Comparative Genome Biology of a Serogroup B Carriage and Disease Strain Supports a Polygenic Nature of Meningococcal Virulence

Joseph B, Schneiker-Bekel S, Schramm-Glueck A, Blom J, Claus H, Linke B, Schwarz RF, Becker A, Goesmann A, Frosch M, Schoen C (2010)
JOURNAL OF BACTERIOLOGY 192(20): 5363-5377.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
Joseph, Biju; Schneiker-Bekel, SusanneUniBi; Schramm-Glueck, Anja; Blom, JochenUniBi; Claus, Heike; Linke, BurkhardUniBi; Schwarz, Roland F.; Becker, Anke; Goesmann, AlexanderUniBi ; Frosch, Matthias; Schoen, Christoph
Abstract / Bemerkung
Neisseria meningitidis serogroup B strains are responsible for most meningococcal cases in the industrialized countries, and strains belonging to the clonal complex ST-41/44 are among the most prevalent serogroup B strains in carriage and disease. Here, we report the first genome and transcriptome comparison of a serogroup B carriage strain from the clonal complex ST-41/44 to the serogroup B disease strain MC58 from the clonal complex ST-32. Both genomes are highly colinear, with only three major genome rearrangements that are associated with the integration of mobile genetic elements. They further differ in about 10% of their gene content, with the highest variability in gene presence as well as gene sequence found for proteins involved in host cell interactions, including Opc, NadA, TonB-dependent receptors, RTX toxin, and two-partner secretion system proteins. Whereas housekeeping genes coding for metabolic functions were highly conserved, there were considerable differences in their expression pattern upon adhesion to human nasopharyngeal cells between both strains, including differences in energy metabolism and stress response. In line with these genomic and transcriptomic differences, both strains also showed marked differences in their in vitro infectivity and in serum resistance. Taken together, these data support the concept of a polygenic nature of meningococcal virulence comprising differences in the repertoire of adhesins as well as in the regulation of metabolic genes and suggest a prominent role for immune selection and genetic drift in shaping the meningococcal genome.
Page URI


Joseph B, Schneiker-Bekel S, Schramm-Glueck A, et al. Comparative Genome Biology of a Serogroup B Carriage and Disease Strain Supports a Polygenic Nature of Meningococcal Virulence. JOURNAL OF BACTERIOLOGY. 2010;192(20):5363-5377.
Joseph, B., Schneiker-Bekel, S., Schramm-Glueck, A., Blom, J., Claus, H., Linke, B., Schwarz, R. F., et al. (2010). Comparative Genome Biology of a Serogroup B Carriage and Disease Strain Supports a Polygenic Nature of Meningococcal Virulence. JOURNAL OF BACTERIOLOGY, 192(20), 5363-5377.
Joseph, Biju, Schneiker-Bekel, Susanne, Schramm-Glueck, Anja, Blom, Jochen, Claus, Heike, Linke, Burkhard, Schwarz, Roland F., et al. 2010. “Comparative Genome Biology of a Serogroup B Carriage and Disease Strain Supports a Polygenic Nature of Meningococcal Virulence”. JOURNAL OF BACTERIOLOGY 192 (20): 5363-5377.
Joseph, B., Schneiker-Bekel, S., Schramm-Glueck, A., Blom, J., Claus, H., Linke, B., Schwarz, R. F., Becker, A., Goesmann, A., Frosch, M., et al. (2010). Comparative Genome Biology of a Serogroup B Carriage and Disease Strain Supports a Polygenic Nature of Meningococcal Virulence. JOURNAL OF BACTERIOLOGY 192, 5363-5377.
Joseph, B., et al., 2010. Comparative Genome Biology of a Serogroup B Carriage and Disease Strain Supports a Polygenic Nature of Meningococcal Virulence. JOURNAL OF BACTERIOLOGY, 192(20), p 5363-5377.
B. Joseph, et al., “Comparative Genome Biology of a Serogroup B Carriage and Disease Strain Supports a Polygenic Nature of Meningococcal Virulence”, JOURNAL OF BACTERIOLOGY, vol. 192, 2010, pp. 5363-5377.
Joseph, B., Schneiker-Bekel, S., Schramm-Glueck, A., Blom, J., Claus, H., Linke, B., Schwarz, R.F., Becker, A., Goesmann, A., Frosch, M., Schoen, C.: Comparative Genome Biology of a Serogroup B Carriage and Disease Strain Supports a Polygenic Nature of Meningococcal Virulence. JOURNAL OF BACTERIOLOGY. 192, 5363-5377 (2010).
Joseph, Biju, Schneiker-Bekel, Susanne, Schramm-Glueck, Anja, Blom, Jochen, Claus, Heike, Linke, Burkhard, Schwarz, Roland F., Becker, Anke, Goesmann, Alexander, Frosch, Matthias, and Schoen, Christoph. “Comparative Genome Biology of a Serogroup B Carriage and Disease Strain Supports a Polygenic Nature of Meningococcal Virulence”. JOURNAL OF BACTERIOLOGY 192.20 (2010): 5363-5377.

