Involvement of K+ channels in the relaxant effects of YC-1 in vascular smooth muscle
Seitz S, Wegener J, Rupp J, Watanabe M, Jost A, Gerhard R, Shainberg A, Ochi R, Nawrath H (1999)
European Journal of Pharmacology 382(1): 11-18.
Zeitschriftenaufsatz
| Veröffentlicht | Englisch
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Autor*in
Seitz, Sabine;
Wegener, JörgUniBi 
;
Rupp, Johanna;
Watanabe, Makino;
Jost, Andreas;
Gerhard, Rolf;
Shainberg, Asher;
Ochi, Rikuo;
Nawrath, Hermann
;
Rupp, Johanna;
Watanabe, Makino;
Jost, Andreas;
Gerhard, Rolf;
Shainberg, Asher;
Ochi, Rikuo;
Nawrath, HermannAbstract / Bemerkung
This study addresses the question whether K+ channels are involved in the vasorelaxant effects of 3-(5′-hydroxymethyl-2′-furyl)-1-benzyl-indazole (YC-1 ). In rat aorta, guinea pig aorta, and guinea pig a. carotis, YC-1 inhibited contractions induced by phenylephrine (3 μM) more potently than those induced by K+(48 mM). In rat aorta, tetraethylammonium (10 mM), charybdotoxin (0.2 μM), and iberiotoxin (0.1 μM), but not glibenclamide (10 μM), attenuated the relaxant effects of YC-1. In guinea pig a. carotis, YC-1 (30 μM) induced a hyperpolarisation which was antagonised by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ; 50 μM). In rat aorta, YC-1 (30 μM) increased the rate constant of 86Rb-efflux. The effect of YC-1 was potentiated by zaprinast (10 μM), but inhibited by ODQ (50 μM) or charybdotoxin (0.2 μM). In smooth muscle cells from rat aorta, YC-1 (10 μM) increased BKCa channel activity. It is suggested that YC-1-induced vasorelaxation is partially mediated by the activation of K+ channels.
Erscheinungsjahr
1999
Zeitschriftentitel
European Journal of Pharmacology
Band
382
Ausgabe
1
Seite(n)
11-18
ISSN
00142999
Page URI
https://pub.uni-bielefeld.de/record/2984507
Zitieren
Seitz S, Wegener J, Rupp J, et al. Involvement of K+ channels in the relaxant effects of YC-1 in vascular smooth muscle. European Journal of Pharmacology. 1999;382(1):11-18.
Seitz, S., Wegener, J., Rupp, J., Watanabe, M., Jost, A., Gerhard, R., Shainberg, A., et al. (1999). Involvement of K+ channels in the relaxant effects of YC-1 in vascular smooth muscle. European Journal of Pharmacology, 382(1), 11-18. https://doi.org/10.1016/S0014-2999(99)00574-9
Seitz, Sabine, Wegener, Jörg, Rupp, Johanna, Watanabe, Makino, Jost, Andreas, Gerhard, Rolf, Shainberg, Asher, Ochi, Rikuo, and Nawrath, Hermann. 1999. “Involvement of K+ channels in the relaxant effects of YC-1 in vascular smooth muscle”. European Journal of Pharmacology 382 (1): 11-18.
Seitz, S., Wegener, J., Rupp, J., Watanabe, M., Jost, A., Gerhard, R., Shainberg, A., Ochi, R., and Nawrath, H. (1999). Involvement of K+ channels in the relaxant effects of YC-1 in vascular smooth muscle. European Journal of Pharmacology 382, 11-18.
Seitz, S., et al., 1999. Involvement of K+ channels in the relaxant effects of YC-1 in vascular smooth muscle. European Journal of Pharmacology, 382(1), p 11-18.
S. Seitz, et al., “Involvement of K+ channels in the relaxant effects of YC-1 in vascular smooth muscle”, European Journal of Pharmacology, vol. 382, 1999, pp. 11-18.
Seitz, S., Wegener, J., Rupp, J., Watanabe, M., Jost, A., Gerhard, R., Shainberg, A., Ochi, R., Nawrath, H.: Involvement of K+ channels in the relaxant effects of YC-1 in vascular smooth muscle. European Journal of Pharmacology. 382, 11-18 (1999).
Seitz, Sabine, Wegener, Jörg, Rupp, Johanna, Watanabe, Makino, Jost, Andreas, Gerhard, Rolf, Shainberg, Asher, Ochi, Rikuo, and Nawrath, Hermann. “Involvement of K+ channels in the relaxant effects of YC-1 in vascular smooth muscle”. European Journal of Pharmacology 382.1 (1999): 11-18.
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