52 Publikationen
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2024 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2986115Rapöhn, M., Cyganek, L., Voigt, N., Hasenfuß, G., Lehnart, S. E., & Wegener, J. (2024). Non-invasive analysis of contractility during identical maturations revealed two phenotypes in ventricular but not in atrial iPSC-CM. American Journal of Physiology-Heart and Circulatory Physiology, 35. https://doi.org/10.1152/ajpheart.00527.2023PUB | DOI
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2023 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984773Wegener, J., Mitronova, G. Y., ElShareif, L., Quentin, C., Belov, V., Pochechueva, T., Hasenfuss, G., et al. (2023). A dual-targeted drug inhibits cardiac ryanodine receptor Ca2+ leak but activates SERCA2a Ca uptake. Life Science Alliance, 7(2), e202302278. https://doi.org/10.26508/lsa.202302278PUB | PDF | DOI | Download (ext.)
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2023 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2984660Mitronova, G. Y., Quentin, C., Belov, V. N., Wegener, J., Kiszka, K. A., & Lehnart, S. E. (2023). 1,4-Benzothiazepines with Cyclopropanol Groups and Their Structural Analogues Exhibit Both RyR2-Stabilizing and SERCA2a-Stimulating Activities. Journal of Medicinal Chemistry. https://doi.org/10.1021/acs.jmedchem.3c01235PUB | PDF | DOI
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2022 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984472Brandenburg, S., Pawlowitz, J., Steckmeister, V., Subramanian, H., Uhlenkamp, D., Scardigli, M., Mushtaq, M., et al. (2022). A junctional cAMP compartment regulates rapid Ca2+ signaling in atrial myocytes. Journal of Molecular and Cellular Cardiology, 165, 141-157. https://doi.org/10.1016/j.yjmcc.2022.01.003PUB | PDF | DOI | Download (ext.)
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2022 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984471Vandewiele, F., Pironet, A., Jacobs, G., Kecskés, M., Wegener, J., Kerselaers, S., Hendrikx, L., et al. (2022). TRPM4 inhibition by meclofenamate suppresses Ca2+-dependent triggered arrhythmias. European Heart Journal, 43(40), 4195-4207. https://doi.org/10.1093/eurheartj/ehac354PUB | DOI
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2021 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984475Peper, J., Kownatzki-Danger, D., Weninger, G., Seibertz, F., Pronto, J. R. D., Sutanto, H., Pacheu-Grau, D., et al. (2021). Caveolin3 Stabilizes McT1-Mediated Lactate/Proton Transport in Cardiomyocytes. Circulation Research, 128(6). https://doi.org/10.1161/CIRCRESAHA.119.316547PUB | DOI
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2021 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984474Berisha, F., Götz, K. R., Wegener, J., Brandenburg, S., Subramanian, H., Molina, C. E., Rüffer, A., et al. (2021). cAMP Imaging at Ryanodine Receptors Reveals β -Adrenoceptor Driven Arrhythmias. Circulation Research, 129(1), 81-94. https://doi.org/10.1161/CIRCRESAHA.120.318234PUB | DOI
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2021 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984473Wegener, J., Wagdi, A., Wagner, E., Katschinski, D. M., Hasenfuss, G., Bruegmann, T., & Lehnart, S. E. (2021). The RyR2-R2474S Mutation Sensitizes Cardiomyocytes and Hearts to Catecholaminergic Stress-Induced Oxidation of the Mitochondrial Glutathione Pool. Frontiers in Physiology, 12. https://doi.org/10.3389/fphys.2021.777770PUB | DOI
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984476Domes, K., Patrucco, E., Loga, F., Dietrich, A., Birnbaumer, L., Wegener, J., & Hofmann, F. (2015). Murine cardiac growth, TRPC channels, and cGMP kinase I. Pflügers Archiv - European Journal of Physiology, 467(10), 2229-2234. https://doi.org/10.1007/s00424-014-1682-0PUB | DOI
