Whole-genome comparison of disease and carriage strains provides insights into virulence evolution in Neisseria meningitidis

Schoen C, Blom J, Claus H, Schramm-Glueck A, Brandt P, Mueller T, Goesmann A, Joseph B, Konietzny S, Kurzai O, Schmitt C, et al. (2008)

Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Schoen, Christoph; Blom, JochenUniBi; Claus, Heike; Schramm-Glueck, Anja; Brandt, Petra; Mueller, Tobias; Goesmann, AlexanderUniBi ; Joseph, Biju; Konietzny, Sebastian; Kurzai, Oliver; Schmitt, Corinna; Friedrich, Torben
Abstract / Bemerkung
Neisseria meningitidis is a leading cause of infectious childhood mortality worldwide. Most research efforts have hitherto focused on disease isolates belonging to only a few hypervirulent clonal lineages. However, up to 10% of the healthy human population is temporarily colonized by genetically diverse strains mostly with little or no pathogenic potential. Currently, little is known about the biology of carriage strains and their evolutionary relationship with disease isolates. The expression of a polysaccharide capsule is the only trait that has been convincingly linked to the pathogenic potential of N. meningitidis. To gain insight into the evolution of virulence traits in this species, whole-genome sequences of three meningococcal carriage isolates were obtained. Gene content comparisons with the available genome sequences from three disease isolates indicate that there is no core pathogenome in N. meningitidis. A comparison of the chromosome structure suggests that a filamentous prophage has mediated large chromosomal rearrangements and the translocation of some candidate virulence genes. Interspecific comparison of the available Neisseria genome sequences and dot blot hybridizations further indicate that the insertion sequence IS1655 is restricted only to N. meningitidis; its low sequence diversity is an indicator of an evolutionarily recent population bottleneck. A genome-based phylogenetic reconstruction provides evidence that N. meningitidis has emerged as an unencapsulated human commensal from a common ancestor with Neisseria gonorrhoeae and Neisseria lactamica and consecutively acquired the genes responsible for capsule synthesis via horizontal gene transfer.
genome evolution; comparative genomics; bacterial capsule; neisserial; prophage; IS1655
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Schoen C, Blom J, Claus H, et al. Whole-genome comparison of disease and carriage strains provides insights into virulence evolution in Neisseria meningitidis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(9):3473-3478.
Schoen, C., Blom, J., Claus, H., Schramm-Glueck, A., Brandt, P., Mueller, T., Goesmann, A., et al. (2008). Whole-genome comparison of disease and carriage strains provides insights into virulence evolution in Neisseria meningitidis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105(9), 3473-3478. https://doi.org/10.1073/pnas.0800151105
Schoen, Christoph, Blom, Jochen, Claus, Heike, Schramm-Glueck, Anja, Brandt, Petra, Mueller, Tobias, Goesmann, Alexander, et al. 2008. “Whole-genome comparison of disease and carriage strains provides insights into virulence evolution in Neisseria meningitidis”. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 105 (9): 3473-3478.
Schoen, C., Blom, J., Claus, H., Schramm-Glueck, A., Brandt, P., Mueller, T., Goesmann, A., Joseph, B., Konietzny, S., Kurzai, O., et al. (2008). Whole-genome comparison of disease and carriage strains provides insights into virulence evolution in Neisseria meningitidis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 105, 3473-3478.
Schoen, C., et al., 2008. Whole-genome comparison of disease and carriage strains provides insights into virulence evolution in Neisseria meningitidis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105(9), p 3473-3478.
C. Schoen, et al., “Whole-genome comparison of disease and carriage strains provides insights into virulence evolution in Neisseria meningitidis”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 105, 2008, pp. 3473-3478.
Schoen, C., Blom, J., Claus, H., Schramm-Glueck, A., Brandt, P., Mueller, T., Goesmann, A., Joseph, B., Konietzny, S., Kurzai, O., Schmitt, C., Friedrich, T., Linke, B., Vogel, U., Frosch, M.: Whole-genome comparison of disease and carriage strains provides insights into virulence evolution in Neisseria meningitidis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 105, 3473-3478 (2008).
