Sequence of the 68,869 bp IncP-1 alpha plasmid pTB11 from a waste-water treatment plant reveals a highly conserved backbone, a Tn402-like integron and other transposable elements

Tennstedt T, Szczepanowski R, Krahn I, Pühler A, Schlüter A (2005)
PLASMID 53(3): 218-238.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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DOI
Autor*in
Tennstedt, T.; Szczepanowski, RafaelUniBi; Krahn, IreneUniBi; Pühler, AlfredUniBi ; Schlüter, AndreasUniBi
Einrichtung
Centrum für Biotechnologie > Institut für Genomforschung und Systembiologie
Centrum für Biotechnologie > Arbeitsgruppe A. Pühler
Fakultät für Biologie > Genetik der Prokaryoten
Abstract / Bemerkung
To analyse the significance of conjugative broad-host-range IncP-lot plasmids for the spread of antibiotic resistance determinants in waste-water treatment plants we isolated and characterised five different IncP-lot plasmids from bacteria of activated sludge and the final effluents of a municipal waste-water treatment plant. These plasmids mediate resistance to ampicillin, cefaclor, cefuroxime, gentamicin, kanamycin, spectinomycin, streptomycin, tetracycline, tobramycin, and trimethoprim. The complete 68,869 bp DNA-sequence of the IncP-1α plasmid pTB11 was determined. The pTB11 backbone modules for replication (Rep), mating pair formation (Trb), multimer resolution (Mrs), post-segregational killing (Psk), conjugative DNA-transfer (Tra), plasmid control (01), and stable maintenance and inheritance (KilA, KilE, and KilC) are highly conserved as compared to the ′ Birmingham′ IncP-lα plasmids. In contrast to the ′ Birmingham′ plasmids pTB11 carries an insert of a Tn402-derivative integrating a class 1 integron in the intergenic region between the multimer resolution operon parCBA and the post-segregational killing operon parDE. The integron comprises the resistance gene cassettes oxa2 (β-lactamase), aacA4 (aminoglycoside-6′ N-acetyltransferase), and aadA1 (aminoglycoside-3′-adenylyltransfetase) and a complete tniABQR transposition module. Integron-specific sequences were also identified on other IncP-lα plasmids analysed in this work. In contrast to the ′ Birmingham′ plasmids the pTB11 tetracycline resistance module carries a pecM- and a pncA-like gene downstream of the tetracycline resistance gene tetA and contains an insertion of the new insertion sequence element ISTB11. The transposable elements IS21 and Tn1 which disrupted, respectively, orf7 and klcB on the ′ Birmingham′ plasmids are not present on pTB11. Identification of IncP-lα plasmids in bacteria of the waste-water treatment plant's final effluents indicates that bacteria carrying these kind of plasmids are released into the environment. © 2004 Elsevier Inc. All rights reserved.
Stichworte
broad-host-range plasmid; multiresistance plasmid; integron; transposable element; activated sludge; conjugative plasmid
Erscheinungsjahr
2005
Zeitschriftentitel
PLASMID
Band
53
Ausgabe
3
Seite(n)
218-238
ISSN
0147-619X
Page URI
https://pub.uni-bielefeld.de/record/1603956

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Tennstedt T, Szczepanowski R, Krahn I, Pühler A, Schlüter A. Sequence of the 68,869 bp IncP-1 alpha plasmid pTB11 from a waste-water treatment plant reveals a highly conserved backbone, a Tn402-like integron and other transposable elements. PLASMID. 2005;53(3):218-238.
Tennstedt, T., Szczepanowski, R., Krahn, I., Pühler, A., & Schlüter, A. (2005). Sequence of the 68,869 bp IncP-1 alpha plasmid pTB11 from a waste-water treatment plant reveals a highly conserved backbone, a Tn402-like integron and other transposable elements. PLASMID, 53(3), 218-238. https://doi.org/10.1016/j.plasmid.2004.09.004
Tennstedt, T., Szczepanowski, Rafael, Krahn, Irene, Pühler, Alfred, and Schlüter, Andreas. 2005. “Sequence of the 68,869 bp IncP-1 alpha plasmid pTB11 from a waste-water treatment plant reveals a highly conserved backbone, a Tn402-like integron and other transposable elements”. PLASMID 53 (3): 218-238.
Tennstedt, T., Szczepanowski, R., Krahn, I., Pühler, A., and Schlüter, A. (2005). Sequence of the 68,869 bp IncP-1 alpha plasmid pTB11 from a waste-water treatment plant reveals a highly conserved backbone, a Tn402-like integron and other transposable elements. PLASMID 53, 218-238.
Tennstedt, T., et al., 2005. Sequence of the 68,869 bp IncP-1 alpha plasmid pTB11 from a waste-water treatment plant reveals a highly conserved backbone, a Tn402-like integron and other transposable elements. PLASMID, 53(3), p 218-238.
T. Tennstedt, et al., “Sequence of the 68,869 bp IncP-1 alpha plasmid pTB11 from a waste-water treatment plant reveals a highly conserved backbone, a Tn402-like integron and other transposable elements”, PLASMID, vol. 53, 2005, pp. 218-238.
Tennstedt, T., Szczepanowski, R., Krahn, I., Pühler, A., Schlüter, A.: Sequence of the 68,869 bp IncP-1 alpha plasmid pTB11 from a waste-water treatment plant reveals a highly conserved backbone, a Tn402-like integron and other transposable elements. PLASMID. 53, 218-238 (2005).
Tennstedt, T., Szczepanowski, Rafael, Krahn, Irene, Pühler, Alfred, and Schlüter, Andreas. “Sequence of the 68,869 bp IncP-1 alpha plasmid pTB11 from a waste-water treatment plant reveals a highly conserved backbone, a Tn402-like integron and other transposable elements”. PLASMID 53.3 (2005): 218-238.

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Thomas CM., Mol. Microbiol. 37(3), 2000
PMID: 10931342
Complete sequence of the IncPbeta plasmid R751: implications for evolution and organisation of the IncP backbone.
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PMID: 9753548
Map of the IncP1beta plasmid pTSA encoding the widespread genes (tsa) for p-toluenesulfonate degradation in Comamonas testosteroni T-2.
Tralau T, Cook AM, Ruff J., Appl. Environ. Microbiol. 67(4), 2001
PMID: 11282598
Genetic organization of the catabolic plasmid pJP4 from Ralstonia eutropha JMP134 (pJP4) reveals mechanisms of adaptation to chloroaromatic pollutants and evolution of specialized chloroaromatic degradation pathways.
Trefault N, De la Iglesia R, Molina AM, Manzano M, Ledger T, Perez-Pantoja D, Sanchez MA, Stuardo M, Gonzalez B., Environ. Microbiol. 6(7), 2004
PMID: 15186344
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