103 Publikationen
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2025 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 2993961Separation and Purification of CHO Secretome and Extracellular Vesicles for Proteome AnalysisPUB | DOI | PubMed | Europe PMC
Lehmkuhl M, Keysberg C, Otte K, Noll T, Hoffrogge R (2025)
In: Heterologous Protein Production in CHO Cells. Methods and Protocols. Meleady P (Ed); Methods in Molecular Biology. New York, NY: Springer US: 155-171. -
2024 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2994240
Perfusion Process Intensification for Lentivirus Production Using a Novel Scale‐Down ModelPUB | PDF | DOI | WoS | PubMed | Europe PMC
Klimpel M, Pflüger‐Müller B, Cascallana MA, Schwingal S, Lal NI, Noll T, Pirzas V, Laux H (2024)
Biotechnology and Bioengineering. -
2024 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2990014Generation of stable suspension producer cell lines for serum-free lentivirus productionPUB | DOI | WoS | PubMed | Europe PMC
Klimpel M, Terrao M, Bräuer M, Dersch H, Biserni M, Do Nascimento LM, Schwingal S, Vogel JE, Ferlemann C, Brandt T, Lal NI, et al. (2024)
Biotechnology Journal 19(5): e2400090. -
2023 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2979009
Development of a perfusion process for continuous lentivirus production using stable suspension producer cell linesPUB | PDF | DOI | Download (ext.) | WoS | PubMed | Europe PMC
Klimpel M, Terrao M, Ching N, Climenti V, Noll T, Pirzas V, Laux H (2023)
Biotechnology and Bioengineering. -
2022 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2962032
Hyperosmolality in CHO cell culture: effects on the proteomePUB | PDF | DOI | WoS | PubMed | Europe PMC
Romanova N, Schelletter L, Hoffrogge R, Noll T (2022)
Applied Microbiology and Biotechnology 106: 2569–2586. -
2022 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2963556
Single-Cell Analysis of CHO Cells Reveals Clonal Heterogeneity in Hyperosmolality-Induced Stress ResponsePUB | PDF | DOI | Download (ext.) | WoS | PubMed | Europe PMC
Romanova N, Schmitz J, Strakeljahn M, Grünberger A, Bahnemann J, Noll T (2022)
Cells 11(11): 1763. -
2022 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2966624
Enhancing stability of recombinant CHO cells by CRISPR/Cas9-mediated site-specific integration into regions with distinct histone modificationsPUB | PDF | DOI | WoS | PubMed | Europe PMC
Hertel O, Neuss A, Busche T, Brandt D, Kalinowski J, Bahnemann J, Noll T (2022)
Frontiers in Bioengineering and Biotechnology 10. -
2021 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2952449
Nanopore Sequencing Reveals Global Transcriptome Signatures of Mitochondrial and Ribosomal Gene Expressions in Various Human Cancer Stem-like Cell PopulationsPUB | PDF | DOI | WoS | PubMed | Europe PMC
Witte KE, Hertel O, Windmöller BA, Helweg L, Höving AL, Knabbe C, Busche T, Greiner J, Kalinowski J, Noll T, Mertzlufft F, et al. (2021)
Cancers 13(5): 1136. -
2021 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2949089
Development and application of a cultivation platform for mammalian suspension cell lines with single-cell resolutionPUB | Dateien verfügbar | DOI | WoS | PubMed | Europe PMC | Preprint
Schmitz J, Täuber S, Westerwalbesloh C, von Lieres E, Noll T, Grünberger A (2021)
Biotechnology and Bioengineering 118(2): 992-1005. -
2021 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2954736
Exploring the molecular content of CHO exosomes during bioprocessingPUB | PDF | DOI | WoS | PubMed | Europe PMC
Keysberg C, Hertel O, Schelletter L, Busche T, Sochart C, Kalinowski J, Hoffrogge R, Otte K, Noll T (2021)
Applied Microbiology and Biotechnology 105(9): 3673-3689. -
2021 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2955090
Growth and eGFP-production of CHO-K1 suspension cells cultivated from single-cell to laboratory scalePUB | PDF | DOI | WoS | PubMed | Europe PMC | Preprint
Schmitz J, Hertel O, Yermakov B, Noll T, Grünberger A (2021)
Frontiers in Bioengineering and Biotechnology 9: 716343. -
2021 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2953580
