32 Publikationen
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2023 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2981179Tromsdorf, Nora, Ullrich, Fabian, Rethmeier, Markus, Sommerhoff, Christian, and Schaschke, Norbert. “E-64c-hydrazide based cathepsin C inhibitors: Optimizing the interactions with the S1'-S2' area”. ChemMedChem (2023): e202300218.PUB | PDF | DOI | WoS | PubMed | Europe PMC
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2703442Mikhaylov, G., Klimpel, Dennis, Schaschke, Norbert, Mikac, U., Vizovisek, M., Fonovic, M., Turk, V., Turk, Boris, and Vasiljeva, Olga. “Selective Targeting of Tumor and Stromal Cells By a Nanocarrier System Displaying Lipidated Cathepsin B Inhibitor”. Angewandte Chemie International Edition 53.38 (2014): 10077-10081.PUB | DOI | WoS | PubMed | Europe PMC
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2699425Tamhane, Tripti, Arampatzidou, Maria, Gerganova, Veneta, Tacke, Marlene, Illukkumbura, Rukshala, Dauth, Stephanie, Schaschke, Norbert, Peters, Christoph, Reinheckel, Thomas, and Brix, Klaudia. “The activity and localization patterns of cathepsins B and X in cells of the mouse gastrointestinal tract differ along its length”. Biological Chemistry 395.10 (2014): 1201-1219.PUB | DOI | WoS | PubMed | Europe PMC
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2622177Radzey, Hanna, Rethmeier, Markus, Klimpel, Dennis, Grundhuber, Maresa, Sommerhoff, Christian P., and Schaschke, Norbert. “E-64c-Hydrazide: A Lead Structure for the Development of Irreversible CathepsinC Inhibitors”. Chemmedchem 8.8 (2013): 1314-1321.PUB | DOI | WoS | PubMed | Europe PMC
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2489346Kalinska, Magdalena, Kantyka, Tomasz, Greenbaum, Doron C., Larsen, Katrine S., Wladyka, Benedykt, Jabaiah, Abeer, Bogyo, Matthew, Daugherty, Patrick S., Wysocka, Magdalena, Jaros, Marcelina, Lesner, Adam, Rolka, Krzysztof, Schaschke, Norbert, Stennicke, Henning, Dubin, Adam, Potempa, Jan, and Dubin, Grzegorz. “Substrate specificity of Staphylococcus aureus cysteine proteases - Staphopains A, B and C”. Biochimie 94.2 (2012): 318-327.PUB | DOI | WoS | PubMed | Europe PMC
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2489135Diederich, Sandra, Sauerhering, Lucie, Weis, Michael, Altmeppen, Hermann, Schaschke, Norbert, Reinheckel, Thomas, Erbar, Stephanie, and Maisner, Andrea. “Activation of the Nipah Virus Fusion Protein in MDCK Cells Is Mediated by Cathepsin B within the Endosome-Recycling Compartment”. Journal of Virology 86.7 (2012): 3736-3745.PUB | DOI | WoS | PubMed | Europe PMC
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2454769Janke, Dennis, Sommerhoff, Christian P., and Schaschke, Norbert. “The arginine mimicking beta-amino acid beta(3)hPhe(3-H(2)N-CH(2)) as S1 ligand in cyclotheonamide-based beta-tryptase inhibitors”. Bioorganic & Medicinal Chemistry 19.23 (2011): 7236-7243.PUB | DOI | WoS | PubMed | Europe PMC
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403684Schurigt, Uta, Schad, Caroline, Glowa, Christin, Baum, Ulrike, Thomale, Katja, Schnitzer, Johannes K., Schultheis, Martina, Schaschke, Norbert, Schirmeister, Tanja, and Moll, Heidrun. “Aziridine-2,3-Dicarboxylate-Based Cysteine Cathepsin Inhibitors Induce Cell Death in Leishmania major Associated with Accumulation of Debris in Autophagy-Related Lysosome-Like Vacuoles”. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 54.12 (2010): 5028-5041.PUB | DOI | WoS | PubMed | Europe PMC
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403708Schaschke, Norbert, and Sommerhoff, Christian P. “Upgrading a Natural Product: Inhibition of Human beta-Tryptase by Cyclotheonamide Analogues”. CHEMMEDCHEM 5.3 (2010): 367-370.PUB | DOI | WoS | PubMed | Europe PMC
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2008 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403720Pfizer, Jose, Assfalg-Machleidt, Irmgard, Machleidt, Werner, and Schaschke, Norbert. “Inhibition of human mu-calpain by conformationally constrained calpastatin peptides”. BIOLOGICAL CHEMISTRY 389.1 (2008): 83-90.PUB | DOI | WoS | PubMed | Europe PMC
