Identifying Gene Clusters by Discovering Common Intervals in Indeterminate Strings

Dörr D, Stoye J, Böcker S, Jahn K (2014)
BMC Genomics 15(Suppl. 6: Proc. of RECOMB-CG 2014): S2.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Abstract / Bemerkung
Background: Comparative analyses of chromosomal gene orders are successfully used to predict gene clusters in bacterial and fungal genomes. Present models for detecting sets of co-localized genes in chromosomal sequences require prior knowledge of gene family assignments of genes in the dataset of interest. These families are often computationally predicted on the basis of sequence similarity or higher order features of gene products. Errors introduced in this process amplify in subsequent gene order analyses and thus may deteriorate gene cluster prediction. Results: In this work, we present a new dynamic model and efficient computational approaches for gene cluster prediction suitable in scenarios ranging from traditional gene family-based gene cluster prediction, via multiple conflicting gene family annotations, to gene family-free analysis, in which gene clusters are predicted solely on the basis of a pairwise similarity measure of the genes of different genomes. We evaluate our gene family-free model against a gene family-based model on a dataset of 93 bacterial genomes. Conclusions: Our model is able to detect gene clusters that would be also detected with well-established gene family-based approaches. Moreover, we show that it is able to detect conserved regions which are missed by gene family-based methods due to wrong or deficient gene family assignments.
Erscheinungsjahr
2014
Zeitschriftentitel
BMC Genomics
Band
15
Ausgabe
Suppl. 6: Proc. of RECOMB-CG 2014
Seite(n)
S2
ISSN
1471-2164
Finanzierungs-Informationen
Article Processing Charge funded by the Deutsche Forschungsgemeinschaft and the Open Access Publication Fund of Bielefeld University.
Page URI
https://pub.uni-bielefeld.de/record/2687033

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Dörr D, Stoye J, Böcker S, Jahn K. Identifying Gene Clusters by Discovering Common Intervals in Indeterminate Strings. BMC Genomics. 2014;15(Suppl. 6: Proc. of RECOMB-CG 2014):S2.
Dörr, D., Stoye, J., Böcker, S., & Jahn, K. (2014). Identifying Gene Clusters by Discovering Common Intervals in Indeterminate Strings. BMC Genomics, 15(Suppl. 6: Proc. of RECOMB-CG 2014), S2. doi:10.1186/1471-2164-15-S6-S2
Dörr, D., Stoye, J., Böcker, S., and Jahn, K. (2014). Identifying Gene Clusters by Discovering Common Intervals in Indeterminate Strings. BMC Genomics 15, S2.
Dörr, D., et al., 2014. Identifying Gene Clusters by Discovering Common Intervals in Indeterminate Strings. BMC Genomics, 15(Suppl. 6: Proc. of RECOMB-CG 2014), p S2.
D. Dörr, et al., “Identifying Gene Clusters by Discovering Common Intervals in Indeterminate Strings”, BMC Genomics, vol. 15, 2014, pp. S2.
Dörr, D., Stoye, J., Böcker, S., Jahn, K.: Identifying Gene Clusters by Discovering Common Intervals in Indeterminate Strings. BMC Genomics. 15, S2 (2014).
Dörr, Daniel, Stoye, Jens, Böcker, Sebastian, and Jahn, Katharina. “Identifying Gene Clusters by Discovering Common Intervals in Indeterminate Strings”. BMC Genomics 15.Suppl. 6: Proc. of RECOMB-CG 2014 (2014): S2.
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2019-09-06T09:18:25Z
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