Schoen, Christoph, Blom, Jochen, Claus, Heike, Schramm-Glueck, Anja, Brandt, Petra, Mueller, Tobias, Goesmann, Alexander, Joseph, Biju, Konietzny, Sebastian, Kurzai, Oliver, Schmitt, Corinna, Friedrich, Torben, Linke, Burkhard, Vogel, Ulrich, and Frosch, Matthias. “Whole-genome comparison of disease and carriage strains provides insights into virulence evolution in Neisseria meningitidis”. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 105.9 (2008): 3473-3478.

107 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Neisseria meningitidis has acquired sequences within the capsule locus by horizontal genetic transfer.
Clemence MEA, Harrison OB, Maiden MCJ., Wellcome Open Res 4(), 2019
PMID: 31346553
Characterization of capsule genes in non-pathogenic Neisseria species.
Clemence MEA, Maiden MCJ, Harrison OB., Microb Genom 4(9), 2018
PMID: 30074474
Tracking a serial killer: Integrating phylogenetic relationships, epidemiology, and geography for two invasive meningococcal disease outbreaks.
Ezeoke I, Galac MR, Lin Y, Liem AT, Roth PA, Kilianski A, Gibbons HS, Bloch D, Kornblum J, Del Rosso P, Janies DA, Weiss D., PLoS One 13(11), 2018
PMID: 30485280
Comparative Genome Sequencing Reveals Within-Host Genetic Changes in Neisseria meningitidis during Invasive Disease.
Klughammer J, Dittrich M, Blom J, Mitesser V, Vogel U, Frosch M, Goesmann A, Müller T, Schoen C., PLoS One 12(1), 2017
PMID: 28081260
Molecular characterization of invasive capsule null Neisseria meningitidis in South Africa.
Ganesh K, Allam M, Wolter N, Bratcher HB, Harrison OB, Lucidarme J, Borrow R, de Gouveia L, Meiring S, Birkhead M, Maiden MC, von Gottberg A, du Plessis M., BMC Microbiol 17(1), 2017
PMID: 28222677
Acquisition of the capsule locus by horizontal gene transfer in Neisseria meningitidis is often accompanied by the loss of UDP-GalNAc synthesis.
Bartley SN, Mowlaboccus S, Mullally CA, Stubbs KA, Vrielink A, Maiden MC, Harrison OB, Perkins TT, Kahler CM., Sci Rep 7(), 2017
PMID: 28290510
Interstrain Cooperation in Meningococcal Biofilms: Role of Autotransporters NalP and AutA.
Pérez-Ortega J, Rodríguez A, Ribes E, Tommassen J, Arenas J., Front Microbiol 8(), 2017
PMID: 28382026
Novel approaches to Neisseria meningitidis vaccine design.
Christodoulides M, Heckels J., Pathog Dis 75(3), 2017
PMID: 28369428
Genetic characterization of a Neisseria meningitidis cluster in Queensland, Australia.
Abady NR, Guglielmino CJD, Graham RM, Adelskov J, Smith HV, Patel BKC, Jennison AV., Can J Microbiol 63(7), 2017
PMID: 28460189
Hierarchical genomic analysis of carried and invasive serogroup A Neisseria meningitidis during the 2011 epidemic in Chad.
Diallo K, Gamougam K, Daugla DM, Harrison OB, Bray JE, Caugant DA, Lucidarme J, Trotter CL, Hassan-King M, Stuart JM, Manigart O, Greenwood BM, Maiden MCJ., BMC Genomics 18(1), 2017
PMID: 28532434
An unwanted guest: Neisseria meningitidis - carriage, risk for invasive disease and the impact of vaccination with insight on Italy incidence.
Gianchecchi E, Piccini G, Torelli A, Rappuoli R, Montomoli E., Expert Rev Anti Infect Ther 15(7), 2017
PMID: 28524748
The primary transcriptome of Neisseria meningitidis and its interaction with the RNA chaperone Hfq.
Heidrich N, Bauriedl S, Barquist L, Li L, Schoen C, Vogel J., Nucleic Acids Res 45(10), 2017
PMID: 28334889
Regulation of capsule in Neisseria meningitidis.
Tzeng YL, Thomas J, Stephens DS., Crit Rev Microbiol 42(5), 2016
PMID: 26089023
Large genomic differences between Moraxella bovoculi isolates acquired from the eyes of cattle with infectious bovine keratoconjunctivitis versus the deep nasopharynx of asymptomatic cattle.
