Comparative Genome Biology of a Serogroup B Carriage and Disease Strain Supports a Polygenic Nature of Meningococcal Virulence
Joseph B, Schneiker-Bekel S, Schramm-Glueck A, Blom J, Claus H, Linke B, Schwarz RF, Becker A, Goesmann A, Frosch M, Schoen C (2010)
JOURNAL OF BACTERIOLOGY 192(20): 5363-5377.
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Autor*in
Joseph, Biju;
Schneiker-Bekel, SusanneUniBi;
Schramm-Glueck, Anja;
Blom, JochenUniBi;
Claus, Heike;
Linke, BurkhardUniBi;
Schwarz, Roland F.;
Becker, Anke;
Goesmann, AlexanderUniBi ;
Frosch, Matthias;
Schoen, Christoph
Einrichtung
Centrum für Biotechnologie > Arbeitsgruppe A. Goesmann
Technische Fakultät > Computational Genomics
Centrum für Biotechnologie > Technologieplattformen > Bioinformatics Resource Facility
Centrum für Biotechnologie > Institut für Genomforschung und Systembiologie
Technische Fakultät > AG Genominformatik
Centrum für Biotechnologie > Institut für Bioinformatik
Centrum für Biotechnologie > Graduate Center
Technische Fakultät > Computational Genomics
Centrum für Biotechnologie > Technologieplattformen > Bioinformatics Resource Facility
Centrum für Biotechnologie > Institut für Genomforschung und Systembiologie
Technische Fakultät > AG Genominformatik
Centrum für Biotechnologie > Institut für Bioinformatik
Centrum für Biotechnologie > Graduate Center
Abstract / Bemerkung
Neisseria meningitidis serogroup B strains are responsible for most meningococcal cases in the industrialized countries, and strains belonging to the clonal complex ST-41/44 are among the most prevalent serogroup B strains in carriage and disease. Here, we report the first genome and transcriptome comparison of a serogroup B carriage strain from the clonal complex ST-41/44 to the serogroup B disease strain MC58 from the clonal complex ST-32. Both genomes are highly colinear, with only three major genome rearrangements that are associated with the integration of mobile genetic elements. They further differ in about 10% of their gene content, with the highest variability in gene presence as well as gene sequence found for proteins involved in host cell interactions, including Opc, NadA, TonB-dependent receptors, RTX toxin, and two-partner secretion system proteins. Whereas housekeeping genes coding for metabolic functions were highly conserved, there were considerable differences in their expression pattern upon adhesion to human nasopharyngeal cells between both strains, including differences in energy metabolism and stress response. In line with these genomic and transcriptomic differences, both strains also showed marked differences in their in vitro infectivity and in serum resistance. Taken together, these data support the concept of a polygenic nature of meningococcal virulence comprising differences in the repertoire of adhesins as well as in the regulation of metabolic genes and suggest a prominent role for immune selection and genetic drift in shaping the meningococcal genome.
Erscheinungsjahr
2010
Zeitschriftentitel
JOURNAL OF BACTERIOLOGY
Band
192
Ausgabe
20
Seite(n)
5363-5377
ISSN
0021-9193
Page URI
https://pub.uni-bielefeld.de/record/1930110
Zitieren
Joseph B, Schneiker-Bekel S, Schramm-Glueck A, et al. Comparative Genome Biology of a Serogroup B Carriage and Disease Strain Supports a Polygenic Nature of Meningococcal Virulence. JOURNAL OF BACTERIOLOGY. 2010;192(20):5363-5377.
Joseph, B., Schneiker-Bekel, S., Schramm-Glueck, A., Blom, J., Claus, H., Linke, B., Schwarz, R. F., et al. (2010). Comparative Genome Biology of a Serogroup B Carriage and Disease Strain Supports a Polygenic Nature of Meningococcal Virulence. JOURNAL OF BACTERIOLOGY, 192(20), 5363-5377. https://doi.org/10.1128/JB.00883-10
Joseph, Biju, Schneiker-Bekel, Susanne, Schramm-Glueck, Anja, Blom, Jochen, Claus, Heike, Linke, Burkhard, Schwarz, Roland F., et al. 2010. “Comparative Genome Biology of a Serogroup B Carriage and Disease Strain Supports a Polygenic Nature of Meningococcal Virulence”. JOURNAL OF BACTERIOLOGY 192 (20): 5363-5377.
Joseph, B., Schneiker-Bekel, S., Schramm-Glueck, A., Blom, J., Claus, H., Linke, B., Schwarz, R. F., Becker, A., Goesmann, A., Frosch, M., et al. (2010). Comparative Genome Biology of a Serogroup B Carriage and Disease Strain Supports a Polygenic Nature of Meningococcal Virulence. JOURNAL OF BACTERIOLOGY 192, 5363-5377.
Joseph, B., et al., 2010. Comparative Genome Biology of a Serogroup B Carriage and Disease Strain Supports a Polygenic Nature of Meningococcal Virulence. JOURNAL OF BACTERIOLOGY, 192(20), p 5363-5377.
B. Joseph, et al., “Comparative Genome Biology of a Serogroup B Carriage and Disease Strain Supports a Polygenic Nature of Meningococcal Virulence”, JOURNAL OF BACTERIOLOGY, vol. 192, 2010, pp. 5363-5377.
Joseph, B., Schneiker-Bekel, S., Schramm-Glueck, A., Blom, J., Claus, H., Linke, B., Schwarz, R.F., Becker, A., Goesmann, A., Frosch, M., Schoen, C.: Comparative Genome Biology of a Serogroup B Carriage and Disease Strain Supports a Polygenic Nature of Meningococcal Virulence. JOURNAL OF BACTERIOLOGY. 192, 5363-5377 (2010).
