Upgrading a Natural Product: Inhibition of Human beta-Tryptase by Cyclotheonamide Analogues

Schaschke N, Sommerhoff CP (2010)
CHEMMEDCHEM 5(3): 367-370.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
Schaschke, NorbertUniBi; Sommerhoff, Christian P.
proteases; relationships; mast cells; beta-amino acids; peptides; structure-activity
Page URI


Schaschke N, Sommerhoff CP. Upgrading a Natural Product: Inhibition of Human beta-Tryptase by Cyclotheonamide Analogues. CHEMMEDCHEM. 2010;5(3):367-370.
Schaschke, N., & Sommerhoff, C. P. (2010). Upgrading a Natural Product: Inhibition of Human beta-Tryptase by Cyclotheonamide Analogues. CHEMMEDCHEM, 5(3), 367-370. https://doi.org/10.1002/cmdc.200900484
Schaschke, N., and Sommerhoff, C. P. (2010). Upgrading a Natural Product: Inhibition of Human beta-Tryptase by Cyclotheonamide Analogues. CHEMMEDCHEM 5, 367-370.
Schaschke, N., & Sommerhoff, C.P., 2010. Upgrading a Natural Product: Inhibition of Human beta-Tryptase by Cyclotheonamide Analogues. CHEMMEDCHEM, 5(3), p 367-370.
N. Schaschke and C.P. Sommerhoff, “Upgrading a Natural Product: Inhibition of Human beta-Tryptase by Cyclotheonamide Analogues”, CHEMMEDCHEM, vol. 5, 2010, pp. 367-370.
Schaschke, N., Sommerhoff, C.P.: Upgrading a Natural Product: Inhibition of Human beta-Tryptase by Cyclotheonamide Analogues. CHEMMEDCHEM. 5, 367-370 (2010).
Schaschke, Norbert, and Sommerhoff, Christian P. “Upgrading a Natural Product: Inhibition of Human beta-Tryptase by Cyclotheonamide Analogues”. CHEMMEDCHEM 5.3 (2010): 367-370.

5 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Marine Sponges as a Drug Treasure.
Anjum K, Abbas SQ, Shah SA, Akhter N, Batool S, Hassan SS., Biomol Ther (Seoul) 24(4), 2016
PMID: 27350338
Synthesis and stereochemical analysis of β-nitromethane substituted γ-amino acids and peptides.
Ganesh Kumar M, Mali SM, Gopi HN., Org Biomol Chem 11(5), 2013
PMID: 23229177
A new approach to inhibit human β-tryptase by protein surface binding of four-armed peptide ligands with two different sets of arms.
Jiang QQ, Bartsch L, Sicking W, Wich PR, Heider D, Hoffmann D, Schmuck C., Org Biomol Chem 11(10), 2013
PMID: 23358683

31 References

Daten bereitgestellt von Europe PubMed Central.

Bronchial asthma: diagnosis and long-term treatment in adults.
Ukena D, Fishman L, Niebling WB., Dtsch Arztebl Int 105(21), 2008
PMID: 19626179
Treatment strategies for allergy and asthma.
Holgate ST, Polosa R., Nat. Rev. Immunol. 8(3), 2008
PMID: 18274559

