Differential effects of isoliquiritigenin and YC-1 in rat aortic smooth muscle
Wegener J, Nawrath H (1997)
European Journal of Pharmacology 323(1): 89-91.
Zeitschriftenaufsatz
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Autor*in
Wegener, JörgUniBi 
;
Nawrath, Hermann
;
Nawrath, HermannAbstract / Bemerkung
We investigated the effects of isoliquiritigenin and YC-1 (3-(5′-hydroxymethyl-2′-furyl)-1-benzyl indazole) on tension in endothelial-free rat aortic rings precontracted with phenylephrine (3 μM). Both compounds induced a concentration-dependent relaxation (EC50 of YC-1 1.9 μM and of isoliquiritigenin 9.4 μM). The effects developed faster with YC-1 than with isoliquiritigenin, and the effects of YC-1 were potentiated by isoliquiritigenin (10 μM). 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one (30 μM) inhibited the effect of YC-1, but not of isoliquiritigenin. These results suggest that the effects of YC-1 are due to stimulation of soluble guanylyl cyclase activity, whereas the effects of isoliquiritigenin are rather related to inhibition of phosphodiesterase activity. © 1997 Elsevier Science B.V.
Erscheinungsjahr
1997
Zeitschriftentitel
European Journal of Pharmacology
Band
323
Ausgabe
1
Seite(n)
89-91
ISSN
00142999
Page URI
https://pub.uni-bielefeld.de/record/2984511
Zitieren
Wegener J, Nawrath H. Differential effects of isoliquiritigenin and YC-1 in rat aortic smooth muscle. European Journal of Pharmacology. 1997;323(1):89-91.
Wegener, J., & Nawrath, H. (1997). Differential effects of isoliquiritigenin and YC-1 in rat aortic smooth muscle. European Journal of Pharmacology, 323(1), 89-91. https://doi.org/10.1016/S0014-2999(97)00111-8
Wegener, Jörg, and Nawrath, Hermann. 1997. “Differential effects of isoliquiritigenin and YC-1 in rat aortic smooth muscle”. European Journal of Pharmacology 323 (1): 89-91.
Wegener, J., and Nawrath, H. (1997). Differential effects of isoliquiritigenin and YC-1 in rat aortic smooth muscle. European Journal of Pharmacology 323, 89-91.
Wegener, J., & Nawrath, H., 1997. Differential effects of isoliquiritigenin and YC-1 in rat aortic smooth muscle. European Journal of Pharmacology, 323(1), p 89-91.
J. Wegener and H. Nawrath, “Differential effects of isoliquiritigenin and YC-1 in rat aortic smooth muscle”, European Journal of Pharmacology, vol. 323, 1997, pp. 89-91.
Wegener, J., Nawrath, H.: Differential effects of isoliquiritigenin and YC-1 in rat aortic smooth muscle. European Journal of Pharmacology. 323, 89-91 (1997).
Wegener, Jörg, and Nawrath, Hermann. “Differential effects of isoliquiritigenin and YC-1 in rat aortic smooth muscle”. European Journal of Pharmacology 323.1 (1997): 89-91.
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