Increased Cardiac Alpha-1-Adrenoceptor Density in Rats Following Treatment with Amiodarone
Budu CE, Balas N, Nawrath H, Wegener J, Shainberg A (2001)
Journal of Basic and Clinical Physiology and Pharmacology 12(1): 33-48.
Zeitschriftenaufsatz
| Veröffentlicht | Englisch
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Autor*in
Budu, C.E.;
Balas, N.;
Nawrath, H.;
Wegener, JörgUniBi 
;
Shainberg, A.
;
Shainberg, A.Abstract / Bemerkung
This study was undertaken to investigate the interaction between amiodarone and alpha-1-adrenoceptors in rat cardiac cells. The level (Bmax) and affinity (Kd) of alpha-1-adrenoceptors in heart cells were determined by [3H]prazosin radioligand binding following amiodarone treatment. In cultured intact cardiocytes treated for 48 h with 10 μΜ amiodarone, [3H]prazosin binding increased by 31% compared with the control cells (p<0.05). The increase was both dose and time dependent and was found to be specific because no significant change occurred in creatine kinase activity. Additionally, under the same conditions, an increase in [3H]prazosin binding to cultured cardiocyte cell membranes was also obtained. Oral gavage of amiodarone to rats for 8 d resulted in a 25% increase in [3H]prazosin binding to isolated ventricle membranes compared with control rats (p<0.05). We conclude that amiodarone treatment can increase the response to alpha-1-adrenoceptors agonist in the heart due to an increase in the density of alpha-1-adrenoceptors.
Erscheinungsjahr
2001
Zeitschriftentitel
Journal of Basic and Clinical Physiology and Pharmacology
Band
12
Ausgabe
1
Seite(n)
33-48
ISSN
0792-6855
eISSN
2191-0286
Page URI
https://pub.uni-bielefeld.de/record/2984504
Zitieren
Budu CE, Balas N, Nawrath H, Wegener J, Shainberg A. Increased Cardiac Alpha-1-Adrenoceptor Density in Rats Following Treatment with Amiodarone. Journal of Basic and Clinical Physiology and Pharmacology. 2001;12(1):33-48.
Budu, C. E., Balas, N., Nawrath, H., Wegener, J., & Shainberg, A. (2001). Increased Cardiac Alpha-1-Adrenoceptor Density in Rats Following Treatment with Amiodarone. Journal of Basic and Clinical Physiology and Pharmacology, 12(1), 33-48. https://doi.org/10.1515/JBCPP.2001.12.1.33
Budu, C.E., Balas, N., Nawrath, H., Wegener, Jörg, and Shainberg, A. 2001. “Increased Cardiac Alpha-1-Adrenoceptor Density in Rats Following Treatment with Amiodarone”. Journal of Basic and Clinical Physiology and Pharmacology 12 (1): 33-48.
Budu, C. E., Balas, N., Nawrath, H., Wegener, J., and Shainberg, A. (2001). Increased Cardiac Alpha-1-Adrenoceptor Density in Rats Following Treatment with Amiodarone. Journal of Basic and Clinical Physiology and Pharmacology 12, 33-48.
Budu, C.E., et al., 2001. Increased Cardiac Alpha-1-Adrenoceptor Density in Rats Following Treatment with Amiodarone. Journal of Basic and Clinical Physiology and Pharmacology, 12(1), p 33-48.
C.E. Budu, et al., “Increased Cardiac Alpha-1-Adrenoceptor Density in Rats Following Treatment with Amiodarone”, Journal of Basic and Clinical Physiology and Pharmacology, vol. 12, 2001, pp. 33-48.
Budu, C.E., Balas, N., Nawrath, H., Wegener, J., Shainberg, A.: Increased Cardiac Alpha-1-Adrenoceptor Density in Rats Following Treatment with Amiodarone. Journal of Basic and Clinical Physiology and Pharmacology. 12, 33-48 (2001).
Budu, C.E., Balas, N., Nawrath, H., Wegener, Jörg, and Shainberg, A. “Increased Cardiac Alpha-1-Adrenoceptor Density in Rats Following Treatment with Amiodarone”. Journal of Basic and Clinical Physiology and Pharmacology 12.1 (2001): 33-48.
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