48 Publikationen
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2023 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2981846Sun, Miao, Kaminsky, Cornelia K., Deppe, Philip, Ilse, Mai-Britt, Vaz, Frédéric M., Plecko, Barbara, Lübke, Torben, and Randolph, Linda M. “A novel homozygous missense variant in ARSK causes MPS X, a new subtype of mucopolysaccharidosis”. Genes & Diseases 11.3 (2023): 101025.PUB | DOI | WoS | PubMed | Europe PMC
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2023 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2988232Smith, Kathryn, Haslund-Gourley, Benjamin S., Aziz, Peter V., Heithoff, Douglas M., Restagno, Damien, Fried, Jeffrey C., Ilse, Mai-Britt, Bäumges, Hannah, Mahan, Michael J., Lübke, Torben, and Marth, Jamey D. “Establishment of Blood Glycosidase Activities and their Excursions in Sepsis”. Glycobiology 33.11 (2023): 1016.PUB | WoS
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2022 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2962857Linhorst, Arne, and Lübke, Torben. “The Human Ntn-Hydrolase Superfamily: Structure, Functions and Perspectives”. Cells 11.10 (2022): 1592.PUB | PDF | DOI | Download (ext.) | WoS | PubMed | Europe PMC
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2022 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2967253Smith, Kathryn, Haslund-Gourley, Benjamin S., Aziz, Peter V., Heithoff, Douglas M., Restagno, Damien, Fried, Jeffrey C., Ilse, Mai-Britt, Bäumges, Hannah, Mahan, Michael J., Lübke, Torben, and Marth, Jamey D. “Establishment of Blood Glycosidase Activities and their Excursions in Sepsis”. Glycobiology 32.11 (2022): 1034-1035.PUB | WoS
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2022 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2965167Haslund-Gourley, Benjamin S, Aziz, Peter V, Heithoff, Douglas M, Restagno, Damien, Fried, Jeffrey C, Ilse, Mai-Britt, Bäumges, Hannah, Mahan, Michael J, Lübke, Torben, and Marth, Jamey D. “Establishment of blood glycosidase activities and their excursions in sepsis”. PNAS Nexus 1.3 (2022): pgac113.PUB | DOI | PubMed | Europe PMC
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2021 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2961637Aziz, Peter V., Lewis, Benjamin J., Haslund-Gourley, Benjamin S., Heithoff, Douglas M., Westman, Julia S., Restagno, Damien, Fried, Jeffrey C., Ilse, Mai-Britt, Lübke, Torben, and Marth, Jamey D. “Excursions of blood glycosidase activities in the pathogenesis and prognosis of Sepsis”. Glycobiology 31.12 (2021): 1700.PUB | DOI | WoS
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2021 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2960244Verheyen, Sarah, Blatterer, Jasmin, Speicher, Michael R, Bhavani, Gandham SriLakshmi, Boons, Geert-Jan, Ilse, Mai-Britt, Andrae, Dominik, Sproß, Jens, Vaz, Frédéric Maxime, Kircher, Susanne G, Posch-Pertl, Laura, Baumgartner, Daniela, Lübke, Torben, Shah, Hitesh, Al Kaissi, Ali, Girisha, Katta M, and Plecko, Barbara. “Novel subtype of mucopolysaccharidosis caused by arylsulfatase K (ARSK) deficiency”. Journal of Medical Genetics (2021): jmedgenet-2021-108061.PUB | PDF | DOI | WoS | PubMed | Europe PMC
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2021 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2956816Kowalewski, Björn, Lange, Heike, Galle, Sabrina, Dierks, Thomas, Lübke, Torben, and Damme, Markus. “Decoding the consecutive lysosomal degradation of 3-O-sulfate containing heparan sulfate by Arylsulfatase G (ARSG)”. Biochemical Journal (2021).PUB | DOI | WoS | PubMed | Europe PMC
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2020 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2946513Aziz, Peter, Haslund-Gourley, Benjamin, Heithoff, Douglas, Westman, Julia, Restagno, Damien, Lewis, Benjamin, Fried, Jeffrey, Ilse, Mai-Britt, Lübke, Torben, and Marth, Jamey. “Altered glycosidase Activities at Physiological pH in the Pathogenesis of Sepsis”. FASEB JOURNAL. Hoboken: Wiley, 2020.Vol. 34.PUB | DOI | WoS