36 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Cysteine biosynthesis in Neisseria species.
Hicks JL, Mullholland CV., Microbiology (), 2018
PMID: 30307392
Differential expression of hemoglobin receptor, HmbR, between carriage and invasive isolates of Neisseria meningitidis contributes to virulence: lessons from a clonal outbreak.
Sevestre J, Diene SM, Aouiti-Trabelsi M, Deghmane AE, Tournier I, François P, Caron F, Taha MK., Virulence 9(1), 2018
PMID: 29638173
Microbiome Helper: a Custom and Streamlined Workflow for Microbiome Research.
Comeau AM, Douglas GM, Langille MG., mSystems 2(1), 2017
PMID: 28066818
Comparative Genome Sequencing Reveals Within-Host Genetic Changes in Neisseria meningitidis during Invasive Disease.
Klughammer J, Dittrich M, Blom J, Mitesser V, Vogel U, Frosch M, Goesmann A, Müller T, Schoen C., PLoS One 12(1), 2017
PMID: 28081260
Transcriptomic buffering of cryptic genetic variation contributes to meningococcal virulence.
Ampattu BJ, Hagmann L, Liang C, Dittrich M, Schlüter A, Blom J, Krol E, Goesmann A, Becker A, Dandekar T, Müller T, Schoen C., BMC Genomics 18(1), 2017
PMID: 28388876
Hierarchical genomic analysis of carried and invasive serogroup A Neisseria meningitidis during the 2011 epidemic in Chad.
Diallo K, Gamougam K, Daugla DM, Harrison OB, Bray JE, Caugant DA, Lucidarme J, Trotter CL, Hassan-King M, Stuart JM, Manigart O, Greenwood BM, Maiden MCJ., BMC Genomics 18(1), 2017
PMID: 28532434
Neisseria genomics: current status and future perspectives.
Harrison OB, Schoen C, Retchless AC, Wang X, Jolley KA, Bray JE, Maiden MCJ., Pathog Dis 75(6), 2017
PMID: 28591853
A deeper mining on the protein composition of VA-MENGOC-BC®: An OMV-based vaccine against N. meningitidis serogroup B and C.
Masforrol Y, Gil J, García D, Noda J, Ramos Y, Betancourt L, Guirola O, González S, Acevedo B, Besada V, Reyes O, González LJ., Hum Vaccin Immunother 13(11), 2017
PMID: 29083947
Survival of Neisseria meningitidis outside of the host: environmental effects and differences among strains.
Swain CL, Martin DR, Sim D, Jordan TW, Mackichan JK., Epidemiol Infect 145(16), 2017
PMID: 29103405
Genomic, Transcriptomic, and Phenotypic Analyses of Neisseria meningitidis Isolates from Disease Patients and Their Household Contacts.
Ren X, Eccles DA, Greig GA, Clapham J, Wheeler NE, Lindgreen S, Gardner PP, MacKichan JK., mSystems 2(6), 2017
PMID: 29152586
Peripheral blood vessels are a niche for blood-borne meningococci.
Capel E, Barnier JP, Zomer AL, Bole-Feysot C, Nussbaumer T, Jamet A, Lécuyer H, Euphrasie D, Virion Z, Frapy E, Pélissier P, Join-Lambert O, Rattei T, Bourdoulous S, Nassif X, Coureuil M., Virulence 8(8), 2017
PMID: 29099305
Sequence, distribution and chromosomal context of class I and class II pilin genes of Neisseria meningitidis identified in whole genome sequences.
Wörmann ME, Horien CL, Bennett JS, Jolley KA, Maiden MC, Tang CM, Aho EL, Exley RM., BMC Genomics 15(), 2014
PMID: 24690385
A genome-wide identification of genes undergoing recombination and positive selection in Neisseria.
Yu D, Jin Y, Yin Z, Ren H, Zhou W, Liang L, Yue J., Biomed Res Int 2014(), 2014
