32 Publikationen
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2023 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2981179Tromsdorf, N., Ullrich, F., Rethmeier, M., Sommerhoff, C., & Schaschke, N. (2023). E-64c-hydrazide based cathepsin C inhibitors: Optimizing the interactions with the S1'-S2' area. ChemMedChem, e202300218. https://doi.org/10.1002/cmdc.202300218PUB | PDF | DOI | WoS | PubMed | Europe PMC
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2703442Mikhaylov, G., Klimpel, D., Schaschke, N., Mikac, U., Vizovisek, M., Fonovic, M., Turk, V., et al. (2014). Selective Targeting of Tumor and Stromal Cells By a Nanocarrier System Displaying Lipidated Cathepsin B Inhibitor. Angewandte Chemie International Edition, 53(38), 10077-10081. doi:10.1002/anie.201402305PUB | DOI | WoS | PubMed | Europe PMC
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2699425Tamhane, T., Arampatzidou, M., Gerganova, V., Tacke, M., Illukkumbura, R., Dauth, S., Schaschke, N., et al. (2014). The activity and localization patterns of cathepsins B and X in cells of the mouse gastrointestinal tract differ along its length. Biological Chemistry, 395(10), 1201-1219. doi:10.1515/hsz-2014-0151PUB | DOI | WoS | PubMed | Europe PMC
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2622177Radzey, H., Rethmeier, M., Klimpel, D., Grundhuber, M., Sommerhoff, C. P., & Schaschke, N. (2013). E-64c-Hydrazide: A Lead Structure for the Development of Irreversible CathepsinC Inhibitors. Chemmedchem, 8(8), 1314-1321. doi:10.1002/cmdc.201300093PUB | DOI | WoS | PubMed | Europe PMC
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2489346Kalinska, M., Kantyka, T., Greenbaum, D. C., Larsen, K. S., Wladyka, B., Jabaiah, A., Bogyo, M., et al. (2012). Substrate specificity of Staphylococcus aureus cysteine proteases - Staphopains A, B and C. Biochimie, 94(2), 318-327. doi:10.1016/j.biochi.2011.07.020PUB | DOI | WoS | PubMed | Europe PMC
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2489135Diederich, S., Sauerhering, L., Weis, M., Altmeppen, H., Schaschke, N., Reinheckel, T., Erbar, S., et al. (2012). Activation of the Nipah Virus Fusion Protein in MDCK Cells Is Mediated by Cathepsin B within the Endosome-Recycling Compartment. Journal of Virology, 86(7), 3736-3745. doi:10.1128/JVI.06628.11PUB | DOI | WoS | PubMed | Europe PMC
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2454769Janke, D., Sommerhoff, C. P., & Schaschke, N. (2011). The arginine mimicking beta-amino acid beta(3)hPhe(3-H(2)N-CH(2)) as S1 ligand in cyclotheonamide-based beta-tryptase inhibitors. Bioorganic & Medicinal Chemistry, 19(23), 7236-7243. doi:10.1016/j.bmc.2011.09.050PUB | DOI | WoS | PubMed | Europe PMC
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403684Schurigt, U., Schad, C., Glowa, C., Baum, U., Thomale, K., Schnitzer, J. K., Schultheis, M., et al. (2010). Aziridine-2,3-Dicarboxylate-Based Cysteine Cathepsin Inhibitors Induce Cell Death in Leishmania major Associated with Accumulation of Debris in Autophagy-Related Lysosome-Like Vacuoles. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 54(12), 5028-5041. https://doi.org/10.1128/AAC.00327-10PUB | DOI | WoS | PubMed | Europe PMC
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403708Schaschke, N., & Sommerhoff, C. P. (2010). Upgrading a Natural Product: Inhibition of Human beta-Tryptase by Cyclotheonamide Analogues. CHEMMEDCHEM, 5(3), 367-370. https://doi.org/10.1002/cmdc.200900484PUB | DOI | WoS | PubMed | Europe PMC
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2008 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403720Pfizer, J., Assfalg-Machleidt, I., Machleidt, W., & Schaschke, N. (2008). Inhibition of human mu-calpain by conformationally constrained calpastatin peptides. BIOLOGICAL CHEMISTRY, 389(1), 83-90. https://doi.org/10.1515/BC.2008.004PUB | DOI | WoS | PubMed | Europe PMC
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2008 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403715Schaschke, N., Assfalg-Machleidt, I., & Machleidt, W. (2008). Inhibition of cathepsin L by epoxysuccinyl peptides simultaneously addressing active-site and remote-site regions. CHEMBIOCHEM, 9(11), 1721-1724. https://doi.org/10.1002/cbic.200800103PUB | DOI | WoS | PubMed | Europe PMC