Dickey AM, Loy JD, Bono JL, Smith TP, Apley MD, Lubbers BV, DeDonder KD, Capik SF, Larson RL, White BJ, Blom J, Chitko-McKown CG, Clawson ML., Vet Res 47(), 2016
PMID: 26872821
Expression of the Gene for Autotransporter AutB of Neisseria meningitidis Affects Biofilm Formation and Epithelial Transmigration.
Arenas J, Paganelli FL, Rodríguez-Castaño P, Cano-Crespo S, van der Ende A, van Putten JP, Tommassen J., Front Cell Infect Microbiol 6(), 2016
PMID: 27921012
The meningococcal autotransporter AutA is implicated in autoaggregation and biofilm formation.
Arenas J, Cano S, Nijland R, van Dongen V, Rutten L, van der Ende A, Tommassen J., Environ Microbiol 17(4), 2015
PMID: 25059714
Ten years of pan-genome analyses.
Vernikos G, Medini D, Riley DR, Tettelin H., Curr Opin Microbiol 23(), 2015
PMID: 25483351
A new family of secreted toxins in pathogenic Neisseria species.
Jamet A, Jousset AB, Euphrasie D, Mukorako P, Boucharlat A, Ducousso A, Charbit A, Nassif X., PLoS Pathog 11(1), 2015
PMID: 25569427
[Meningococcal vaccines. Global epidemiological situation and strategies for prevention by vaccination].
Rivero Calle I, Rodriguez-Tenreiro Sánchez C, Martinón-Torres F., Enferm Infecc Microbiol Clin 33(4), 2015
PMID: 25795150
Genome-Based Characterization of Emergent Invasive Neisseria meningitidis Serogroup Y Isolates in Sweden from 1995 to 2012.
Törös B, Hedberg ST, Unemo M, Jacobsson S, Hill DM, Olcén P, Fredlund H, Bratcher HB, Jolley KA, Maiden MC, Mölling P., J Clin Microbiol 53(7), 2015
PMID: 25926489
Phylogenetic study of clonal complex (CC)198 capsule null locus (cnl) genomes: A distinctive group within the species Neisseria meningitidis.
Xu Z, Du P, Zhu B, Xu L, Wang H, Gao Y, Zhou H, Zhang W, Chen C, Shao Z., Infect Genet Evol 34(), 2015
PMID: 26171575
A Single Amino Acid Replacement in the Sensor Kinase LiaS Contributes to a Carrier Phenotype in Group A Streptococcus.
Flores AR, Jewell BE, Yelamanchili D, Olsen RJ, Musser JM., Infect Immun 83(11), 2015
PMID: 26283331
Sequence, distribution and chromosomal context of class I and class II pilin genes of Neisseria meningitidis identified in whole genome sequences.
Wörmann ME, Horien CL, Bennett JS, Jolley KA, Maiden MC, Tang CM, Aho EL, Exley RM., BMC Genomics 15(), 2014
PMID: 24690385
Neisseria meningitidis; clones, carriage, and disease.
Read RC., Clin Microbiol Infect 20(5), 2014
PMID: 24766477
Neisseria proteomics for antigen discovery and vaccine development.
Christodoulides M., Expert Rev Proteomics 11(5), 2014
PMID: 25017717
A genome-wide identification of genes undergoing recombination and positive selection in Neisseria.
Yu D, Jin Y, Yin Z, Ren H, Zhou W, Liang L, Yue J., Biomed Res Int 2014(), 2014
PMID: 25180194
Metabolism and virulence in Neisseria meningitidis.
Schoen C, Kischkies L, Elias J, Ampattu BJ., Front Cell Infect Microbiol 4(), 2014
PMID: 25191646
The genetics of Neisseria species.
Rotman E, Seifert HS., Annu Rev Genet 48(), 2014
PMID: 25251852
Neisseria meningitidis elicits a pro-inflammatory response involving IκBζ in a human blood-cerebrospinal fluid barrier model.
Borkowski J, Li L, Steinmann U, Quednau N, Stump-Guthier C, Weiss C, Findeisen P, Gretz N, Ishikawa H, Tenenbaum T, Schroten H, Schwerk C., J Neuroinflammation 11(), 2014
PMID: 25347003
The use of genome wide association methods to investigate pathogenicity, population structure and serovar in Haemophilus parasuis.