PMID: 25180194
Metabolism and virulence in Neisseria meningitidis.
Schoen C, Kischkies L, Elias J, Ampattu BJ., Front Cell Infect Microbiol 4(), 2014
PMID: 25191646
Genetic and antigenic characterization of invasive endemic serogroup B Neisseria meningitidis from Ontario, Canada, in 2001-2010.
Jamieson FB, Rawte P, Deeks SL, Zhou J, Law DK, Deng S, Tsang RS., J Med Microbiol 62(pt 1), 2013
PMID: 23038803
Neisseria conserved hypothetical protein DMP12 is a DNA mimic that binds to histone-like HU protein.
Wang HC, Wu ML, Ko TP, Wang AH., Nucleic Acids Res 41(9), 2013
PMID: 23531546
Controlling serogroup B invasive meningococcal disease: the Canadian perspective.
Bettinger JA, Deeks SL, Halperin SA, Tsang R, Scheifele DW., Expert Rev Vaccines 12(5), 2013
PMID: 23659299
Invasive potential of nonencapsulated disease isolates of Neisseria meningitidis.
Johswich KO, Zhou J, Law DK, St Michael F, McCaw SE, Jamieson FB, Cox AD, Tsang RS, Gray-Owen SD., Infect Immun 80(7), 2012
PMID: 22508859
Evolutionary and genomic insights into meningococcal biology.
Bratcher HB, Bennett JS, Maiden MC., Future Microbiol 7(7), 2012
PMID: 22827308
Genome sequence of a Neisseria meningitidis capsule null locus strain from the clonal complex of sequence type 198.
Schork S, Schlüter A, Blom J, Schneiker-Bekel S, Pühler A, Goesmann A, Frosch M, Schoen C., J Bacteriol 194(18), 2012
PMID: 22933768
Whole-genome sequence of the transformable Neisseria meningitidis serogroup A strain WUE2594.
Schoen C, Weber-Lehmann J, Blom J, Joseph B, Goesmann A, Strittmatter A, Frosch M., J Bacteriol 193(8), 2011
PMID: 21296965
Characterization of Neisseria meningitidis isolates that do not express the virulence factor and vaccine antigen factor H binding protein.
Lucidarme J, Tan L, Exley RM, Findlow J, Borrow R, Tang CM., Clin Vaccine Immunol 18(6), 2011
PMID: 21508163
Virulence evolution of the human pathogen Neisseria meningitidis by recombination in the core and accessory genome.
Joseph B, Schwarz RF, Linke B, Blom J, Becker A, Claus H, Goesmann A, Frosch M, Müller T, Vogel U, Schoen C., PLoS One 6(4), 2011
PMID: 21541312
Transcriptome analysis of Neisseria meningitidis in human whole blood and mutagenesis studies identify virulence factors involved in blood survival.
Echenique-Rivera H, Muzzi A, Del Tordello E, Seib KL, Francois P, Rappuoli R, Pizza M, Serruto D., PLoS Pathog 7(5), 2011
PMID: 21589640
Using single-nucleotide polymorphisms to discriminate disease-associated from carried genomes of Neisseria meningitidis.
Katz LS, Sharma NV, Harcourt BH, Thomas JD, Wang X, Mayer LW, Jordan IK., J Bacteriol 193(14), 2011
PMID: 21622743
Transport genes and chemotaxis in Laribacter hongkongensis: a genome-wide analysis.
Lau SK, Fan RY, Wong GK, Teng JL, Sze KH, Tse H, Yuen KY, Woo PC., Cell Biosci 1(), 2011
PMID: 21849034
Neisseria Base: a comparative genomics database for Neisseria meningitidis.
Katz LS, Humphrey JC, Conley AB, Nelakuditi V, Kislyuk AO, Agrawal S, Jayaraman P, Harcourt BH, Olsen-Rasmussen MA, Frace M, Sharma NV, Mayer LW, Jordan IK., Database (Oxford) 2011(), 2011
PMID: 21930505