Interaction of leachable model compounds and their impact on Chinese hamster ovary cell cultivationPUB | PDF | DOI | Download (ext.) | WoS | PubMed | Europe PMC
Budde D, Albano G-L, Noll T, Jurkiewicz E (2021)
Biotechnology Progress: e3150. -
2021 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2952639
Hyperosmolality in CHO Culture: Effects on cellular behavior and morphologyPUB | PDF | DOI | Download (ext.) | WoS | PubMed | Europe PMC
Romanova N, Niemann T, Greiner J, Kaltschmidt B, Kaltschmidt C, Noll T (2021)
Biotechnology and Bioengineering 118(6): 2348-2359. -
2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2944311
A Positive Pressure Workstation for Semi Automated Peptide Purification of Complex Proteomic Samples.PUB | PDF | DOI | WoS | PubMed | Europe PMC
Schelletter L, Hertel O, Antar SJ, Scherling C, Lattig J, Noll T, Hoffrogge R (2020)
Rapid communications in mass spectrometry 35(2): e8873. -
2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2948753Cancer-associated hypersialylated MUC1 drives the differentiation of human monocytes into macrophages with a pathogenic phenotypePUB | DOI | WoS | PubMed | Europe PMC
Beatson R, Graham R, Grundland Freile F, Cozzetto D, Kannambath S, Pfeifer E, Woodman N, Owen J, Nuamah R, Mandel U, Pinder S, et al. (2020)
Communications biology 3(1): 644. -
2020 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2945942Impact of NaBu and RA on histones and nuclear signaling in CHO cellsPUB
Pries A, Brachtvogel L, Noll T, Hoffrogge R (2020)
BMC Proceedings 14(Suppl 5): P-159. -
2020 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2945943Media supplement induced signaling in CHO cells via triple SILAC-MSPUB
Schelletter L, Noll T, Hoffrogge R (2020)
BMC Proceedings 14(Suppl 5): P-565. -
2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2945107
Application of an Inclined Settler for Cell Culture-Based Influenza A Virus Production in Perfusion ModePUB | PDF | DOI | WoS | PubMed | Europe PMC
Coronel J, Gränicher G, Sandig V, Noll T, Genzel Y, Reichl U (2020)
Frontiers in Bioengineering and Biotechnology 8: 672. -
2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2944324Identification and evaluation of cell- growth-inhibiting bDtBPP-analogue degradation products from phosphite antioxidants used in polyolefin bioprocessing materials.PUB | DOI | WoS | PubMed | Europe PMC
Budde D, Maier TV, Jurkiewicz E, Pahl I, Hauk A, Tauscher E, Gorls H, Noll T, Menzel R (2020)
Analytical and bioanalytical chemistry 412(19): 4505-4518. -
2019 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2936490Assessment of mixture toxicity of (tri)azoles and their hepatotoxic effects in vitro by means of omics technologies.PUB | DOI | WoS | PubMed | Europe PMC
Seeger B, Mentz A, Knebel C, Schmidt F, Bednarz H, Niehaus K, Albaum S, Kalinowski J, Noll T, Steinberg P, Marx-Stoelting P, et al. (2019)
Archives of toxicology 93(8): 2321-2333. -
2019 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2934600Effect of manufacturing temperature and storage duration on stability of chemically defined media measured with LC-MS/MSPUB | DOI | WoS
Krattenmacher F, Heermann T, Calvet A, Krawczyk B, Noll T (2019)
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY 94(4): 1144-1155. -
2019 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2938369Perfusion process combining low temperature and valeric acid for enhanced recombinant factor VIII production.PUB | DOI | WoS | PubMed | Europe PMC
Coronel J, Heinrich C, Klausing S, Noll T, Figueredo-Cardero A, Castilho LR (2019)
Biotechnology progress 36(1): e2915. -
2019 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2937250Clonal variations in CHO IGF signaling investigated by SILAC-based phosphoproteomics and LFQ-MSPUB | DOI | WoS | PubMed | Europe PMC
Schelletter L, Albaum S, Walter S, Noll T, Hoffrogge R (2019)
Applied microbiology and biotechnology 103(19): 8127-8143. -
2019 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2933358Heterogeneity Studies of Mammalian Cells for Bioproduction. From Tools to ApplicationPUB | DOI | WoS | PubMed | Europe PMC