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2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2948390Lübke, Torben, and Damme, Markus. “Lysosomal sulfatases: a growing family*”. Biochemical Journal 477.20 (2020): 3963-3983.PUB | DOI | WoS | PubMed | Europe PMC
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2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2945876Trabszo, Christof, Ramms, Bastian, Chopra, Pradeep, Lüllmann-Rauch, Renate, Stroobants, Stijn, Sproß, Jens, Jeschke, Anke, Schinke, Thorsten, Boons, Geert-Jan, Esko, Jeffrey, Lübke, Torben, and Dierks, Thomas. “Arylsulfatase K inactivation causes mucopolysaccharidosis due to deficient glucuronate desulfation of heparan and chondroitin sulfate”. Biochemical Journal (2020).PUB | DOI | WoS | PubMed | Europe PMC
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2019 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2937243Korf-Klingebiel, Mortimer, Reboll, Marc R, Grote, Karsten, Schleiner, Hauke, Wang, Yong, Wu, Xuekun, Klede, Stefanie, Mikhed, Yuliya, Bauersachs, Johann, Klintschar, Michael, Rudat, Carsten, Kispert, Andreas, Niessen, Hans Wm, Lübke, Torben, Dierks, Thomas, and Wollert, Kai C. “Heparan Sulfate-Editing Extracellular Sulfatases Enhance Vascular Endothelial Growth Factor Bioavailability for Ischemic Heart Repair”. Circulation research 125.9 (2019): 787-801.PUB | DOI | WoS | PubMed | Europe PMC
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2018 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2920271Stroobants, Stijn, Wolf, Heike, Callaerts-Vegh, Zsuzsanna, Dierks, Thomas, Lübke, Torben, and D'Hooge, Rudi. “Sensorimotor and Neurocognitive Dysfunctions Parallel Early Telencephalic Neuropathology in Fucosidosis Mice”. FRONTIERS IN BEHAVIORAL NEUROSCIENCE 12 (2018): 15.PUB | DOI | WoS | PubMed | Europe PMC
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2909150Pan, Xuefang, Wang, Yanting, Lübke, Torben, Hinek, Aleksander, and Pshezhetsky, Alexey V. “Mice, double deficient in lysosomal serine carboxypeptidases Scpep1 and Cathepsin A develop the hyperproliferative vesicular corneal dystrophy and hypertrophic skin thickenings”. PLoS One 12.2 (2017): e0172854.PUB | DOI | WoS | PubMed | Europe PMC
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2908778Dhamale, Omkar P., Lawrence, Roger, Wiegmann, Elena, Shah, Bhawal A., Al-Mafraji, Kanar, Lamanna, William C., Lübke, Torben, Dierks, Thomas, Boons, Geert-Jan, and Esko, Jeffrey D. “Arylsulfatase K is the Lysosomal 2-Sulfoglucuronate Sulfatase”. ACS Chemical Biology 12.2 (2017): 367-373.PUB | DOI | WoS | PubMed | Europe PMC
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2905616Wolf, Heike, Damme, Markus, Stroobants, Stijn, D'Hooge, Rudi, Beck, Hans Christian, Hermans-Borgmeyer, Irm, Lüllmann-Rauch, Renate, Dierks, Thomas, and Lübke, Torben. “A mouse model for fucosidosis recapitulates storage pathology and neurological features of the milder form of the human disease”. Disease Models & Mechanisms 9.9 (2016): 1015-1028.PUB | PDF | DOI | WoS | PubMed | Europe PMC
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2658538Kong, Xiang Yi, Nesset, Cecilie K., Damme, Markus, Loeberg, Else-Marit, Lübke, Torben, Maehlen, Jan, Andersson, Kristin B., Roos, Norbert, Thoresen, G. Hege, Rustan, Arild C., Kase, Eili T., and Eskild, Winnie. “Loss of lysosomal membrane protein NCU-G1 in mice results in spontaneous liver fibrosis with accumulation of lipofuscin and iron in Kupffer cells”. Disease Models & Mechanisms 7.3 (2014): 351-362.PUB | PDF | DOI | WoS | PubMed | Europe PMC
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2672894Pan, Xuefang, Grigoryeva, Lubov, Seyrantepe, Volkan, Peng, Junzheng, Kollmann, Katrin, Tremblay, Johanne, Lavoie, Julie L., Hinek, Aleksander, Lübke, Torben, and Pshezhetsky, Alexey V. “Serine carboxypeptidase SCPEP1 and Cathepsin A play complementary roles in regulation of vasoconstriction via inactivation of endothelin-1”. PLoS genetics 10.2 (2014): e1004146.PUB | PDF | DOI | WoS | PubMed | Europe PMC
