Complete genome sequence, lifestyle, and multi-drug resistance of the human pathogen Corynebacterium resistens DSM 45100 isolated from blood samples of a leukemia patient

Schröder J, Maus I, Meyer K, Wördemann S, Blom J, Jaenicke S, Schneider J, Trost E, Tauch A (2012)
BMC Genomics 13(1): 141.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
Abstract / Bemerkung
BACKGROUND: Corynebacterium resistens was initially recovered from human infections and recognized as a new coryneform species that is highly resistant to antimicrobial agents. Bacteremia associated with this organism in immunocompromised patients was rapidly fatal as standard minocycline therapies failed. C. resistens DSM 45100 was isolated from a blood culture of samples taken from a patient with acute myelocytic leukemia. The complete genome sequence of C. resistens DSM 45100 was determined by pyrosequencing to identify genes contributing to multi-drug resistance, virulence, and the lipophilic lifestyle of this newly described human pathogen. RESULTS: The genome of C. resistens DSM 45100 consists of a circular chromosome of 2,601,311 bp in size and the 28,312-bp plasmid pJA144188. Metabolic analysis showed that the genome of C. resistens DSM 45100 lacks genes for typical sugar uptake systems, anaplerotic functions, and a fatty acid synthase, explaining the strict lipophilic lifestyle of this species. The genome encodes a broad spectrum of enzymes ensuring the availability of exogenous fatty acids for growth, including predicted virulence factors that probably contribute to fatty acid metabolism by damaging host tissue. C. resistens DSM 45100 is able to use external L-histidine as a combined carbon and nitrogen source, presumably as a result of adaptation to the hitherto unknown habitat on the human skin. Plasmid pJA144188 harbors several genes contributing to antibiotic resistance of C. resistens DSM 45100, including a tetracycline resistance region of the Tet W type known from Lactobacillus reuteri and Streptococcus suis. The tet(W) gene of pJA144188 was cloned in Corynebacterium glutamicum and was shown to confer high levels of resistance to tetracycline, doxycycline, and minocycline in vitro. CONCLUSIONS: The detected gene repertoire of C. resistens DSM 45100 provides insights into the lipophilic lifestyle and virulence functions of this newly recognized pathogen. Plasmid pJA144188 revealed a modular architecture of gene regions that contribute to the multi-drug resistance of C. resistens DSM 45100. The tet(W) gene encoding a ribosomal protection protein is reported here for the first time in corynebacteria. Cloning of the tet(W) gene mediated resistance to second generation tetracyclines in C. glutamicum, indicating that it might be responsible for the failure of minocycline therapies in patients with C. resistens bacteremia.
BMC Genomics
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Schröder J, Maus I, Meyer K, et al. Complete genome sequence, lifestyle, and multi-drug resistance of the human pathogen Corynebacterium resistens DSM 45100 isolated from blood samples of a leukemia patient. BMC Genomics. 2012;13(1): 141.
Schröder, J., Maus, I., Meyer, K., Wördemann, S., Blom, J., Jaenicke, S., Schneider, J., et al. (2012). Complete genome sequence, lifestyle, and multi-drug resistance of the human pathogen Corynebacterium resistens DSM 45100 isolated from blood samples of a leukemia patient. BMC Genomics, 13(1), 141. doi:10.1186/1471-2164-13-141
Schröder, Jasmin, Maus, Irena, Meyer, Katja, Wördemann, Stephanie, Blom, Jochen, Jaenicke, Sebastian, Schneider, Jessica, Trost, Eva, and Tauch, Andreas. 2012. “Complete genome sequence, lifestyle, and multi-drug resistance of the human pathogen Corynebacterium resistens DSM 45100 isolated from blood samples of a leukemia patient”. BMC Genomics 13 (1): 141.
Schröder, J., Maus, I., Meyer, K., Wördemann, S., Blom, J., Jaenicke, S., Schneider, J., Trost, E., and Tauch, A. (2012). Complete genome sequence, lifestyle, and multi-drug resistance of the human pathogen Corynebacterium resistens DSM 45100 isolated from blood samples of a leukemia patient. BMC Genomics 13:141.
Schröder, J., et al., 2012. Complete genome sequence, lifestyle, and multi-drug resistance of the human pathogen Corynebacterium resistens DSM 45100 isolated from blood samples of a leukemia patient. BMC Genomics, 13(1): 141.
J. Schröder, et al., “Complete genome sequence, lifestyle, and multi-drug resistance of the human pathogen Corynebacterium resistens DSM 45100 isolated from blood samples of a leukemia patient”, BMC Genomics, vol. 13, 2012, : 141.
Schröder, J., Maus, I., Meyer, K., Wördemann, S., Blom, J., Jaenicke, S., Schneider, J., Trost, E., Tauch, A.: Complete genome sequence, lifestyle, and multi-drug resistance of the human pathogen Corynebacterium resistens DSM 45100 isolated from blood samples of a leukemia patient. BMC Genomics. 13, : 141 (2012).