Schmitz J, Noll T, Grünberger A (2019)
Trends in Biotechnology 37(6): 645-660. -
2018 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2945946MS-SILAC approach for phosphoproteomics of IGF signaling in producer CHO cellsPUB
Brachtvogel L, Walter S, Noll T, Hoffrogge R (2018)
BMC Proceedings 12( Suppl. 1): 3. -
2018 | Konferenzbeitrag | PUB-ID: 2933363Towards Microfluidic Single-Cell Cultivation of Mammalian Cell LinesPUB
Schmitz J, Noll T, Grünberger A (2018)
Presented at the Young Scientist Cell Culture Biotechnology Retreat, Laupheim. -
2018 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2933359Towards dynamic single-cell cultivation systems for industrially relevant mammalian cell linesPUB
Schmitz J, Kerkhoff Y, Noll T, Kohlheyer D, Grünberger A (2018)
Presented at the BioProcessing Days 2018, Recklinghausen. -
2018 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2933362Dynamic microfluidical single-cell cultivation of mammalian cell lines. From experiment to analysisPUB
Schmitz J, Kerkhoff Y, Noll T, Grünberger A (2018)
Presented at the CeBiTec Symposium 2018, Bielefeld. -
2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2915619Engineered and Natural Promoters and Chromatin-Modifying Elements for Recombinant Protein Expression in CHO CellsPUB | DOI | WoS | PubMed | Europe PMC
Romanova N, Noll T (2017)
Biotechnology Journal 13(3): e1700232. -
2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2911396Label-free protein quantification of sodium butyrate treated CHO cells by ESI-UHR-TOF-MSPUB | DOI | WoS | PubMed | Europe PMC
Müller B, Heinrich C, Jabs W, Kaspar-Schönefeld S, Schmidt A, Wehmeier N, Albaum S, Baessmann C, Noll T, Hoffrogge R (2017)
Journal of Biotechnology 257: 87-98. -
2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2914045 PUB | DOI | WoS | PubMed | Europe PMC
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2906640Valeric acid supplementation combined to mild hypothermia increases productivity in CHO cell cultivationsPUB | DOI | WoS
Coronel J, Klausing S, Heinrich C, Noll T, Figueredo-Cardero A, Castilho LR (2016)
Biochemical Engineering Journal 114: 101-109. -
2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2907079Integrative analysis of DNA methylation and gene expression in butyrate-treated CHO cellsPUB | DOI | WoS | PubMed | Europe PMC
Wippermann A, Rupp O, Brinkrolf K, Hoffrogge R, Noll T (2016)
Journal of Biotechnology 257: 150-161. -
2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2906641The mucin MUC1 modulates the tumor immunological microenvironment through engagement of the lectin Siglec-9PUB | DOI | WoS | PubMed | Europe PMC
Beatson R, Tajadura-Ortega V, Achkova D, Picco G, Tsourouktsoglou T-D, Klausing S, Hillier M, Maher J, Noll T, Crocker PR, Taylor-Papadimitriou J, et al. (2016)
Nature Immunology 17(11): 1273-1281. -
2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 27187672D-DIGE screening of high-productive CHO cells under glucose limitation — Basic changes in the proteome equipment and hints for epigenetic effectsPUB | DOI | WoS | PubMed | Europe PMC
Wingens M, Gätgens J, Schmidt A, Albaum S, Büntemeyer H, Noll T, Hoffrogge R (2015)
Journal of Biotechnology 201: 86-97. -
2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2718773The DNA methylation landscape of Chinese hamster ovary (CHO) DP-12 cellsPUB | DOI | WoS | PubMed | Europe PMC
Wippermann A, Rupp O, Brinkrolf K, Hoffrogge R, Noll T (2015)
Journal of Biotechnology 199: 38-46. -
2015 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2902782Multi-level omics analysis of combination effects of (tri-)azoles in a set of different cell linesPUB | DOI | WoS
Knebel C, Marx-Stoelting P, Pfeil R, Seeger B, Steinberg P, Mentz A, Bednarz H, Niehaus K, Kalinowski J, Noll T, Heise T (2015)
Toxicology Letters 238(2): S355. -
2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2656819Establishment of a CpG island microarray for analyses of genome-wide DNA methylation in Chinese hamster ovary cellsPUB | DOI | WoS | PubMed | Europe PMC
Wippermann A, Klausing S, Rupp O, Albaum S, Büntemeyer H, Noll T, Hoffrogge R (2014)
