PUB - Publikationen an der Universität Bielefeld

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• [32]
  

  2023 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2981179

  Tromsdorf, N., Ullrich, F., Rethmeier, M., Sommerhoff, C., & Schaschke, N. (2023). E-64c-hydrazide based cathepsin C inhibitors: Optimizing the interactions with the S1'-S2' area. ChemMedChem, e202300218. https://doi.org/10.1002/cmdc.202300218

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• [31]
  

  2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2703442

  Mikhaylov, G., Klimpel, D., Schaschke, N., Mikac, U., Vizovisek, M., Fonovic, M., Turk, V., et al. (2014). Selective Targeting of Tumor and Stromal Cells By a Nanocarrier System Displaying Lipidated Cathepsin B Inhibitor. Angewandte Chemie International Edition, 53(38), 10077-10081. doi:10.1002/anie.201402305

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• [30]
  

  2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2699425

  Tamhane, T., Arampatzidou, M., Gerganova, V., Tacke, M., Illukkumbura, R., Dauth, S., Schaschke, N., et al. (2014). The activity and localization patterns of cathepsins B and X in cells of the mouse gastrointestinal tract differ along its length. Biological Chemistry, 395(10), 1201-1219. doi:10.1515/hsz-2014-0151

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• [29]
  

  2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2622177

  Radzey, H., Rethmeier, M., Klimpel, D., Grundhuber, M., Sommerhoff, C. P., & Schaschke, N. (2013). E-64c-Hydrazide: A Lead Structure for the Development of Irreversible CathepsinC Inhibitors. Chemmedchem, 8(8), 1314-1321. doi:10.1002/cmdc.201300093

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• [28]
  

  2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2489346

  Kalinska, M., Kantyka, T., Greenbaum, D. C., Larsen, K. S., Wladyka, B., Jabaiah, A., Bogyo, M., et al. (2012). Substrate specificity of Staphylococcus aureus cysteine proteases - Staphopains A, B and C. Biochimie, 94(2), 318-327. doi:10.1016/j.biochi.2011.07.020

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• [27]
  

  2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2489135

  Diederich, S., Sauerhering, L., Weis, M., Altmeppen, H., Schaschke, N., Reinheckel, T., Erbar, S., et al. (2012). Activation of the Nipah Virus Fusion Protein in MDCK Cells Is Mediated by Cathepsin B within the Endosome-Recycling Compartment. Journal of Virology, 86(7), 3736-3745. doi:10.1128/JVI.06628.11

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• [26]
  

  2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2454769

  Janke, D., Sommerhoff, C. P., & Schaschke, N. (2011). The arginine mimicking beta-amino acid beta(3)hPhe(3-H(2)N-CH(2)) as S1 ligand in cyclotheonamide-based beta-tryptase inhibitors. Bioorganic & Medicinal Chemistry, 19(23), 7236-7243. doi:10.1016/j.bmc.2011.09.050

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• [25]
  

  2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403684

  Schurigt, U., Schad, C., Glowa, C., Baum, U., Thomale, K., Schnitzer, J. K., Schultheis, M., et al. (2010). Aziridine-2,3-Dicarboxylate-Based Cysteine Cathepsin Inhibitors Induce Cell Death in Leishmania major Associated with Accumulation of Debris in Autophagy-Related Lysosome-Like Vacuoles. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 54(12), 5028-5041. https://doi.org/10.1128/AAC.00327-10

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• [24]
  

  2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403708

  Schaschke, N., & Sommerhoff, C. P. (2010). Upgrading a Natural Product: Inhibition of Human beta-Tryptase by Cyclotheonamide Analogues. CHEMMEDCHEM, 5(3), 367-370. https://doi.org/10.1002/cmdc.200900484

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• [23]
  

  2008 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403720

  Pfizer, J., Assfalg-Machleidt, I., Machleidt, W., & Schaschke, N. (2008). Inhibition of human mu-calpain by conformationally constrained calpastatin peptides. BIOLOGICAL CHEMISTRY, 389(1), 83-90. https://doi.org/10.1515/BC.2008.004

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• [22]
  

