32 Publikationen
-
2023 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2981179Tromsdorf, N.; Ullrich, F.; Rethmeier, M.; Sommerhoff, C.; Schaschke, N. (2023): E-64c-hydrazide based cathepsin C inhibitors: Optimizing the interactions with the S1'-S2' area ChemMedChem,e202300218PUB | PDF | DOI | WoS | PubMed | Europe PMC
-
2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2703442Mikhaylov, G.; Klimpel, D.; Schaschke, N.; Mikac, U.; Vizovisek, M.; Fonovic, M.; Turk, V.; Turk, B.; Vasiljeva, O. (2014): Selective Targeting of Tumor and Stromal Cells By a Nanocarrier System Displaying Lipidated Cathepsin B Inhibitor Angewandte Chemie International Edition,53:(38): 10077-10081.PUB | DOI | WoS | PubMed | Europe PMC
-
2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2699425Tamhane, T.; Arampatzidou, M.; Gerganova, V.; Tacke, M.; Illukkumbura, R.; Dauth, S.; Schaschke, N.; Peters, C.; Reinheckel, T.; Brix, K. (2014): The activity and localization patterns of cathepsins B and X in cells of the mouse gastrointestinal tract differ along its length Biological Chemistry,395:(10): 1201-1219.PUB | DOI | WoS | PubMed | Europe PMC
-
2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2622177Radzey, H.; Rethmeier, M.; Klimpel, D.; Grundhuber, M.; Sommerhoff, C. P.; Schaschke, N. (2013): E-64c-Hydrazide: A Lead Structure for the Development of Irreversible CathepsinC Inhibitors Chemmedchem,8:(8): 1314-1321.PUB | DOI | WoS | PubMed | Europe PMC
-
2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2489346Kalinska, M.; Kantyka, T.; Greenbaum, D. C.; Larsen, K. S.; Wladyka, B.; Jabaiah, A.; Bogyo, M.; Daugherty, P. S.; Wysocka, M.; Jaros, M.; Lesner, A.; Rolka, K.; Schaschke, N.; Stennicke, H.; Dubin, A.; Potempa, J.; Dubin, G. (2012): Substrate specificity of Staphylococcus aureus cysteine proteases - Staphopains A, B and C Biochimie,94:(2): 318-327.PUB | DOI | WoS | PubMed | Europe PMC
-
2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2489135Diederich, S.; Sauerhering, L.; Weis, M.; Altmeppen, H.; Schaschke, N.; Reinheckel, T.; Erbar, S.; Maisner, A. (2012): Activation of the Nipah Virus Fusion Protein in MDCK Cells Is Mediated by Cathepsin B within the Endosome-Recycling Compartment Journal of Virology,86:(7): 3736-3745.PUB | DOI | WoS | PubMed | Europe PMC
-
2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2454769Janke, D.; Sommerhoff, C. P.; Schaschke, N. (2011): The arginine mimicking beta-amino acid beta(3)hPhe(3-H(2)N-CH(2)) as S1 ligand in cyclotheonamide-based beta-tryptase inhibitors Bioorganic & Medicinal Chemistry,19:(23): 7236-7243.PUB | DOI | WoS | PubMed | Europe PMC
-
2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403684Schurigt, U.; Schad, C.; Glowa, C.; Baum, U.; Thomale, K.; Schnitzer, J. K.; Schultheis, M.; Schaschke, N.; Schirmeister, T.; Moll, H. (2010): Aziridine-2,3-Dicarboxylate-Based Cysteine Cathepsin Inhibitors Induce Cell Death in Leishmania major Associated with Accumulation of Debris in Autophagy-Related Lysosome-Like Vacuoles ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,54:(12): 5028-5041.PUB | DOI | WoS | PubMed | Europe PMC
-
2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403708Schaschke, N.; Sommerhoff, C. P. (2010): Upgrading a Natural Product: Inhibition of Human beta-Tryptase by Cyclotheonamide Analogues CHEMMEDCHEM,5:(3): 367-370.PUB | DOI | WoS | PubMed | Europe PMC
-
2008 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403720Pfizer, J.; Assfalg-Machleidt, I.; Machleidt, W.; Schaschke, N. (2008): Inhibition of human mu-calpain by conformationally constrained calpastatin peptides BIOLOGICAL CHEMISTRY,389:(1): 83-90.PUB | DOI | WoS | PubMed | Europe PMC