Schröder, Jasmin, Maus, Irena, Meyer, Katja, Wördemann, Stephanie, Blom, Jochen, Jaenicke, Sebastian, Schneider, Jessica, Trost, Eva, and Tauch, Andreas. “Complete genome sequence, lifestyle, and multi-drug resistance of the human pathogen Corynebacterium resistens DSM 45100 isolated from blood samples of a leukemia patient”. BMC Genomics 13.1 (2012): 141.
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Ramos JN, Souza C, Faria YV, da Silva EC, Veras JFC, Baio PVP, Seabra SH, de Oliveira Moreira L, Hirata Júnior R, Mattos-Guaraldi AL, Vieira VV., BMC Infect Dis 19(1), 2019
PMID: 31357945
Comparative evolutionary genomics of Corynebacterium with special reference to codon and amino acid usage diversities.
Pal S, Sarkar I, Roy A, Mohapatra PKD, Mondal KC, Sen A., Genetica 146(1), 2018
PMID: 28921302
Otitis in a cat associated with Corynebacterium provencense.
Kittl S, Brodard I, Rychener L, Jores J, Roosje P, Gobeli Brawand S., BMC Vet Res 14(1), 2018
PMID: 29940943
Occurrence of Corynebacterium striatum as an emerging antibiotic-resistant nosocomial pathogen in a Tunisian hospital.
Alibi S, Ferjani A, Boukadida J, Cano ME, Fernández-Martínez M, Martínez-Martínez L, Navas J., Sci Rep 7(1), 2017
PMID: 28848236
Insight of Genus Corynebacterium: Ascertaining the Role of Pathogenic and Non-pathogenic Species.
Oliveira A, Oliveira LC, Aburjaile F, Benevides L, Tiwari S, Jamal SB, Silva A, Figueiredo HCP, Ghosh P, Portela RW, De Carvalho Azevedo VA, Wattam AR., Front Microbiol 8(), 2017
PMID: 29075239
A microbiological and clinical review on Corynebacterium kroppenstedtii.
Tauch A, Fernández-Natal I, Soriano F., Int J Infect Dis 48(), 2016
PMID: 27155209
Characterization and antimicrobial susceptibility of one antibiotic-sensitive and one multidrug-resistant Corynebacterium kroppenstedtii strain isolated from patients with granulomatous mastitis.
Fernández-Natal I, Rodríguez-Lázaro D, Marrodán-Ciordia T, Sáez-Nieto JA, Valdezate S, Rodríguez-Pollán H, Tauch A, Soriano F., New Microbes New Infect 14(), 2016
PMID: 27818775
Susceptibility to Aminoglycosides and Distribution of aph and aac(3)-XI Genes among Corynebacterium striatum Clinical Isolates.
Navas J, Fernández-Martínez M, Salas C, Cano ME, Martínez-Martínez L., PLoS One 11(12), 2016
PMID: 27936101
Chassis organism from Corynebacterium glutamicum--a top-down approach to identify and delete irrelevant gene clusters.
Unthan S, Baumgart M, Radek A, Herbst M, Siebert D, Brühl N, Bartsch A, Bott M, Wiechert W, Marin K, Hans S, Krämer R, Seibold G, Frunzke J, Kalinowski J, Rückert C, Wendisch VF, Noack S., Biotechnol J 10(2), 2015
PMID: 25139579
Draft Genome Sequences of Corynebacterium kroppenstedtii CNM633/14 and CNM632/14, Multidrug-Resistant and Antibiotic-Sensitive Isolates from Nodules of Granulomatous Mastitis Patients.
Fernández-Natal MI, Soriano F, Ariza-Miguel J, Marrodan-Ciordia T, Acedo A, Hernandez M, Tauch A, Rodríguez-Lázaro D., Genome Announc 3(3), 2015
PMID: 25999560
Genome informatics and vaccine targets in Corynebacterium urealyticum using two whole genomes, comparative genomics, and reverse vaccinology.
Guimarães L, Soares S, Trost E, Blom J, Ramos R, Silva A, Barh D, Azevedo V., BMC Genomics 16 Suppl 5(), 2015
PMID: 26041051
Histidine biosynthesis, its regulation and biotechnological application in Corynebacterium glutamicum.
Kulis-Horn RK, Persicke M, Kalinowski J., Microb Biotechnol 7(1), 2014
PMID: 23617600
Draft Genome Sequence of the Multidrug-Resistant Clinical Isolate Dermabacter hominis 1368.
