Analysis of Calcium Channels by Conditional Mutagenesis
Moosmang S, Kleppisch T, Wegener J, Welling A, Hofmann F (2007)
In: Conditional Mutagenesis: An Approach to Disease Models. Feil R, Metzger D (Eds); Handbook of Experimental Pharmacology. Berlin, Heidelberg: Springer Berlin Heidelberg: 469-490.
Sammelwerksbeitrag
| Veröffentlicht | Englisch
Download
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
Autor*in
Moosmang, S.;
Kleppisch, T.;
Wegener, JörgUniBi
;
Welling, A.;
Hofmann, F.
![](https://pub.uni-bielefeld.de/images/icon_orcid.png)
Herausgeber*in
Feil, Robert;
Metzger, Daniel
Abstract / Bemerkung
Ca2+ influx through various ion channels is an important determinant of the cytosolic Ca2+ concentration, which plays a pivotal role in countless cellular processes. The cardiac L-type Ca2+ channel, Cav1.2, represents a major pathway for Ca2+ entry and is in many cells expressed together with other high- and low-voltage-activated Ca2+ channels. This article will focus on the use of conditional transgenic mouse models to clarify the roles of Ca2+ channels in several biological systems. The phenotypes of conditional Ca2+ channel transgenic mice have provided novel, and often unexpected, insights into the in vivo function of L-type and T-type Ca2+ channels as mediators of signaling between cell membrane and intracellular processes in blood pressure regulation, smooth muscle contractility, insulin secretion, cardiac function, sleep, learning, and memory.
Erscheinungsjahr
2007
Buchtitel
Conditional Mutagenesis: An Approach to Disease Models
Serientitel
Handbook of Experimental Pharmacology
Seite(n)
469-490
ISBN
978-3-540-35108-5
Page URI
https://pub.uni-bielefeld.de/record/2984493
Zitieren
Moosmang S, Kleppisch T, Wegener J, Welling A, Hofmann F. Analysis of Calcium Channels by Conditional Mutagenesis. In: Feil R, Metzger D, eds. Conditional Mutagenesis: An Approach to Disease Models. Handbook of Experimental Pharmacology. Berlin, Heidelberg: Springer Berlin Heidelberg; 2007: 469-490.
Moosmang, S., Kleppisch, T., Wegener, J., Welling, A., & Hofmann, F. (2007). Analysis of Calcium Channels by Conditional Mutagenesis. In R. Feil & D. Metzger (Eds.), Handbook of Experimental Pharmacology. Conditional Mutagenesis: An Approach to Disease Models (pp. 469-490). Berlin, Heidelberg: Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-540-35109-2_19
Moosmang, S., Kleppisch, T., Wegener, Jörg, Welling, A., and Hofmann, F. 2007. “Analysis of Calcium Channels by Conditional Mutagenesis”. In Conditional Mutagenesis: An Approach to Disease Models, ed. Robert Feil and Daniel Metzger, 469-490. Handbook of Experimental Pharmacology. Berlin, Heidelberg: Springer Berlin Heidelberg.
Moosmang, S., Kleppisch, T., Wegener, J., Welling, A., and Hofmann, F. (2007). “Analysis of Calcium Channels by Conditional Mutagenesis” in Conditional Mutagenesis: An Approach to Disease Models, Feil, R., and Metzger, D. eds. Handbook of Experimental Pharmacology (Berlin, Heidelberg: Springer Berlin Heidelberg), 469-490.
Moosmang, S., et al., 2007. Analysis of Calcium Channels by Conditional Mutagenesis. In R. Feil & D. Metzger, eds. Conditional Mutagenesis: An Approach to Disease Models. Handbook of Experimental Pharmacology. Berlin, Heidelberg: Springer Berlin Heidelberg, pp. 469-490.
S. Moosmang, et al., “Analysis of Calcium Channels by Conditional Mutagenesis”, Conditional Mutagenesis: An Approach to Disease Models, R. Feil and D. Metzger, eds., Handbook of Experimental Pharmacology, Berlin, Heidelberg: Springer Berlin Heidelberg, 2007, pp.469-490.
Moosmang, S., Kleppisch, T., Wegener, J., Welling, A., Hofmann, F.: Analysis of Calcium Channels by Conditional Mutagenesis. In: Feil, R. and Metzger, D. (eds.) Conditional Mutagenesis: An Approach to Disease Models. Handbook of Experimental Pharmacology. p. 469-490. Springer Berlin Heidelberg, Berlin, Heidelberg (2007).
Moosmang, S., Kleppisch, T., Wegener, Jörg, Welling, A., and Hofmann, F. “Analysis of Calcium Channels by Conditional Mutagenesis”. Conditional Mutagenesis: An Approach to Disease Models. Ed. Robert Feil and Daniel Metzger. Berlin, Heidelberg: Springer Berlin Heidelberg, 2007. Handbook of Experimental Pharmacology. 469-490.