32 Publikationen

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  • [32]
    2023 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2981179 OA
    N. Tromsdorf, et al., “E-64c-hydrazide based cathepsin C inhibitors: Optimizing the interactions with the S1'-S2' area”, ChemMedChem, 2023, : e202300218.
    PUB | PDF | DOI | WoS | PubMed | Europe PMC
     
  • [31]
    2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2703442
    G. Mikhaylov, et al., “Selective Targeting of Tumor and Stromal Cells By a Nanocarrier System Displaying Lipidated Cathepsin B Inhibitor”, Angewandte Chemie International Edition, vol. 53, 2014, pp. 10077-10081.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [30]
    2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2699425
    T. Tamhane, et al., “The activity and localization patterns of cathepsins B and X in cells of the mouse gastrointestinal tract differ along its length”, Biological Chemistry, vol. 395, 2014, pp. 1201-1219.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [29]
    2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2622177
    H. Radzey, et al., “E-64c-Hydrazide: A Lead Structure for the Development of Irreversible CathepsinC Inhibitors”, Chemmedchem, vol. 8, 2013, pp. 1314-1321.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [28]
    2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2489346
    M. Kalinska, et al., “Substrate specificity of Staphylococcus aureus cysteine proteases - Staphopains A, B and C”, Biochimie, vol. 94, 2012, pp. 318-327.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [27]
    2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2489135
    S. Diederich, et al., “Activation of the Nipah Virus Fusion Protein in MDCK Cells Is Mediated by Cathepsin B within the Endosome-Recycling Compartment”, Journal of Virology, vol. 86, 2012, pp. 3736-3745.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [26]
    2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2454769
    D. Janke, C.P. Sommerhoff, and N. Schaschke, “The arginine mimicking beta-amino acid beta(3)hPhe(3-H(2)N-CH(2)) as S1 ligand in cyclotheonamide-based beta-tryptase inhibitors”, Bioorganic & Medicinal Chemistry, vol. 19, 2011, pp. 7236-7243.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [25]
    2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403684
    U. Schurigt, et al., “Aziridine-2,3-Dicarboxylate-Based Cysteine Cathepsin Inhibitors Induce Cell Death in Leishmania major Associated with Accumulation of Debris in Autophagy-Related Lysosome-Like Vacuoles”, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 54, 2010, pp. 5028-5041.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [24]
    2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403708
    N. Schaschke and C.P. Sommerhoff, “Upgrading a Natural Product: Inhibition of Human beta-Tryptase by Cyclotheonamide Analogues”, CHEMMEDCHEM, vol. 5, 2010, pp. 367-370.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [23]
    2008 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403720
    J. Pfizer, et al., “Inhibition of human mu-calpain by conformationally constrained calpastatin peptides”, BIOLOGICAL CHEMISTRY, vol. 389, 2008, pp. 83-90.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [22]
    2008 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403715
    N. Schaschke, I. Assfalg-Machleidt, and W. Machleidt, “Inhibition of cathepsin L by epoxysuccinyl peptides simultaneously addressing active-site and remote-site regions”, CHEMBIOCHEM, vol. 9, 2008, pp. 1721-1724.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [21]
    2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403726
    H. Bueth, et al., “Cathepsin B is essential for regeneration of scratch-wounded normal human epidermal keratinocytes”, EUROPEAN JOURNAL OF CELL BIOLOGY, vol. 86, 2007, pp. 747-761.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [20]
    2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403747
    C.P. Sommerhoff and N. Schaschke, “Mast cell tryptase beta as a target in allergic inflammation: An evolving story”, CURRENT PHARMACEUTICAL DESIGN, vol. 13, 2007, pp. 313-332.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [19]
    2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403737
    J.M. Pfizer, et al., “Primed-site probing of papain-like cysteine proteases”, INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS, vol. 13, 2007, pp. 93-104.
    PUB | DOI | WoS
     