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2684327Dongmo, A. B., Nkeng-Efouet, P. A., Devkota, K. P., Wegener, J., Sewald, N., Wagner, H., & Vierling, W. (2014). Tetra-acetylajugasterone a new constituent of Vitex cienkowskii with vasorelaxant activity. Phytomedicine, 21(6), 787-792. https://doi.org/10.1016/j.phymed.2014.02.009PUB | DOI | WoS | PubMed | Europe PMC
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984477Hofmann, F., Flockerzi, V., Kahl, S., & Wegener, J. (2014). L-Type Ca 1.2 Calcium Channels: From In Vitro Findings to In Vivo Function. Physiological Reviews, 94(1), 303-326. https://doi.org/10.1152/physrev.00016.2013PUB | DOI
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2013 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 2984481Hofmann, F., & Wegener, J. (2013). cGMP-Dependent Protein Kinases (cGK). In T. Krieg & R. Lukowski (Eds.), Methods in Molecular Biology. Guanylate Cyclase and Cyclic GMP. Methods and Protocols (pp. 17-50). Totowa, NJ: Humana Press. https://doi.org/10.1007/978-1-62703-459-3_2PUB | DOI
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984480Ding, J., Domes, K., Hofmann, F., & Wegener, J. (2013). Truncation of murine CaV1.2 at Asp 1904 increases CaV1.3 expression in embryonic atrial cardiomyocytes. Pflügers Archiv - European Journal of Physiology, 465(7), 955-964. https://doi.org/10.1007/s00424-012-1212-xPUB | DOI
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984479Loga, F., Domes, K., Freichel, M., Flockerzi, V., Dietrich, A., Birnbaumer, L., Hofmann, F., et al. (2013). The role of cGMP/cGKI signalling and Trpc channels in regulation of vascular tone. Cardiovascular Research, 100(2), 280-287. https://doi.org/10.1093/cvr/cvt176PUB | DOI
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984478Wegener, J., Loga, F., Stegner, D., Nieswandt, B., & Hofmann, F. (2013). Phospholipase D1 is involved in α‐adrenergic contraction of murine vascular smooth muscle. The FASEB Journal, 28(3), 1044-1048. https://doi.org/10.1096/fj.13-237925PUB | DOI
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984483Blaich, A., Pahlavan, S., Tian, Q., Oberhofer, M., Poomvanicha, M., Lenhardt, P., Domes, K., et al. (2012). Mutation of the Calmodulin Binding Motif IQ of the L-type Cav1.2 Ca2+ Channel to EQ Induces Dilated Cardiomyopathy and Death. Journal of Biological Chemistry, 287(27), 22616-22625. https://doi.org/10.1074/jbc.M112.357921PUB | PDF | DOI | Download (ext.)
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984482Brandmayr, J., Poomvanicha, M., Domes, K., Ding, J., Blaich, A., Wegener, J., Moosmang, S., et al. (2012). Deletion of the C-terminal Phosphorylation Sites in the Cardiac β-Subunit Does Not Affect the Basic β-Adrenergic Response of the Heart and the Cav1.2 Channel. Journal of Biological Chemistry, 287(27), 22584-22592. https://doi.org/10.1074/jbc.M112.366484PUB | PDF | DOI | Download (ext.)
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984487Poomvanicha, M., Wegener, J., Blaich, A., Fischer, S., Domes, K., Moosmang, S., & Hofmann, F. (2011). Facilitation and Ca2+-dependent Inactivation Are Modified by Mutation of the Cav1.2 Channel IQ Motif. Journal of Biological Chemistry, 286(30), 26702-26707. https://doi.org/10.1074/jbc.M111.247841PUB | PDF | DOI | Download (ext.)
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984486Domes, K., Ding, J., Lemke, T., Blaich, A., Wegener, J., Brandmayr, J., Moosmang, S., et al. (2011). Truncation of Murine Cav1.2 at Asp-1904 Results in Heart Failure after Birth. Journal of Biological Chemistry, 286(39), 33863-33871. https://doi.org/10.1074/jbc.M111.252312PUB | PDF | DOI | Download (ext.)