92 References

Daten bereitgestellt von Europe PubMed Central.

Basic local alignment search tool.
Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ., J. Mol. Biol. 215(3), 1990
PMID: 2231712
Meningococcal genetic variation mechanisms viewed through comparative analysis of serogroup C strain FAM18.
Bentley SD, Vernikos GS, Snyder LA, Churcher C, Arrowsmith C, Chillingworth T, Cronin A, Davis PH, Holroyd NE, Jagels K, Maddison M, Moule S, Rabbinowitsch E, Sharp S, Unwin L, Whitehead S, Quail MA, Achtman M, Barrell B, Saunders NJ, Parkhill J., PLoS Genet. 3(2), 2006
PMID: 17305430

Role of selection in the emergence of lineages and the evolution of virulence in Neisseria meningitidis.
Buckee CO, Jolley KA, Recker M, Penman B, Kriz P, Gupta S, Maiden MC., Proc. Natl. Acad. Sci. U.S.A. 105(39), 2008
PMID: 18815379
Opa protein repertoires of disease-causing and carried meningococci.
Callaghan MJ, Buckee C, McCarthy ND, Ibarz Pavon AB, Jolley KA, Faust S, Gray SJ, Kaczmarski EB, Levin M, Kroll JS, Maiden MC, Pollard AJ., J. Clin. Microbiol. 46(9), 2008
PMID: 18508936
The effect of immune selection on the structure of the meningococcal opa protein repertoire.
Callaghan MJ, Buckee CO, Jolley KA, Kriz P, Maiden MC, Gupta S., PLoS Pathog. 4(3), 2008
PMID: 18369470
Neisseria meningitidis NadA is a new invasin which promotes bacterial adhesion to and penetration into human epithelial cells.
Capecchi B, Adu-Bobie J, Di Marcello F, Ciucchi L, Masignani V, Taddei A, Rappuoli R, Pizza M, Arico B., Mol. Microbiol. 55(3), 2005
PMID: 15660996
Meningococcal interactions with the host.
Carbonnelle E, Hill DJ, Morand P, Griffiths NJ, Bourdoulous S, Murillo I, Nassif X, Virji M., Vaccine 27 Suppl 2(), 2009
PMID: 19481311
ACT: the Artemis Comparison Tool.
Carver TJ, Rutherford KM, Berriman M, Rajandream MA, Barrell BG, Parkhill J., Bioinformatics 21(16), 2005
PMID: 15976072
Meningococcal carriage and disease--population biology and evolution.
Caugant DA, Maiden MC., Vaccine 27 Suppl 2(), 2009
PMID: 19464092
Lessons from meningococcal carriage studies.
Caugant DA, Tzanakaki G, Kriz P., FEMS Microbiol. Rev. 31(1), 2007
PMID: 17233635
Genetic analysis of meningococci carried by children and young adults.
Claus H, Maiden MC, Wilson DJ, McCarthy ND, Jolley KA, Urwin R, Hessler F, Frosch M, Vogel U., J. Infect. Dis. 191(8), 2005
PMID: 15776372
NadA diversity and carriage in Neisseria meningitidis.
Comanducci M, Bambini S, Caugant DA, Mora M, Brunelli B, Capecchi B, Ciucchi L, Rappuoli R, Pizza M., Infect. Immun. 72(7), 2004
PMID: 15213166
The role of neisserial Opa proteins in interactions with host cells.
Dehio C, Gray-Owen SD, Meyer TF., Trends Microbiol. 6(12), 1998
PMID: 10036728
Transcriptome analysis of Neisseria meningitidis during infection.
Dietrich G, Kurz S, Hubner C, Aepinus C, Theiss S, Guckenberger M, Panzner U, Weber J, Frosch M., J. Bacteriol. 185(1), 2003
PMID: 12486052
Evolvability is a selectable trait.
Earl DJ, Deem MW., Proc. Natl. Acad. Sci. U.S.A. 101(32), 2004
PMID: 15289608
Carbon metabolism of intracellular bacterial pathogens and possible links to virulence.
Eisenreich W, Dandekar T, Heesemann J, Goebel W., Nat. Rev. Microbiol. 8(6), 2010
PMID: 20453875
Neutral microepidemic evolution of bacterial pathogens.
Fraser C, Hanage WP, Spratt BG., Proc. Natl. Acad. Sci. U.S.A. 102(6), 2005
PMID: 15684071

