32 Publikationen

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  • [32]
    2023 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2981179 OA
    N. Tromsdorf, F. Ullrich, M. Rethmeier, C. Sommerhoff, and N. Schaschke, “E-64c-hydrazide based cathepsin C inhibitors: Optimizing the interactions with the S1'-S2' area”, ChemMedChem, 2023, : e202300218.
    PUB | PDF | DOI | WoS | PubMed | Europe PMC
     
  • [31]
    2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2703442
    G. Mikhaylov, D. Klimpel, N. Schaschke, U. Mikac, M. Vizovisek, M. Fonovic, V. Turk, B. Turk, and O. Vasiljeva, “Selective Targeting of Tumor and Stromal Cells By a Nanocarrier System Displaying Lipidated Cathepsin B Inhibitor”, Angewandte Chemie International Edition, 2014, 53, 10077-10081.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [30]
    2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2699425
    T. Tamhane, M. Arampatzidou, V. Gerganova, M. Tacke, R. Illukkumbura, S. Dauth, N. Schaschke, C. Peters, T. Reinheckel, and K. Brix, “The activity and localization patterns of cathepsins B and X in cells of the mouse gastrointestinal tract differ along its length”, Biological Chemistry, 2014, 395, 1201-1219.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [29]
    2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2622177
    H. Radzey, M. Rethmeier, D. Klimpel, M. Grundhuber, C. P. Sommerhoff, and N. Schaschke, “E-64c-Hydrazide: A Lead Structure for the Development of Irreversible CathepsinC Inhibitors”, Chemmedchem, 2013, 8, 1314-1321.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [28]
    2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2489346
    M. Kalinska, T. Kantyka, D. C. Greenbaum, K. S. Larsen, B. Wladyka, A. Jabaiah, M. Bogyo, P. S. Daugherty, M. Wysocka, M. Jaros, et al., “Substrate specificity of Staphylococcus aureus cysteine proteases - Staphopains A, B and C”, Biochimie, 2012, 94, 318-327.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [27]
    2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2489135
    S. Diederich, L. Sauerhering, M. Weis, H. Altmeppen, N. Schaschke, T. Reinheckel, S. Erbar, and A. Maisner, “Activation of the Nipah Virus Fusion Protein in MDCK Cells Is Mediated by Cathepsin B within the Endosome-Recycling Compartment”, Journal of Virology, 2012, 86, 3736-3745.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [26]
    2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2454769
    D. Janke, C. P. Sommerhoff, and N. Schaschke, “The arginine mimicking beta-amino acid beta(3)hPhe(3-H(2)N-CH(2)) as S1 ligand in cyclotheonamide-based beta-tryptase inhibitors”, Bioorganic & Medicinal Chemistry, 2011, 19, 7236-7243.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [25]
    2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403684
    U. Schurigt, C. Schad, C. Glowa, U. Baum, K. Thomale, J. K. Schnitzer, M. Schultheis, N. Schaschke, T. Schirmeister, and H. Moll, “Aziridine-2,3-Dicarboxylate-Based Cysteine Cathepsin Inhibitors Induce Cell Death in Leishmania major Associated with Accumulation of Debris in Autophagy-Related Lysosome-Like Vacuoles”, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2010, 54, 5028-5041.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [24]
    2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403708
    N. Schaschke, and C. P. Sommerhoff, “Upgrading a Natural Product: Inhibition of Human beta-Tryptase by Cyclotheonamide Analogues”, CHEMMEDCHEM, 2010, 5, 367-370.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [23]
    2008 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403720
    J. Pfizer, I. Assfalg-Machleidt, W. Machleidt, and N. Schaschke, “Inhibition of human mu-calpain by conformationally constrained calpastatin peptides”, BIOLOGICAL CHEMISTRY, 2008, 389, 83-90.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [22]
    2008 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403715
    N. Schaschke, I. Assfalg-Machleidt, and W. Machleidt, “Inhibition of cathepsin L by epoxysuccinyl peptides simultaneously addressing active-site and remote-site regions”, CHEMBIOCHEM, 2008, 9, 1721-1724.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [21]
    2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403726
    H. Bueth, P. L. Buttigieg, R. Ostafe, M. Rehders, S. R. Dannenmann, N. Schaschke, H. - J. Stark, P. Boukamp, and K. Brix, “Cathepsin B is essential for regeneration of scratch-wounded normal human epidermal keratinocytes”, EUROPEAN JOURNAL OF CELL BIOLOGY, 2007, 86, 747-761.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [20]
    2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403747
    C. P. Sommerhoff, and N. Schaschke, “Mast cell tryptase beta as a target in allergic inflammation: An evolving story”, CURRENT PHARMACEUTICAL DESIGN, 2007, 13, 313-332.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [19]
    2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403737
    J. M. Pfizer, I. Assfalg-Machleidt, W. Machleidt, L. Moroder, and N. Schaschke, “Primed-site probing of papain-like cysteine proteases”, INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS, 2007, 13, 93-104.
    PUB | DOI | WoS
     
