32 Publikationen
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2023 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2981179Tromsdorf, N., Ullrich, F., Rethmeier, M., Sommerhoff, C., and Schaschke, N. (2023). E-64c-hydrazide based cathepsin C inhibitors: Optimizing the interactions with the S1'-S2' area. ChemMedChem:e202300218.PUB | PDF | DOI | WoS | PubMed | Europe PMC
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2703442Mikhaylov, G., Klimpel, D., Schaschke, N., Mikac, U., Vizovisek, M., Fonovic, M., Turk, V., Turk, B., and Vasiljeva, O. (2014). Selective Targeting of Tumor and Stromal Cells By a Nanocarrier System Displaying Lipidated Cathepsin B Inhibitor. Angewandte Chemie International Edition 53, 10077-10081.PUB | DOI | WoS | PubMed | Europe PMC
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2699425Tamhane, T., Arampatzidou, M., Gerganova, V., Tacke, M., Illukkumbura, R., Dauth, S., Schaschke, N., Peters, C., Reinheckel, T., and Brix, K. (2014). The activity and localization patterns of cathepsins B and X in cells of the mouse gastrointestinal tract differ along its length. Biological Chemistry 395, 1201-1219.PUB | DOI | WoS | PubMed | Europe PMC
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2622177Radzey, H., Rethmeier, M., Klimpel, D., Grundhuber, M., Sommerhoff, C. P., and Schaschke, N. (2013). E-64c-Hydrazide: A Lead Structure for the Development of Irreversible CathepsinC Inhibitors. Chemmedchem 8, 1314-1321.PUB | DOI | WoS | PubMed | Europe PMC
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2489346Kalinska, M., Kantyka, T., Greenbaum, D. C., Larsen, K. S., Wladyka, B., Jabaiah, A., Bogyo, M., Daugherty, P. S., Wysocka, M., Jaros, M., et al. (2012). Substrate specificity of Staphylococcus aureus cysteine proteases - Staphopains A, B and C. Biochimie 94, 318-327.PUB | DOI | WoS | PubMed | Europe PMC
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2489135Diederich, S., Sauerhering, L., Weis, M., Altmeppen, H., Schaschke, N., Reinheckel, T., Erbar, S., and Maisner, A. (2012). Activation of the Nipah Virus Fusion Protein in MDCK Cells Is Mediated by Cathepsin B within the Endosome-Recycling Compartment. Journal of Virology 86, 3736-3745.PUB | DOI | WoS | PubMed | Europe PMC
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2454769Janke, D., Sommerhoff, C. P., and Schaschke, N. (2011). The arginine mimicking beta-amino acid beta(3)hPhe(3-H(2)N-CH(2)) as S1 ligand in cyclotheonamide-based beta-tryptase inhibitors. Bioorganic & Medicinal Chemistry 19, 7236-7243.PUB | DOI | WoS | PubMed | Europe PMC
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403684Schurigt, U., Schad, C., Glowa, C., Baum, U., Thomale, K., Schnitzer, J. K., Schultheis, M., Schaschke, N., Schirmeister, T., and Moll, H. (2010). Aziridine-2,3-Dicarboxylate-Based Cysteine Cathepsin Inhibitors Induce Cell Death in Leishmania major Associated with Accumulation of Debris in Autophagy-Related Lysosome-Like Vacuoles. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 54, 5028-5041.PUB | DOI | WoS | PubMed | Europe PMC
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403708Schaschke, N., and Sommerhoff, C. P. (2010). Upgrading a Natural Product: Inhibition of Human beta-Tryptase by Cyclotheonamide Analogues. CHEMMEDCHEM 5, 367-370.PUB | DOI | WoS | PubMed | Europe PMC
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2008 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403720Pfizer, J., Assfalg-Machleidt, I., Machleidt, W., and Schaschke, N. (2008). Inhibition of human mu-calpain by conformationally constrained calpastatin peptides. BIOLOGICAL CHEMISTRY 389, 83-90.PUB | DOI | WoS | PubMed | Europe PMC
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2008 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403715Schaschke, N., Assfalg-Machleidt, I., and Machleidt, W. (2008). Inhibition of cathepsin L by epoxysuccinyl peptides simultaneously addressing active-site and remote-site regions. CHEMBIOCHEM 9, 1721-1724.PUB | DOI | WoS | PubMed | Europe PMC
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2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403726Bueth, H., Buttigieg, P. L., Ostafe, R., Rehders, M., Dannenmann, S. R., Schaschke, N., Stark, H. - J., Boukamp, P., and Brix, K. (2007). Cathepsin B is essential for regeneration of scratch-wounded normal human epidermal keratinocytes. EUROPEAN JOURNAL OF CELL BIOLOGY 86, 747-761.PUB | DOI | WoS | PubMed | Europe PMC
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2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403747Sommerhoff, C. P., and Schaschke, N. (2007). Mast cell tryptase beta as a target in allergic inflammation: An evolving story. CURRENT PHARMACEUTICAL DESIGN 13, 313-332.PUB | DOI | WoS | PubMed | Europe PMC
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2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403744Schaschke, N. (2007). (2S,3S)-Oxirane-2,3-dicarboxylic acid: A privileged platform for probing human cysteine cathepsins. JOURNAL OF BIOTECHNOLOGY 129, 308-315.PUB | DOI | WoS | PubMed | Europe PMC
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2005 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403754Schaschke, N., Gabrijelcic-Geiger, D., Dominik, A., and Sommerhoff, C. P. (2005). Affinity chromatography of tryptases: Design, synthesis and characterization of a novel matrix-bound bivalent inhibitor. CHEMBIOCHEM 6, 95-103.PUB | DOI | WoS | PubMed | Europe PMC
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2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403774Stern, I., Schaschke, N., Moroder, L., and Turk, D. (2004). Crystal structure of NS-134 in complex with bovine cathepsin B: a two-headed epoxysuccinyl inhibitor extends along the entire active-site cleft. BIOCHEMICAL JOURNAL 381, 511-517.PUB | DOI | WoS | PubMed | Europe PMC