Arac/XylS family of transcriptional regulators.
Gallegos MT, Schleif R, Bairoch A, Hofmann K, Ramos JL., Microbiol. Mol. Biol. Rev. 61(4), 1997
PMID: 9409145
New metrics for comparative genomics.
Galperin MY, Kolker E., Curr. Opin. Biotechnol. 17(5), 2006
PMID: 16978854
PSORTb v.2.0: expanded prediction of bacterial protein subcellular localization and insights gained from comparative proteome analysis.
Gardy JL, Laird MR, Chen F, Rey S, Walsh CJ, Ester M, Brinkman FS., Bioinformatics 21(5), 2004
PMID: 15501914
Gene expression profile in Neisseria meningitidis and Neisseria lactamica upon host-cell contact: from basic research to vaccine development.
Grifantini R, Bartolini E, Muzzi A, Draghi M, Frigimelica E, Berger J, Randazzo F, Grandi G., Ann. N. Y. Acad. Sci. 975(), 2002
PMID: 12538166
Previously unrecognized vaccine candidates against group B meningococcus identified by DNA microarrays.
Grifantini R, Bartolini E, Muzzi A, Draghi M, Frigimelica E, Berger J, Ratti G, Petracca R, Galli G, Agnusdei M, Giuliani MM, Santini L, Brunelli B, Tettelin H, Rappuoli R, Randazzo F, Grandi G., Nat. Biotechnol. 20(9), 2002
PMID: 12172557
The maintenance of strain structure in populations of recombining infectious agents.
Gupta S, Maiden MC, Feavers IM, Nee S, May RM, Anderson RM., Nat. Med. 2(4), 1996
PMID: 8597954
The transcriptional programme of Salmonella enterica serovar Typhimurium reveals a key role for tryptophan metabolism in biofilms.
Hamilton S, Bongaerts RJ, Mulholland F, Cochrane B, Porter J, Lucchini S, Lappin-Scott HM, Hinton JC., BMC Genomics 10(), 2009
PMID: 20003355
Global epidemiology of meningococcal disease.
Harrison LH, Trotter CL, Ramsay ME., Vaccine 27 Suppl 2(), 2009
PMID: 19477562
Epidemiological evidence for the role of the hemoglobin receptor, hmbR, in meningococcal virulence.
Harrison OB, Evans NJ, Blair JM, Grimes HS, Tinsley CR, Nassif X, Kriz P, Ure R, Gray SJ, Derrick JP, Maiden MC, Feavers IM., J. Infect. Dis. 200(1), 2009
PMID: 19476432
Comparative genomics of Neisseria meningitidis: core genome, islands of horizontal transfer and pathogen-specific genes.
Dunning Hotopp JC, Grifantini R, Kumar N, Tzeng YL, Fouts D, Frigimelica E, Draghi M, Giuliani MM, Rappuoli R, Stephens DS, Grandi G, Tettelin H., Microbiology (Reading, Engl.) 152(Pt 12), 2006
PMID: 17159225
SplitsTree: analyzing and visualizing evolutionary data.
Huson DH., Bioinformatics 14(1), 1998
PMID: 9520503
Binding of the complement inhibitor C4bp to serogroup B Neisseria meningitidis.
Jarva H, Ram S, Vogel U, Blom AM, Meri S., J. Immunol. 174(10), 2005
PMID: 15879129
Carried meningococci in the Czech Republic: a diverse recombining population.
Jolley KA, Kalmusova J, Feil EJ, Gupta S, Musilek M, Kriz P, Maiden MC., J. Clin. Microbiol. 38(12), 2000
PMID: 11101585
Glycerol metabolism and PrfA activity in Listeria monocytogenes.
Joseph B, Mertins S, Stoll R, Schar J, Umesha KR, Luo Q, Muller-Altrock S, Goebel W., J. Bacteriol. 190(15), 2008
PMID: 18502850
Polymorphisms in pilin glycosylation Locus of Neisseria meningitidis expressing class II pili.
Kahler CM, Martin LE, Tzeng YL, Miller YK, Sharkey K, Stephens DS, Davies JK., Infect. Immun. 69(6), 2001
PMID: 11349019
The consequences of genetic drift for bacterial genome complexity.
Kuo CH, Moran NA, Ochman H., Genome Res. 19(8), 2009
PMID: 19502381
Carbohydrate composition of meningococcal lipopolysaccharide modulates the interaction of Neisseria meningitidis with human dendritic cells.
Kurzai O, Schmitt C, Claus H, Vogel U, Frosch M, Kolb-Maurer A., Cell. Microbiol. 7(9), 2005
PMID: 16098219
Meningococcal biofilm formation: structure, development and phenotypes in a standardized continuous flow system.
Lappann M, Haagensen JA, Claus H, Vogel U, Molin S., Mol. Microbiol. 62(5), 2006
PMID: 17121595
VanX, a bacterial D-alanyl-D-alanine dipeptidase: resistance, immunity, or survival function?
Lessard IA, Walsh CT., Proc. Natl. Acad. Sci. U.S.A. 96(20), 1999
PMID: 10500118
The meningococcal vaccine candidate GNA1870 binds the complement regulatory protein factor H and enhances serum resistance.
Madico G, Welsch JA, Lewis LA, McNaughton A, Perlman DH, Costello CE, Ngampasutadol J, Vogel U, Granoff DM, Ram S., J. Immunol. 177(1), 2006
PMID: 16785547
Population genomics: diversity and virulence in the Neisseria.
Maiden MC., Curr. Opin. Microbiol. 11(5), 2008
PMID: 18822386