  • [18]
    2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403744
    N. Schaschke, “(2S,3S)-Oxirane-2,3-dicarboxylic acid: A privileged platform for probing human cysteine cathepsins”, JOURNAL OF BIOTECHNOLOGY, 2007, 129, 308-315.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [17]
    2005 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403754
    N. Schaschke, D. Gabrijelcic-Geiger, A. Dominik, and C. P. Sommerhoff, “Affinity chromatography of tryptases: Design, synthesis and characterization of a novel matrix-bound bivalent inhibitor”, CHEMBIOCHEM, 2005, 6, 95-103.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [16]
    2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403774
    I. Stern, N. Schaschke, L. Moroder, and D. Turk, “Crystal structure of NS-134 in complex with bovine cathepsin B: a two-headed epoxysuccinyl inhibitor extends along the entire active-site cleft”, BIOCHEMICAL JOURNAL, 2004, 381, 511-517.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [15]
    2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403779
    C. Giragossian, N. Schaschke, L. Moroder, and D. F. Mierke, “Conformational and molecular modeling studies of beta-cyclodextrin-heptagastrin and the third extracellular loop of the cholecystokinin 2 receptor”, BIOCHEMISTRY, 2004, 43, 2724-2731.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [14]
    2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403785
    N. Schaschke, “Miraziridine A: natures blueprint towards protease class-spanning inhibitors”, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14, 855-857.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [13]
    2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403760
    H. Buth, B. Wolters, B. Hartwig, R. Meier-Bornheim, H. Veith, M. Hansen, C. P. Sommerhoff, N. Schaschke, N. Machleidt, N. E. Fusenig, et al., “HaCaT keratinocytes secrete lysosomal cysteine proteinases during migration”, EUROPEAN JOURNAL OF CELL BIOLOGY, 2004, 83, 781-795.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [12]
    2003 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403798
    S. Gil-Parrado, I. Assfalg-Machleidt, F. Fiorino, D. Deluca, D. Pfeiler, N. Schaschke, L. Moroder, and W. Machleidt, “Calpastatin exon 1B-derived peptide, a selective inhibitor of calpain: Enhancing cell permeability by conjugation with penetratin”, BIOLOGICAL CHEMISTRY, 2003, 384, 395-402.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [11]
    2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403813
    K. N. Balaji, N. Schaschke, W. Machleidt, M. Catalfamo, and P. A. Henkart, “Surface cathepsin B protects cytotoxic lymphocytes from self-destruction after degranulation”, JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 196, 493-503.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [10]
    2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403820
    N. Schaschke, D. Deluca, I. Assfalg-Machleidt, C. Hohneke, C. P. Sommerhoff, and W. Machleidt, “Epoxysuccinyl peptide-derived cathepsin B inhibitors: Modulating membrane permeability by conjugation with the C-terminal heptapeptide segment of penetratin”, BIOLOGICAL CHEMISTRY, 2002, 383, 849-852.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [9]
    2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403828
    N. Schaschke, A. Dominik, G. Matschiner, and C. P. Sommerhoff, “Bivalent inhibition of beta-tryptase: Distance scan of neighboring subunits by dibasic inhibitors”, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2002, 12, 985-988.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [8]
    2001 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403834
    N. Schaschke, G. Matschiner, F. Zettl, U. Marquardt, A. Bergner, W. Bode, C. P. Sommerhoff, and L. Moroder, “Bivalent inhibition of human beta-tryptase”, CHEMISTRY & BIOLOGY, 2001, 8, 313-327.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [7]
    2000 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403844
    N. Schaschke, I. Assfalg-Machleidt, T. Lassleben, C. P. Sommerhoff, L. Moroder, and W. Machleidt, “Epoxysuccinyl peptide-derived affinity labels for cathepsin B”, FEBS LETTERS, 2000, 482, 91-96.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [6]
    2000 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403852
    N. Schaschke, I. Assfalg-Machleidt, W. Machleidt, T. Lassleben, C. P. Sommerhoff, and L. Moroder, “beta-cyclodextrin/epoxysuccinyl peptide conjugates: new drug targeting system for tumor cells”, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10, 677-680.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [5]
    1998 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403860
    N. Schaschke, S. Fiori, E. Weyher, C. Escrieut, D. Fourmy, G. Muller, and L. Moroder, “Cyclodextrin as carrier of peptide hormones. Conformational and biological properties of beta-cyclodextrin/gastrin constructs”, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120, 7030-7038.
    PUB | DOI | WoS
     
  • [4]
    1998 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403869
    N. Schaschke, I. Assfalg-Machleidt, W. Machleidt, and L. Moroder, “Substrate/propeptide-derived endo-epoxysuccinyl peptides as highly potent and selective cathepsin B inhibitors”, FEBS LETTERS, 1998, 421, 80-82.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [3]
    1997 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403875
    N. Schaschke, H. J. Musiol, I. AssfalgMachleidt, W. Machleidt, and L. Moroder, “Oligopresentation of protease inhibitors with beta-cyclodextrin as template”, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1997, 7, 2507-2512.
    PUB | DOI | WoS
     
  • [2]
    1997 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403882
    N. Schaschke, I. AssfalgMachleidt, W. Machleidt, D. Turk, and L. Moroder, “E-64 analogues as inhibitors of cathepsin B. On the role of the absolute configuration of the epoxysuccinyl group”, BIOORGANIC & MEDICINAL CHEMISTRY, 1997, 5, 1789-1797.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [1]
    1996 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403889
    N. Schaschke, H. J. Musiol, I. AssfalgMachleidt, W. Machleidt, S. RudolphBohner, and L. Moroder, “Cyclodextrins as templates for the presentation of protease inhibitors”, FEBS LETTERS, 1996, 391, 297-301.
    PUB | DOI | WoS | PubMed | Europe PMC
     

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