  2008 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403715

  Schaschke, N., Assfalg-Machleidt, I., & Machleidt, W. (2008). Inhibition of cathepsin L by epoxysuccinyl peptides simultaneously addressing active-site and remote-site regions. CHEMBIOCHEM, 9(11), 1721-1724. https://doi.org/10.1002/cbic.200800103

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• [21]
  

  2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403726

  Bueth, H., Buttigieg, P. L., Ostafe, R., Rehders, M., Dannenmann, S. R., Schaschke, N., Stark, H. - J., et al. (2007). Cathepsin B is essential for regeneration of scratch-wounded normal human epidermal keratinocytes. EUROPEAN JOURNAL OF CELL BIOLOGY, 86(11-12), 747-761. https://doi.org/10.1016/j.ejcb.2007.03.009

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• [20]
  

  2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403747

  Sommerhoff, C. P., & Schaschke, N. (2007). Mast cell tryptase beta as a target in allergic inflammation: An evolving story. CURRENT PHARMACEUTICAL DESIGN, 13(3), 313-332. https://doi.org/10.2174/138161207779313579

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• [19]
  

  2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403737

  Pfizer, J. M., Assfalg-Machleidt, I., Machleidt, W., Moroder, L., & Schaschke, N. (2007). Primed-site probing of papain-like cysteine proteases. INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS, 13(1-2), 93-104. https://doi.org/10.1007/s10989-006-9050-3

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• [18]
  

  2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403744

  Schaschke, N. (2007). (2S,3S)-Oxirane-2,3-dicarboxylic acid: A privileged platform for probing human cysteine cathepsins. JOURNAL OF BIOTECHNOLOGY, 129(2), 308-315. https://doi.org/10.1016/j.jbiotec.2007.01.023

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• [17]
  

  2005 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403754

  Schaschke, N., Gabrijelcic-Geiger, D., Dominik, A., & Sommerhoff, C. P. (2005). Affinity chromatography of tryptases: Design, synthesis and characterization of a novel matrix-bound bivalent inhibitor. CHEMBIOCHEM, 6(1), 95-103. https://doi.org/10.1002/cbic.200400217

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• [16]
  

  2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403774

  Stern, I., Schaschke, N., Moroder, L., & Turk, D. (2004). Crystal structure of NS-134 in complex with bovine cathepsin B: a two-headed epoxysuccinyl inhibitor extends along the entire active-site cleft. BIOCHEMICAL JOURNAL, 381(2), 511-517. https://doi.org/10.1042/bj20040237

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• [15]
  

  2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403779

  Giragossian, C., Schaschke, N., Moroder, L., & Mierke, D. F. (2004). Conformational and molecular modeling studies of beta-cyclodextrin-heptagastrin and the third extracellular loop of the cholecystokinin 2 receptor. BIOCHEMISTRY, 43(10), 2724-2731. https://doi.org/10.1021/bi035509w

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• [14]
  

  2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403785

  Schaschke, N. (2004). Miraziridine A: natures blueprint towards protease class-spanning inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 14(4), 855-857. https://doi.org/10.1016/j.bmcl.2003.12.030

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• [13]
  

  2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403760

  Buth, H., Wolters, B., Hartwig, B., Meier-Bornheim, R., Veith, H., Hansen, M., Sommerhoff, C. P., et al. (2004). HaCaT keratinocytes secrete lysosomal cysteine proteinases during migration. EUROPEAN JOURNAL OF CELL BIOLOGY, 83(11-12), 781-795. https://doi.org/10.1078/0171-9335-00428

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• [12]
  

  2003 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403798

  Gil-Parrado, S., Assfalg-Machleidt, I., Fiorino, F., Deluca, D., Pfeiler, D., Schaschke, N., Moroder, L., et al. (2003). Calpastatin exon 1B-derived peptide, a selective inhibitor of calpain: Enhancing cell permeability by conjugation with penetratin. BIOLOGICAL CHEMISTRY, 384(3), 395-402. https://doi.org/10.1515/BC.2003.045

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• [11]
  