Applied Microbiology and Biotechnology 98(2): 579-589. -
2014 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 2694187Functional -Omics for Cell Lines and Processes - The -Omics Technologies on the Example of CHO CellsPUB
Brinkrolf K, Hoffrogge R, Hackl M, Tauch A, Baumann M, Noll T, Goesmann A, Pühler A, Borth N (2014)
In: Animal Cell Biotechnology In Biologics Production. Hauser H, Wagner R (Eds); Berlin, Germany: Walter de Gruyter: 702. -
2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2685988Discovery of transcription start sites in the Chinese hamster genome by next-generation RNA sequencingPUB | DOI | WoS | PubMed | Europe PMC
Jakobi T, Brinkrolf K, Tauch A, Noll T, Stoye J, Pühler A, Goesmann A (2014)
Journal of Biotechnology 190: 64-75. -
2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2676552Transcriptome analyses of CHO cells with the next-generation microarray CHO41K: Development and validation by analysing the influence of the growth stimulating substance IGF-1 substitute LongR(3.)PUB | DOI | WoS | PubMed | Europe PMC
Becker J, Timmermann C, Rupp O, Albaum S, Brinkrolf K, Goesmann A, Pühler A, Tauch A, Noll T (2014)
Journal of biotechnology 178: 23-31. -
2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2701280The Genomics Revolution and its Impact on Future BiotechnologyPUB | DOI | WoS | PubMed | Europe PMC
Noll T, Pühler A, Weisshaar B, Wendisch VF (2014)
Journal of Biotechnology 190: 1. -
2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2656773Construction of a Public CHO Cell Line Transcript Database Using Versatile Bioinformatics Analysis PipelinesPUB | DOI | WoS | PubMed | Europe PMC
Rupp O, Becker J, Brinkrolf K, Timmermann C, Borth N, Pühler A, Noll T, Goesmann A (2014)
PLoS ONE 9(1): e85568. -
2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2679670The influence of cell growth and enzyme activity changes on intracellular metabolite dynamics in AGE1.HN.AAT cellsPUB | DOI | WoS | PubMed | Europe PMC
Rath AG, Rehberg M, Janke R, Genzel Y, Scholz S, Noll T, Rose T, Sandig V, Reichl U (2014)
Journal of Biotechnology 178: 43-53. -
2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2615581Chinese hamster genome sequenced from sorted chromosomesPUB | DOI | WoS | PubMed | Europe PMC
Brinkrolf K, Rupp O, Laux H, Kollin F, Ernst W, Linke B, Kofler R, Romand S, Hesse F, Budach WE, Galosy S, et al. (2013)
Nature Biotechnology 31(8): 694-695. -
2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2577265
Hsc70 is a novel interactor of NF-kappaB p65 in living hippocampal neuronsPUB | PDF | DOI | WoS | PubMed | Europe PMC
Klenke C, Widera D, Engelen T, Müller J, Noll T, Niehaus K, Schmitz M, Kaltschmidt B, Kaltschmidt C (2013)
PLoS ONE 8(6): e65280. -
2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2351519Evaluation of sulfatase-directed quinone methide traps for proteomicsPUB | DOI | WoS | PubMed | Europe PMC
Lenger J, Schröder M, Ennemann E, Müller B, Wong C-H, Noll T, Dierks T, Hanson SR, Sewald N (2012)
Bioorganic & Medicinal Chemistry 20(2): 622-627. -
2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2553404How can measurement, monitoring, modeling and control advance cell culture in industrial biotechnology?PUB | DOI | WoS | PubMed | Europe PMC
Carrondo MJT, Alves PM, Carinhas N, Glassey J, Hesse F, Merten O-W, Micheletti M, Noll T, Oliveira R, Reichl U, Staby A, et al. (2012)
Biotechnology Journal 7(12): 1522-1529. -
2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2424989Effects of high passage cultivation on CHO cells: a global analysisPUB | DOI | WoS | PubMed | Europe PMC
Beckmann T, Krämer O, Klausing S, Heinrich C, Thüte T, Büntemeyer H, Hoffrogge R, Noll T (2012)
Applied Microbiology Biotechnology 94(3): 659-671. -
2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2501364Utilization and evaluation of CHO-specific sequence databases for mass spectrometry based proteomicsPUB | DOI | WoS | PubMed | Europe PMC
Meleady P, Hoffrogge R, Henry M, Rupp O, Bort JH, Clarke C, Brinkrolf K, Kelly S, Müller B, Doolan P, Hackl M, et al. (2012)
Biotechnology and Bioengineering 109(6): 1386-1394. -