Albersmeier A, Bomholt C, Glaub A, Rückert C, Soriano F, Fernández-Natal I, Tauch A., Genome Announc 2(4), 2014
PMID: 25059872
novel 6'-n-aminoglycoside acetyltransferase AAC(6')-Iaj from a clinical isolate of Pseudomonas aeruginosa.
Tada T, Miyoshi-Akiyama T, Shimada K, Shimojima M, Kirikae T., Antimicrob Agents Chemother 57(1), 2013
PMID: 23070167
The pan-genome of the animal pathogen Corynebacterium pseudotuberculosis reveals differences in genome plasticity between the biovar ovis and equi strains.
Soares SC, Silva A, Trost E, Blom J, Ramos R, Carneiro A, Ali A, Santos AR, Pinto AC, Diniz C, Barbosa EG, Dorella FA, Aburjaile F, Rocha FS, Nascimento KK, Guimarães LC, Almeida S, Hassan SS, Bakhtiar SM, Pereira UP, Abreu VA, Schneider MP, Miyoshi A, Tauch A, Azevedo V., PLoS One 8(1), 2013
PMID: 23342011
Whole-Genome Sequence of the Clinical Strain Corynebacterium argentoratense DSM 44202, Isolated from a Human Throat Specimen.
Bomholt C, Glaub A, Gravermann K, Albersmeier A, Brinkrolf K, Rückert C, Tauch A., Genome Announc 1(5), 2013
PMID: 24092787
Pediatric fecal microbiota harbor diverse and novel antibiotic resistance genes.
Moore AM, Patel S, Forsberg KJ, Wang B, Bentley G, Razia Y, Qin X, Tarr PI, Dantas G., PLoS One 8(11), 2013
PMID: 24236055
Dermabacter hominis: a usually daptomycin-resistant gram-positive organism infrequently isolated from human clinical samples.
Fernández-Natal I, Sáez-Nieto JA, Medina-Pascual MJ, Albersmeier A, Valdezate S, Guerra-Laso JM, Rodríguez H, Marrodán T, Parras T, Tauch A, Soriano F., New Microbes New Infect 1(3), 2013
PMID: 25356327
Pangenomic study of Corynebacterium diphtheriae that provides insights into the genomic diversity of pathogenic isolates from cases of classical diphtheria, endocarditis, and pneumonia.
Trost E, Blom J, Soares Sde C, Huang IH, Al-Dilaimi A, Schröder J, Jaenicke S, Dorella FA, Rocha FS, Miyoshi A, Azevedo V, Schneider MP, Silva A, Camello TC, Sabbadini PS, Santos CS, Santos LS, Hirata R, Mattos-Guaraldi AL, Efstratiou A, Schmitt MP, Ton-That H, Tauch A., J Bacteriol 194(12), 2012
PMID: 22505676

125 References

Daten bereitgestellt von Europe PubMed Central.

Genomics of Actinobacteria: tracing the evolutionary history of an ancient phylum.
Ventura M, Canchaya C, Tauch A, Chandra G, Fitzgerald GF, Chater KF, van Sinderen D., Microbiol. Mol. Biol. Rev. 71(3), 2007
PMID: 17804669
Diphtheria remains a threat to health in the developing world--an overview.
Mattos-Guaraldi AL, Moreira LO, Damasco PV, Hirata Junior R., Mem. Inst. Oswaldo Cruz 98(8), 2003
PMID: 15049077
Clinical microbiology of coryneform bacteria.
Funke G, von Graevenitz A, Clarridge JE 3rd, Bernard KA., Clin. Microbiol. Rev. 10(1), 1997
PMID: 8993861
Characteristics of rare or recently described corynebacterium species recovered from human clinical material in Canada.
Bernard KA, Munro C, Wiebe D, Ongsansoy E., J. Clin. Microbiol. 40(11), 2002
PMID: 12409436
The Genus Corynebacterium--Medical
rpoB gene sequencing for identification of Corynebacterium species.
Khamis A, Raoult D, La Scola B., J. Clin. Microbiol. 42(9), 2004
PMID: 15364970
Corynebacterium endocarditis species-specific risk factors and outcomes.
Belmares J, Detterline S, Pak JB, Parada JP., BMC Infect. Dis. 7(), 2007
PMID: 17284316
Corynebacterium CDC group JK (Corynebacterium jeikeium) sepsis in haematological patients: a report of three cases and a systematic literature review.
van der Lelie H, Leverstein-Van Hall M, Mertens M, van Zaanen HC, van Oers RH, Thomas BL, von dem Borne AE, Kuijper EJ., Scand. J. Infect. Dis. 27(6), 1995
PMID: 8685637
In vitro activity of 79 antimicrobial agents against Corynebacterium group D2.
Garcia-Rodriguez JA, Garcia Sanchez JE, Munoz Bellido JL, Nebreda Mayoral T, Garcia Sanchez E, Garcia Garcia I., Antimicrob. Agents Chemother. 35(10), 1991
PMID: 1759839
Biochemical, antimicrobial susceptibility and genotyping studies on Corynebacterium urealyticum isolates from diverse sources.