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984485Ertl, C., Lukowski, R., Sigl, K., Schlossmann, J., Hofmann, F., & Wegener, J. (2011). Kinetics of relaxation by cGMP/cGKI signaling in fundus smooth muscle. European Journal of Pharmacology, 670(1), 266-271. https://doi.org/10.1016/j.ejphar.2011.07.048PUB | DOI
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984484Singh, A. K., Spieβberger, B., Zheng, W., Xiao, F., Lukowski, R., Wegener, J., Weinmeister, P., et al. (2011). Neuronal cGMP kinase I is essential for stimulation of duodenal bicarbonate secretion by luminal acid. The FASEB Journal, 26(4), 1745-1754. https://doi.org/10.1096/fj.11-200394PUB | DOI
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984489Desch, M., Sigl, K., Hieke, B., Salb, K., Kees, F., Bernhard, D., Jochim, A., et al. (2010). IRAG determines nitric oxide- and atrial natriuretic peptide-mediated smooth muscle relaxation. Cardiovascular Research, 86(3), 496-505. https://doi.org/10.1093/cvr/cvq008PUB | DOI
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984488Huster, M., Frei, E., Hofmann, F., & Wegener, J. (2010). A complex of Ca 1.2/PKC is involved in muscarinic signaling in smooth muscle. The FASEB Journal, 24(8), 2651-2659. https://doi.org/10.1096/fj.09-149856PUB | DOI
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2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2985980Frei, E., Huster, M., Smital, P., Schlossmann, J., Hofmann, F., & Wegener, J. (2009). Calcium-dependent and calcium-independent inhibition of contraction by cGMP/cGKI in intestinal smooth muscle. American Journal of Physiology-Gastrointestinal and Liver Physiology, 297(4), G834-G839. https://doi.org/10.1152/ajpgi.00095.2009PUB | DOI
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2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984490Frei, E., Hofmann, F., & Wegener, J. (2009). Phospholipase C mediated Ca2+ signals in murine urinary bladder smooth muscle. European Journal of Pharmacology, 610(1-3), 106-109. https://doi.org/10.1016/j.ejphar.2009.03.036PUB | DOI
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2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984494Wörner, R., Lukowski, R., Hofmann, F., & Wegener, J. (2007). cGMP signals mainly through cAMP kinase in permeabilized murine aorta. American Journal of Physiology-Heart and Circulatory Physiology, 292(1), H237-H244. https://doi.org/10.1152/ajpheart.00079.2006PUB | DOI
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2007 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 2984493Moosmang, S., Kleppisch, T., Wegener, J., Welling, A., & Hofmann, F. (2007). Analysis of Calcium Channels by Conditional Mutagenesis. In R. Feil & D. Metzger (Eds.), Handbook of Experimental Pharmacology. Conditional Mutagenesis: An Approach to Disease Models (pp. 469-490). Berlin, Heidelberg: Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-540-35109-2_19PUB | DOI
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2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984492Angstenberger, M., Wegener, J., Pichler, B. J., Judenhofer, M. S., Feil, S., Alberti, S., Feil, R., et al. (2007). Severe Intestinal Obstruction on Induced Smooth Muscle–Specific Ablation of the Transcription Factor SRF in Adult Mice. Gastroenterology, 133(6), 1948-1959. https://doi.org/10.1053/j.gastro.2007.08.078PUB | DOI
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2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984491Weber, S., Bernhard, D., Lukowski, R., Weinmeister, P., Wörner, R., Wegener, J., Valtcheva, N., et al. (2007). Rescue of cGMP Kinase I Knockout Mice by Smooth Muscle–Specific Expression of Either Isozyme. Circulation Research, 101(11), 1096-1103. https://doi.org/10.1161/CIRCRESAHA.107.154351PUB | DOI
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2006 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984495Wegener, J., Schulla, V., Koller, A., Klugbauer, N., Feil, R., Hofmann, F., Wegener, J. W., et al. (2006). Control of intestinal motility by the Ca 1.2 L‐type calcium channel in mice. The FASEB Journal, 20(8), 1260-1262. https://doi.org/10.1096/fj.05-5292fjePUB | DOI
