52 Publikationen
-
2024 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2986115Rapöhn, M., Cyganek, L., Voigt, N., Hasenfuß, G., Lehnart, S.E., Wegener, J.: Non-invasive analysis of contractility during identical maturations revealed two phenotypes in ventricular but not in atrial iPSC-CM. American Journal of Physiology-Heart and Circulatory Physiology. 35 (2024).PUB | DOI
-
2023 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984773
Wegener, J., Mitronova, G.Y., ElShareif, L., Quentin, C., Belov, V., Pochechueva, T., Hasenfuss, G., Ackermann, L., Lehnart, S.E.: A dual-targeted drug inhibits cardiac ryanodine receptor Ca2+ leak but activates SERCA2a Ca uptake. Life Science Alliance. 7, : e202302278 (2023).PUB | PDF | DOI | Download (ext.) -
2023 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2984660
Mitronova, G.Y., Quentin, C., Belov, V.N., Wegener, J., Kiszka, K.A., Lehnart, S.E.: 1,4-Benzothiazepines with Cyclopropanol Groups and Their Structural Analogues Exhibit Both RyR2-Stabilizing and SERCA2a-Stimulating Activities. Journal of Medicinal Chemistry. (2023).PUB | PDF | DOI
-
2022 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984472
Brandenburg, S., Pawlowitz, J., Steckmeister, V., Subramanian, H., Uhlenkamp, D., Scardigli, M., Mushtaq, M., Amlaz, S.I., Kohl, T., Wegener, J., Arvanitis, D.A., Sanoudou, D., Sacconi, L., Hasenfuß, G., Voigt, N., Nikolaev, V.O., Lehnart, S.E.: A junctional cAMP compartment regulates rapid Ca2+ signaling in atrial myocytes. Journal of Molecular and Cellular Cardiology. 165, 141-157 (2022).PUB | PDF | DOI | Download (ext.)
-
2022 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984471Vandewiele, F., Pironet, A., Jacobs, G., Kecskés, M., Wegener, J., Kerselaers, S., Hendrikx, L., Verelst, J., Philippaert, K., Oosterlinck, W., Segal, A., Van Den Broeck, E., Pinto, S., Priori, S.G., Lehnart, S.E., Nilius, B., Voets, T., Vennekens, R.: TRPM4 inhibition by meclofenamate suppresses Ca2+-dependent triggered arrhythmias. European Heart Journal. 43, 4195-4207 (2022).PUB | DOI
-
2021 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984475Peper, J., Kownatzki-Danger, D., Weninger, G., Seibertz, F., Pronto, J.R.D., Sutanto, H., Pacheu-Grau, D., Hindmarsh, R., Brandenburg, S., Kohl, T., Hasenfuss, G., Gotthardt, M., Rog-Zielinska, E.A., Wollnik, B., Rehling, P., Urlaub, H., Wegener, J., Heijman, J., Voigt, N., Cyganek, L., Lenz, C., Lehnart, S.E.: Caveolin3 Stabilizes McT1-Mediated Lactate/Proton Transport in Cardiomyocytes. Circulation Research. 128, (2021).PUB | DOI
-
2021 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984474Berisha, F., Götz, K.R., Wegener, J., Brandenburg, S., Subramanian, H., Molina, C.E., Rüffer, A., Petersen, J., Bernhardt, A., Girdauskas, E., Jungen, C., Pape, U., Kraft, A.E., Warnke, S., Lindner, D., Westermann, D., Blankenberg, S., Meyer, C., Hasenfuß, G., Lehnart, S.E., Nikolaev, V.O.: cAMP Imaging at Ryanodine Receptors Reveals β -Adrenoceptor Driven Arrhythmias. Circulation Research. 129, 81-94 (2021).PUB | DOI
-
2021 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984473Wegener, J., Wagdi, A., Wagner, E., Katschinski, D.M., Hasenfuss, G., Bruegmann, T., Lehnart, S.E.: The RyR2-R2474S Mutation Sensitizes Cardiomyocytes and Hearts to Catecholaminergic Stress-Induced Oxidation of the Mitochondrial Glutathione Pool. Frontiers in Physiology. 12, (2021).PUB | DOI
-
-
2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2684327Dongmo, A.B., Nkeng-Efouet, P.A., Devkota, K.P., Wegener, J., Sewald, N., Wagner, H., Vierling, W.: Tetra-acetylajugasterone a new constituent of Vitex cienkowskii with vasorelaxant activity. Phytomedicine. 21, 787-792 (2014).PUB | DOI | WoS | PubMed | Europe PMC
-
-
