32 Publikationen
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2023 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2981179Tromsdorf, Nora, Ullrich, Fabian, Rethmeier, Markus, Sommerhoff, Christian, and Schaschke, Norbert. 2023. “E-64c-hydrazide based cathepsin C inhibitors: Optimizing the interactions with the S1'-S2' area”. ChemMedChem: e202300218.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2703442Mikhaylov, G., Klimpel, Dennis, Schaschke, Norbert, Mikac, U., Vizovisek, M., Fonovic, M., Turk, V., Turk, Boris, and Vasiljeva, Olga. 2014. “Selective Targeting of Tumor and Stromal Cells By a Nanocarrier System Displaying Lipidated Cathepsin B Inhibitor”. Angewandte Chemie International Edition 53 (38): 10077-10081.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2699425Tamhane, Tripti, Arampatzidou, Maria, Gerganova, Veneta, Tacke, Marlene, Illukkumbura, Rukshala, Dauth, Stephanie, Schaschke, Norbert, Peters, Christoph, Reinheckel, Thomas, and Brix, Klaudia. 2014. “The activity and localization patterns of cathepsins B and X in cells of the mouse gastrointestinal tract differ along its length”. Biological Chemistry 395 (10): 1201-1219.
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2622177Radzey, Hanna, Rethmeier, Markus, Klimpel, Dennis, Grundhuber, Maresa, Sommerhoff, Christian P., and Schaschke, Norbert. 2013. “E-64c-Hydrazide: A Lead Structure for the Development of Irreversible CathepsinC Inhibitors”. Chemmedchem 8 (8): 1314-1321.
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2489346Kalinska, Magdalena, Kantyka, Tomasz, Greenbaum, Doron C., Larsen, Katrine S., Wladyka, Benedykt, Jabaiah, Abeer, Bogyo, Matthew, et al. 2012. “Substrate specificity of Staphylococcus aureus cysteine proteases - Staphopains A, B and C”. Biochimie 94 (2): 318-327.
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2489135Diederich, Sandra, Sauerhering, Lucie, Weis, Michael, Altmeppen, Hermann, Schaschke, Norbert, Reinheckel, Thomas, Erbar, Stephanie, and Maisner, Andrea. 2012. “Activation of the Nipah Virus Fusion Protein in MDCK Cells Is Mediated by Cathepsin B within the Endosome-Recycling Compartment”. Journal of Virology 86 (7): 3736-3745.
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2454769Janke, Dennis, Sommerhoff, Christian P., and Schaschke, Norbert. 2011. “The arginine mimicking beta-amino acid beta(3)hPhe(3-H(2)N-CH(2)) as S1 ligand in cyclotheonamide-based beta-tryptase inhibitors”. Bioorganic & Medicinal Chemistry 19 (23): 7236-7243.
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403684Schurigt, Uta, Schad, Caroline, Glowa, Christin, Baum, Ulrike, Thomale, Katja, Schnitzer, Johannes K., Schultheis, Martina, Schaschke, Norbert, Schirmeister, Tanja, and Moll, Heidrun. 2010. “Aziridine-2,3-Dicarboxylate-Based Cysteine Cathepsin Inhibitors Induce Cell Death in Leishmania major Associated with Accumulation of Debris in Autophagy-Related Lysosome-Like Vacuoles”. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 54 (12): 5028-5041.
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403708Schaschke, Norbert, and Sommerhoff, Christian P. 2010. “Upgrading a Natural Product: Inhibition of Human beta-Tryptase by Cyclotheonamide Analogues”. CHEMMEDCHEM 5 (3): 367-370.
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2008 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403720Pfizer, Jose, Assfalg-Machleidt, Irmgard, Machleidt, Werner, and Schaschke, Norbert. 2008. “Inhibition of human mu-calpain by conformationally constrained calpastatin peptides”. BIOLOGICAL CHEMISTRY 389 (1): 83-90.
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2008 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403715Schaschke, Norbert, Assfalg-Machleidt, Irmgard, and Machleidt, Werner. 2008. “Inhibition of cathepsin L by epoxysuccinyl peptides simultaneously addressing active-site and remote-site regions”. CHEMBIOCHEM 9 (11): 1721-1724.
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2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403726Bueth, Heiko, Buttigieg, Pier Luigi, Ostafe, Raluca, Rehders, Maren, Dannenmann, Stefanie R., Schaschke, Norbert, Stark, Hans-Juergen, Boukamp, Petra, and Brix, Klaudia. 2007. “Cathepsin B is essential for regeneration of scratch-wounded normal human epidermal keratinocytes”. EUROPEAN JOURNAL OF CELL BIOLOGY 86 (11-12): 747-761.
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2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403747Sommerhoff, C. P., and Schaschke, Norbert. 2007. “Mast cell tryptase beta as a target in allergic inflammation: An evolving story”. CURRENT PHARMACEUTICAL DESIGN 13 (3): 313-332.
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2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403737Pfizer, Jose Maria, Assfalg-Machleidt, Irmgard, Machleidt, Werner, Moroder, Luis, and Schaschke, Norbert. 2007. “Primed-site probing of papain-like cysteine proteases”. INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS 13 (1-2): 93-104.
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2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403744Schaschke, Norbert. 2007. “(2S,3S)-Oxirane-2,3-dicarboxylic acid: A privileged platform for probing human cysteine cathepsins”. JOURNAL OF BIOTECHNOLOGY 129 (2): 308-315.