Highly conserved Neisseria meningitidis surface protein confers protection against experimental infection.
Martin D, Cadieux N, Hamel J, Brodeur BR., J. Exp. Med. 185(7), 1997
PMID: 9104804
Mu-like Prophage in serogroup B Neisseria meningitidis coding for surface-exposed antigens.
Masignani V, Giuliani MM, Tettelin H, Comanducci M, Rappuoli R, Scarlato V., Infect. Immun. 69(4), 2001
PMID: 11254622
Point mutation in meningococcal por A gene associated with increased endemic disease.
McGuinness BT, Clarke IN, Lambden PR, Barlow AK, Poolman JT, Jones DM, Heckels JE., Lancet 337(8740), 1991
PMID: 1705642
GenDB--an open source genome annotation system for prokaryote genomes.
Meyer F, Goesmann A, McHardy AC, Bartels D, Bekel T, Clausen J, Kalinowski J, Linke B, Rupp O, Giegerich R, Puhler A., Nucleic Acids Res. 31(8), 2003
PMID: 12682369
The InterPro Database, 2003 brings increased coverage and new features.
Mulder NJ, Apweiler R, Attwood TK, Bairoch A, Barrell D, Bateman A, Binns D, Biswas M, Bradley P, Bork P, Bucher P, Copley RR, Courcelle E, Das U, Durbin R, Falquet L, Fleischmann W, Griffiths-Jones S, Haft D, Harte N, Hulo N, Kahn D, Kanapin A, Krestyaninova M, Lopez R, Letunic I, Lonsdale D, Silventoinen V, Orchard SE, Pagni M, Peyruc D, Ponting CP, Selengut JD, Servant F, Sigrist CJ, Vaughan R, Zdobnov EM., Nucleic Acids Res. 31(1), 2003
PMID: 12520011
Roles of pilin and PilC in adhesion of Neisseria meningitidis to human epithelial and endothelial cells.
Nassif X, Beretti JL, Lowy J, Stenberg P, O'Gaora P, Pfeifer J, Normark S, So M., Proc. Natl. Acad. Sci. U.S.A. 91(9), 1994
PMID: 7909606
Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491.
Parkhill J, Achtman M, James KD, Bentley SD, Churcher C, Klee SR, Morelli G, Basham D, Brown D, Chillingworth T, Davies RM, Davis P, Devlin K, Feltwell T, Hamlin N, Holroyd S, Jagels K, Leather S, Moule S, Mungall K, Quail MA, Rajandream MA, Rutherford KM, Simmonds M, Skelton J, Whitehead S, Spratt BG, Barrell BG., Nature 404(6777), 2000
PMID: 10761919
Identification and characterization of a Neisseria gonorrhoeae gene encoding a glycolipid-binding adhesin.
Paruchuri DK, Seifert HS, Ajioka RS, Karlsson KA, So M., Proc. Natl. Acad. Sci. U.S.A. 87(1), 1990
PMID: 2153292
Characterization of ST-4821 complex, a unique Neisseria meningitidis clone.
Peng J, Yang L, Yang F, Yang J, Yan Y, Nie H, Zhang X, Xiong Z, Jiang Y, Cheng F, Xu X, Chen S, Sun L, Li W, Shen Y, Shao Z, Liang X, Xu J, Jin Q., Genomics 91(1), 2007
PMID: 18031983

