32 Publikationen
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2023 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2981179Tromsdorf, N., Ullrich, F., Rethmeier, M., Sommerhoff, C., Schaschke, N.: E-64c-hydrazide based cathepsin C inhibitors: Optimizing the interactions with the S1'-S2' area. ChemMedChem. : e202300218 (2023).PUB | PDF | DOI | WoS | PubMed | Europe PMC
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2703442Mikhaylov, G., Klimpel, D., Schaschke, N., Mikac, U., Vizovisek, M., Fonovic, M., Turk, V., Turk, B., Vasiljeva, O.: Selective Targeting of Tumor and Stromal Cells By a Nanocarrier System Displaying Lipidated Cathepsin B Inhibitor. Angewandte Chemie International Edition. 53, 10077-10081 (2014).PUB | DOI | WoS | PubMed | Europe PMC
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2699425Tamhane, T., Arampatzidou, M., Gerganova, V., Tacke, M., Illukkumbura, R., Dauth, S., Schaschke, N., Peters, C., Reinheckel, T., Brix, K.: The activity and localization patterns of cathepsins B and X in cells of the mouse gastrointestinal tract differ along its length. Biological Chemistry. 395, 1201-1219 (2014).PUB | DOI | WoS | PubMed | Europe PMC
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2622177Radzey, H., Rethmeier, M., Klimpel, D., Grundhuber, M., Sommerhoff, C.P., Schaschke, N.: E-64c-Hydrazide: A Lead Structure for the Development of Irreversible CathepsinC Inhibitors. Chemmedchem. 8, 1314-1321 (2013).PUB | DOI | WoS | PubMed | Europe PMC
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2489346Kalinska, M., Kantyka, T., Greenbaum, D.C., Larsen, K.S., Wladyka, B., Jabaiah, A., Bogyo, M., Daugherty, P.S., Wysocka, M., Jaros, M., Lesner, A., Rolka, K., Schaschke, N., Stennicke, H., Dubin, A., Potempa, J., Dubin, G.: Substrate specificity of Staphylococcus aureus cysteine proteases - Staphopains A, B and C. Biochimie. 94, 318-327 (2012).PUB | DOI | WoS | PubMed | Europe PMC
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2489135Diederich, S., Sauerhering, L., Weis, M., Altmeppen, H., Schaschke, N., Reinheckel, T., Erbar, S., Maisner, A.: Activation of the Nipah Virus Fusion Protein in MDCK Cells Is Mediated by Cathepsin B within the Endosome-Recycling Compartment. Journal of Virology. 86, 3736-3745 (2012).PUB | DOI | WoS | PubMed | Europe PMC
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2454769Janke, D., Sommerhoff, C.P., Schaschke, N.: The arginine mimicking beta-amino acid beta(3)hPhe(3-H(2)N-CH(2)) as S1 ligand in cyclotheonamide-based beta-tryptase inhibitors. Bioorganic & Medicinal Chemistry. 19, 7236-7243 (2011).PUB | DOI | WoS | PubMed | Europe PMC
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403684Schurigt, U., Schad, C., Glowa, C., Baum, U., Thomale, K., Schnitzer, J.K., Schultheis, M., Schaschke, N., Schirmeister, T., Moll, H.: Aziridine-2,3-Dicarboxylate-Based Cysteine Cathepsin Inhibitors Induce Cell Death in Leishmania major Associated with Accumulation of Debris in Autophagy-Related Lysosome-Like Vacuoles. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 54, 5028-5041 (2010).PUB | DOI | WoS | PubMed | Europe PMC
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403708Schaschke, N., Sommerhoff, C.P.: Upgrading a Natural Product: Inhibition of Human beta-Tryptase by Cyclotheonamide Analogues. CHEMMEDCHEM. 5, 367-370 (2010).PUB | DOI | WoS | PubMed | Europe PMC
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2008 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403720Pfizer, J., Assfalg-Machleidt, I., Machleidt, W., Schaschke, N.: Inhibition of human mu-calpain by conformationally constrained calpastatin peptides. BIOLOGICAL CHEMISTRY. 389, 83-90 (2008).PUB | DOI | WoS | PubMed | Europe PMC
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2008 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403715Schaschke, N., Assfalg-Machleidt, I., Machleidt, W.: Inhibition of cathepsin L by epoxysuccinyl peptides simultaneously addressing active-site and remote-site regions. CHEMBIOCHEM. 9, 1721-1724 (2008).PUB | DOI | WoS | PubMed | Europe PMC
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2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403726Bueth, H., Buttigieg, P.L., Ostafe, R., Rehders, M., Dannenmann, S.R., Schaschke, N., Stark, H.-J., Boukamp, P., Brix, K.: Cathepsin B is essential for regeneration of scratch-wounded normal human epidermal keratinocytes. EUROPEAN JOURNAL OF CELL BIOLOGY. 86, 747-761 (2007).PUB | DOI | WoS | PubMed | Europe PMC
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2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403747Sommerhoff, C.P., Schaschke, N.: Mast cell tryptase beta as a target in allergic inflammation: An evolving story. CURRENT PHARMACEUTICAL DESIGN. 13, 313-332 (2007).PUB | DOI | WoS | PubMed | Europe PMC
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2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403744Schaschke, N.: (2S,3S)-Oxirane-2,3-dicarboxylic acid: A privileged platform for probing human cysteine cathepsins. JOURNAL OF BIOTECHNOLOGY. 129, 308-315 (2007).PUB | DOI | WoS | PubMed | Europe PMC
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2005 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403754Schaschke, N., Gabrijelcic-Geiger, D., Dominik, A., Sommerhoff, C.P.: Affinity chromatography of tryptases: Design, synthesis and characterization of a novel matrix-bound bivalent inhibitor. CHEMBIOCHEM. 6, 95-103 (2005).PUB | DOI | WoS | PubMed | Europe PMC