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2699273Kowalewski, Björn, Lübke, Torben, Kollmann, Katrin, Braulke, Thomas, Reinheckel, Thomas, Dierks, Thomas, and Damme, Markus. “Molecular Characterization of Arylsulfatase G: EXPRESSION, PROCESSING, GLYCOSYLATION, TRANSPORT, AND ACTIVITY”. The Journal of biological chemistry 289.40 (2014): 27992-28005.PUB | DOI | WoS | PubMed | Europe PMC
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2623550Wiegmann, Elena, Westendorf, Eva, Kalus, Ina, Pringle, Thomas H., Lübke, Torben, and Dierks, Thomas. “Arylsulfatase K, a Novel Lysosomal Sulfatase”. Journal of Biological Chemistry 288.42 (2013): 30019-30028.PUB | DOI | WoS | PubMed | Europe PMC
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2623533Milz, Fabian, Harder, Alexander, Neuhaus, Phillipp, Breitkreuz-Korff, Olga, Walhorn, Volker, Lübke, Torben, Anselmetti, Dario, and Dierks, Thomas. “Cooperation of binding sites at the hydrophilic domain of cell-surface sulfatase Sulf1 allows for dynamic interaction of the enzyme with its substrate heparan sulfate”. Biochim Biophys Acta 1830.11 (2013): 5287-5298.PUB | DOI | WoS | PubMed | Europe PMC
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2471754Makrypidi, Georgia, Damme, Markus, Müller-Loennies, Sven, Trusch, Maria, Schmidt, Bernhard, Schlüter, Hartmut, Heeren, Joerg, Lübke, Torben, Saftig, Paul, and Braulke, Thomas. “Mannose 6 dephosphorylation of lysosomal proteins mediated by Acid phosphatases acp2 and acp5”. Molecular and cellular biology 32.4 (2012): 774-782.PUB | DOI | WoS | PubMed | Europe PMC
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2529586Kollmann, K, Damme, Markus, Markmann, S, Morelle, W, Schweizer, M, Hermans-Borgmeyer, I, Rochert, A K, Pohl, S, Lübke, Torben, Michalski, J-C, Kakela, R, Walkley, S U, and Braulke, T. “Lysosomal dysfunction causes neurodegeneration in mucolipidosis II 'knock-in' mice”. Brain 135.9 (2012): 2661-2675.PUB | DOI | WoS | PubMed | Europe PMC
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2494022Kowalewski, Björn, Lamanna, William Christopher, Lawrence, Roger, Damme, Markus, Padva, Michael, Stroobants, Stijn, Kalus, Ina, Frese, Marc-André, Lübke, Torben, Lüllmann-Rauch, Renate, D'Hooge, Rudi, Esko, Jeffrey D, and Dierks, Thomas. “Arylsulfatase G Inactivation Causes Loss of Heparan Sulfate 3-O-Sulfatase Activity and Mucopolysaccharidosis in Mice”. Proc. Natl. Acad. Sci. USA 109.26 (2012): 10310-10315.PUB | DOI | WoS | PubMed | Europe PMC
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1940515Damme, Markus, Stroobants, Stijn, Walkley, Steven U., Lüllmann-Rauch, Renate, D'Hooge, Rudi, Fogh, Jens, Saftig, Paul, Lübke, Torben, and Blanz, Judith. “Cerebellar alterations and gait defects as therapeutic outcome measures for enzyme replacement therapy in alpha-mannosidosis”. Journal of Neuropathology & Experimental Neurology 70.1 (2011): 83-94.PUB | DOI | WoS | PubMed | Europe PMC
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2352585Savalas, LR, Gasnier, B, Damme, Markus, Lübke, Torben, Wrocklage, C, Debacker, C, Jezeqou, A, Reinheckel, T, Hasilik, A, Saftig, P, and Schröder, Bernd. “Disrupted in renal carcinoma 2 (DIRC2), a novel transporter of the lysosomal membrane, is proteolytically processed by cathepsin L.”. Biochemical Journal 436.1 (2011): 113-121.PUB | DOI | WoS | PubMed | Europe PMC
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1939855Rosner, Cornelia, Kruse, Philip H., Lübke, Torben, and Walter, Lutz. “Erratum to: Rhesus macaque MHC class I molecules show differential subcellular localizations”. Immunogenetics 62.6 (2010): 409-418.PUB | DOI | WoS | PubMed | Europe PMC
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2776186Rosner, Cornelia, Kruse, Philip H., Lübke, Torben, and Walter, Lutz. “Rhesus macaque MHC class I molecules show differential subcellular localizations”. Immunogenetics 62.3 (2010): 149-158.PUB | DOI | WoS | PubMed | Europe PMC