-
2008 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403715Schaschke, N.; Assfalg-Machleidt, I.; Machleidt, W. (2008): Inhibition of cathepsin L by epoxysuccinyl peptides simultaneously addressing active-site and remote-site regions CHEMBIOCHEM,9:(11): 1721-1724.PUB | DOI | WoS | PubMed | Europe PMC
-
2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403726Bueth, H.; Buttigieg, P. L.; Ostafe, R.; Rehders, M.; Dannenmann, S. R.; Schaschke, N.; Stark, H. - J.; Boukamp, P.; Brix, K. (2007): Cathepsin B is essential for regeneration of scratch-wounded normal human epidermal keratinocytes EUROPEAN JOURNAL OF CELL BIOLOGY,86:(11-12): 747-761.PUB | DOI | WoS | PubMed | Europe PMC
-
2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403747Sommerhoff, C. P.; Schaschke, N. (2007): Mast cell tryptase beta as a target in allergic inflammation: An evolving story CURRENT PHARMACEUTICAL DESIGN,13:(3): 313-332.PUB | DOI | WoS | PubMed | Europe PMC
-
-
2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403744Schaschke, N. (2007): (2S,3S)-Oxirane-2,3-dicarboxylic acid: A privileged platform for probing human cysteine cathepsins JOURNAL OF BIOTECHNOLOGY,129:(2): 308-315.PUB | DOI | WoS | PubMed | Europe PMC
-
2005 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403754Schaschke, N.; Gabrijelcic-Geiger, D.; Dominik, A.; Sommerhoff, C. P. (2005): Affinity chromatography of tryptases: Design, synthesis and characterization of a novel matrix-bound bivalent inhibitor CHEMBIOCHEM,6:(1): 95-103.PUB | DOI | WoS | PubMed | Europe PMC
-
2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403774Stern, I.; Schaschke, N.; Moroder, L.; Turk, D. (2004): Crystal structure of NS-134 in complex with bovine cathepsin B: a two-headed epoxysuccinyl inhibitor extends along the entire active-site cleft BIOCHEMICAL JOURNAL,381:(2): 511-517.PUB | DOI | WoS | PubMed | Europe PMC
-
2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403779Giragossian, C.; Schaschke, N.; Moroder, L.; Mierke, D. F. (2004): Conformational and molecular modeling studies of beta-cyclodextrin-heptagastrin and the third extracellular loop of the cholecystokinin 2 receptor BIOCHEMISTRY,43:(10): 2724-2731.PUB | DOI | WoS | PubMed | Europe PMC
-
2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403785Schaschke, N. (2004): Miraziridine A: natures blueprint towards protease class-spanning inhibitors BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,14:(4): 855-857.PUB | DOI | WoS | PubMed | Europe PMC
-
2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403760Buth, H.; Wolters, B.; Hartwig, B.; Meier-Bornheim, R.; Veith, H.; Hansen, M.; Sommerhoff, C. P.; Schaschke, N.; Machleidt, N.; Fusenig, N. E.; Boukamp, P.; Brix, K. (2004): HaCaT keratinocytes secrete lysosomal cysteine proteinases during migration EUROPEAN JOURNAL OF CELL BIOLOGY,83:(11-12): 781-795.PUB | DOI | WoS | PubMed | Europe PMC
-
2003 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403798Gil-Parrado, S.; Assfalg-Machleidt, I.; Fiorino, F.; Deluca, D.; Pfeiler, D.; Schaschke, N.; Moroder, L.; Machleidt, W. (2003): Calpastatin exon 1B-derived peptide, a selective inhibitor of calpain: Enhancing cell permeability by conjugation with penetratin BIOLOGICAL CHEMISTRY,384:(3): 395-402.PUB | DOI | WoS | PubMed | Europe PMC
-