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2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403774Stern, I., Schaschke, N., Moroder, L., Turk, D.: Crystal structure of NS-134 in complex with bovine cathepsin B: a two-headed epoxysuccinyl inhibitor extends along the entire active-site cleft. BIOCHEMICAL JOURNAL. 381, 511-517 (2004).PUB | DOI | WoS | PubMed | Europe PMC
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2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403779Giragossian, C., Schaschke, N., Moroder, L., Mierke, D.F.: Conformational and molecular modeling studies of beta-cyclodextrin-heptagastrin and the third extracellular loop of the cholecystokinin 2 receptor. BIOCHEMISTRY. 43, 2724-2731 (2004).PUB | DOI | WoS | PubMed | Europe PMC
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2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403785Schaschke, N.: Miraziridine A: natures blueprint towards protease class-spanning inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 14, 855-857 (2004).PUB | DOI | WoS | PubMed | Europe PMC
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2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403760Buth, H., Wolters, B., Hartwig, B., Meier-Bornheim, R., Veith, H., Hansen, M., Sommerhoff, C.P., Schaschke, N., Machleidt, N., Fusenig, N.E., Boukamp, P., Brix, K.: HaCaT keratinocytes secrete lysosomal cysteine proteinases during migration. EUROPEAN JOURNAL OF CELL BIOLOGY. 83, 781-795 (2004).PUB | DOI | WoS | PubMed | Europe PMC
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2003 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403798Gil-Parrado, S., Assfalg-Machleidt, I., Fiorino, F., Deluca, D., Pfeiler, D., Schaschke, N., Moroder, L., Machleidt, W.: Calpastatin exon 1B-derived peptide, a selective inhibitor of calpain: Enhancing cell permeability by conjugation with penetratin. BIOLOGICAL CHEMISTRY. 384, 395-402 (2003).PUB | DOI | WoS | PubMed | Europe PMC
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2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403813Balaji, K.N., Schaschke, N., Machleidt, W., Catalfamo, M., Henkart, P.A.: Surface cathepsin B protects cytotoxic lymphocytes from self-destruction after degranulation. JOURNAL OF EXPERIMENTAL MEDICINE. 196, 493-503 (2002).PUB | DOI | WoS | PubMed | Europe PMC
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2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403820Schaschke, N., Deluca, D., Assfalg-Machleidt, I., Hohneke, C., Sommerhoff, C.P., Machleidt, W.: Epoxysuccinyl peptide-derived cathepsin B inhibitors: Modulating membrane permeability by conjugation with the C-terminal heptapeptide segment of penetratin. BIOLOGICAL CHEMISTRY. 383, 849-852 (2002).PUB | DOI | WoS | PubMed | Europe PMC
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2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403828Schaschke, N., Dominik, A., Matschiner, G., Sommerhoff, C.P.: Bivalent inhibition of beta-tryptase: Distance scan of neighboring subunits by dibasic inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 12, 985-988 (2002).PUB | DOI | WoS | PubMed | Europe PMC
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2001 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403834Schaschke, N., Matschiner, G., Zettl, F., Marquardt, U., Bergner, A., Bode, W., Sommerhoff, C.P., Moroder, L.: Bivalent inhibition of human beta-tryptase. CHEMISTRY & BIOLOGY. 8, 313-327 (2001).PUB | DOI | WoS | PubMed | Europe PMC
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2000 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403844Schaschke, N., Assfalg-Machleidt, I., Lassleben, T., Sommerhoff, C.P., Moroder, L., Machleidt, W.: Epoxysuccinyl peptide-derived affinity labels for cathepsin B. FEBS LETTERS. 482, 91-96 (2000).PUB | DOI | WoS | PubMed | Europe PMC
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2000 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403852Schaschke, N., Assfalg-Machleidt, I., Machleidt, W., Lassleben, T., Sommerhoff, C.P., Moroder, L.: beta-cyclodextrin/epoxysuccinyl peptide conjugates: new drug targeting system for tumor cells. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 10, 677-680 (2000).PUB | DOI | WoS | PubMed | Europe PMC
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1998 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403860Schaschke, N., Fiori, S., Weyher, E., Escrieut, C., Fourmy, D., Muller, G., Moroder, L.: Cyclodextrin as carrier of peptide hormones. Conformational and biological properties of beta-cyclodextrin/gastrin constructs. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 120, 7030-7038 (1998).PUB | DOI | WoS
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1998 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403869Schaschke, N., Assfalg-Machleidt, I., Machleidt, W., Moroder, L.: Substrate/propeptide-derived endo-epoxysuccinyl peptides as highly potent and selective cathepsin B inhibitors. FEBS LETTERS. 421, 80-82 (1998).PUB | DOI | WoS | PubMed | Europe PMC
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1997 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403882Schaschke, N., AssfalgMachleidt, I., Machleidt, W., Turk, D., Moroder, L.: E-64 analogues as inhibitors of cathepsin B. On the role of the absolute configuration of the epoxysuccinyl group. BIOORGANIC & MEDICINAL CHEMISTRY. 5, 1789-1797 (1997).PUB | DOI | WoS | PubMed | Europe PMC
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1996 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403889Schaschke, N., Musiol, H.J., AssfalgMachleidt, I., Machleidt, W., RudolphBohner, S., Moroder, L.: Cyclodextrins as templates for the presentation of protease inhibitors. FEBS LETTERS. 391, 297-301 (1996).PUB | DOI | WoS | PubMed | Europe PMC