Caughey, 2004

Schwartz, 1994

Sommerhoff, Curr. Pharm. Design 13(), 2007
Dipeptidyl peptidase I is essential for activation of mast cell chymases, but not tryptases, in mice.
Wolters PJ, Pham CT, Muilenburg DJ, Ley TJ, Caughey GH., J. Biol. Chem. 276(21), 2001
PMID: 11279033
Mast cells as "tunable" effector and immunoregulatory cells: recent advances.
Galli SJ, Kalesnikoff J, Grimbaldeston MA, Piliponsky AM, Williams CM, Tsai M., Annu. Rev. Immunol. 23(), 2005
PMID: 15771585
Mast cell tryptase and chymase reverse airway smooth muscle relaxation induced by vasoactive intestinal peptide in the ferret.
Franconi GM, Graf PD, Lazarus SC, Nadel JA, Caughey GH., J. Pharmacol. Exp. Ther. 248(3), 1989
PMID: 2495355
Human mast cell tryptase attenuates the vasodilator activity of calcitonin gene-related peptide.
Walls AF, Brain SD, Desai A, Jose PJ, Hawkings E, Church MK, Williams TJ., Biochem. Pharmacol. 43(6), 1992
PMID: 1562277
Tryptase-induced airway microvascular leakage in guinea pigs: involvement of tachykinins and leukotrienes.
Greenfeder S, Sehring S, McHugh N, Corboz M, Rivelli M, Anthes JC, Billah M, Egan RW, Chapman RW., Eur. J. Pharmacol. 419(2-3), 2001
PMID: 11426850
Evaluation of the substrate specificity of human mast cell tryptase beta I and demonstration of its importance in bacterial infections of the lung.
Huang C, De Sanctis GT, O'Brien PJ, Mizgerd JP, Friend DS, Drazen JM, Brass LF, Stevens RL., J. Biol. Chem. 276(28), 2001
PMID: 11335723
Granulocyte recruitment by human mast cell tryptase.
Walls AF, He S, Teran LM, Buckley MG, Jung KS, Holgate ST, Shute JK, Cairns JA., Int. Arch. Allergy Immunol. 107(1-3), 1995
PMID: 7613178
Tryptase's potent mitogenic effects in human airway smooth muscle cells are via nonproteolytic actions.
Brown JK, Jones CA, Rooney LA, Caughey GH, Hall IP., Am. J. Physiol. Lung Cell Mol. Physiol. 282(2), 2002
PMID: 11792624
Tryptase and agonists of PAR-2 induce the proliferation of human airway smooth muscle cells.
Berger P, Perng DW, Thabrew H, Compton SJ, Cairns JA, McEuen AR, Marthan R, Tunon De Lara JM, Walls AF., J. Appl. Physiol. 91(3), 2001
PMID: 11509538
Role of tryptase in immediate cutaneous responses in allergic sheep.
Molinari JF, Moore WR, Clark J, Tanaka R, Butterfield JH, Abraham WM., J. Appl. Physiol. 79(6), 1995
PMID: 8847261
Inhaled tryptase causes bronchoconstriction in sheep via histamine release.
Molinari JF, Scuri M, Moore WR, Clark J, Tanaka R, Abraham WM., Am. J. Respir. Crit. Care Med. 154(3 Pt 1), 1996
PMID: 8810600
Inhibition of mast cell tryptase by inhaled APC 366 attenuates allergen-induced late-phase airway obstruction in asthma.
Krishna MT, Chauhan A, Little L, Sampson K, Hawksworth R, Mant T, Djukanovic R, Lee T, Holgate S., J. Allergy Clin. Immunol. 107(6), 2001
PMID: 11398082

Lee, J. Am. Chem. Soc. 115(), 1993
Molecular basis for the inhibition of human alpha-thrombin by the macrocyclic peptide cyclotheonamide A.
Maryanoff BE, Qiu X, Padmanabhan KP, Tulinsky A, Almond HR Jr, Andrade-Gordon P, Greco MN, Kauffman JA, Nicolaou KC, Liu A., Proc. Natl. Acad. Sci. U.S.A. 90(17), 1993
PMID: 8367461
Definition of the extended substrate specificity determinants for beta-tryptases I and II.
Harris JL, Niles A, Burdick K, Maffitt M, Backes BJ, Ellman JA, Kuntz I, Haak-Frendscho M, Craik CS., J. Biol. Chem. 276(37), 2001
PMID: 11438529
Cyclotheonamide E4 and E5, new potent tryptase inhibitors from an Ircinia species of sponge.
Murakami Y, Takei M, Shindo K, Kitazume C, Tanaka J, Higa T, Fukamachi H., J. Nat. Prod. 65(3), 2002
PMID: 11908961
The structure of the human betaII-tryptase tetramer: fo(u)r better or worse.
Sommerhoff CP, Bode W, Pereira PJ, Stubbs MT, Sturzebecher J, Piechottka GP, Matschiner G, Bergner A., Proc. Natl. Acad. Sci. U.S.A. 96(20), 1999
PMID: 10500112
Bicyclic homodetic peptide libraries: comparison of synthetic strategies for their solid-phase synthesis.
Teixido M, Altamura M, Quartara L, Giolitti A, Maggi CA, Giralt E, Albericio F., J Comb Chem 5(6), 2003
PMID: 14606803
A Kazal-type inhibitor of human mast cell tryptase: isolation from the medical leech Hirudo medicinalis, characterization, and sequence analysis.
Sommerhoff CP, Sollner C, Mentele R, Piechottka GP, Auerswald EA, Fritz H., Biol. Chem. Hoppe-Seyler 375(10), 1994
PMID: 7888081
Cyclotheonamide derivatives: synthesis and thrombin inhibition. Exploration of specific structure-function issues.
Maryanoff BE, Zhang HC, Greco MN, Glover KA, Kauffman JA, Andrade-Gordon P., Bioorg. Med. Chem. 3(8), 1995
PMID: 7582977
Kinetic and crystallographic studies of thrombin with Ac-(D)Phe-Pro-boroArg-OH and its lysine, amidine, homolysine, and ornithine analogs.
Weber PC, Lee SL, Lewandowski FA, Schadt MC, Chang CW, Kettner CA., Biochemistry 34(11), 1995
PMID: 7893672


Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®


PMID: 20077463
PubMed | Europe PMC

Suchen in

Google Scholar