Alkalinisation does not modify the effect of verapamil on myocardial Ca2+ current
Wegener J, Nawrath H (1995)
European Journal of Pharmacology 287(1): 89-92.
Zeitschriftenaufsatz
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Autor*in
Wegener, JörgUniBi 
;
Nawrath, Hermann
;
Nawrath, HermannAbstract / Bemerkung
The effect of verapamil on L-type Ca2+ current (ICa) was compared at external pH 7.4 and 8.5 in rat ventricular myocytes. Alkalinisation increases the fraction of uncharged molecules of verapamil (pK 8.75) and thereby facilitates membrane permeation of the drug. Verapamil (1 μM) reduced the amplitude of ICa (ICa(peak)) by 36 ± 4% at pH 7.4 and by 40 ± 6% at pH 8.5, whereas alkalinisation from pH 7.4 to 8.5, without drug, increased ICa(peak) by 12 ± 3%. It is suggested that the efficiency of verapamil is not influenced by the amount of protonation or membrane permeation.
Erscheinungsjahr
1995
Zeitschriftentitel
European Journal of Pharmacology
Band
287
Ausgabe
1
Seite(n)
89-92
ISSN
00142999
Page URI
https://pub.uni-bielefeld.de/record/2984514
Zitieren
Wegener J, Nawrath H. Alkalinisation does not modify the effect of verapamil on myocardial Ca2+ current. European Journal of Pharmacology. 1995;287(1):89-92.
Wegener, J., & Nawrath, H. (1995). Alkalinisation does not modify the effect of verapamil on myocardial Ca2+ current. European Journal of Pharmacology, 287(1), 89-92. https://doi.org/10.1016/0014-2999(95)00626-1
Wegener, Jörg, and Nawrath, Hermann. 1995. “Alkalinisation does not modify the effect of verapamil on myocardial Ca2+ current”. European Journal of Pharmacology 287 (1): 89-92.
Wegener, J., and Nawrath, H. (1995). Alkalinisation does not modify the effect of verapamil on myocardial Ca2+ current. European Journal of Pharmacology 287, 89-92.
Wegener, J., & Nawrath, H., 1995. Alkalinisation does not modify the effect of verapamil on myocardial Ca2+ current. European Journal of Pharmacology, 287(1), p 89-92.
J. Wegener and H. Nawrath, “Alkalinisation does not modify the effect of verapamil on myocardial Ca2+ current”, European Journal of Pharmacology, vol. 287, 1995, pp. 89-92.
Wegener, J., Nawrath, H.: Alkalinisation does not modify the effect of verapamil on myocardial Ca2+ current. European Journal of Pharmacology. 287, 89-92 (1995).
Wegener, Jörg, and Nawrath, Hermann. “Alkalinisation does not modify the effect of verapamil on myocardial Ca2+ current”. European Journal of Pharmacology 287.1 (1995): 89-92.
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