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1939885Kollmann, Katrin, Pohl, Sandra, Marschner, Katrin, Encarnacao, Marisa, Sakwa, Imme, Tiede, Stephan, Poorthuis, Ben J., Lübke, Torben, Müller-Loennies, Sven, Storch, Stephan, and Braulke, Thomas. “Mannose phosphorylation in health and disease”. European Journal of Cell Biology 89.1 (2010): 117-123.PUB | DOI | WoS | PubMed | Europe PMC
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1902203Damme, Markus, Morelle, Willy, Schmidt, Bernhard, Andersson, Claes, Fogh, Jens, Michalski, Jean-Claude, and Lübke, Torben. “Impaired lysosomal trimming of N-linked oligosaccharides leads to hyperglycosylation of native lysosomal proteins in mice with alpha-mannosidosis.”. Molecular and Cellular Biology 30.1 (2010): 273-283.PUB | DOI | WoS | PubMed | Europe PMC
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2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1939923Lakomek, Kristina, Dickmanns, Achim, Kettwig, Matthias, Urlaub, Henning, Ficner, Ralf, and Lübke, Torben. “Initial insight into the function of the lysosomal 66.3 kDa protein from mouse by means of X-ray crystallography”. BMC Structural Biology 9.1 (2009): 56-72.PUB | DOI | WoS | PubMed | Europe PMC
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2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1902143Schieweck, Oliver, Damme, Markus, Schröder, Bernd, Hasilik, Andrey, Schmidt, Bernhard, and Lübke, Torben. “NCU-G1 is a highly glycosylated integral membrane protein of the lysosome.”. Biochemical Journal 422.1 (2009): 83-90.PUB | DOI | WoS | PubMed | Europe PMC
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2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1939981Lübke, Torben, Lobel, Peter, and Sleat, David E. “Proteomics of the lysosome”. Biochimica et Biophysica Acta 1793.4 (2009): 625-635.PUB | DOI | WoS | PubMed | Europe PMC
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2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1940533Kollmann, Katrin, Damme, Markus, Deuschl, Florian, Kahle, Jörg, D'Hooge, Rudi, Lüllmann-Rauch, Renate, and Lübke, Torben. “Molecular characterization and gene disruption of mouse lysosomal putative serine carboxypeptidase 1”. Febs Journal 276.5 (2009): 1356-1369.PUB | DOI | WoS | PubMed | Europe PMC
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2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1939939Lakomek, Kristina, Dickmanns, Achim, Mueller, Uwe, Kollmann, Katrin, Deuschl, Florian, Berndt, Annette, Lübke, Torben, and Ficner, Ralf. “De novo sulfur SAD phasing of the lysosomal 66.3 kDa protein from mouse”. Acta Crystallographica Section D 65.3 (2009): 220-228.PUB | DOI | WoS | PubMed | Europe PMC
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2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1939993Fedele, Anthony O., Filocamo, Mirella, Di Rocco, Maja, Sersale, Giovanna, Lübke, Torben, di Natale, Paola, Cosma, Maria Pia, and Ballabio, Andrea. “Mutational analysis of the HGSNAT gene in Italian patients with mucopolysaccharidosis IIIC (Sanfilippo C syndrome)”. Human Mutation 28.5 (2007): 523.PUB | DOI
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2007 | Zeitschriftenaufsatz | PUB-ID: 1940006Hellbusch, Christina, Sperandio, Markus, Frommhold, David, Yakubenia, Sviatlana, Wild, Martin K., Popovici, Diana, Vestweber, Dietmar, Gröne, Hermann-Josef, von Figura, Kurt, Lübke, Torben, and Körner, Christian. “Golgi GDP-fucose transporter-deficient mice mimic congenital disorder of glycosylation IIc/leukocyte adhesion deficiency II”. Journal of Biological Chemistry 282.14 (2007): 10762-10772.PUB | DOI | WoS | PubMed | Europe PMC
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2006 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1940030Deuschl, Florian, Kollmann, Katrin, von Figura, Kurt, and Lübke, Torben. “Molecular characterization of the hypothetical 66.3-kDa protein in mouse: lysosomal targeting, glycosylation, processing and tissue distribution”. Febs Letters 580.24 (2006): 5747-5752.PUB | DOI | WoS | PubMed | Europe PMC