  • [18]
    2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403744
    N. Schaschke, “(2S,3S)-Oxirane-2,3-dicarboxylic acid: A privileged platform for probing human cysteine cathepsins”, JOURNAL OF BIOTECHNOLOGY, vol. 129, 2007, pp. 308-315.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [17]
    2005 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403754
    N. Schaschke, et al., “Affinity chromatography of tryptases: Design, synthesis and characterization of a novel matrix-bound bivalent inhibitor”, CHEMBIOCHEM, vol. 6, 2005, pp. 95-103.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [16]
    2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403774
    I. Stern, et al., “Crystal structure of NS-134 in complex with bovine cathepsin B: a two-headed epoxysuccinyl inhibitor extends along the entire active-site cleft”, BIOCHEMICAL JOURNAL, vol. 381, 2004, pp. 511-517.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [15]
    2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403779
    C. Giragossian, et al., “Conformational and molecular modeling studies of beta-cyclodextrin-heptagastrin and the third extracellular loop of the cholecystokinin 2 receptor”, BIOCHEMISTRY, vol. 43, 2004, pp. 2724-2731.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [14]
    2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403785
    N. Schaschke, “Miraziridine A: natures blueprint towards protease class-spanning inhibitors”, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 14, 2004, pp. 855-857.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [13]
    2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403760
    H. Buth, et al., “HaCaT keratinocytes secrete lysosomal cysteine proteinases during migration”, EUROPEAN JOURNAL OF CELL BIOLOGY, vol. 83, 2004, pp. 781-795.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [12]
    2003 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403798
    S. Gil-Parrado, et al., “Calpastatin exon 1B-derived peptide, a selective inhibitor of calpain: Enhancing cell permeability by conjugation with penetratin”, BIOLOGICAL CHEMISTRY, vol. 384, 2003, pp. 395-402.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [11]
    2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403813
    K.N. Balaji, et al., “Surface cathepsin B protects cytotoxic lymphocytes from self-destruction after degranulation”, JOURNAL OF EXPERIMENTAL MEDICINE, vol. 196, 2002, pp. 493-503.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [10]
    2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403820
    N. Schaschke, et al., “Epoxysuccinyl peptide-derived cathepsin B inhibitors: Modulating membrane permeability by conjugation with the C-terminal heptapeptide segment of penetratin”, BIOLOGICAL CHEMISTRY, vol. 383, 2002, pp. 849-852.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [9]
    2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403828
    N. Schaschke, et al., “Bivalent inhibition of beta-tryptase: Distance scan of neighboring subunits by dibasic inhibitors”, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 12, 2002, pp. 985-988.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [8]
    2001 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403834
    N. Schaschke, et al., “Bivalent inhibition of human beta-tryptase”, CHEMISTRY & BIOLOGY, vol. 8, 2001, pp. 313-327.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [7]
    2000 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403844
    N. Schaschke, et al., “Epoxysuccinyl peptide-derived affinity labels for cathepsin B”, FEBS LETTERS, vol. 482, 2000, pp. 91-96.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [6]
    2000 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403852
    N. Schaschke, et al., “beta-cyclodextrin/epoxysuccinyl peptide conjugates: new drug targeting system for tumor cells”, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 10, 2000, pp. 677-680.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [5]
    1998 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403860
    N. Schaschke, et al., “Cyclodextrin as carrier of peptide hormones. Conformational and biological properties of beta-cyclodextrin/gastrin constructs”, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 120, 1998, pp. 7030-7038.
    PUB | DOI | WoS
     
  • [4]
    1998 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403869
    N. Schaschke, et al., “Substrate/propeptide-derived endo-epoxysuccinyl peptides as highly potent and selective cathepsin B inhibitors”, FEBS LETTERS, vol. 421, 1998, pp. 80-82.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [3]
    1997 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403875
    N. Schaschke, et al., “Oligopresentation of protease inhibitors with beta-cyclodextrin as template”, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 7, 1997, pp. 2507-2512.
    PUB | DOI | WoS
     
  • [2]
    1997 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403882
    N. Schaschke, et al., “E-64 analogues as inhibitors of cathepsin B. On the role of the absolute configuration of the epoxysuccinyl group”, BIOORGANIC & MEDICINAL CHEMISTRY, vol. 5, 1997, pp. 1789-1797.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [1]
    1996 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403889
    N. Schaschke, et al., “Cyclodextrins as templates for the presentation of protease inhibitors”, FEBS LETTERS, vol. 391, 1996, pp. 297-301.
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