Establishment of a CpG island microarray for analyses of genome-wide DNA methylation in Chinese hamster ovary cells
Wippermann A, Klausing S, Rupp O, Albaum S, Büntemeyer H, Noll T, Hoffrogge R (2014)
Applied Microbiology and Biotechnology 98(2): 579-589.
Zeitschriftenaufsatz
| Veröffentlicht | Englisch
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Autor*in
Einrichtung
Technische Fakultät > AG Fermentationstechnik
Centrum für Biotechnologie > Technologieplattformen > Bioinformatics Resource Facility
Centrum für Biotechnologie > Arbeitsgruppe T. Noll
Technische Fakultät > AG Zellkulturtechnik
Centrum für Biotechnologie > Graduate Center > Graduate Cluster Industrial Biotechnology
Centrum für Biotechnologie > Technologieplattformen > Bioinformatics Resource Facility
Centrum für Biotechnologie > Arbeitsgruppe T. Noll
Technische Fakultät > AG Zellkulturtechnik
Centrum für Biotechnologie > Graduate Center > Graduate Cluster Industrial Biotechnology
Abstract / Bemerkung
Optimizing productivity and growth rates of recombinant Chinese hamster ovary (CHO) cells requires insight into the regulation of cellular processes. In this regard, the elucidation of the epigenetic process of DNA methylation, known to influence transcription by a differential occurrence in CpG islands in promoter regions, is increasingly gaining importance. However, DNA methylation has not yet been investigated on a genomic scale in CHO cells and suitable tools have not existed until now. Based on the genomic and transcriptomic CHO data currently available, we developed a customized oligonucleotide microarray covering 19598 CpG islands (89 % of total bioinformatically identified CpG islands) in the CHO genome. We applied our CHO-specific CpG island microarray to investigate the effect of butyrate treatment on differential DNA methylation in CHO cultures in a time-dependent approach. Supplementation of butyrate is known to enhance cell specific productivities in CHO cells and leads to alterations of epigenetic silencing events. Gene ontology clusters regarding, e.g., chromatin modification or DNA repair, were significantly overrepresented 24 h after butyrate addition. Functional classifications furthermore indicated that several major signaling systems such as the Wnt/beta-catenin pathway were affected by butyrate treatment. Our novel CHO-specific CpG island microarray will provide valuable information in future studies of cellular processes associated with productivity and product characteristics.
Stichworte
Chinese hamster ovary cells;
DNA methylation;
Epigenetics;
Butyrate;
CpG island;
microarray
Erscheinungsjahr
2014
Zeitschriftentitel
Applied Microbiology and Biotechnology
Band
98
Ausgabe
2
Seite(n)
579-589
ISSN
0175-7598
eISSN
1432-0614
Page URI
https://pub.uni-bielefeld.de/record/2656819
Zitieren
Wippermann A, Klausing S, Rupp O, et al. Establishment of a CpG island microarray for analyses of genome-wide DNA methylation in Chinese hamster ovary cells. Applied Microbiology and Biotechnology. 2014;98(2):579-589.
Wippermann, A., Klausing, S., Rupp, O., Albaum, S., Büntemeyer, H., Noll, T., & Hoffrogge, R. (2014). Establishment of a CpG island microarray for analyses of genome-wide DNA methylation in Chinese hamster ovary cells. Applied Microbiology and Biotechnology, 98(2), 579-589. doi:10.1007/s00253-013-5282-2
Wippermann, Anna, Klausing, Sandra, Rupp, Oliver, Albaum, Stefan, Büntemeyer, Heino, Noll, Thomas, and Hoffrogge, Raimund. 2014. “Establishment of a CpG island microarray for analyses of genome-wide DNA methylation in Chinese hamster ovary cells”. Applied Microbiology and Biotechnology 98 (2): 579-589.
Wippermann, A., Klausing, S., Rupp, O., Albaum, S., Büntemeyer, H., Noll, T., and Hoffrogge, R. (2014). Establishment of a CpG island microarray for analyses of genome-wide DNA methylation in Chinese hamster ovary cells. Applied Microbiology and Biotechnology 98, 579-589.
Wippermann, A., et al., 2014. Establishment of a CpG island microarray for analyses of genome-wide DNA methylation in Chinese hamster ovary cells. Applied Microbiology and Biotechnology, 98(2), p 579-589.
A. Wippermann, et al., “Establishment of a CpG island microarray for analyses of genome-wide DNA methylation in Chinese hamster ovary cells”, Applied Microbiology and Biotechnology, vol. 98, 2014, pp. 579-589.
Wippermann, A., Klausing, S., Rupp, O., Albaum, S., Büntemeyer, H., Noll, T., Hoffrogge, R.: Establishment of a CpG island microarray for analyses of genome-wide DNA methylation in Chinese hamster ovary cells. Applied Microbiology and Biotechnology. 98, 579-589 (2014).
Wippermann, Anna, Klausing, Sandra, Rupp, Oliver, Albaum, Stefan, Büntemeyer, Heino, Noll, Thomas, and Hoffrogge, Raimund. “Establishment of a CpG island microarray for analyses of genome-wide DNA methylation in Chinese hamster ovary cells”. Applied Microbiology and Biotechnology 98.2 (2014): 579-589.
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