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2008 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403715Schaschke, Norbert, Assfalg-Machleidt, Irmgard, and Machleidt, Werner. “Inhibition of cathepsin L by epoxysuccinyl peptides simultaneously addressing active-site and remote-site regions”. CHEMBIOCHEM 9.11 (2008): 1721-1724.PUB | DOI | WoS | PubMed | Europe PMC
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2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403726Bueth, Heiko, Buttigieg, Pier Luigi, Ostafe, Raluca, Rehders, Maren, Dannenmann, Stefanie R., Schaschke, Norbert, Stark, Hans-Juergen, Boukamp, Petra, and Brix, Klaudia. “Cathepsin B is essential for regeneration of scratch-wounded normal human epidermal keratinocytes”. EUROPEAN JOURNAL OF CELL BIOLOGY 86.11-12 (2007): 747-761.PUB | DOI | WoS | PubMed | Europe PMC
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2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403747Sommerhoff, C. P., and Schaschke, Norbert. “Mast cell tryptase beta as a target in allergic inflammation: An evolving story”. CURRENT PHARMACEUTICAL DESIGN 13.3 (2007): 313-332.PUB | DOI | WoS | PubMed | Europe PMC
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2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403737Pfizer, Jose Maria, Assfalg-Machleidt, Irmgard, Machleidt, Werner, Moroder, Luis, and Schaschke, Norbert. “Primed-site probing of papain-like cysteine proteases”. INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS 13.1-2 (2007): 93-104.PUB | DOI | WoS
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2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403744Schaschke, Norbert. “(2S,3S)-Oxirane-2,3-dicarboxylic acid: A privileged platform for probing human cysteine cathepsins”. JOURNAL OF BIOTECHNOLOGY 129.2 (2007): 308-315.PUB | DOI | WoS | PubMed | Europe PMC
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2005 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403754Schaschke, Norbert, Gabrijelcic-Geiger, D, Dominik, A, and Sommerhoff, CP. “Affinity chromatography of tryptases: Design, synthesis and characterization of a novel matrix-bound bivalent inhibitor”. CHEMBIOCHEM 6.1 (2005): 95-103.PUB | DOI | WoS | PubMed | Europe PMC
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2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403774Stern, I, Schaschke, Norbert, Moroder, L, and Turk, D. “Crystal structure of NS-134 in complex with bovine cathepsin B: a two-headed epoxysuccinyl inhibitor extends along the entire active-site cleft”. BIOCHEMICAL JOURNAL 381.2 (2004): 511-517.PUB | DOI | WoS | PubMed | Europe PMC
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2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403779Giragossian, C, Schaschke, Norbert, Moroder, L, and Mierke, DF. “Conformational and molecular modeling studies of beta-cyclodextrin-heptagastrin and the third extracellular loop of the cholecystokinin 2 receptor”. BIOCHEMISTRY 43.10 (2004): 2724-2731.PUB | DOI | WoS | PubMed | Europe PMC
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2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403785Schaschke, Norbert. “Miraziridine A: natures blueprint towards protease class-spanning inhibitors”. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 14.4 (2004): 855-857.PUB | DOI | WoS | PubMed | Europe PMC
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2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403760Buth, H, Wolters, B, Hartwig, B, Meier-Bornheim, R, Veith, H, Hansen, M, Sommerhoff, CP, Schaschke, Norbert, Machleidt, N, Fusenig, NE, Boukamp, P, and Brix, K. “HaCaT keratinocytes secrete lysosomal cysteine proteinases during migration”. EUROPEAN JOURNAL OF CELL BIOLOGY 83.11-12 (2004): 781-795.PUB | DOI | WoS | PubMed | Europe PMC
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2003 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403798Gil-Parrado, S, Assfalg-Machleidt, I, Fiorino, F, Deluca, D, Pfeiler, D, Schaschke, Norbert, Moroder, L, and Machleidt, W. “Calpastatin exon 1B-derived peptide, a selective inhibitor of calpain: Enhancing cell permeability by conjugation with penetratin”. BIOLOGICAL CHEMISTRY 384.3 (2003): 395-402.PUB | DOI | WoS | PubMed | Europe PMC