2013 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 2984481Hofmann, F., Wegener, J.: cGMP-Dependent Protein Kinases (cGK). In: Krieg, T. and Lukowski, R. (eds.) Guanylate Cyclase and Cyclic GMP. Methods and Protocols. Methods in Molecular Biology. p. 17-50. Humana Press, Totowa, NJ (2013).PUB | DOI
-
-
2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984479Loga, F., Domes, K., Freichel, M., Flockerzi, V., Dietrich, A., Birnbaumer, L., Hofmann, F., Wegener, J.: The role of cGMP/cGKI signalling and Trpc channels in regulation of vascular tone. Cardiovascular Research. 100, 280-287 (2013).PUB | DOI
-
-
2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984483
Blaich, A., Pahlavan, S., Tian, Q., Oberhofer, M., Poomvanicha, M., Lenhardt, P., Domes, K., Wegener, J., Moosmang, S., Ruppenthal, S., Scholz, A., Lipp, P., Hofmann, F.: Mutation of the Calmodulin Binding Motif IQ of the L-type Cav1.2 Ca2+ Channel to EQ Induces Dilated Cardiomyopathy and Death. Journal of Biological Chemistry. 287, 22616-22625 (2012).PUB | PDF | DOI | Download (ext.)
-
2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984482
Brandmayr, J., Poomvanicha, M., Domes, K., Ding, J., Blaich, A., Wegener, J., Moosmang, S., Hofmann, F.: Deletion of the C-terminal Phosphorylation Sites in the Cardiac β-Subunit Does Not Affect the Basic β-Adrenergic Response of the Heart and the Cav1.2 Channel. Journal of Biological Chemistry. 287, 22584-22592 (2012).PUB | PDF | DOI | Download (ext.)
-
2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984487
Poomvanicha, M., Wegener, J., Blaich, A., Fischer, S., Domes, K., Moosmang, S., Hofmann, F.: Facilitation and Ca2+-dependent Inactivation Are Modified by Mutation of the Cav1.2 Channel IQ Motif. Journal of Biological Chemistry. 286, 26702-26707 (2011).PUB | PDF | DOI | Download (ext.)
-
2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984486
Domes, K., Ding, J., Lemke, T., Blaich, A., Wegener, J., Brandmayr, J., Moosmang, S., Hofmann, F.: Truncation of Murine Cav1.2 at Asp-1904 Results in Heart Failure after Birth. Journal of Biological Chemistry. 286, 33863-33871 (2011).PUB | PDF | DOI | Download (ext.)
-
-
2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984484Singh, A.K., Spieβberger, B., Zheng, W., Xiao, F., Lukowski, R., Wegener, J., Weinmeister, P., Saur, D., Klein, S., Schemann, M., Krueger, D., Seidler, U., Hofmann, F.: Neuronal cGMP kinase I is essential for stimulation of duodenal bicarbonate secretion by luminal acid. The FASEB Journal. 26, 1745-1754 (2011).PUB | DOI
-
2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984489Desch, M., Sigl, K., Hieke, B., Salb, K., Kees, F., Bernhard, D., Jochim, A., Spiessberger, B., Höcherl, K., Feil, R., Feil, S., Lukowski, R., Wegener, J., Hofmann, F., Schlossmann, J.: IRAG determines nitric oxide- and atrial natriuretic peptide-mediated smooth muscle relaxation. Cardiovascular Research. 86, 496-505 (2010).PUB | DOI
-
-
2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2985980Frei, E., Huster, M., Smital, P., Schlossmann, J., Hofmann, F., Wegener, J.: Calcium-dependent and calcium-independent inhibition of contraction by cGMP/cGKI in intestinal smooth muscle. American Journal of Physiology-Gastrointestinal and Liver Physiology. 297, G834-G839 (2009).PUB | DOI
-
-
-
2007 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 2984493Moosmang, S., Kleppisch, T., Wegener, J., Welling, A., Hofmann, F.: Analysis of Calcium Channels by Conditional Mutagenesis. In: Feil, R. and Metzger, D. (eds.) Conditional Mutagenesis: An Approach to Disease Models. Handbook of Experimental Pharmacology. p. 469-490. Springer Berlin Heidelberg, Berlin, Heidelberg (2007).PUB | DOI
-