Nieto E, Vindel A, Valero-Guillen PL, Saez-Nieto JA, Soriano F., J. Med. Microbiol. 49(8), 2000
PMID: 10933263
Influence of external factors in resistance of Corynebacterium urealyticum to antimicrobial agents.
Garcia-Bravo M, Aguado JM, Morales JM, Noriega AR., Antimicrob. Agents Chemother. 40(2), 1996
PMID: 8834909
Corynebacterium resistens sp. nov., a new multidrug-resistant coryneform bacterium isolated from human infections.
Otsuka Y, Kawamura Y, Koyama T, Iihara H, Ohkusu K, Ezaki T., J. Clin. Microbiol. 43(8), 2005
PMID: 16081900
The tetracycline resistome.
Thaker M, Spanogiannopoulos P, Wright GD., Cell. Mol. Life Sci. 67(3), 2009
PMID: 19862477
Consed: a graphical tool for sequence finishing.
Gordon D, Abajian C, Green P., Genome Res. 8(3), 1998
PMID: 9521923
GenDB--an open source genome annotation system for prokaryote genomes.
Meyer F, Goesmann A, McHardy AC, Bartels D, Bekel T, Clausen J, Kalinowski J, Linke B, Rupp O, Giegerich R, Puhler A., Nucleic Acids Res. 31(8), 2003
PMID: 12682369
RNAmmer: consistent and rapid annotation of ribosomal RNA genes.
Lagesen K, Hallin P, Rodland EA, Staerfeldt HH, Rognes T, Ussery DW., Nucleic Acids Res. 35(9), 2007
PMID: 17452365
Selection for chromosome architecture in bacteria.
Hendrickson H, Lawrence JG., J. Mol. Evol. 62(5), 2006
PMID: 16612541
EDGAR: a software framework for the comparative analysis of prokaryotic genomes.
Blom J, Albaum SP, Doppmeier D, Puhler A, Vorholter FJ, Zakrzewski M, Goesmann A., BMC Bioinformatics 10(), 2009
PMID: 19457249
The genome stability in Corynebacterium species due to lack of the recombinational repair system.
Nakamura Y, Nishio Y, Ikeo K, Gojobori T., Gene 317(1-2), 2003
PMID: 14604803
The lifestyle of Corynebacterium urealyticum derived from its complete genome sequence established by pyrosequencing.
Tauch A, Trost E, Tilker A, Ludewig U, Schneiker S, Goesmann A, Arnold W, Bekel T, Brinkrolf K, Brune I, Gotker S, Kalinowski J, Kamp PB, Lobo FP, Viehoever P, Weisshaar B, Soriano F, Droge M, Puhler A., J. Biotechnol. 136(1-2), 2008
PMID: 18367281
Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora.
Tauch A, Kaiser O, Hain T, Goesmann A, Weisshaar B, Albersmeier A, Bekel T, Bischoff N, Brune I, Chakraborty T, Kalinowski J, Meyer F, Rupp O, Schneiker S, Viehoever P, Puhler A., J. Bacteriol. 187(13), 2005
PMID: 15968079
Ultrafast pyrosequencing of Corynebacterium kroppenstedtii DSM44385 revealed insights into the physiology of a lipophilic corynebacterium that lacks mycolic acids.
Tauch A, Schneider J, Szczepanowski R, Tilker A, Viehoever P, Gartemann KH, Arnold W, Blom J, Brinkrolf K, Brune I, Gotker S, Weisshaar B, Goesmann A, Droge M, Puhler A., J. Biotechnol. 136(1-2), 2008
PMID: 18430482
Flip-flop around the origin and terminus of replication in prokaryotic genomes.
Mackiewicz P, Mackiewicz D, Kowalczuk M, Cebrat S., Genome Biol. 2(12), 2001
PMID: 11790247
Essentiality, not expressiveness, drives gene-strand bias in bacteria.
Rocha EP, Danchin A., Nat. Genet. 34(4), 2003
PMID: 12847524
High-throughput transposon mutagenesis of Corynebacterium glutamicum and construction of a single-gene disruptant mutant library.
Suzuki N, Okai N, Nonaka H, Tsuge Y, Inui M, Yukawa H., Appl. Environ. Microbiol. 72(5), 2006
PMID: 16672528
CRISPRFinder: a web tool to identify clustered regularly interspaced short palindromic repeats.
Grissa I, Vergnaud G, Pourcel C., Nucleic Acids Res. 35(Web Server issue), 2007
PMID: 17537822
The complete genomic sequence of Nocardia farcinica IFM 10152.