2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403813Balaji, K. N.; Schaschke, N.; Machleidt, W.; Catalfamo, M.; Henkart, P. A. (2002): Surface cathepsin B protects cytotoxic lymphocytes from self-destruction after degranulation JOURNAL OF EXPERIMENTAL MEDICINE,196:(4): 493-503.PUB | DOI | WoS | PubMed | Europe PMC
-
2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403820Schaschke, N.; Deluca, D.; Assfalg-Machleidt, I.; Hohneke, C.; Sommerhoff, C. P.; Machleidt, W. (2002): Epoxysuccinyl peptide-derived cathepsin B inhibitors: Modulating membrane permeability by conjugation with the C-terminal heptapeptide segment of penetratin BIOLOGICAL CHEMISTRY,383:(5): 849-852.PUB | DOI | WoS | PubMed | Europe PMC
-
2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403828Schaschke, N.; Dominik, A.; Matschiner, G.; Sommerhoff, C. P. (2002): Bivalent inhibition of beta-tryptase: Distance scan of neighboring subunits by dibasic inhibitors BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,12:(6): 985-988.PUB | DOI | WoS | PubMed | Europe PMC
-
2001 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403834Schaschke, N.; Matschiner, G.; Zettl, F.; Marquardt, U.; Bergner, A.; Bode, W.; Sommerhoff, C. P.; Moroder, L. (2001): Bivalent inhibition of human beta-tryptase CHEMISTRY & BIOLOGY,8:(4): 313-327.PUB | DOI | WoS | PubMed | Europe PMC
-
2000 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403844Schaschke, N.; Assfalg-Machleidt, I.; Lassleben, T.; Sommerhoff, C. P.; Moroder, L.; Machleidt, W. (2000): Epoxysuccinyl peptide-derived affinity labels for cathepsin B FEBS LETTERS,482:(1-2): 91-96.PUB | DOI | WoS | PubMed | Europe PMC
-
2000 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403852Schaschke, N.; Assfalg-Machleidt, I.; Machleidt, W.; Lassleben, T.; Sommerhoff, C. P.; Moroder, L. (2000): beta-cyclodextrin/epoxysuccinyl peptide conjugates: new drug targeting system for tumor cells BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,10:(7): 677-680.PUB | DOI | WoS | PubMed | Europe PMC
-
1998 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403860Schaschke, N.; Fiori, S.; Weyher, E.; Escrieut, C.; Fourmy, D.; Muller, G.; Moroder, L. (1998): Cyclodextrin as carrier of peptide hormones. Conformational and biological properties of beta-cyclodextrin/gastrin constructs JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,120:(28): 7030-7038.PUB | DOI | WoS
-
1998 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403869Schaschke, N.; Assfalg-Machleidt, I.; Machleidt, W.; Moroder, L. (1998): Substrate/propeptide-derived endo-epoxysuccinyl peptides as highly potent and selective cathepsin B inhibitors FEBS LETTERS,421:(1): 80-82.PUB | DOI | WoS | PubMed | Europe PMC
-
1997 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403875Schaschke, N.; Musiol, H. J.; AssfalgMachleidt, I.; Machleidt, W.; Moroder, L. (1997): Oligopresentation of protease inhibitors with beta-cyclodextrin as template BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,7:(19): 2507-2512.PUB | DOI | WoS
-
1997 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403882Schaschke, N.; AssfalgMachleidt, I.; Machleidt, W.; Turk, D.; Moroder, L. (1997): E-64 analogues as inhibitors of cathepsin B. On the role of the absolute configuration of the epoxysuccinyl group BIOORGANIC & MEDICINAL CHEMISTRY,5:(9): 1789-1797.PUB | DOI | WoS | PubMed | Europe PMC
-
1996 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403889Schaschke, N.; Musiol, H. J.; AssfalgMachleidt, I.; Machleidt, W.; RudolphBohner, S.; Moroder, L. (1996): Cyclodextrins as templates for the presentation of protease inhibitors FEBS LETTERS,391:(3): 297-301.PUB | DOI | WoS | PubMed | Europe PMC