2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984492Angstenberger, M., Wegener, J., Pichler, B.J., Judenhofer, M.S., Feil, S., Alberti, S., Feil, R., Nordheim, A.: Severe Intestinal Obstruction on Induced Smooth Muscle–Specific Ablation of the Transcription Factor SRF in Adult Mice. Gastroenterology. 133, 1948-1959 (2007).PUB | DOI
-
2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984491Weber, S., Bernhard, D., Lukowski, R., Weinmeister, P., Wörner, R., Wegener, J., Valtcheva, N., Feil, S., Schlossmann, J., Hofmann, F., Feil, R.: Rescue of cGMP Kinase I Knockout Mice by Smooth Muscle–Specific Expression of Either Isozyme. Circulation Research. 101, 1096-1103 (2007).PUB | DOI
-
2006 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984495Wegener, J., Schulla, V., Koller, A., Klugbauer, N., Feil, R., Hofmann, F., Wegener, J.W., Schulla, V., Koller, A., Klugbauer, N., Feil, R., Hofmann, F.: Control of intestinal motility by the Ca 1.2 L‐type calcium channel in mice. The FASEB Journal. 20, 1260-1262 (2006).PUB | DOI
-
2005 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984496Welling, A., Hofmann, F., Wegener, J.: Inhibition of L-Type Ca 1.2 Ca Channels by 2,(4-Morpholinyl)-8-phenyl-4 -1-benzopyran-4-one (LY294002) and 2-[1-(3-Dimethyl-aminopropyl)-5-methoxyindol-3-yl]-3-(1 -indol-3-yl) Maleimide (Gö6983). Molecular Pharmacology. 67, 541-544 (2005).PUB | DOI
-
2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984498Wegener, J., Schulla, V., Lee, T.‐S., Koller, A., Feil, S., Feil, R., Kleppisch, T., Klugbauer, N., Moosmang, S., Welling, A., Hofmann, F.: An essential role of Ca 1.2 L‐type calcium channel for urinary bladder function. The FASEB Journal. 18, 1159-1161 (2004).PUB | DOI
-
2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984497Geiselhöringer, A., Werner, M., Sigl, K., Smital, P., Wörner, R., Acheo, L., Stieber, J., Weinmeister, P., Feil, R., Feil, S., Wegener, J., Hofmann, F., Schlossmann, J.: IRAG is essential for relaxation of receptor-triggered smooth muscle contraction by cGMP kinase. The EMBO Journal. 23, 4222-4231 (2004).PUB | DOI
-
-
-
2003 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984499Moosmang, S., Schulla, V., Welling, A., Feil, R., Feil, S., Wegener, J., Hofmann, F., Klugbauer, N.: Dominant role of smooth muscle L-type calcium channel Cav1.2 for blood pressure regulation. The EMBO Journal. 22, 6027-6034 (2003).PUB | DOI
-
2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984503Wegener, J., Nawrath, H., Wolfsgruber, W., Kühbandner, S., Werner, C., Hofmann, F., Feil, R.: cGMP-Dependent Protein Kinase I Mediates the Negative Inotropic Effect of cGMP in the Murine Myocardium. Circulation Research. 90, 18-20 (2002).PUB | DOI
-
-
2001 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984504Budu, C.E., Balas, N., Nawrath, H., Wegener, J., Shainberg, A.: Increased Cardiac Alpha-1-Adrenoceptor Density in Rats Following Treatment with Amiodarone. Journal of Basic and Clinical Physiology and Pharmacology. 12, 33-48 (2001).PUB | DOI
-
-
2000 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984505Nawrath, H., Wegener, J., Rupp, J., Habermeier, A., Closs, E.I.: Voltage dependence of -arginine transport by hCAT-2A and hCAT-2B expressed in oocytes from. American Journal of Physiology-Cell Physiology. 279, C1336-C1344 (2000).PUB | DOI
-
-
1999 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984507Seitz, S., Wegener, J., Rupp, J., Watanabe, M., Jost, A., Gerhard, R., Shainberg, A., Ochi, R., Nawrath, H.: Involvement of K+ channels in the relaxant effects of YC-1 in vascular smooth muscle. European Journal of Pharmacology. 382, 11-18 (1999).PUB | DOI
-
-
-
-
-
-
-
-
1993 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984640Wegener, J., Boekhoff, I., Tareilus, E., Breer, H.: Olfactory signalling in antennal receptor neurones of the locust (Locusta migratoria). Journal of Insect Physiology. 39, 153-163 (1993).PUB | DOI | Download (ext.)
-