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2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403813Balaji, KN, Schaschke, Norbert, Machleidt, W, Catalfamo, M, and Henkart, PA. “Surface cathepsin B protects cytotoxic lymphocytes from self-destruction after degranulation”. JOURNAL OF EXPERIMENTAL MEDICINE 196.4 (2002): 493-503.PUB | DOI | WoS | PubMed | Europe PMC
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2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403820Schaschke, Norbert, Deluca, D, Assfalg-Machleidt, I, Hohneke, C, Sommerhoff, CP, and Machleidt, W. “Epoxysuccinyl peptide-derived cathepsin B inhibitors: Modulating membrane permeability by conjugation with the C-terminal heptapeptide segment of penetratin”. BIOLOGICAL CHEMISTRY 383.5 (2002): 849-852.PUB | DOI | WoS | PubMed | Europe PMC
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2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403828Schaschke, Norbert, Dominik, A, Matschiner, G, and Sommerhoff, CP. “Bivalent inhibition of beta-tryptase: Distance scan of neighboring subunits by dibasic inhibitors”. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 12.6 (2002): 985-988.PUB | DOI | WoS | PubMed | Europe PMC
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2001 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403834Schaschke, Norbert, Matschiner, G, Zettl, F, Marquardt, U, Bergner, A, Bode, W, Sommerhoff, CP, and Moroder, L. “Bivalent inhibition of human beta-tryptase”. CHEMISTRY & BIOLOGY 8.4 (2001): 313-327.PUB | DOI | WoS | PubMed | Europe PMC
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2000 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403844Schaschke, Norbert, Assfalg-Machleidt, I, Lassleben, T, Sommerhoff, CP, Moroder, L, and Machleidt, W. “Epoxysuccinyl peptide-derived affinity labels for cathepsin B”. FEBS LETTERS 482.1-2 (2000): 91-96.PUB | DOI | WoS | PubMed | Europe PMC
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2000 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403852Schaschke, Norbert, Assfalg-Machleidt, I, Machleidt, W, Lassleben, T, Sommerhoff, CP, and Moroder, L. “beta-cyclodextrin/epoxysuccinyl peptide conjugates: new drug targeting system for tumor cells”. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 10.7 (2000): 677-680.PUB | DOI | WoS | PubMed | Europe PMC
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1998 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403860Schaschke, Norbert, Fiori, S, Weyher, E, Escrieut, C, Fourmy, D, Muller, G, and Moroder, L. “Cyclodextrin as carrier of peptide hormones. Conformational and biological properties of beta-cyclodextrin/gastrin constructs”. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 120.28 (1998): 7030-7038.PUB | DOI | WoS
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1998 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403869Schaschke, Norbert, Assfalg-Machleidt, I, Machleidt, W, and Moroder, L. “Substrate/propeptide-derived endo-epoxysuccinyl peptides as highly potent and selective cathepsin B inhibitors”. FEBS LETTERS 421.1 (1998): 80-82.PUB | DOI | WoS | PubMed | Europe PMC
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1997 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403875Schaschke, Norbert, Musiol, HJ, AssfalgMachleidt, I, Machleidt, W, and Moroder, L. “Oligopresentation of protease inhibitors with beta-cyclodextrin as template”. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 7.19 (1997): 2507-2512.PUB | DOI | WoS
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1997 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403882Schaschke, Norbert, AssfalgMachleidt, I, Machleidt, W, Turk, D, and Moroder, L. “E-64 analogues as inhibitors of cathepsin B. On the role of the absolute configuration of the epoxysuccinyl group”. BIOORGANIC & MEDICINAL CHEMISTRY 5.9 (1997): 1789-1797.PUB | DOI | WoS | PubMed | Europe PMC
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1996 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403889Schaschke, Norbert, Musiol, HJ, AssfalgMachleidt, I, Machleidt, W, RudolphBohner, S, and Moroder, L. “Cyclodextrins as templates for the presentation of protease inhibitors”. FEBS LETTERS 391.3 (1996): 297-301.PUB | DOI | WoS | PubMed | Europe PMC