhibitor. CHEMBIOCHEM. 2005;6(1):95-103.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [16]
    2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403774
    Stern I, Schaschke N, Moroder L, Turk D. Crystal structure of NS-134 in complex with bovine cathepsin B: a two-headed epoxysuccinyl inhibitor extends along the entire active-site cleft. BIOCHEMICAL JOURNAL. 2004;381(2):511-517.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [15]
    2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403779
    Giragossian C, Schaschke N, Moroder L, Mierke DF. Conformational and molecular modeling studies of beta-cyclodextrin-heptagastrin and the third extracellular loop of the cholecystokinin 2 receptor. BIOCHEMISTRY. 2004;43(10):2724-2731.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [14]
    2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403785
    Schaschke N. Miraziridine A: natures blueprint towards protease class-spanning inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2004;14(4):855-857.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [13]
    2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403760
    Buth H, Wolters B, Hartwig B, et al. HaCaT keratinocytes secrete lysosomal cysteine proteinases during migration. EUROPEAN JOURNAL OF CELL BIOLOGY. 2004;83(11-12):781-795.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [12]
    2003 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403798
    Gil-Parrado S, Assfalg-Machleidt I, Fiorino F, et al. Calpastatin exon 1B-derived peptide, a selective inhibitor of calpain: Enhancing cell permeability by conjugation with penetratin. BIOLOGICAL CHEMISTRY. 2003;384(3):395-402.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [11]
    2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403813
    Balaji KN, Schaschke N, Machleidt W, Catalfamo M, Henkart PA. Surface cathepsin B protects cytotoxic lymphocytes from self-destruction after degranulation. JOURNAL OF EXPERIMENTAL MEDICINE. 2002;196(4):493-503.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [10]
    2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403820
    Schaschke N, Deluca D, Assfalg-Machleidt I, Hohneke C, Sommerhoff CP, Machleidt W. Epoxysuccinyl peptide-derived cathepsin B inhibitors: Modulating membrane permeability by conjugation with the C-terminal heptapeptide segment of penetratin. BIOLOGICAL CHEMISTRY. 2002;383(5):849-852.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [9]
    2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403828
    Schaschke N, Dominik A, Matschiner G, Sommerhoff CP. Bivalent inhibition of beta-tryptase: Distance scan of neighboring subunits by dibasic inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2002;12(6):985-988.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [8]
    2001 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403834
    Schaschke N, Matschiner G, Zettl F, et al. Bivalent inhibition of human beta-tryptase. CHEMISTRY & BIOLOGY. 2001;8(4):313-327.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [7]
    2000 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403844
    Schaschke N, Assfalg-Machleidt I, Lassleben T, Sommerhoff CP, Moroder L, Machleidt W. Epoxysuccinyl peptide-derived affinity labels for cathepsin B. FEBS LETTERS. 2000;482(1-2):91-96.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [6]
    2000 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403852
    Schaschke N, Assfalg-Machleidt I, Machleidt W, Lassleben T, Sommerhoff CP, Moroder L. beta-cyclodextrin/epoxysuccinyl peptide conjugates: new drug targeting system for tumor cells. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2000;10(7):677-680.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [5]
    1998 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403860
    Schaschke N, Fiori S, Weyher E, et al. Cyclodextrin as carrier of peptide hormones. Conformational and biological properties of beta-cyclodextrin/gastrin constructs. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 1998;120(28):7030-7038.
    PUB | DOI | WoS
     
  • [4]
    1998 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403869
    Schaschke N, Assfalg-Machleidt I, Machleidt W, Moroder L. Substrate/propeptide-derived endo-epoxysuccinyl peptides as highly potent and selective cathepsin B inhibitors. FEBS LETTERS. 1998;421(1):80-82.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [3]
    1997 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403875
    Schaschke N, Musiol HJ, AssfalgMachleidt I, Machleidt W, Moroder L. Oligopresentation of protease inhibitors with beta-cyclodextrin as template. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 1997;7(19):2507-2512.
    PUB | DOI | WoS
     
  • [2]
    1997 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403882
    Schaschke N, AssfalgMachleidt I, Machleidt W, Turk D, Moroder L. E-64 analogues as inhibitors of cathepsin B. On the role of the absolute configuration of the epoxysuccinyl group. BIOORGANIC & MEDICINAL CHEMISTRY. 1997;5(9):1789-1797.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [1]
    1996 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403889
    Schaschke N, Musiol HJ, AssfalgMachleidt I, Machleidt W, RudolphBohner S, Moroder L. Cyclodextrins as templates for the presentation of protease inhibitors. FEBS LETTERS. 1996;391(3):297-301.
    PUB | DOI | WoS | PubMed | Europe PMC
     

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