Ishikawa J, Yamashita A, Mikami Y, Hoshino Y, Kurita H, Hotta K, Shiba T, Hattori M., Proc. Natl. Acad. Sci. U.S.A. 101(41), 2004
PMID: 15466710
CRISPR provides acquired resistance against viruses in prokaryotes.
Barrangou R, Fremaux C, Deveau H, Richards M, Boyaval P, Moineau S, Romero DA, Horvath P., Science 315(5819), 2007
PMID: 17379808
Corynebacterium glutamicum: a dissection of the PTS.
Parche S, Burkovski A, Sprenger GA, Weil B, Kramer R, Titgemeyer F., J. Mol. Microbiol. Biotechnol. 3(3), 2001
PMID: 11361073
The LacI/GalR family transcriptional regulator UriR negatively controls uridine utilization of Corynebacterium glutamicum by binding to catabolite-responsive element (cre)-like sequences.
Brinkrolf K, Ploger S, Solle S, Brune I, Nentwich SS, Huser AT, Kalinowski J, Puhler A, Tauch A., Microbiology (Reading, Engl.) 154(Pt 4), 2008
PMID: 18375800
Microbial type I fatty acid synthases (FAS): major players in a network of cellular FAS systems.
Schweizer E, Hofmann J., Microbiol. Mol. Biol. Rev. 68(3), 2004
PMID: 15353567
The Pks13/FadD32 crosstalk for the biosynthesis of mycolic acids in Mycobacterium tuberculosis.
Gavalda S, Leger M, van der Rest B, Stella A, Bardou F, Montrozier H, Chalut C, Burlet-Schiltz O, Marrakchi H, Daffe M, Quemard A., J. Biol. Chem. 284(29), 2009
PMID: 19436070
FadD is required for utilization of endogenous fatty acids released from membrane lipids.
Pech-Canul A, Nogales J, Miranda-Molina A, Alvarez L, Geiger O, Soto MJ, Lopez-Lara IM., J. Bacteriol. 193(22), 2011
PMID: 21926226
beta-oxidation - strategies for the metabolism of a wide variety of acyl-CoA esters.
Hiltunen JK, Qin Y., Biochim. Biophys. Acta 1484(2-3), 2000
PMID: 10760462
Role of the methylcitrate cycle in Mycobacterium tuberculosis metabolism, intracellular growth, and virulence.
Munoz-Elias EJ, Upton AM, Cherian J, McKinney JD., Mol. Microbiol. 60(5), 2006
PMID: 16689789
A polyketide synthase catalyzes the last condensation step of mycolic acid biosynthesis in mycobacteria and related organisms.
Portevin D, De Sousa-D'Auria C, Houssin C, Grimaldi C, Chami M, Daffe M, Guilhot C., Proc. Natl. Acad. Sci. U.S.A. 101(1), 2003
PMID: 14695899
The reductase that catalyzes mycolic motif synthesis is required for efficient attachment of mycolic acids to arabinogalactan.
Lea-Smith DJ, Pyke JS, Tull D, McConville MJ, Coppel RL, Crellin PK., J. Biol. Chem. 282(15), 2007
PMID: 17308303
Identification of a stress-induced factor of Corynebacterineae that is involved in the regulation of the outer membrane lipid composition.
Meniche X, Labarre C, de Sousa-d'Auria C, Huc E, Laval F, Tropis M, Bayan N, Portevin D, Guilhot C, Daffe M, Houssin C., J. Bacteriol. 191(23), 2009
PMID: 19801408
Identification of Corynebacterium glucuronolyticum strains from the urogenital tract of humans and pigs.
Devriese LA, Riegel P, Hommez J, Vaneechoutte M, de Baere T, Haesebrouck F., J. Clin. Microbiol. 38(12), 2000
PMID: 11101617
Taxonomic characterization of nine strains isolated from clinical and environmental specimens, and proposal of Corynebacterium tuberculostearicum sp. nov.
Feurer C, Clermont D, Bimet F, Candrea A, Jackson M, Glaser P, Bizet C, Dauga C., Int. J. Syst. Evol. Microbiol. 54(Pt 4), 2004
PMID: 15280269
Corynebacterium pseudogenitalium urinary tract infection.
Vedel G, Toussaint G, Riegel P, Fouilladieu JL, Billoet A, Poyart C., Emerging Infect. Dis. 12(2), 2006
PMID: 17080582
Corynebacterium lipophiloflavum sp. nov. isolated from a patient with bacterial vaginosis.
Funke G, Hutson RA, Hilleringmann M, Heizmann WR, Collins MD., FEMS Microbiol. Lett. 150(2), 1997
PMID: 9170265
Complete genome sequence and lifestyle of black-pigmented Corynebacterium aurimucosum ATCC 700975 (formerly C. nigricans CN-1) isolated from a vaginal swab of a woman with spontaneous abortion.