Joseph, Biju, Schneiker-Bekel, Susanne, Schramm-Glueck, Anja, Blom, Jochen, Claus, Heike, Linke, Burkhard, Schwarz, Roland F., Becker, Anke, Goesmann, Alexander, Frosch, Matthias, and Schoen, Christoph. “Comparative Genome Biology of a Serogroup B Carriage and Disease Strain Supports a Polygenic Nature of Meningococcal Virulence”. JOURNAL OF BACTERIOLOGY 192.20 (2010): 5363-5377.
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Gardy JL, Laird MR, Chen F, Rey S, Walsh CJ, Ester M, Brinkman FS., Bioinformatics 21(5), 2004
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Grifantini R, Bartolini E, Muzzi A, Draghi M, Frigimelica E, Berger J, Randazzo F, Grandi G., Ann. N. Y. Acad. Sci. 975(), 2002
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Hamilton S, Bongaerts RJ, Mulholland F, Cochrane B, Porter J, Lucchini S, Lappin-Scott HM, Hinton JC., BMC Genomics 10(), 2009
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Harrison LH, Trotter CL, Ramsay ME., Vaccine 27 Suppl 2(), 2009
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Kawai M, Uchiyama I, Kobayashi I., DNA Res. 12(6), 2005
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Kuo CH, Moran NA, Ochman H., Genome Res. 19(8), 2009
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Lappann M, Haagensen JA, Claus H, Vogel U, Molin S., Mol. Microbiol. 62(5), 2006
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Liu Y, Harrison PM, Kunin V, Gerstein M., Genome Biol. 5(9), 2004
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Lo H, Tang CM, Exley RM., Lancet Infect Dis 9(7), 2009
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Maiden MC., Curr. Opin. Microbiol. 11(5), 2008
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Osicka R, Kalmusova J, Krizova P, Sebo P., Infect. Immun. 69(9), 2001
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Peng J, Yang L, Yang F, Yang J, Yan Y, Nie H, Zhang X, Xiong Z, Jiang Y, Cheng F, Xu X, Chen S, Sun L, Li W, Shen Y, Shao Z, Liang X, Xu J, Jin Q., Genomics 91(1), 2007
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Rocha EP, Smith JM, Hurst LD, Holden MT, Cooper JE, Smith NH, Feil EJ., J. Theor. Biol. 239(2), 2005
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Roussel-Jazede V, Jongerius I, Bos MP, Tommassen J, van Ulsen P., Infect. Immun. 78(7), 2010
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NeMeSys: a biological resource for narrowing the gap between sequence and function in the human pathogen Neisseria meningitidis.
Rusniok C, Vallenet D, Floquet S, Ewles H, Mouze-Soulama C, Brown D, Lajus A, Buchrieser C, Medigue C, Glaser P, Pelicic V., Genome Biol. 10(10), 2009
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Saunders NJ, Snyder LA., Microbiology (Reading, Engl.) 148(Pt 12), 2002
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Scarselli M, Serruto D, Montanari P, Capecchi B, Adu-Bobie J, Veggi D, Rappuoli R, Pizza M, Arico B., Mol. Microbiol. 61(3), 2006
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Schmitt C, Turner D, Boesl M, Abele M, Frosch M, Kurzai O., J. Bacteriol. 189(22), 2007
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Schneider MC, Exley RM, Ram S, Sim RB, Tang CM., Trends Microbiol. 15(5), 2007
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Schoen C, Blom J, Claus H, Schramm-Gluck A, Brandt P, Muller T, Goesmann A, Joseph B, Konietzny S, Kurzai O, Schmitt C, Friedrich T, Linke B, Vogel U, Frosch M., Proc. Natl. Acad. Sci. U.S.A. 105(9), 2008
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Schoen C, Tettelin H, Parkhill J, Frosch M., Vaccine 27 Suppl 2(), 2009
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Schwarz R, Joseph B, Gerlach G, Schramm-Gluck A, Engelhard K, Frosch M, Muller T, Schoen C., J. Clin. Microbiol. 48(9), 2010
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Serruto D, Spadafina T, Ciucchi L, Lewis LA, Ram S, Tontini M, Santini L, Biolchi A, Seib KL, Giuliani MM, Donnelly JJ, Berti F, Savino S, Scarselli M, Costantino P, Kroll JS, O'Dwyer C, Qiu J, Plaut AG, Moxon R, Rappuoli R, Pizza M, Arico B., Proc. Natl. Acad. Sci. U.S.A. 107(8), 2010
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AUTHOR UNKNOWN, 2005
The majority of genes in the pathogenic Neisseria species are present in non-pathogenic Neisseria lactamica, including those designated as 'virulence genes'.
Snyder LA, Saunders NJ., BMC Genomics 7(), 2006
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Stabler RA, Marsden GL, Witney AA, Li Y, Bentley SD, Tang CM, Hinds J., Microbiology (Reading, Engl.) 151(Pt 9), 2005
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Stephens DS, Greenwood B, Brandtzaeg P., Lancet 369(9580), 2007
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Sun YH, Bakshi S, Chalmers R, Tang CM., Nat. Med. 6(11), 2000
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Takahashi H, Kim KS, Watanabe H., FEMS Immunol. Med. Microbiol. 52(1), 2007
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Tatusov RL, Galperin MY, Natale DA, Koonin EV., Nucleic Acids Res. 28(1), 2000
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Turner DP, Wooldridge KG, Ala'Aldeen DA., Infect. Immun. 70(8), 2002
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van Ulsen P, Rutten L, Feller M, Tommassen J, van der Ende A., Infect. Immun. 76(10), 2008
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AUTHOR UNKNOWN, 2006
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