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2005 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984496Welling, A., Hofmann, F., & Wegener, J. (2005). Inhibition of L-Type Ca 1.2 Ca Channels by 2,(4-Morpholinyl)-8-phenyl-4 -1-benzopyran-4-one (LY294002) and 2-[1-(3-Dimethyl-aminopropyl)-5-methoxyindol-3-yl]-3-(1 -indol-3-yl) Maleimide (Gö6983). Molecular Pharmacology, 67(2), 541-544. https://doi.org/10.1124/mol.104.006049PUB | DOI
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2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984498Wegener, J., Schulla, V., Lee, T. ‐S., Koller, A., Feil, S., Feil, R., Kleppisch, T., et al. (2004). An essential role of Ca 1.2 L‐type calcium channel for urinary bladder function. The FASEB Journal, 18(10), 1159-1161. https://doi.org/10.1096/fj.04-1516fjePUB | DOI
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2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984497Geiselhöringer, A., Werner, M., Sigl, K., Smital, P., Wörner, R., Acheo, L., Stieber, J., et al. (2004). IRAG is essential for relaxation of receptor-triggered smooth muscle contraction by cGMP kinase. The EMBO Journal, 23(21), 4222-4231. https://doi.org/10.1038/sj.emboj.7600440PUB | DOI
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2003 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984501Wegener, J., Korstanje, C., & Nawrath, H. (2003). Voltage-Dependent Effects of Barnidipine in Rat Vascular Smooth Muscle. Journal of Cardiovascular Pharmacology, 42(2), 218-223. https://doi.org/10.1097/00005344-200308000-00010PUB | DOI
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2003 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984500Wegener, J., Lee, M., & Hofmann, F. (2003). Hypothyroidism does not affect the dihydropyridine sensitivity of precontracted murine uterus. Canadian Journal of Physiology and Pharmacology, 81(9), 890-893. https://doi.org/10.1139/y03-090PUB | DOI
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2003 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984499Moosmang, S., Schulla, V., Welling, A., Feil, R., Feil, S., Wegener, J., Hofmann, F., et al. (2003). Dominant role of smooth muscle L-type calcium channel Cav1.2 for blood pressure regulation. The EMBO Journal, 22(22), 6027-6034. https://doi.org/10.1093/emboj/cdg583PUB | DOI
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2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984503Wegener, J., Nawrath, H., Wolfsgruber, W., Kühbandner, S., Werner, C., Hofmann, F., & Feil, R. (2002). cGMP-Dependent Protein Kinase I Mediates the Negative Inotropic Effect of cGMP in the Murine Myocardium. Circulation Research, 90(1), 18-20. https://doi.org/10.1161/hh0102.103222PUB | DOI
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2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984502Michel, D., Wegener, J., & Nawrath, H. (2002). Effects of Quinine and Quinidine on the Transient Outward and on the L-Type Ca<sup>2+</sup> Current in Rat Ventricular Cardiomyocytes. Pharmacology, 65(4), 187-192. https://doi.org/10.1159/000064342PUB | DOI
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2001 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984504Budu, C. E., Balas, N., Nawrath, H., Wegener, J., & Shainberg, A. (2001). Increased Cardiac Alpha-1-Adrenoceptor Density in Rats Following Treatment with Amiodarone. Journal of Basic and Clinical Physiology and Pharmacology, 12(1), 33-48. https://doi.org/10.1515/JBCPP.2001.12.1.33PUB | DOI
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2000 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984506Vulcu, S. D., Wegener, J., & Nawrath, H. (2000). Differences in the nitric oxide/soluble guanylyl cyclase signalling pathway in the myocardium of neonatal and adult rats. European Journal of Pharmacology, 406(2), 247-255. https://doi.org/10.1016/S0014-2999(00)00654-3PUB | DOI
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2000 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984505Nawrath, H., Wegener, J., Rupp, J., Habermeier, A., & Closs, E. I. (2000). Voltage dependence of -arginine transport by hCAT-2A and hCAT-2B expressed in oocytes from. American Journal of Physiology-Cell Physiology, 279(5), C1336-C1344. https://doi.org/10.1152/ajpcell.2000.279.5.C1336PUB | DOI
