32 Publikationen
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2023 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2981179N. Tromsdorf, F. Ullrich, M. Rethmeier, C. Sommerhoff, and N. Schaschke, “E-64c-hydrazide based cathepsin C inhibitors: Optimizing the interactions with the S1'-S2' area”, ChemMedChem, 2023, : e202300218.PUB | PDF | DOI | WoS | PubMed | Europe PMC
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2703442G. Mikhaylov, D. Klimpel, N. Schaschke, U. Mikac, M. Vizovisek, M. Fonovic, V. Turk, B. Turk, and O. Vasiljeva, “Selective Targeting of Tumor and Stromal Cells By a Nanocarrier System Displaying Lipidated Cathepsin B Inhibitor”, Angewandte Chemie International Edition, 2014, 53, 10077-10081.PUB | DOI | WoS | PubMed | Europe PMC
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2699425T. Tamhane, M. Arampatzidou, V. Gerganova, M. Tacke, R. Illukkumbura, S. Dauth, N. Schaschke, C. Peters, T. Reinheckel, and K. Brix, “The activity and localization patterns of cathepsins B and X in cells of the mouse gastrointestinal tract differ along its length”, Biological Chemistry, 2014, 395, 1201-1219.PUB | DOI | WoS | PubMed | Europe PMC
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2622177H. Radzey, M. Rethmeier, D. Klimpel, M. Grundhuber, C. P. Sommerhoff, and N. Schaschke, “E-64c-Hydrazide: A Lead Structure for the Development of Irreversible CathepsinC Inhibitors”, Chemmedchem, 2013, 8, 1314-1321.PUB | DOI | WoS | PubMed | Europe PMC
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2489346M. Kalinska, T. Kantyka, D. C. Greenbaum, K. S. Larsen, B. Wladyka, A. Jabaiah, M. Bogyo, P. S. Daugherty, M. Wysocka, M. Jaros, et al., “Substrate specificity of Staphylococcus aureus cysteine proteases - Staphopains A, B and C”, Biochimie, 2012, 94, 318-327.PUB | DOI | WoS | PubMed | Europe PMC
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2489135S. Diederich, L. Sauerhering, M. Weis, H. Altmeppen, N. Schaschke, T. Reinheckel, S. Erbar, and A. Maisner, “Activation of the Nipah Virus Fusion Protein in MDCK Cells Is Mediated by Cathepsin B within the Endosome-Recycling Compartment”, Journal of Virology, 2012, 86, 3736-3745.PUB | DOI | WoS | PubMed | Europe PMC
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2454769D. Janke, C. P. Sommerhoff, and N. Schaschke, “The arginine mimicking beta-amino acid beta(3)hPhe(3-H(2)N-CH(2)) as S1 ligand in cyclotheonamide-based beta-tryptase inhibitors”, Bioorganic & Medicinal Chemistry, 2011, 19, 7236-7243.PUB | DOI | WoS | PubMed | Europe PMC
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403684U. Schurigt, C. Schad, C. Glowa, U. Baum, K. Thomale, J. K. Schnitzer, M. Schultheis, N. Schaschke, T. Schirmeister, and H. Moll, “Aziridine-2,3-Dicarboxylate-Based Cysteine Cathepsin Inhibitors Induce Cell Death in Leishmania major Associated with Accumulation of Debris in Autophagy-Related Lysosome-Like Vacuoles”, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2010, 54, 5028-5041.PUB | DOI | WoS | PubMed | Europe PMC
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403708N. Schaschke, and C. P. Sommerhoff, “Upgrading a Natural Product: Inhibition of Human beta-Tryptase by Cyclotheonamide Analogues”, CHEMMEDCHEM, 2010, 5, 367-370.PUB | DOI | WoS | PubMed | Europe PMC
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2008 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403720J. Pfizer, I. Assfalg-Machleidt, W. Machleidt, and N. Schaschke, “Inhibition of human mu-calpain by conformationally constrained calpastatin peptides”, BIOLOGICAL CHEMISTRY, 2008, 389, 83-90.PUB | DOI | WoS | PubMed | Europe PMC
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2008 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403715N. Schaschke, I. Assfalg-Machleidt, and W. Machleidt, “Inhibition of cathepsin L by epoxysuccinyl peptides simultaneously addressing active-site and remote-site regions”, CHEMBIOCHEM, 2008, 9, 1721-1724.PUB | DOI | WoS | PubMed | Europe PMC
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2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403726H. Bueth, P. L. Buttigieg, R. Ostafe, M. Rehders, S. R. Dannenmann, N. Schaschke, H. - J. Stark, P. Boukamp, and K. Brix, “Cathepsin B is essential for regeneration of scratch-wounded normal human epidermal keratinocytes”, EUROPEAN JOURNAL OF CELL BIOLOGY, 2007, 86, 747-761.PUB | DOI | WoS | PubMed | Europe PMC
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2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403747C. P. Sommerhoff, and N. Schaschke, “Mast cell tryptase beta as a target in allergic inflammation: An evolving story”, CURRENT PHARMACEUTICAL DESIGN, 2007, 13, 313-332.PUB | DOI | WoS | PubMed | Europe PMC
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2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403744N. Schaschke, “(2S,3S)-Oxirane-2,3-dicarboxylic acid: A privileged platform for probing human cysteine cathepsins”, JOURNAL OF BIOTECHNOLOGY, 2007, 129, 308-315.PUB | DOI | WoS | PubMed | Europe PMC
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2005 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403754N. Schaschke, D. Gabrijelcic-Geiger, A. Dominik, and C. P. Sommerhoff, “Affinity chromatography of tryptases: Design, synthesis and characterization of a novel matrix-bound bivalent inhibitor”, CHEMBIOCHEM, 2005, 6, 95-103.PUB | DOI | WoS | PubMed | Europe PMC
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2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403774I. Stern, N. Schaschke, L. Moroder, and D. Turk, “Crystal structure of NS-134 in complex with bovine cathepsin B: a two-headed epoxysuccinyl inhibitor extends along the entire active-site cleft”, BIOCHEMICAL JOURNAL, 2004, 381, 511-517.PUB | DOI | WoS | PubMed | Europe PMC