Howell KJ, Weinert LA, Chaudhuri RR, Luan SL, Peters SE, Corander J, Harris D, Angen Ø, Aragon V, Bensaid A, Williamson SM, Parkhill J, Langford PR, Rycroft AN, Wren BW, Holden MT, Tucker AW, Maskell DJ, BRADP1T Consortium., BMC Genomics 15(), 2014
PMID: 25539682
Homologous recombination drives both sequence diversity and gene content variation in Neisseria meningitidis.
Kong Y, Ma JH, Warren K, Tsang RS, Low DE, Jamieson FB, Alexander DC, Hao W., Genome Biol Evol 5(9), 2013
PMID: 23902748
Dialects of the DNA uptake sequence in Neisseriaceae.
Frye SA, Nilsen M, Tønjum T, Ambur OH., PLoS Genet 9(4), 2013
PMID: 23637627
The biology of Neisseria adhesins.
Hung MC, Christodoulides M., Biology (Basel) 2(3), 2013
PMID: 24833056
Natural variation in the promoter of the gene encoding the Mga regulator alters host-pathogen interactions in group a Streptococcus carrier strains.
Flores AR, Olsen RJ, Wunsche A, Kumaraswami M, Shelburne SA, Carroll RK, Musser JM., Infect Immun 81(11), 2013
PMID: 23980109
Domain exchange at the 3' end of the gene encoding the fratricide meningococcal two-partner secretion protein A.
Arenas J, Schipper K, van Ulsen P, van der Ende A, Tommassen J., BMC Genomics 14(), 2013
PMID: 24034852
Development of a multiplex PCR assay for detection and genogrouping of Neisseria meningitidis.
Zhu H, Wang Q, Wen L, Xu J, Shao Z, Chen M, Chen M, Reeves PR, Cao B, Wang L., J Clin Microbiol 50(1), 2012
PMID: 22090406
Neisseria meningitidis: biology, microbiology, and epidemiology.
Rouphael NG, Stephens DS., Methods Mol Biol 799(), 2012
PMID: 21993636
Patterns of sequence variation within the Neisseria meningitidis lactoferrin binding proteins.
Adamiak P, Beddek AJ, Pajon R, Schryvers AB., Biochem Cell Biol 90(3), 2012
PMID: 22397513
A genomic approach to bacterial taxonomy: an examination and proposed reclassification of species within the genus Neisseria.
Bennett JS, Jolley KA, Earle SG, Corton C, Bentley SD, Parkhill J, Maiden MC., Microbiology 158(pt 6), 2012
PMID: 22422752
Invasive potential of nonencapsulated disease isolates of Neisseria meningitidis.
Johswich KO, Zhou J, Law DK, St Michael F, McCaw SE, Jamieson FB, Cox AD, Tsang RS, Gray-Owen SD., Infect Immun 80(7), 2012
PMID: 22508859
Whole genome sequencing to investigate the emergence of clonal complex 23 Neisseria meningitidis serogroup Y disease in the United States.
Krauland MG, Dunning Hotopp JC, Riley DR, Daugherty SC, Marsh JW, Messonnier NE, Mayer LW, Tettelin H, Harrison LH., PLoS One 7(4), 2012
PMID: 22558202
Can we, should we, eradicate the meningococcus?
Maiden MC, Frosch M., Vaccine 30 Suppl 2(), 2012
PMID: 22607899
Genome sequence of a Neisseria meningitidis capsule null locus strain from the clonal complex of sequence type 198.
Schork S, Schlüter A, Blom J, Schneiker-Bekel S, Pühler A, Goesmann A, Frosch M, Schoen C., J Bacteriol 194(18), 2012
PMID: 22933768
Sequence features contributing to chromosomal rearrangements in Neisseria gonorrhoeae.
Spencer-Smith R, Varkey EM, Fielder MD, Snyder LA., PLoS One 7(9), 2012
PMID: 23029370
Vaccine development against Neisseria meningitidis.
Vogel U, Claus H., Microb Biotechnol 4(1), 2011
PMID: 21255369
The rise and fall of the Mycobacterium tuberculosis genome.
Veyrier FJ, Dufort A, Behr MA., Trends Microbiol 19(4), 2011
PMID: 21277778
Whole-genome sequence of the transformable Neisseria meningitidis serogroup A strain WUE2594.
