Effects of Quinine and Quinidine on the Transient Outward and on the L-Type Ca<sup>2+</sup> Current in Rat Ventricular Cardiomyocytes
Michel D, Wegener J, Nawrath H (2002)
Pharmacology 65(4): 187-192.
Zeitschriftenaufsatz
| Veröffentlicht | Englisch
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Autor*in
Michel, Delia;
Wegener, JörgUniBi
;
Nawrath, Hermann
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Abstract / Bemerkung
The effects of the enantiomers quinine and quinidine on the transient outward current (Ito) and on the L-type Ca2+ current (ICa) were investigated in rat ventricular cardiomyocytes using the patch-clamp technique. At a stimulation frequency of 2 Hz, both quinine and quinidine depressed the magnitude of Ito and ICa; the half-maximal effects on Ito were achieved at 11 and 15 µmol/l, respectively, and those on ICa at 14 and 10 µmol/l, respectively. At 0.2 Hz, both drugs depressed the magnitude of Ito, but not that of ICa. A change in extracellular pH from 7.3 to 8.3 did not significantly influence the effects of the drugs (which are protonated to 98% at pH 7.3) on Ito or ICa. It is concluded that neither the different chemical structure nor the amount of protonation of quinine and quinidine controls their effects on Ito or ICa.
Erscheinungsjahr
2002
Zeitschriftentitel
Pharmacology
Band
65
Ausgabe
4
Seite(n)
187-192
ISSN
0031-7012
eISSN
1423-0313
Page URI
https://pub.uni-bielefeld.de/record/2984502
Zitieren
Michel D, Wegener J, Nawrath H. Effects of Quinine and Quinidine on the Transient Outward and on the L-Type Ca<sup>2+</sup> Current in Rat Ventricular Cardiomyocytes. Pharmacology. 2002;65(4):187-192.
Michel, D., Wegener, J., & Nawrath, H. (2002). Effects of Quinine and Quinidine on the Transient Outward and on the L-Type Ca<sup>2+</sup> Current in Rat Ventricular Cardiomyocytes. Pharmacology, 65(4), 187-192. https://doi.org/10.1159/000064342
Michel, Delia, Wegener, Jörg, and Nawrath, Hermann. 2002. “Effects of Quinine and Quinidine on the Transient Outward and on the L-Type Ca<sup>2+</sup> Current in Rat Ventricular Cardiomyocytes”. Pharmacology 65 (4): 187-192.
Michel, D., Wegener, J., and Nawrath, H. (2002). Effects of Quinine and Quinidine on the Transient Outward and on the L-Type Ca<sup>2+</sup> Current in Rat Ventricular Cardiomyocytes. Pharmacology 65, 187-192.
Michel, D., Wegener, J., & Nawrath, H., 2002. Effects of Quinine and Quinidine on the Transient Outward and on the L-Type Ca<sup>2+</sup> Current in Rat Ventricular Cardiomyocytes. Pharmacology, 65(4), p 187-192.
D. Michel, J. Wegener, and H. Nawrath, “Effects of Quinine and Quinidine on the Transient Outward and on the L-Type Ca<sup>2+</sup> Current in Rat Ventricular Cardiomyocytes”, Pharmacology, vol. 65, 2002, pp. 187-192.
Michel, D., Wegener, J., Nawrath, H.: Effects of Quinine and Quinidine on the Transient Outward and on the L-Type Ca<sup>2+</sup> Current in Rat Ventricular Cardiomyocytes. Pharmacology. 65, 187-192 (2002).
Michel, Delia, Wegener, Jörg, and Nawrath, Hermann. “Effects of Quinine and Quinidine on the Transient Outward and on the L-Type Ca<sup>2+</sup> Current in Rat Ventricular Cardiomyocytes”. Pharmacology 65.4 (2002): 187-192.