  2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403813

  Balaji, K. N., Schaschke, N., Machleidt, W., Catalfamo, M., & Henkart, P. A. (2002). Surface cathepsin B protects cytotoxic lymphocytes from self-destruction after degranulation. JOURNAL OF EXPERIMENTAL MEDICINE, 196(4), 493-503. https://doi.org/10.1084/jem.20011836

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• [10]
  

  2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403820

  Schaschke, N., Deluca, D., Assfalg-Machleidt, I., Hohneke, C., Sommerhoff, C. P., & Machleidt, W. (2002). Epoxysuccinyl peptide-derived cathepsin B inhibitors: Modulating membrane permeability by conjugation with the C-terminal heptapeptide segment of penetratin. BIOLOGICAL CHEMISTRY, 383(5), 849-852. https://doi.org/10.1515/BC.2002.090

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• [9]
  

  2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403828

  Schaschke, N., Dominik, A., Matschiner, G., & Sommerhoff, C. P. (2002). Bivalent inhibition of beta-tryptase: Distance scan of neighboring subunits by dibasic inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 12(6), 985-988. https://doi.org/10.1016/S0960-894X(02)00063-X

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• [8]
  

  2001 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403834

  Schaschke, N., Matschiner, G., Zettl, F., Marquardt, U., Bergner, A., Bode, W., Sommerhoff, C. P., et al. (2001). Bivalent inhibition of human beta-tryptase. CHEMISTRY & BIOLOGY, 8(4), 313-327. https://doi.org/10.1016/S1074-5521(01)00011-4

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• [7]
  

  2000 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403844

  Schaschke, N., Assfalg-Machleidt, I., Lassleben, T., Sommerhoff, C. P., Moroder, L., & Machleidt, W. (2000). Epoxysuccinyl peptide-derived affinity labels for cathepsin B. FEBS LETTERS, 482(1-2), 91-96. https://doi.org/10.1016/S0014-5793(00)02047-0

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• [6]
  

  2000 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403852

  Schaschke, N., Assfalg-Machleidt, I., Machleidt, W., Lassleben, T., Sommerhoff, C. P., & Moroder, L. (2000). beta-cyclodextrin/epoxysuccinyl peptide conjugates: new drug targeting system for tumor cells. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 10(7), 677-680. https://doi.org/10.1016/S0960-894X(00)00078-0

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• [5]
  

  1998 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403860

  Schaschke, N., Fiori, S., Weyher, E., Escrieut, C., Fourmy, D., Muller, G., & Moroder, L. (1998). Cyclodextrin as carrier of peptide hormones. Conformational and biological properties of beta-cyclodextrin/gastrin constructs. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 120(28), 7030-7038. https://doi.org/10.1021/ja973852g

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• [4]
  

  1998 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403869

  Schaschke, N., Assfalg-Machleidt, I., Machleidt, W., & Moroder, L. (1998). Substrate/propeptide-derived endo-epoxysuccinyl peptides as highly potent and selective cathepsin B inhibitors. FEBS LETTERS, 421(1), 80-82. https://doi.org/10.1016/S0014-5793(97)01538-X

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• [3]
  

  1997 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403875

  Schaschke, N., Musiol, H. J., AssfalgMachleidt, I., Machleidt, W., & Moroder, L. (1997). Oligopresentation of protease inhibitors with beta-cyclodextrin as template. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 7(19), 2507-2512. https://doi.org/10.1016/S0960-894X(97)10004-X

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• [2]
  

  1997 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403882

  Schaschke, N., AssfalgMachleidt, I., Machleidt, W., Turk, D., & Moroder, L. (1997). E-64 analogues as inhibitors of cathepsin B. On the role of the absolute configuration of the epoxysuccinyl group. BIOORGANIC & MEDICINAL CHEMISTRY, 5(9), 1789-1797. https://doi.org/10.1016/S0968-0896(97)00105-3

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• [1]
  

  1996 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403889

  Schaschke, N., Musiol, H. J., AssfalgMachleidt, I., Machleidt, W., RudolphBohner, S., & Moroder, L. (1996). Cyclodextrins as templates for the presentation of protease inhibitors. FEBS LETTERS, 391(3), 297-301. https://doi.org/10.1016/0014-5793(96)00752-1

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