2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2478526Computational identification of microRNA gene loci and precursor microRNA sequences in CHO cell linesPUB | DOI | WoS | PubMed | Europe PMC
Hackl M, Jadhav V, Jakobi T, Rupp O, Brinkrolf K, Goesmann A, Pühler A, Noll T, Borth N, Grillari J (2012)
Journal of Biotechnology 158(3): 151-155. -
2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2544205Evaluation of criteria for bioreactor comparison and operation standardization for mammalian cell culturePUB | DOI | WoS
Barradas OP, Jandt U, Da Minh Phan L, Villanueva ME, Schaletzky M, Rath A, Freund S, Reichl U, Skerhutt EM, Scholz S, Noll T, et al. (2012)
Engineering In Life Sciences 12(5): 518-528. -
2011 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2375038Proteomic and metabolomic characterization of CHO DP-12 cell lines with different high passage historiesPUB | DOI | PubMed | Europe PMC
Beckmann T, Thüte T, Heinrich C, Büntemeyer H, Noll T (2011)
BMC Proceedings 5(Suppl 8): P92. -
2011 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2375605Bioreactor cultivation of CHO DP-12 cells under sodium butyrate treatment – comparative transcriptome analysis with CHO cDNA microarraysPUB | DOI | PubMed | Europe PMC
Klausing S, Krämer O, Noll T (2011)
BMC Proceedings 5(Suppl 8): P98 . -
2011 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2453752A method for metabolomic sampling of suspended animal cells using fast filtrationPUB | DOI | PubMed | Europe PMC
Volmer M, Gettmann J, Scholz S, Büntemeyer H, Noll T (2011)
BMC Proceedings 5(8): 95. -
2011 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2453760Growth characterization of CHO DP-12 cell lines with different high passage historiesPUB | DOI | PubMed | Europe PMC
Heinrich C, Timo W, Christina K, Northoff S, Noll T (2011)
In: BMC Proceedings. Hansjörg H (Ed); BMC Proceedings, 5(8). BioMed Central. -
2011 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2453768Next-generation sequencing of the CHO cell transcriptomePUB | DOI
Becker J, Timmermann C, Jakobi T, Rupp O, Szczepanowski R, Hackl M, Goesmann A, Tauch A, Borth N, Grillari J, Pühler A, et al. (2011)
BMC Proceedings 5(Suppl. 8): P6. -
2011 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2447643Characterization of the human AGE1.HN cell line: a systems biology approachPUB | DOI | PubMed | Europe PMC
Scholz S, Luebbecke M, Rath A, Schräder EM, Rose T, Büntemeyer H, Scheper T, Reichl U, Noll T (2011)
BMC Proceedings 5(8). -
2011 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2447654Criteria for bioreactor comparison and operation standardisation during process development for mammalian cell culturePUB | DOI | PubMed | Europe PMC
Platas Barradas O, Jandt U, Da Minh Phan L, Villanueva M, Rath A, Reichl U, Schräder EM, Scholz S, Noll T, Sandig V, Pörtner R, et al. (2011)
BMC Proceedings 5(8). -
2011 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2442810Analysis of the mitochondrial subproteome of the human cell line AGE1.HN – a contribution to a systems biology approachPUB | DOI | PubMed | Europe PMC
Skerhutt EM, Scholz S, Sandig V, Hoffrogge R, Noll T (2011)
BMC Proceedings 5(8). -
2011 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2442843Characterisation of cultivation of the human cell line AGE1.HN.AATPUB | DOI | PubMed | Europe PMC
Skerhutt EM, Scholz S, Niklas J, Rath A, Platas Barradas O, Jandt U, Sandig V, Rose T, Pörtner R, Reichl U, Zeng A-P, et al. (2011)
BMC Proceedings 5(8). -
2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2289895Quantitative characterization of metabolism and metabolic shifts during growth of the new human cell line AGE1.HN using time resolved metabolic flux analysisPUB | DOI | WoS | PubMed | Europe PMC
Niklas J, Skerhutt EM, Sandig V, Noll T, Heinzle E (2011)
Bioprocess and Biosystems Engineering 34(5): 533-545. -
2011 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2375051Utilization of multifrequency permittivity measurements in addition to biomass monitoringPUB | DOI | PubMed | Europe PMC
Heinrich C, Beckmann T, Büntemeyer H, Noll T (2011)