Schoen C, Weber-Lehmann J, Blom J, Joseph B, Goesmann A, Strittmatter A, Frosch M., J Bacteriol 193(8), 2011
PMID: 21296965
Neisseria meningitidis is structured in clades associated with restriction modification systems that modulate homologous recombination.
Budroni S, Siena E, Dunning Hotopp JC, Seib KL, Serruto D, Nofroni C, Comanducci M, Riley DR, Daugherty SC, Angiuoli SV, Covacci A, Pizza M, Rappuoli R, Moxon ER, Tettelin H, Medini D., Proc Natl Acad Sci U S A 108(11), 2011
PMID: 21368196
Genotypic and phenotypic modifications of Neisseria meningitidis after an accidental human passage.
Omer H, Rose G, Jolley KA, Frapy E, Zahar JR, Maiden MC, Bentley SD, Tinsley CR, Nassif X, Bille E., PLoS One 6(2), 2011
PMID: 21386889
Characterization of Neisseria meningitidis isolates that do not express the virulence factor and vaccine antigen factor H binding protein.
Lucidarme J, Tan L, Exley RM, Findlow J, Borrow R, Tang CM., Clin Vaccine Immunol 18(6), 2011
PMID: 21508163
Virulence evolution of the human pathogen Neisseria meningitidis by recombination in the core and accessory genome.
Joseph B, Schwarz RF, Linke B, Blom J, Becker A, Claus H, Goesmann A, Frosch M, Müller T, Vogel U, Schoen C., PLoS One 6(4), 2011
PMID: 21541312
Using single-nucleotide polymorphisms to discriminate disease-associated from carried genomes of Neisseria meningitidis.
Katz LS, Sharma NV, Harcourt BH, Thomas JD, Wang X, Mayer LW, Jordan IK., J Bacteriol 193(14), 2011
PMID: 21622743
Transport genes and chemotaxis in Laribacter hongkongensis: a genome-wide analysis.
Lau SK, Fan RY, Wong GK, Teng JL, Sze KH, Tse H, Yuen KY, Woo PC., Cell Biosci 1(), 2011
PMID: 21849034
Neisseria Base: a comparative genomics database for Neisseria meningitidis.
Katz LS, Humphrey JC, Conley AB, Nelakuditi V, Kislyuk AO, Agrawal S, Jayaraman P, Harcourt BH, Olsen-Rasmussen MA, Frace M, Sharma NV, Mayer LW, Jordan IK., Database (Oxford) 2011(), 2011
PMID: 21930505
The genomics of Acinetobacter baumannii: insights into genome plasticity, antimicrobial resistance and pathogenicity.
Imperi F, Antunes LC, Blom J, Villa L, Iacono M, Visca P, Carattoli A., IUBMB Life 63(12), 2011
PMID: 22034231
Extensive genomic variation within clonal complexes of Neisseria meningitidis.
Hao W, Ma JH, Warren K, Tsang RS, Low DE, Jamieson FB, Alexander DC., Genome Biol Evol 3(), 2011
PMID: 22084315
Calculating orthologs in bacteria and Archaea: a divide and conquer approach.
Halachev MR, Loman NJ, Pallen MJ., PLoS One 6(12), 2011
PMID: 22174796
Genotypic diversity in Oenococcus oeni by high-density microarray comparative genome hybridization and whole genome sequencing.
Borneman AR, Bartowsky EJ, McCarthy J, Chambers PJ., Appl Microbiol Biotechnol 86(2), 2010
PMID: 20111862
A dual role of extracellular DNA during biofilm formation of Neisseria meningitidis.
Lappann M, Claus H, van Alen T, Harmsen M, Elias J, Molin S, Vogel U., Mol Microbiol 75(6), 2010
PMID: 20180907
Biofilm formation by the human pathogen Neisseria meningitidis.
Lappann M, Vogel U., Med Microbiol Immunol 199(3), 2010
PMID: 20376486
A computational genomics pipeline for prokaryotic sequencing projects.
Kislyuk AO, Katz LS, Agrawal S, Hagen MS, Conley AB, Jayaraman P, Nelakuditi V, Humphrey JC, Sammons SA, Govil D, Mair RD, Tatti KM, Tondella ML, Harcourt BH, Mayer LW, Jordan IK., Bioinformatics 26(15), 2010
PMID: 20519285
Evaluation of one- and two-color gene expression arrays for microbial comparative genome hybridization analyses in routine applications.
