Complete genome sequence of Saccharothrix espanaensis DSM 44229T and comparison to the other completely sequenced Pseudonocardiaceae

Strobel T, Al-Dilaimi A, Blom J, Gessner A, Kalinowski J, Luzhetska M, Pühler A, Szczepanowski R, Bechthold A, Rückert C (2012)
BMC Genomics 13(1): 465.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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URN
urn:nbn:de:0070-pub-25262695
Autor*in
Strobel, Tina; Al-Dilaimi, ArwaUniBi; Blom, JochenUniBi; Gessner, Arne; Kalinowski, JörnUniBi; Luzhetska, Marta; Pühler, AlfredUniBi ; Szczepanowski, RafaelUniBi; Bechthold, Andreas; Rückert, ChristianUniBi
Einrichtung
Centrum für Biotechnologie > Technologieplattformen > Bioinformatics Resource Facility
Centrum für Biotechnologie > Arbeitsgruppe J. Kalinowski
Technische Fakultät > Computational Genomics
Centrum für Biotechnologie > Arbeitsgruppe J. Stoye
Centrum für Biotechnologie > Arbeitsgruppe A. Pühler
Abstract / Bemerkung
ABSTRACT: BACKGROUND: The genus Saccharothrix is a representative of the family Pseudonocardiaceae, known to include producer strains of a wide variety of potent antibiotics. Saccharothrix espanaensis produces both saccharomicins A and B of the promising new class of heptadecaglycoside antibiotics, active against both bacteria and yeast. RESULTS: To better assess its capabilities, the complete genome sequence of S. espanaensis was established. With a size of 9,360,653 bp, coding for 8,501 genes, it stands alongside other Pseudonocardiaceae with large genomes. Besides a predicted core genome of 810 genes shared in the family, S. espanaensis has a large number of accessory genes: 2,967 singletons when compared to the family, of which 1,292 have no clear orthologs in the RefSeq database. The genome analysis revealed the presence of 26 biosynthetic gene clusters potentially encoding secondary metabolites. Among them, the cluster coding for the saccharomicins could be identified. CONCLUSION: S. espanaensis is the first completely sequenced species of the genus Saccharothrix. The genome discloses the cluster responsible for the biosynthesis of the saccharomicins, the largest oligosaccharide antibiotic currently identified. Moreover, the genome revealed 25 additional putative secondary metabolite gene clusters further suggesting the strain's potential for natural product synthesis.
Erscheinungsjahr
2012
Zeitschriftentitel
BMC Genomics
Band
13
Ausgabe
1
Art.-Nr.
465
ISSN
1471-2164
Page URI
https://pub.uni-bielefeld.de/record/2526269

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Strobel T, Al-Dilaimi A, Blom J, et al. Complete genome sequence of Saccharothrix espanaensis DSM 44229T and comparison to the other completely sequenced Pseudonocardiaceae. BMC Genomics. 2012;13(1): 465.
Strobel, T., Al-Dilaimi, A., Blom, J., Gessner, A., Kalinowski, J., Luzhetska, M., Pühler, A., et al. (2012). Complete genome sequence of Saccharothrix espanaensis DSM 44229T and comparison to the other completely sequenced Pseudonocardiaceae. BMC Genomics, 13(1), 465. doi:10.1186/1471-2164-13-465
Strobel, Tina, Al-Dilaimi, Arwa, Blom, Jochen, Gessner, Arne, Kalinowski, Jörn, Luzhetska, Marta, Pühler, Alfred, Szczepanowski, Rafael, Bechthold, Andreas, and Rückert, Christian. 2012. “Complete genome sequence of Saccharothrix espanaensis DSM 44229T and comparison to the other completely sequenced Pseudonocardiaceae”. BMC Genomics 13 (1): 465.
Strobel, T., Al-Dilaimi, A., Blom, J., Gessner, A., Kalinowski, J., Luzhetska, M., Pühler, A., Szczepanowski, R., Bechthold, A., and Rückert, C. (2012). Complete genome sequence of Saccharothrix espanaensis DSM 44229T and comparison to the other completely sequenced Pseudonocardiaceae. BMC Genomics 13:465.
Strobel, T., et al., 2012. Complete genome sequence of Saccharothrix espanaensis DSM 44229T and comparison to the other completely sequenced Pseudonocardiaceae. BMC Genomics, 13(1): 465.
T. Strobel, et al., “Complete genome sequence of Saccharothrix espanaensis DSM 44229T and comparison to the other completely sequenced Pseudonocardiaceae”, BMC Genomics, vol. 13, 2012, : 465.
Strobel, T., Al-Dilaimi, A., Blom, J., Gessner, A., Kalinowski, J., Luzhetska, M., Pühler, A., Szczepanowski, R., Bechthold, A., Rückert, C.: Complete genome sequence of Saccharothrix espanaensis DSM 44229T and comparison to the other completely sequenced Pseudonocardiaceae. BMC Genomics. 13, : 465 (2012).
Strobel, Tina, Al-Dilaimi, Arwa, Blom, Jochen, Gessner, Arne, Kalinowski, Jörn, Luzhetska, Marta, Pühler, Alfred, Szczepanowski, Rafael, Bechthold, Andreas, and Rückert, Christian. “Complete genome sequence of Saccharothrix espanaensis DSM 44229T and comparison to the other completely sequenced Pseudonocardiaceae”. BMC Genomics 13.1 (2012): 465.
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