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2006 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1940045Thiel, Christian, Lübke, Torben, Matthijs, Gert, von Figura, Kurt, and Körner, Christian. “Targeted disruption of the mouse phosphomannomutase 2 gene causes early embryonic lethality”. Molecular and Cellular Biology 26.15 (2006): 5615-5620.PUB | DOI | WoS | PubMed | Europe PMC
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2006 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1940057Tiede, Stephan, Storch, Stephan, Lübke, Torben, Henrissat, Bernhard, Bargal, Ruth, Raas-Rothschild, Annick, and Braulke, Thomas. “Mucolipidosis II is caused by mutations in GNPTA encoding the alpha/beta GlcNAc-1-phosphotransferase”. Nature Medicine 11.10 (2006): 1109-1112.PUB | DOI | WoS | PubMed | Europe PMC
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2005 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1940072Kollmann, Katrin, Mutenda, Kudzai E., Balleininger, Martina, Eckermann, Ellen, von Figura, Kurt, Schmidt, Bernhard, and Lübke, Torben. “Identification of novel lysosomal matrix proteins by proteome analysis”. Proteomics 5.15 (2005): 3966-3978.PUB | DOI | WoS | PubMed | Europe PMC
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2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1940085Hartmann, Dieter, de Strooper, Bart, Serneels, Lutgarde, Craessaerts, Katleen, Herreman, An, Annaert, Wim, Umans, Lieve, Lübke, Torben, Illert, Anna Lena, von Figura, Kurt, and Saftig, Paul. “The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts”. Human Molecular Genetics 11.21 (2002): 2615-2624.PUB | DOI | WoS | PubMed | Europe PMC
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2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1940103Hansske, Bengt, Thiel, Christian, Lübke, Torben, Hasilik, Martin, Höning, Stefan, Peters, Verena, Heidemann, Peter H., Hoffmann, Georg F., Berger, Eric G., von Figura, Kurt, and Körner, Christian. “Deficiency of UDP-galactose:N-acetylglucosamine beta-1,4-galactosyltransferase I causes the congenital disorder of glycosylation type IId”. Journal of Clinical Investigation 109.6 (2002): 725-733.PUB | DOI | WoS | PubMed | Europe PMC
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2001 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1940119Lübke, Torben, Marquardt, Thorsten, Etzioni, Amos, Hartmann, Enno, von Figura, Kurt, and Körner, Christian. “Complementation cloning identifies CDG-IIc, a new type of congenital disorders of glycosylation, as a GDP-fucose transporter deficiency”. Nature Genetics 28.1 (2001): 73-76.PUB | DOI | WoS | PubMed | Europe PMC
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2001 | Dissertation | PUB-ID: 1940291Lübke, Torben. Congenital Disorder of Glycosylation (CDG)-IIc: Eine retrovirale Expressionsklonierung identifiziert das CDG-IIc Syndrom (Leukozyten Adhäsionsdefekt II) als eine GDP-Fukose Transporter Defizienz. Göttingen, Deutschland: Elektronische Dissertation der Georg-August-Universität Göttingen, 2001.PUB
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2000 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1940146Andersson, Lisa A., McNairn, Elizabeth, Lübke, Torben, Pau, Richard N., and Boxer, David H. “ModE-dependent molybdate regulation of the molybdenum cofactor operon moa in Escherichia coli”. Journal of Bacteriology 182.24 (2000): 7035-7043.PUB | DOI | WoS | PubMed | Europe PMC
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1999 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1940173Lübke, Torben, Marquardt, Thorsten, von Figura, Kurt, and Körner, Christian. “A new type of carbohydrate-deficient glycoprotein syndrome due to a decreased import of GDP-fucose into the golgi”. Journal of Biological Chemistry 274.37 (1999): 25986-25989.PUB | DOI | WoS | PubMed | Europe PMC