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2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403779Giragossian, C., Schaschke, N., Moroder, L., and Mierke, D. F. (2004). Conformational and molecular modeling studies of beta-cyclodextrin-heptagastrin and the third extracellular loop of the cholecystokinin 2 receptor. BIOCHEMISTRY 43, 2724-2731.PUB | DOI | WoS | PubMed | Europe PMC
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2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403785Schaschke, N. (2004). Miraziridine A: natures blueprint towards protease class-spanning inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 14, 855-857.PUB | DOI | WoS | PubMed | Europe PMC
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2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403760Buth, H., Wolters, B., Hartwig, B., Meier-Bornheim, R., Veith, H., Hansen, M., Sommerhoff, C. P., Schaschke, N., Machleidt, N., Fusenig, N. E., et al. (2004). HaCaT keratinocytes secrete lysosomal cysteine proteinases during migration. EUROPEAN JOURNAL OF CELL BIOLOGY 83, 781-795.PUB | DOI | WoS | PubMed | Europe PMC
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2003 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403798Gil-Parrado, S., Assfalg-Machleidt, I., Fiorino, F., Deluca, D., Pfeiler, D., Schaschke, N., Moroder, L., and Machleidt, W. (2003). Calpastatin exon 1B-derived peptide, a selective inhibitor of calpain: Enhancing cell permeability by conjugation with penetratin. BIOLOGICAL CHEMISTRY 384, 395-402.PUB | DOI | WoS | PubMed | Europe PMC
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2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403813Balaji, K. N., Schaschke, N., Machleidt, W., Catalfamo, M., and Henkart, P. A. (2002). Surface cathepsin B protects cytotoxic lymphocytes from self-destruction after degranulation. JOURNAL OF EXPERIMENTAL MEDICINE 196, 493-503.PUB | DOI | WoS | PubMed | Europe PMC
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2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403820Schaschke, N., Deluca, D., Assfalg-Machleidt, I., Hohneke, C., Sommerhoff, C. P., and Machleidt, W. (2002). Epoxysuccinyl peptide-derived cathepsin B inhibitors: Modulating membrane permeability by conjugation with the C-terminal heptapeptide segment of penetratin. BIOLOGICAL CHEMISTRY 383, 849-852.PUB | DOI | WoS | PubMed | Europe PMC
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2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403828Schaschke, N., Dominik, A., Matschiner, G., and Sommerhoff, C. P. (2002). Bivalent inhibition of beta-tryptase: Distance scan of neighboring subunits by dibasic inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 12, 985-988.PUB | DOI | WoS | PubMed | Europe PMC
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2001 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403834Schaschke, N., Matschiner, G., Zettl, F., Marquardt, U., Bergner, A., Bode, W., Sommerhoff, C. P., and Moroder, L. (2001). Bivalent inhibition of human beta-tryptase. CHEMISTRY & BIOLOGY 8, 313-327.PUB | DOI | WoS | PubMed | Europe PMC
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2000 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403844Schaschke, N., Assfalg-Machleidt, I., Lassleben, T., Sommerhoff, C. P., Moroder, L., and Machleidt, W. (2000). Epoxysuccinyl peptide-derived affinity labels for cathepsin B. FEBS LETTERS 482, 91-96.PUB | DOI | WoS | PubMed | Europe PMC
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2000 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403852Schaschke, N., Assfalg-Machleidt, I., Machleidt, W., Lassleben, T., Sommerhoff, C. P., and Moroder, L. (2000). beta-cyclodextrin/epoxysuccinyl peptide conjugates: new drug targeting system for tumor cells. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 10, 677-680.PUB | DOI | WoS | PubMed | Europe PMC
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1998 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403860Schaschke, N., Fiori, S., Weyher, E., Escrieut, C., Fourmy, D., Muller, G., and Moroder, L. (1998). Cyclodextrin as carrier of peptide hormones. Conformational and biological properties of beta-cyclodextrin/gastrin constructs. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 120, 7030-7038.PUB | DOI | WoS
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1998 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403869Schaschke, N., Assfalg-Machleidt, I., Machleidt, W., and Moroder, L. (1998). Substrate/propeptide-derived endo-epoxysuccinyl peptides as highly potent and selective cathepsin B inhibitors. FEBS LETTERS 421, 80-82.PUB | DOI | WoS | PubMed | Europe PMC
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1997 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403875Schaschke, N., Musiol, H. J., AssfalgMachleidt, I., Machleidt, W., and Moroder, L. (1997). Oligopresentation of protease inhibitors with beta-cyclodextrin as template. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 7, 2507-2512.PUB | DOI | WoS
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1997 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403882Schaschke, N., AssfalgMachleidt, I., Machleidt, W., Turk, D., and Moroder, L. (1997). E-64 analogues as inhibitors of cathepsin B. On the role of the absolute configuration of the epoxysuccinyl group. BIOORGANIC & MEDICINAL CHEMISTRY 5, 1789-1797.PUB | DOI | WoS | PubMed | Europe PMC
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1996 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403889Schaschke, N., Musiol, H. J., AssfalgMachleidt, I., Machleidt, W., RudolphBohner, S., and Moroder, L. (1996). Cyclodextrins as templates for the presentation of protease inhibitors. FEBS LETTERS 391, 297-301.PUB | DOI | WoS | PubMed | Europe PMC