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1999 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984508Fassbender, V., Wegener, J., Shainberg, A., & Nawrath, H. (1999). Inhibition by Fendiline of the Transient Outward Current in Rat Ventricular Cardiomyocytes. Journal of Cardiovascular Pharmacology, 33(6), 905-911. https://doi.org/10.1097/00005344-199906000-00011PUB | DOI
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1999 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984507Seitz, S., Wegener, J., Rupp, J., Watanabe, M., Jost, A., Gerhard, R., Shainberg, A., et al. (1999). Involvement of K+ channels in the relaxant effects of YC-1 in vascular smooth muscle. European Journal of Pharmacology, 382(1), 11-18. https://doi.org/10.1016/S0014-2999(99)00574-9PUB | DOI
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1997 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984511Wegener, J., & Nawrath, H. (1997). Differential effects of isoliquiritigenin and YC-1 in rat aortic smooth muscle. European Journal of Pharmacology, 323(1), 89-91. https://doi.org/10.1016/S0014-2999(97)00111-8PUB | DOI
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1997 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984510Wegener, J., & Nawrath, H. (1997). Cardiac effects of isoliquiritigenin. European Journal of Pharmacology, 326(1), 37-44. https://doi.org/10.1016/S0014-2999(97)00134-9PUB | DOI
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1997 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984509Wegener, J., Hanke, W., & Breer, H. (1997). Second messenger-controlled membrane conductance in locust (Locusta migratoria) olfactory neurons. Journal of Insect Physiology, 43(6), 595-603. https://doi.org/10.1016/S0022-1910(97)00008-5PUB | DOI
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1996 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984513Wegener, J., & Nawrath, H. (1996). Action of tertiary phenylalkylamines on cardiac transient outward current from outside the cell membrane. Naunyn-Schmiedeberg's Archives of Pharmacology, 354(6), 746-754. https://doi.org/10.1007/BF00166901PUB | DOI
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1996 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984512Nawrath, H., & Wegener, J. (1996). Kinetics and state-dependent effects of verapamil on cardiac L-type calcium channels. Naunyn-Schmiedeberg's Archives of Pharmacology, 355(1), 79-86. https://doi.org/10.1007/PL00004921PUB | DOI
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1995 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984515Wegener, J., & Nawrath, H. (1995). Extracellular site of action of phenylalkylamines on L-type calcium current in rat ventricular myocytes. Naunyn-Schmiedeberg's Archives of Pharmacology, 352(3). https://doi.org/10.1007/BF00168564PUB | DOI
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1995 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984514Wegener, J., & Nawrath, H. (1995). Alkalinisation does not modify the effect of verapamil on myocardial Ca2+ current. European Journal of Pharmacology, 287(1), 89-92. https://doi.org/10.1016/0014-2999(95)00626-1PUB | DOI
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1993 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984640Wegener, J., Boekhoff, I., Tareilus, E., & Breer, H. (1993). Olfactory signalling in antennal receptor neurones of the locust (Locusta migratoria). Journal of Insect Physiology, 39(2), 153-163. https://doi.org/10.1016/0022-1910(93)90107-3PUB | DOI | Download (ext.)
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1992 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2984636Wegener, J., Tareilus, E., & Breer, H. (1992). Characterization of calcium-dependent potassium channels in antennal receptor neurones of Locusta migratoria. Journal of Insect Physiology, 38(4), 237-248. https://doi.org/10.1016/0022-1910(92)90124-VPUB | DOI