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2005 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403754Schaschke, Norbert, Gabrijelcic-Geiger, D, Dominik, A, and Sommerhoff, CP. 2005. “Affinity chromatography of tryptases: Design, synthesis and characterization of a novel matrix-bound bivalent inhibitor”. CHEMBIOCHEM 6 (1): 95-103.
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2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403774Stern, I, Schaschke, Norbert, Moroder, L, and Turk, D. 2004. “Crystal structure of NS-134 in complex with bovine cathepsin B: a two-headed epoxysuccinyl inhibitor extends along the entire active-site cleft”. BIOCHEMICAL JOURNAL 381 (2): 511-517.
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2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403779Giragossian, C, Schaschke, Norbert, Moroder, L, and Mierke, DF. 2004. “Conformational and molecular modeling studies of beta-cyclodextrin-heptagastrin and the third extracellular loop of the cholecystokinin 2 receptor”. BIOCHEMISTRY 43 (10): 2724-2731.
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2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403785Schaschke, Norbert. 2004. “Miraziridine A: natures blueprint towards protease class-spanning inhibitors”. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 14 (4): 855-857.
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2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403760Buth, H, Wolters, B, Hartwig, B, Meier-Bornheim, R, Veith, H, Hansen, M, Sommerhoff, CP, et al. 2004. “HaCaT keratinocytes secrete lysosomal cysteine proteinases during migration”. EUROPEAN JOURNAL OF CELL BIOLOGY 83 (11-12): 781-795.
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2003 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403798Gil-Parrado, S, Assfalg-Machleidt, I, Fiorino, F, Deluca, D, Pfeiler, D, Schaschke, Norbert, Moroder, L, and Machleidt, W. 2003. “Calpastatin exon 1B-derived peptide, a selective inhibitor of calpain: Enhancing cell permeability by conjugation with penetratin”. BIOLOGICAL CHEMISTRY 384 (3): 395-402.
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2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403813Balaji, KN, Schaschke, Norbert, Machleidt, W, Catalfamo, M, and Henkart, PA. 2002. “Surface cathepsin B protects cytotoxic lymphocytes from self-destruction after degranulation”. JOURNAL OF EXPERIMENTAL MEDICINE 196 (4): 493-503.
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2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403820Schaschke, Norbert, Deluca, D, Assfalg-Machleidt, I, Hohneke, C, Sommerhoff, CP, and Machleidt, W. 2002. “Epoxysuccinyl peptide-derived cathepsin B inhibitors: Modulating membrane permeability by conjugation with the C-terminal heptapeptide segment of penetratin”. BIOLOGICAL CHEMISTRY 383 (5): 849-852.
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2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403828Schaschke, Norbert, Dominik, A, Matschiner, G, and Sommerhoff, CP. 2002. “Bivalent inhibition of beta-tryptase: Distance scan of neighboring subunits by dibasic inhibitors”. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 12 (6): 985-988.
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2001 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403834Schaschke, Norbert, Matschiner, G, Zettl, F, Marquardt, U, Bergner, A, Bode, W, Sommerhoff, CP, and Moroder, L. 2001. “Bivalent inhibition of human beta-tryptase”. CHEMISTRY & BIOLOGY 8 (4): 313-327.
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2000 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403844Schaschke, Norbert, Assfalg-Machleidt, I, Lassleben, T, Sommerhoff, CP, Moroder, L, and Machleidt, W. 2000. “Epoxysuccinyl peptide-derived affinity labels for cathepsin B”. FEBS LETTERS 482 (1-2): 91-96.
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2000 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403852Schaschke, Norbert, Assfalg-Machleidt, I, Machleidt, W, Lassleben, T, Sommerhoff, CP, and Moroder, L. 2000. “beta-cyclodextrin/epoxysuccinyl peptide conjugates: new drug targeting system for tumor cells”. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 10 (7): 677-680.
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1998 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403860Schaschke, Norbert, Fiori, S, Weyher, E, Escrieut, C, Fourmy, D, Muller, G, and Moroder, L. 1998. “Cyclodextrin as carrier of peptide hormones. Conformational and biological properties of beta-cyclodextrin/gastrin constructs”. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 120 (28): 7030-7038.
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1998 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403869Schaschke, Norbert, Assfalg-Machleidt, I, Machleidt, W, and Moroder, L. 1998. “Substrate/propeptide-derived endo-epoxysuccinyl peptides as highly potent and selective cathepsin B inhibitors”. FEBS LETTERS 421 (1): 80-82.
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1997 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403875Schaschke, Norbert, Musiol, HJ, AssfalgMachleidt, I, Machleidt, W, and Moroder, L. 1997. “Oligopresentation of protease inhibitors with beta-cyclodextrin as template”. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 7 (19): 2507-2512.
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1997 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403882Schaschke, Norbert, AssfalgMachleidt, I, Machleidt, W, Turk, D, and Moroder, L. 1997. “E-64 analogues as inhibitors of cathepsin B. On the role of the absolute configuration of the epoxysuccinyl group”. BIOORGANIC & MEDICINAL CHEMISTRY 5 (9): 1789-1797.
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1996 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403889Schaschke, Norbert, Musiol, HJ, AssfalgMachleidt, I, Machleidt, W, RudolphBohner, S, and Moroder, L. 1996. “Cyclodextrins as templates for the presentation of protease inhibitors”. FEBS LETTERS 391 (3): 297-301.