Trost E, Gotker S, Schneider J, Schneiker-Bekel S, Szczepanowski R, Tilker A, Viehoever P, Arnold W, Bekel T, Blom J, Gartemann KH, Linke B, Goesmann A, Puhler A, Shukla SK, Tauch A., BMC Genomics 11(), 2010
PMID: 20137072
Histidine in human vaginal fluid.
Dusitsin N, Gregoire AT, Johnson WD, Rakoff AE., Obstet Gynecol 29(1), 1967
PMID: 4289424
Coryneform bacteria in infectious diseases: clinical and laboratory aspects.
Coyle MB, Lipsky BA., Clin. Microbiol. Rev. 3(3), 1990
PMID: 2116939
The NIH Human Microbiome Project.
NIH HMP Working Group, Peterson J, Garges S, Giovanni M, McInnes P, Wang L, Schloss JA, Bonazzi V, McEwen JE, Wetterstrand KA, Deal C, Baker CC, Di Francesco V, Howcroft TK, Karp RW, Lunsford RD, Wellington CR, Belachew T, Wright M, Giblin C, David H, Mills M, Salomon R, Mullins C, Akolkar B, Begg L, Davis C, Grandison L, Humble M, Khalsa J, Little AR, Peavy H, Pontzer C, Portnoy M, Sayre MH, Starke-Reed P, Zakhari S, Read J, Watson B, Guyer M., Genome Res. 19(12), 2009
PMID: 19819907
A neural network method for identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites.
Nielsen H, Engelbrecht J, Brunak S, von Heijne G., Int J Neural Syst 8(5-6), 1997
PMID: 10065837
Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A, Larsson B, von Heijne G, Sonnhammer EL., J. Mol. Biol. 305(3), 2001
PMID: 11152613
Sortase transpeptidases: insights into mechanism, substrate specificity, and inhibition.
Clancy KW, Melvin JA, McCafferty DG., Biopolymers 94(4), 2010
PMID: 20593474
Large, identical, tandem repeating units in the C protein alpha antigen gene, bca, of group B streptococci.
Michel JL, Madoff LC, Olson K, Kling DE, Kasper DL, Ausubel FM., Proc. Natl. Acad. Sci. U.S.A. 89(21), 1992
PMID: 1438195
Adhesion by pathogenic corynebacteria.
Rogers EA, Das A, Ton-That H., Adv. Exp. Med. Biol. 715(), 2011
PMID: 21557059
Corynebacterium diphtheriae employs specific minor pilins to target human pharyngeal epithelial cells.
Mandlik A, Swierczynski A, Das A, Ton-That H., Mol. Microbiol. 64(1), 2007
PMID: 17376076
A mycobacterial enzyme essential for cell division synergizes with resuscitation-promoting factor.
Hett EC, Chao MC, Deng LL, Rubin EJ., PLoS Pathog. 4(2), 2008
PMID: 18463693
Corynebacterium diphtheriae invasion-associated protein (DIP1281) is involved in cell surface organization, adhesion and internalization in epithelial cells.
Ott L, Holler M, Gerlach RG, Hensel M, Rheinlaender J, Schaffer TE, Burkovski A., BMC Microbiol. 10(), 2010
PMID: 20051108
CDD: a Conserved Domain Database for the functional annotation of proteins.
Marchler-Bauer A, Lu S, Anderson JB, Chitsaz F, Derbyshire MK, DeWeese-Scott C, Fong JH, Geer LY, Geer RC, Gonzales NR, Gwadz M, Hurwitz DI, Jackson JD, Ke Z, Lanczycki CJ, Lu F, Marchler GH, Mullokandov M, Omelchenko MV, Robertson CL, Song JS, Thanki N, Yamashita RA, Zhang D, Zhang N, Zheng C, Bryant SH., Nucleic Acids Res. 39(Database issue), 2010
PMID: 21109532
Identification of Corynebacterium diphtheriae gene involved in adherence to epithelial cells.
Kolodkina V, Denisevich T, Titov L., Infect. Genet. Evol. 11(2), 2010
PMID: 21111065
Oxidation of macrophage membrane cholesterol by intracellular Rhodococcus equi.
Linder R, Bernheimer AW., Vet. Microbiol. 56(3-4), 1997
PMID: 9226841
Cholesterol oxidase is required for virulence of Mycobacterium tuberculosis.
Brzostek A, Dziadek B, Rumijowska-Galewicz A, Pawelczyk J, Dziadek J., FEMS Microbiol. Lett. 275(1), 2007
PMID: 17651430
Cholesterol oxidase: sources, physical properties and analytical applications.
MacLachlan J, Wotherspoon AT, Ansell RO, Brooks CJ., J. Steroid Biochem. Mol. Biol. 72(5), 2000
PMID: 10822008
Molecular cloning and characterization of the alkaline ceramidase from Pseudomonas aeruginosa PA01.