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2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403726Bueth, H., Buttigieg, P. L., Ostafe, R., Rehders, M., Dannenmann, S. R., Schaschke, N., Stark, H. - J., et al. (2007). Cathepsin B is essential for regeneration of scratch-wounded normal human epidermal keratinocytes. EUROPEAN JOURNAL OF CELL BIOLOGY, 86(11-12), 747-761. https://doi.org/10.1016/j.ejcb.2007.03.009PUB | DOI | WoS | PubMed | Europe PMC
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2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403747Sommerhoff, C. P., & Schaschke, N. (2007). Mast cell tryptase beta as a target in allergic inflammation: An evolving story. CURRENT PHARMACEUTICAL DESIGN, 13(3), 313-332. https://doi.org/10.2174/138161207779313579PUB | DOI | WoS | PubMed | Europe PMC
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2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403737Pfizer, J. M., Assfalg-Machleidt, I., Machleidt, W., Moroder, L., & Schaschke, N. (2007). Primed-site probing of papain-like cysteine proteases. INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS, 13(1-2), 93-104. https://doi.org/10.1007/s10989-006-9050-3PUB | DOI | WoS
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2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403744Schaschke, N. (2007). (2S,3S)-Oxirane-2,3-dicarboxylic acid: A privileged platform for probing human cysteine cathepsins. JOURNAL OF BIOTECHNOLOGY, 129(2), 308-315. https://doi.org/10.1016/j.jbiotec.2007.01.023PUB | DOI | WoS | PubMed | Europe PMC
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2005 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403754Schaschke, N., Gabrijelcic-Geiger, D., Dominik, A., & Sommerhoff, C. P. (2005). Affinity chromatography of tryptases: Design, synthesis and characterization of a novel matrix-bound bivalent inhibitor. CHEMBIOCHEM, 6(1), 95-103. https://doi.org/10.1002/cbic.200400217PUB | DOI | WoS | PubMed | Europe PMC
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2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403774Stern, I., Schaschke, N., Moroder, L., & Turk, D. (2004). Crystal structure of NS-134 in complex with bovine cathepsin B: a two-headed epoxysuccinyl inhibitor extends along the entire active-site cleft. BIOCHEMICAL JOURNAL, 381(2), 511-517. https://doi.org/10.1042/bj20040237PUB | DOI | WoS | PubMed | Europe PMC
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2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403779Giragossian, C., Schaschke, N., Moroder, L., & Mierke, D. F. (2004). Conformational and molecular modeling studies of beta-cyclodextrin-heptagastrin and the third extracellular loop of the cholecystokinin 2 receptor. BIOCHEMISTRY, 43(10), 2724-2731. https://doi.org/10.1021/bi035509wPUB | DOI | WoS | PubMed | Europe PMC
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2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403785Schaschke, N. (2004). Miraziridine A: natures blueprint towards protease class-spanning inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 14(4), 855-857. https://doi.org/10.1016/j.bmcl.2003.12.030PUB | DOI | WoS | PubMed | Europe PMC
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2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403760Buth, H., Wolters, B., Hartwig, B., Meier-Bornheim, R., Veith, H., Hansen, M., Sommerhoff, C. P., et al. (2004). HaCaT keratinocytes secrete lysosomal cysteine proteinases during migration. EUROPEAN JOURNAL OF CELL BIOLOGY, 83(11-12), 781-795. https://doi.org/10.1078/0171-9335-00428PUB | DOI | WoS | PubMed | Europe PMC
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2003 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403798Gil-Parrado, S., Assfalg-Machleidt, I., Fiorino, F., Deluca, D., Pfeiler, D., Schaschke, N., Moroder, L., et al. (2003). Calpastatin exon 1B-derived peptide, a selective inhibitor of calpain: Enhancing cell permeability by conjugation with penetratin. BIOLOGICAL CHEMISTRY, 384(3), 395-402. https://doi.org/10.1515/BC.2003.045PUB | DOI | WoS | PubMed | Europe PMC
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2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403813Balaji, K. N., Schaschke, N., Machleidt, W., Catalfamo, M., & Henkart, P. A. (2002). Surface cathepsin B protects cytotoxic lymphocytes from self-destruction after degranulation. JOURNAL OF EXPERIMENTAL MEDICINE, 196(4), 493-503. https://doi.org/10.1084/jem.20011836PUB | DOI | WoS | PubMed | Europe PMC