BMC Proceedings 5(Suppl 8). -
2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2396576Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencingPUB | DOI | WoS | PubMed | Europe PMC
Becker J, Hackel M, Jakobi T, Rupp O, Schneider J, Szczepanowski R, Bekel T, Borth N, Goesmann A, Grillari J, Kaltschmidt C, et al. (2011)
Journal of Biotechnology 156(3): 227-235. -
2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2094364Fast filtration for metabolome sampling of suspended animal cellsPUB | DOI | WoS | PubMed | Europe PMC
Volmer M, Northoff S, Scholz S, Thüte T, Büntemeyer H, Noll T (2011)
Biotechnology Letters 33(3): 495-502. -
2010 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2396494An integrated production process for human growth hormonePUB
Nottorf T, Büntemeyer H, Siwiora Brenke S, Lütkemeyer D, Loa A, Noll T, Lehmann J (2010)
In: ESACT Proceedings. Noll T, European Society of Animal Cell Technology (Eds); ESACT proceedings, 4. Dordrecht : Springer: 205-208. -
2010 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2396499O-glycans on recombinant MUC1 produced in CHO K1 cells becomes less sialylated with increased productivity as determined by LC ESI MSPUB
Bäckström M, Karlsson H, Gätgens J, Noll T, Hansson GC (2010)
In: ESACT Proceedings. Noll T, European Society of Animal Cell Technology (Eds); ESACT proceedings, 4. Dordrecht : Springer: 285-288. -
2010 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2396502Metabolome analysis in mammalian cells: Development and application of a sampling techniquePUB | DOI
Wiendahl C, Brandner JJ, Klein B, Küppers C, Luo B, Ritchie S, Mazurek S, Scheefers H, Noll T, Schygulla U, Oldiges M (2010)
In: ESACT Proceedings. Noll T, European Society of Animal Cell Technology (Eds); ESACT proceedings, 4. Dordrecht: Springer: 413-420. -
2010 | Herausgeber*in Sammelwerk | Veröffentlicht | PUB-ID: 2453825Cells and CulturePUB
Noll T, European Society of Animal Cell Technology (Eds) (2010) ESACT Proceedings; 4.
Dordrecht : Springer. -
2010 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2396497Proteomic characterization of a glucose-limited CHO perfusion process-analysis of metabolic changes and increase in productivityPUB
Wingens M, Gätgens J, Hoffrogge R, Noll T (2010)
In: ESACT Proceedings. Noll T, European Society of Animal Cell Technology (Eds); ESACT proceedings, 4. Dordrecht : Springer: 265-269. -
2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2396489Methods in mammalian cell line engineering: from random mutagenesis to sequence specific approachesPUB | DOI | WoS | PubMed | Europe PMC
Krämer O, Klausing S, Noll T (2010)
Applied Microbiology and Biotechnology 88(2): 425-436. -
2010 | Konferenzbeitrag | PUB-ID: 2396573Characterization of the novel human AGE1hn cell line for production of recombinant proteinsPUB
Northoff S, Büntemeyer H, Sandig V, Zietze S, Noll T (2010)
In: ESACT Proceedings. Noll T, European Society of Animal Cell Technology (Eds); ESACT proceedings, 4. Dordrecht : Spinger: 693-697. -
2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1929340CellViCAM-Cell viability classification for animal cell cultures using dark field micrographsPUB | DOI | WoS | PubMed | Europe PMC
Burgemeister S, Nattkemper TW, Noll T, Hoffrogge R, Flaschel E (2010)
JOURNAL OF BIOTECHNOLOGY 149(4): 310-316. -
2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1590674Adult Palatum as a Novel Source of Neural Crest-Related Stem CellsPUB | DOI | WoS | PubMed | Europe PMC
Widera D, Zander C, Heidbreder M, Kasperek Y, Noll T, Seitz O, Saldamli B, Sudhoff H, Sader R, Kaltschmidt C, Kaltschmidt B (2009)
Stem Cells 27(8): 1899-1910. -
2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2396483Application of immobilized bovine enterokinase in repetitive fusion protein cleavage for the production of MUC1PUB | DOI | PubMed | Europe PMC
Kubitzki T, Minör D, Mackfeld U, Noll T (2009)
Journal of Biotechnology 4(11): 1610-1618. -
2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2395472Primary cells as feeder cells for clinical co-culture expansion of human hematopoietic stem cells from umbilical cord blood – a comparative studyPUB | DOI | WoS | PubMed | Europe PMC