Nieuwenhuizen WF, van Leeuwen S, Jack RW, Egmond MR, Gotz F., Protein Expr. Purif. 30(1), 2003
PMID: 12821326
Secreted lipases of Candida albicans: cloning, characterisation and expression analysis of a new gene family with at least ten members.
Hube B, Stehr F, Bossenz M, Mazur A, Kretschmar M, Schafer W., Arch. Microbiol. 174(5), 2000
PMID: 11131027
GDSL family of serine esterases/lipases.
Akoh CC, Lee GC, Liaw YC, Huang TH, Shaw JF., Prog. Lipid Res. 43(6), 2004
PMID: 15522763
The beta-lactam-sensitive D,D-carboxypeptidase activity of Pbp4 controls the L,D and D,D transpeptidation pathways in Corynebacterium jeikeium.
Lavollay M, Arthur M, Fourgeaud M, Dubost L, Marie A, Riegel P, Gutmann L, Mainardi JL., Mol. Microbiol. 74(3), 2009
PMID: 19807868
Mechanisms of fluoroquinolone resistance.
Hooper DC., Drug Resist. Updat. 2(1), 1999
PMID: 11504468
High-level fluoroquinolone resistance in ophthalmic clinical isolates belonging to the species Corynebacterium macginleyi.
Eguchi H, Kuwahara T, Miyamoto T, Nakayama-Imaohji H, Ichimura M, Hayashi T, Shiota H., J. Clin. Microbiol. 46(2), 2007
PMID: 18077650
Relationship between mutations in the gyrA gene and quinolone resistance in clinical isolates of Corynebacterium striatum and Corynebacterium amycolatum.
Sierra JM, Martinez-Martinez L, Vazquez F, Giralt E, Vila J., Antimicrob. Agents Chemother. 49(5), 2005
PMID: 15855486
Plasmids in Corynebacterium glutamicum and their molecular classification by comparative genomics.
Tauch A, Puhler A, Kalinowski J, Thierbach G., J. Biotechnol. 104(1-3), 2003
PMID: 12948627
Characterization of pGA1, a new plasmid from Corynebacterium glutamicum LP-6.
Sonnen H, Thierbach G, Kautz S, Kalinowski J, Schneider J, Puhler A, Kutzner HJ., Gene 107(1), 1991
PMID: 1660431
Facile recovery of individual high-molecular-weight, low-copy-number natural plasmids for genomic sequencing.
Williams LE, Detter C, Barry K, Lapidus A, Summers AO., Appl. Environ. Microbiol. 72(7), 2006
PMID: 16820486
Control of plasmid DNA replication by iterons: no longer paradoxical.
Chattoraj DK., Mol. Microbiol. 37(3), 2000
PMID: 10931340
Insights into erythromycin action from studies of its activity as inducer of resistance.
Weisblum B., Antimicrob. Agents Chemother. 39(4), 1995
PMID: 7785974
Plasmids in Corynebacterium diphtheriae and diphtheroids mediating erythromycin resistance.
Schiller J, Groman N, Coyle M., Antimicrob. Agents Chemother. 18(5), 1980
PMID: 6255866
Inducible macrolide resistance in Corynebacterium jeikeium.
Rosato AE, Lee BS, Nash KA., Antimicrob. Agents Chemother. 45(7), 2001
PMID: 11408212
Macrolide myths.
Mankin AS., Curr. Opin. Microbiol. 11(5), 2008
PMID: 18804176
Determination of nucleotide sequence of Corynebacterium plasmid pXZ10145.
Shen T, Jia P, Na S, Men D., Chin. J. Biotechnol. 9(3), 1993
PMID: 8049348
Antibiotic use in plant agriculture.
McManus PS, Stockwell VO, Sundin GW, Jones AL., Annu Rev Phytopathol 40(), 2002
PMID: 12147767
Versatility of aminoglycosides and prospects for their future.
Vakulenko SB, Mobashery S., Clin. Microbiol. Rev. 16(3), 2003
PMID: 12857776
Integrons: an antibiotic resistance gene capture and expression system.
Ploy MC, Lambert T, Couty JP, Denis F., Clin. Chem. Lab. Med. 38(6), 2000
PMID: 10987194
Gene cassettes and cassette arrays in mobile resistance integrons.
Partridge SR, Tsafnat G, Coiera E, Iredell JR., FEMS Microbiol. Rev. 33(4), 2009
PMID: 19416365
Nosocomial spread of ceftazidime-resistant Klebsiella pneumoniae strains producing a novel class a beta-lactamase, GES-3, in a neonatal intensive care unit in Japan.