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2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403820Schaschke, N., Deluca, D., Assfalg-Machleidt, I., Hohneke, C., Sommerhoff, C. P., & Machleidt, W. (2002). Epoxysuccinyl peptide-derived cathepsin B inhibitors: Modulating membrane permeability by conjugation with the C-terminal heptapeptide segment of penetratin. BIOLOGICAL CHEMISTRY, 383(5), 849-852. https://doi.org/10.1515/BC.2002.090PUB | DOI | WoS | PubMed | Europe PMC
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2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403828Schaschke, N., Dominik, A., Matschiner, G., & Sommerhoff, C. P. (2002). Bivalent inhibition of beta-tryptase: Distance scan of neighboring subunits by dibasic inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 12(6), 985-988. https://doi.org/10.1016/S0960-894X(02)00063-XPUB | DOI | WoS | PubMed | Europe PMC
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2001 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403834Schaschke, N., Matschiner, G., Zettl, F., Marquardt, U., Bergner, A., Bode, W., Sommerhoff, C. P., et al. (2001). Bivalent inhibition of human beta-tryptase. CHEMISTRY & BIOLOGY, 8(4), 313-327. https://doi.org/10.1016/S1074-5521(01)00011-4PUB | DOI | WoS | PubMed | Europe PMC
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2000 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403844Schaschke, N., Assfalg-Machleidt, I., Lassleben, T., Sommerhoff, C. P., Moroder, L., & Machleidt, W. (2000). Epoxysuccinyl peptide-derived affinity labels for cathepsin B. FEBS LETTERS, 482(1-2), 91-96. https://doi.org/10.1016/S0014-5793(00)02047-0PUB | DOI | WoS | PubMed | Europe PMC
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2000 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403852Schaschke, N., Assfalg-Machleidt, I., Machleidt, W., Lassleben, T., Sommerhoff, C. P., & Moroder, L. (2000). beta-cyclodextrin/epoxysuccinyl peptide conjugates: new drug targeting system for tumor cells. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 10(7), 677-680. https://doi.org/10.1016/S0960-894X(00)00078-0PUB | DOI | WoS | PubMed | Europe PMC
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1998 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403860Schaschke, N., Fiori, S., Weyher, E., Escrieut, C., Fourmy, D., Muller, G., & Moroder, L. (1998). Cyclodextrin as carrier of peptide hormones. Conformational and biological properties of beta-cyclodextrin/gastrin constructs. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 120(28), 7030-7038. https://doi.org/10.1021/ja973852gPUB | DOI | WoS
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1998 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403869Schaschke, N., Assfalg-Machleidt, I., Machleidt, W., & Moroder, L. (1998). Substrate/propeptide-derived endo-epoxysuccinyl peptides as highly potent and selective cathepsin B inhibitors. FEBS LETTERS, 421(1), 80-82. https://doi.org/10.1016/S0014-5793(97)01538-XPUB | DOI | WoS | PubMed | Europe PMC
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1997 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403875Schaschke, N., Musiol, H. J., AssfalgMachleidt, I., Machleidt, W., & Moroder, L. (1997). Oligopresentation of protease inhibitors with beta-cyclodextrin as template. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 7(19), 2507-2512. https://doi.org/10.1016/S0960-894X(97)10004-XPUB | DOI | WoS
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1997 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403882Schaschke, N., AssfalgMachleidt, I., Machleidt, W., Turk, D., & Moroder, L. (1997). E-64 analogues as inhibitors of cathepsin B. On the role of the absolute configuration of the epoxysuccinyl group. BIOORGANIC & MEDICINAL CHEMISTRY, 5(9), 1789-1797. https://doi.org/10.1016/S0968-0896(97)00105-3PUB | DOI | WoS | PubMed | Europe PMC
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1996 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403889Schaschke, N., Musiol, H. J., AssfalgMachleidt, I., Machleidt, W., RudolphBohner, S., & Moroder, L. (1996). Cyclodextrins as templates for the presentation of protease inhibitors. FEBS LETTERS, 391(3), 297-301. https://doi.org/10.1016/0014-5793(96)00752-1PUB | DOI | WoS | PubMed | Europe PMC