Magin S, Körfer N, Partenheimer H, Lange C, Zander A, Noll T (2009)
Stem Cell and Development 18(1): 173-186. -
2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2395445Localisation of O-glycans in MUC1 glycoproteins using electron-capture dissociation fragmentation mass spectrometryPUB | DOI | WoS | PubMed | Europe PMC
Sihlbom C, van Dijk Härd I, Lidell M, Noll T, Hansson G, Bäckström M (2009)
Glycobiology 19(4): 375-381. -
2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1633988Influence of culture conditions on recombinant Drosophila melanogaster S2 cells producing rabies virus glycoprotein cultivated in serum-free mediumPUB | DOI | WoS | PubMed | Europe PMC
Batista FRX, Moraes AM, Büntemeyer H, Noll T (2009)
BIOLOGICALS 37(2): 108-118. -
2008 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1592705Immunisation with 'naive' syngeneic dendritic cells protects mice from tumour challengePUB | DOI | WoS | PubMed | Europe PMC
Grimshaw MJ, Papazisis K, Picco G, Bohnenkamp H, Noll T, Taylor-Papadimitriou J, Burchell J (2008)
British Journal of Cancer 98(4): 784-791. -
2008 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1592236Immobilisation of bovine enterokinase and application of the immobilised enzyme in fusion protein cleavagePUB | DOI | WoS | PubMed | Europe PMC
Kubitzki T, Noll T, Luetz S (2008)
BIOPROCESS AND BIOSYSTEMS ENGINEERING 31(3): 173-182. -
2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1595232A microstructure heat exchanger for quenching the metabolism of mammalian cellsPUB | DOI | WoS
Wiendahl C, Brandner JJ, Kueppers C, Luo B, Schygulla U, Noll T, Oldiges M (2007)
CHEMICAL ENGINEERING & TECHNOLOGY 30(3): 322-328. -
2006 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2395430Systematic Screening of All Signal Peptides from Bacillus subtilis: A Powerful Strategy in Optimizing Heterologous Protein Secretion in Gram-positive BacteriaPUB | DOI | WoS | PubMed | Europe PMC
Brockmeier U, Caspers M, Freudl R, Jockwer A, Noll T, Eggert T (2006)
Journal of Molecular Biology 362(3): 393-402. -
2006 | Zeitschriftenaufsatz | PUB-ID: 2395413Human ST6GalNAcI localizes throughout the Golgi and is responsible for the expression of the sialyl-Tn O-glycan in breast cancersPUB
Sewell R, Dalziel M, Hansson G, Noll T, Clausen H, Burchell J, Taylor-Papadimitriou J (2006)
Journal of Biological Chemistry 281: 3586-3594. -
2005 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2395377Process development for standardized generation of monocyte-derived dendritic cells: Applicability in breast cancer immunotherapyPUB
Bohnenkamp H, Noll T (2005)
In: ESACT Proceedings., 2. Springer: 221-227. -
2005 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2395286Apoptosis of monocytes and the influence on yield of monocyte-derived dendritic cellsPUB | DOI | WoS | PubMed | Europe PMC
Bohnenkamp H, Burchell J, Taylor-Papadimitriou J, Noll T (2005)
Journal of Immunological Methods 294(1-2): 67-80. -
2005 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2395363Membrane-separated cocultivation of cord blood hematopoietic stem cells with stromal cell linesPUB
Fischbach K, Noll T (2005)
In: ESACT Proceedings., 2. Springer: 269-271. -
2005 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2395387Recombinant tumor associated MUC1 impairs differentiation and function of Dendritic CellsPUB
Rughetti A, Pellicciotta I, Biffoni M, Backström M, Noll T, Hansson G, Clausen H, Burchell J, Taylor-Papadimitriou J, Nuti M (2005)
Journal of Immunology 174(12): 7764-7772. -
2005 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2395311Development of metabolically optimized fermentation process based on glucose-limited CHO perfusion culturePUB
Link T, Essers R, Zörner K, de Graaf A, Bäckström M, Hansson G, Noll T (2005)
In: ESACT Proceedings., 2. Springer: 423-430. -
2004 | Zeitschriftenaufsatz | PUB-ID: 2395241Bioprocess development for a recombinant Mucin-1 fusion protein expressed by CHO cells in protein-free mediumPUB | DOI | WoS | PubMed | Europe PMC