Wachino J, Doi Y, Yamane K, Shibata N, Yagi T, Kubota T, Ito H, Arakawa Y., Antimicrob. Agents Chemother. 48(6), 2004
PMID: 15155185
Characterization of a novel plasmid-mediated cephalosporinase (CMY-9) and its genetic environment in an Escherichia coli clinical isolate.
Doi Y, Shibata N, Shibayama K, Kamachi K, Kurokawa H, Yokoyama K, Yagi T, Arakawa Y., Antimicrob. Agents Chemother. 46(8), 2002
PMID: 12121914
The chloramphenicol acetyltransferase gene of Tn2424: a new breed of cat.
Parent R, Roy PH., J. Bacteriol. 174(9), 1992
PMID: 1314803
An integron of class 1 is present on the plasmid pCG4 from gram-positive bacterium Corynebacterium glutamicum.
Nesvera J, Hochmannova J, Patek M., FEMS Microbiol. Lett. 169(2), 1998
PMID: 9868786
Ribosomal protection proteins and their mechanism of tetracycline resistance.
Connell SR, Tracz DM, Nierhaus KH, Taylor DE., Antimicrob. Agents Chemother. 47(12), 2003
PMID: 14638464
Genetic diversity of Streptococcus suis clinical isolates from pigs and humans in Italy (2003-2007).
Princivalli MS, Palmieri C, Magi G, Vignaroli C, Manzin A, Camporese A, Barocci S, Magistrali C, Facinelli B., Euro Surveill. 14(33), 2009
PMID: 19712640
Comparative analysis of sequences flanking tet(W) resistance genes in multiple species of gut bacteria.
Kazimierczak KA, Flint HJ, Scott KP., Antimicrob. Agents Chemother. 50(8), 2006
PMID: 16870752
Evidence that tetracycline analogs whose primary target is not the bacterial ribosome cause lysis of Escherichia coli.
Oliva B, Gordon G, McNicholas P, Ellestad G, Chopra I., Antimicrob. Agents Chemother. 36(5), 1992
PMID: 1510413
Molecular basis of tetracycline action: identification of analogs whose primary target is not the bacterial ribosome.
Rasmussen B, Noller HF, Daubresse G, Oliva B, Misulovin Z, Rothstein DM, Ellestad GA, Gluzman Y, Tally FP, Chopra I., Antimicrob. Agents Chemother. 35(11), 1991
PMID: 1725100
Cloning and nucleotide sequence of a chromosomally encoded tetracycline resistance determinant, tetA(M), from a pathogenic, methicillin-resistant strain of Staphylococcus aureus.
Nesin M, Svec P, Lupski JR, Godson GN, Kreiswirth B, Kornblum J, Projan SJ., Antimicrob. Agents Chemother. 34(11), 1990
PMID: 2073121
Characterization of antibiotic-resistant Corynebacterium striatum strains.
Roberts MC, Leonard RB, Briselden A, Schoenknecht FD, Coyle MB., J. Antimicrob. Chemother. 30(4), 1992
PMID: 1490919
Clonal multidrug-resistant Corynebacterium striatum strains, Italy.
Campanile F, Carretto E, Barbarini D, Grigis A, Falcone M, Goglio A, Venditti M, Stefani S., Emerging Infect. Dis. 15(1), 2009
PMID: 19116057


DNAPlotter: circular and linear interactive genome visualization.
Carver T, Thomson N, Bleasby A, Berriman M, Parkhill J., Bioinformatics 25(1), 2008
PMID: 18990721
CARMEN - Comparative Analysis and in silico Reconstruction of organism-specific MEtabolic Networks.
Schneider J, Vorholter FJ, Trost E, Blom J, Musa YR, Neuweger H, Niehaus K, Schatschneider S, Tauch A, Goesmann A., Genet. Mol. Res. 9(3), 2010
PMID: 20799163
Methods for Antimicrobial Dilution and Disk Susceptibility Testing of Infrequently Isolated or Fastidious Bacteria: Approved Guideline
Corynebacterium glutamicum DNA is subjected to methylation-restriction in Escherichia coli.
Tauch A, Kirchner O, Wehmeier L, Kalinowski J, Puhler A., FEMS Microbiol. Lett. 123(3), 1994
PMID: 7988915
Efficient electrotransformation of corynebacterium diphtheriae with a mini-replicon derived from the Corynebacterium glutamicum plasmid pGA1.
Tauch A, Kirchner O, Loffler B, Gotker S, Puhler A, Kalinowski J., Curr. Microbiol. 45(5), 2002
PMID: 12232668
The IclR-type transcriptional repressor LtbR regulates the expression of leucine and tryptophan biosynthesis genes in the amino acid producer Corynebacterium glutamicum.
Brune I, Jochmann N, Brinkrolf K, Huser AT, Gerstmeir R, Eikmanns BJ, Kalinowski J, Puhler A, Tauch A., J. Bacteriol. 189(7), 2007
PMID: 17259312

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