The Human Ntn-Hydrolase Superfamily: Structure, Functions and Perspectives

Linhorst A, Lübke T (2022)
Cells 11(10): 1592.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
Download
OA 1.94 MB
Abstract / Bemerkung
N-terminal nucleophile (Ntn)-hydrolases catalyze the cleavage of amide bonds in a variety of macromolecules, including the peptide bond in proteins, the amide bond in N-linked protein glycosylation, and the amide bond linking a fatty acid to sphingosine in complex sphingolipids. Ntn-hydrolases are all sharing two common hallmarks: Firstly, the enzymes are synthesized as inactive precursors that undergo auto-proteolytic self-activation, which, as a consequence, reveals the active site nucleophile at the newly formed N-terminus. Secondly, all Ntn-hydrolases share a structural consistent αββα-fold, notwithstanding the total lack of amino acid sequence homology. In humans, five subclasses of the Ntn-superfamily have been identified so far, comprising relevant members such as the catalytic active subunits of the proteasome or a number of lysosomal hydrolases, which are often associated with lysosomal storage diseases. This review gives an updated overview on the structural, functional, and (patho-)physiological characteristics of human Ntn-hydrolases, in particular.
Stichworte
N-terminal nucleophile (Ntn)-hydrolases; Ntn-fold; auto-activation; amide bond cleavage; asparaginases; proteasome subunits; penicillin acylases; γ-glutamyl transpeptidases
Erscheinungsjahr
2022
Zeitschriftentitel
Cells
Band
11
Ausgabe
10
Art.-Nr.
1592
eISSN
2073-4409
Finanzierungs-Informationen
Open-Access-Publikationskosten wurden durch die Universität Bielefeld gefördert.
Page URI
https://pub.uni-bielefeld.de/record/2962857

Zitieren

Linhorst A, Lübke T. The Human Ntn-Hydrolase Superfamily: Structure, Functions and Perspectives. Cells. 2022;11(10): 1592.
Linhorst, A., & Lübke, T. (2022). The Human Ntn-Hydrolase Superfamily: Structure, Functions and Perspectives. Cells, 11(10), 1592. https://doi.org/10.3390/cells11101592
Linhorst, Arne, and Lübke, Torben. 2022. “The Human Ntn-Hydrolase Superfamily: Structure, Functions and Perspectives”. Cells 11 (10): 1592.
Linhorst, A., and Lübke, T. (2022). The Human Ntn-Hydrolase Superfamily: Structure, Functions and Perspectives. Cells 11:1592.
Linhorst, A., & Lübke, T., 2022. The Human Ntn-Hydrolase Superfamily: Structure, Functions and Perspectives. Cells, 11(10): 1592.
A. Linhorst and T. Lübke, “The Human Ntn-Hydrolase Superfamily: Structure, Functions and Perspectives”, Cells, vol. 11, 2022, : 1592.
Linhorst, A., Lübke, T.: The Human Ntn-Hydrolase Superfamily: Structure, Functions and Perspectives. Cells. 11, : 1592 (2022).
Linhorst, Arne, and Lübke, Torben. “The Human Ntn-Hydrolase Superfamily: Structure, Functions and Perspectives”. Cells 11.10 (2022): 1592.
Alle Dateien verfügbar unter der/den folgenden Lizenz(en):
Creative Commons Namensnennung 4.0 International Public License (CC-BY 4.0):
Volltext(e)
Access Level
OA Open Access
Zuletzt Hochgeladen
2022-05-12T06:48:47Z
MD5 Prüfsumme
067451bac1ae84db13a6991b75b07ad9

Link(s) zu Volltext(en)
Access Level
OA Open Access
Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®
Quellen

PMID: 35626629
PubMed | Europe PMC

Suchen in

Google Scholar