Link T, Backstrom M, Graham R, Essers R, Zörner K, Gätgens J, Burchell J, Taylor-Papadimitriou J, Hansson G, Noll T (2004)
Journal of Biotechnology 110(1): 51-62. -
2003 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2395163Recombinant MUC1 with breast cancer-like O-glycosylation produced in large amounts in CHO-K1 cellsPUB
Bäckström M, Link T, Olson FJ, Karlsson H, Graham R, Picco G, Burchell J, Taylor-Papadimitriou J, Noll T (2003)
Biochemical Journal 376: 677-686. -
2003 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2395226Stammzellen – Möglichkeiten ihrer Expansion am Beispiel hämatopoetischer Stammzellen aus NabelschnurblutPUB
Noll T (2003)
Med Klin 98(Suppl II): 7-10. -
2003 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2395236Process Development for standardized generation of mature monocyte-derived dendritic cells suitable for clinical application, CytotechnologyPUB
Bohnenkamp H, Noll T (2003)
Cytotechnology 42: 121-131. -
2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2394881Cultivation of Hematopoietic Stem and Progenitor Cells: Biochemical Engineering AspectsPUB
Noll T, Jelinek N, Schmidt S, Biselli M, Wandrey M (2002)
Advances in Biochemical Engineering and Biotechnology 74: 111-128. -
2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2394913Improved product formation in high density Chinese hamster ovary cell cultures transfected at confluencyPUB
Noll T, Eisenkrätzer D, Kiesewetter A, Dinter A, Zeng S, Wandrey C, Biselli M, Berger EG (2002)
Biotechnological letters 24: 861-866. -
2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2394956Bioprocess Development for the Cultivation of human T-lymphocytes in a clinical scalePUB
Bohnenkamp H, Hilbert U, Noll T (2002)
Cytotechnology 38: 135-145. -
2002 | Zeitschriftenaufsatz | PUB-ID: 2395110'Identifizierung von Stoffwechsellimitierungen mit Hilfe der metabolic flux analysis am Beispiel des Nukleotidstoffwechsels von rekombinanten BHK-ZellenPUB
Paul W, Kribben T, Gätgens J, de Graaf A, Marx A, Noll T, Wandrey C (2002)
Chemie Ingenieur Technik 74(690). -
2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2395044Integrierte Bioprozessentwicklung zur Produktion eines potentiellen Tumorvaccins in rekombinanten CHO-ZellenPUB
Link T, Zörner K, Backström M, Hansson G, Wandrey C, Noll T (2002)
Chemie Ingenieur Technik 74(671). -
2001 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2393293Bioprocess Development for the cultivation of human T-lymphocytesPUB
Bohnenkamp H, Hilbert U, Noll T (2001)
Presented at the 17th European Society for Animal Cell Technology (ESACT) Meeting on Cell Based Technologies, Sweden. -
2001 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2393315Cultivation of human CMV-specific lymphocytes - an example for adoptive immunoterapyPUB
Hilbert U, Biselli M, Noll T (2001)
Presented at the 17th European Society for Animal Cell Technology (ESACT) Meeting on Cell Based Technologies, Sweden. -
2001 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2394851Metabolic flux analysis in mammalian cells - network modelling as an example for metabolic design in recombinant BHK cellsPUB
Paul W, de Graaf A, Marx A, Wagner R, Noll T (2001)
Presented at the 17th European Society for Animal Cell Technology (ESACT) Meeting on Cell Based Technologies, Sweden. -
2000 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2393281A cell culture reactor for the on-line evaluation of radiopharmaceuticals: Evaluation of the lumped constant of FDG in human glioma cellsPUB
Noll T (2000)
Journal of Nuclear Medicine 41(3): 556-564. -
1998 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2393268Dielectric spectroscopy in the cultivation of suspended and immobilized hybridoma cells.PUB
Noll T, M B (1998)
Journal of Biotechnology 63: 187-198. -
1997 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2393237On-line biomass monitoring of immobilized hybridoma cells by dielectrical measurementsPUB
Noll T, Biselli M, Wandrey C (1997)
Presented at the 14th European Society for Animal Cell Technology (ESACT) Meeting on Cell Based Technologies, Portugal.