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2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403779C. Giragossian, N. Schaschke, L. Moroder, and D. F. Mierke, “Conformational and molecular modeling studies of beta-cyclodextrin-heptagastrin and the third extracellular loop of the cholecystokinin 2 receptor”, BIOCHEMISTRY, 2004, 43, 2724-2731.PUB | DOI | WoS | PubMed | Europe PMC
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2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403785N. Schaschke, “Miraziridine A: natures blueprint towards protease class-spanning inhibitors”, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14, 855-857.PUB | DOI | WoS | PubMed | Europe PMC
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2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403760H. Buth, B. Wolters, B. Hartwig, R. Meier-Bornheim, H. Veith, M. Hansen, C. P. Sommerhoff, N. Schaschke, N. Machleidt, N. E. Fusenig, et al., “HaCaT keratinocytes secrete lysosomal cysteine proteinases during migration”, EUROPEAN JOURNAL OF CELL BIOLOGY, 2004, 83, 781-795.PUB | DOI | WoS | PubMed | Europe PMC
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2003 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403798S. Gil-Parrado, I. Assfalg-Machleidt, F. Fiorino, D. Deluca, D. Pfeiler, N. Schaschke, L. Moroder, and W. Machleidt, “Calpastatin exon 1B-derived peptide, a selective inhibitor of calpain: Enhancing cell permeability by conjugation with penetratin”, BIOLOGICAL CHEMISTRY, 2003, 384, 395-402.PUB | DOI | WoS | PubMed | Europe PMC
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2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403813K. N. Balaji, N. Schaschke, W. Machleidt, M. Catalfamo, and P. A. Henkart, “Surface cathepsin B protects cytotoxic lymphocytes from self-destruction after degranulation”, JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 196, 493-503.PUB | DOI | WoS | PubMed | Europe PMC
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2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403820N. Schaschke, D. Deluca, I. Assfalg-Machleidt, C. Hohneke, C. P. Sommerhoff, and W. Machleidt, “Epoxysuccinyl peptide-derived cathepsin B inhibitors: Modulating membrane permeability by conjugation with the C-terminal heptapeptide segment of penetratin”, BIOLOGICAL CHEMISTRY, 2002, 383, 849-852.PUB | DOI | WoS | PubMed | Europe PMC
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2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403828N. Schaschke, A. Dominik, G. Matschiner, and C. P. Sommerhoff, “Bivalent inhibition of beta-tryptase: Distance scan of neighboring subunits by dibasic inhibitors”, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2002, 12, 985-988.PUB | DOI | WoS | PubMed | Europe PMC
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2001 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403834N. Schaschke, G. Matschiner, F. Zettl, U. Marquardt, A. Bergner, W. Bode, C. P. Sommerhoff, and L. Moroder, “Bivalent inhibition of human beta-tryptase”, CHEMISTRY & BIOLOGY, 2001, 8, 313-327.PUB | DOI | WoS | PubMed | Europe PMC
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2000 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403844N. Schaschke, I. Assfalg-Machleidt, T. Lassleben, C. P. Sommerhoff, L. Moroder, and W. Machleidt, “Epoxysuccinyl peptide-derived affinity labels for cathepsin B”, FEBS LETTERS, 2000, 482, 91-96.PUB | DOI | WoS | PubMed | Europe PMC
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2000 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403852N. Schaschke, I. Assfalg-Machleidt, W. Machleidt, T. Lassleben, C. P. Sommerhoff, and L. Moroder, “beta-cyclodextrin/epoxysuccinyl peptide conjugates: new drug targeting system for tumor cells”, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10, 677-680.PUB | DOI | WoS | PubMed | Europe PMC
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1998 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403860N. Schaschke, S. Fiori, E. Weyher, C. Escrieut, D. Fourmy, G. Muller, and L. Moroder, “Cyclodextrin as carrier of peptide hormones. Conformational and biological properties of beta-cyclodextrin/gastrin constructs”, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120, 7030-7038.PUB | DOI | WoS
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1998 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403869N. Schaschke, I. Assfalg-Machleidt, W. Machleidt, and L. Moroder, “Substrate/propeptide-derived endo-epoxysuccinyl peptides as highly potent and selective cathepsin B inhibitors”, FEBS LETTERS, 1998, 421, 80-82.PUB | DOI | WoS | PubMed | Europe PMC
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1997 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403882N. Schaschke, I. AssfalgMachleidt, W. Machleidt, D. Turk, and L. Moroder, “E-64 analogues as inhibitors of cathepsin B. On the role of the absolute configuration of the epoxysuccinyl group”, BIOORGANIC & MEDICINAL CHEMISTRY, 1997, 5, 1789-1797.PUB | DOI | WoS | PubMed | Europe PMC
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1996 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2403889N. Schaschke, H. J. Musiol, I. AssfalgMachleidt, W. Machleidt, S. RudolphBohner, and L. Moroder, “Cyclodextrins as templates for the presentation of protease inhibitors”, FEBS LETTERS, 1996, 391, 297-301.PUB | DOI | WoS | PubMed | Europe PMC