Comparisons of dN/dS are time dependent for closely related bacterial genomes.
Rocha EP, Smith JM, Hurst LD, Holden MT, Cooper JE, Smith NH, Feil EJ., J. Theor. Biol. 239(2), 2005
PMID: 16239014
NalP-mediated proteolytic release of lactoferrin-binding protein B from the meningococcal cell surface.
Roussel-Jazede V, Jongerius I, Bos MP, Tommassen J, van Ulsen P., Infect. Immun. 78(7), 2010
PMID: 20421383
NeMeSys: a biological resource for narrowing the gap between sequence and function in the human pathogen Neisseria meningitidis.
Rusniok C, Vallenet D, Floquet S, Ewles H, Mouze-Soulama C, Brown D, Lajus A, Buchrieser C, Medigue C, Glaser P, Pelicic V., Genome Biol. 10(10), 2009
PMID: 19818133
The minimal mobile element.
Saunders NJ, Snyder LA., Microbiology (Reading, Engl.) 148(Pt 12), 2002
PMID: 12480877
Neisseria meningitidis NhhA is a multifunctional trimeric autotransporter adhesin.
Scarselli M, Serruto D, Montanari P, Capecchi B, Adu-Bobie J, Veggi D, Rappuoli R, Pizza M, Arico B., Mol. Microbiol. 61(3), 2006
PMID: 16803596
A functional two-partner secretion system contributes to adhesion of Neisseria meningitidis to epithelial cells.
Schmitt C, Turner D, Boesl M, Abele M, Frosch M, Kurzai O., J. Bacteriol. 189(22), 2007
PMID: 17873034
Interactions between Neisseria meningitidis and the complement system.
Schneider MC, Exley RM, Ram S, Sim RB, Tang CM., Trends Microbiol. 15(5), 2007
PMID: 17398100
Whole-genome comparison of disease and carriage strains provides insights into virulence evolution in Neisseria meningitidis.
Schoen C, Blom J, Claus H, Schramm-Gluck A, Brandt P, Muller T, Goesmann A, Joseph B, Konietzny S, Kurzai O, Schmitt C, Friedrich T, Linke B, Vogel U, Frosch M., Proc. Natl. Acad. Sci. U.S.A. 105(9), 2008
PMID: 18305155
Genome flexibility in Neisseria meningitidis.
Schoen C, Tettelin H, Parkhill J, Frosch M., Vaccine 27 Suppl 2(), 2009
PMID: 19477564
Evaluation of one- and two-color gene expression arrays for microbial comparative genome hybridization analyses in routine applications.
Schwarz R, Joseph B, Gerlach G, Schramm-Gluck A, Engelhard K, Frosch M, Muller T, Schoen C., J. Clin. Microbiol. 48(9), 2010
PMID: 20592156
Neisseria meningitidis App, a new adhesin with autocatalytic serine protease activity.
Serruto D, Adu-Bobie J, Scarselli M, Veggi D, Pizza M, Rappuoli R, Arico B., Mol. Microbiol. 48(2), 2003
PMID: 12675794
Neisseria meningitidis GNA2132, a heparin-binding protein that induces protective immunity in humans.
Serruto D, Spadafina T, Ciucchi L, Lewis LA, Ram S, Tontini M, Santini L, Biolchi A, Seib KL, Giuliani MM, Donnelly JJ, Berti F, Savino S, Scarselli M, Costantino P, Kroll JS, O'Dwyer C, Qiu J, Plaut AG, Moxon R, Rappuoli R, Pizza M, Arico B., Proc. Natl. Acad. Sci. U.S.A. 107(8), 2010
PMID: 20133713

Identification of pathogen-specific genes through microarray analysis of pathogenic and commensal Neisseria species.
Stabler RA, Marsden GL, Witney AA, Li Y, Bentley SD, Tang CM, Hinds J., Microbiology (Reading, Engl.) 151(Pt 9), 2005
PMID: 16151203
Epidemic meningitis, meningococcaemia, and Neisseria meningitidis.
Stephens DS, Greenwood B, Brandtzaeg P., Lancet 369(9580), 2007
PMID: 17604802
Functional genomics of Neisseria meningitidis pathogenesis.
Sun YH, Bakshi S, Chalmers R, Tang CM., Nat. Med. 6(11), 2000
PMID: 11062540
The COG database: a tool for genome-scale analysis of protein functions and evolution.
Tatusov RL, Galperin MY, Natale DA, Koonin EV., Nucleic Acids Res. 28(1), 2000
PMID: 10592175
Complete genome sequence of Neisseria meningitidis serogroup B strain MC58.
Tettelin H, Saunders NJ, Heidelberg J, Jeffries AC, Nelson KE, Eisen JA, Ketchum KA, Hood DW, Peden JF, Dodson RJ, Nelson WC, Gwinn ML, DeBoy R, Peterson JD, Hickey EK, Haft DH, Salzberg SL, White O, Fleischmann RD, Dougherty BA, Mason T, Ciecko A, Parksey DS, Blair E, Cittone H, Clark EB, Cotton MD, Utterback TR, Khouri H, Qin H, Vamathevan J, Gill J, Scarlato V, Masignani V, Pizza M, Grandi G, Sun L, Smith HO, Fraser CM, Moxon ER, Rappuoli R, Venter JC., Science 287(5459), 2000
PMID: 10710307
Neisseria meningitidis produces iron-regulated proteins related to the RTX family of exoproteins.
Thompson SA, Wang LL, West A, Sparling PF., J. Bacteriol. 175(3), 1993
PMID: 8423153
Characterization of MspA, an immunogenic autotransporter protein that mediates adhesion to epithelial and endothelial cells in Neisseria meningitidis.
Turner DP, Marietou AG, Johnston L, Ho KK, Rogers AJ, Wooldridge KG, Ala'Aldeen DA., Infect. Immun. 74(5), 2006
PMID: 16622234
Two-partner secretion systems of Neisseria meningitidis associated with invasive clonal complexes.
van Ulsen P, Rutten L, Feller M, Tommassen J, van der Ende A., Infect. Immun. 76(10), 2008
PMID: 18678657
Protein secretion and secreted proteins in pathogenic Neisseriaceae.
van Ulsen P, Tommassen J., FEMS Microbiol. Rev. 30(2), 2006
PMID: 16472308
The role of pili in the interactions of pathogenic Neisseria with cultured human endothelial cells.
Virji M, Kayhty H, Ferguson DJ, Alexandrescu C, Heckels JE, Moxon ER., Mol. Microbiol. 5(8), 1991
PMID: 1722554
Expression of the Opc protein correlates with invasion of epithelial and endothelial cells by Neisseria meningitidis.
Virji M, Makepeace K, Ferguson DJ, Achtman M, Sarkari J, Moxon ER., Mol. Microbiol. 6(19), 1992
PMID: 1435257
Complement factor C3 deposition and serum resistance in isogenic capsule and lipooligosaccharide sialic acid mutants of serogroup B Neisseria meningitidis.
Vogel U, Weinberger A, Frank R, Muller A, Kohl J, Atkinson JP, Frosch M., Infect. Immun. 65(10), 1997
PMID: 9317002

Design issues for cDNA microarray experiments.
Yang YH, Speed T., Nat. Rev. Genet. 3(8), 2002
PMID: 12154381
Distribution of serogroups and genotypes among disease-associated and carried isolates of Neisseria meningitidis from the Czech Republic, Greece, and Norway.
Yazdankhah SP, Kriz P, Tzanakaki G, Kremastinou J, Kalmusova J, Musilek M, Alvestad T, Jolley KA, Wilson DJ, McCarthy ND, Caugant DA, Maiden MC., J. Clin. Microbiol. 42(11), 2004
PMID: 15528708
Fit genotypes and escape variants of subgroup III Neisseria meningitidis during three pandemics of epidemic meningitis.
Zhu P, van der Ende A, Falush D, Brieske N, Morelli G, Linz B, Popovic T, Schuurman IG, Adegbola RA, Zurth K, Gagneux S, Platonov AE, Riou JY, Caugant DA, Nicolas P, Achtman M., Proc. Natl. Acad. Sci. U.S.A. 98(9), 2001
PMID: 11287631


Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

PMID: 20709895
PubMed | Europe PMC

Suchen in

Google Scholar