Schwarz R, Joseph B, Gerlach G, Schramm-Glück A, Engelhard K, Frosch M, Müller T, Schoen C., J Clin Microbiol 48(9), 2010
PMID: 20592156
Genome sequencing reveals widespread virulence gene exchange among human Neisseria species.
Marri PR, Paniscus M, Weyand NJ, Rendón MA, Calton CM, Hernández DR, Higashi DL, Sodergren E, Weinstock GM, Rounsley SD, So M., PLoS One 5(7), 2010
PMID: 20676376
Draft genome sequences of two Neisseria meningitidis serogroup C clinical isolates.
Lavezzo E, Toppo S, Barzon L, Cobelli C, Di Camillo B, Finotello F, Franchin E, Peruzzo D, Toffolo GM, Trevisan M, Palù G., J Bacteriol 192(19), 2010
PMID: 20675487
Comparative genome biology of a serogroup B carriage and disease strain supports a polygenic nature of meningococcal virulence.
Joseph B, Schneiker-Bekel S, Schramm-Glück A, Blom J, Claus H, Linke B, Schwarz RF, Becker A, Goesmann A, Frosch M, Schoen C., J Bacteriol 192(20), 2010
PMID: 20709895
Structural alterations in a component of cytochrome c oxidase and molecular evolution of pathogenic Neisseria in humans.
Aspholm M, Aas FE, Harrison OB, Quinn D, Vik A, Viburiene R, Tønjum T, Moir J, Maiden MC, Koomey M., PLoS Pathog 6(8), 2010
PMID: 20808844
Independent evolution of the core and accessory gene sets in the genus Neisseria: insights gained from the genome of Neisseria lactamica isolate 020-06.
Bennett JS, Bentley SD, Vernikos GS, Quail MA, Cherevach I, White B, Parkhill J, Maiden MC., BMC Genomics 11(), 2010
PMID: 21092259
Expression of the meningococcal adhesin NadA is controlled by a transcriptional regulator of the MarR family.
Schielke S, Huebner C, Spatz C, Nägele V, Ackermann N, Frosch M, Kurzai O, Schubert-Unkmeir A., Mol Microbiol 72(4), 2009
PMID: 19400792
Metagenomic analysis of stressed coral holobionts.
Vega Thurber R, Willner-Hall D, Rodriguez-Mueller B, Desnues C, Edwards RA, Angly F, Dinsdale E, Kelly L, Rohwer F., Environ Microbiol 11(8), 2009
PMID: 19397678
Differential modulation of TNF-alpha-induced apoptosis by Neisseria meningitidis.
Deghmane AE, Veckerlé C, Giorgini D, Hong E, Ruckly C, Taha MK., PLoS Pathog 5(5), 2009
PMID: 19412525
Evidence for capsule switching between carried and disease-causing Neisseria meningitidis strains.
Beddek AJ, Li MS, Kroll JS, Jordan TW, Martin DR., Infect Immun 77(7), 2009
PMID: 19451248
EDGAR: a software framework for the comparative analysis of prokaryotic genomes.
Blom J, Albaum SP, Doppmeier D, Pühler A, Vorhölter FJ, Zakrzewski M, Goesmann A., BMC Bioinformatics 10(), 2009
PMID: 19457249
Meningococcal carriage and disease--population biology and evolution.
Caugant DA, Maiden MC., Vaccine 27 Suppl 2(), 2009
PMID: 19464092
Genome flexibility in Neisseria meningitidis.
Schoen C, Tettelin H, Parkhill J, Frosch M., Vaccine 27 Suppl 2(), 2009
PMID: 19477564
Influenza A virus neuraminidase enhances meningococcal adhesion to epithelial cells through interaction with sialic acid-containing meningococcal capsules.
Rameix-Welti MA, Zarantonelli ML, Giorgini D, Ruckly C, Marasescu M, van der Werf S, Alonso JM, Naffakh N, Taha MK., Infect Immun 77(9), 2009
PMID: 19528219
Role of the type III secretion system in a hypervirulent lineage of Bordetella bronchiseptica.
Buboltz AM, Nicholson TL, Weyrich LS, Harvill ET., Infect Immun 77(9), 2009
PMID: 19596779
Lateral genetic transfer: open issues.
Ragan MA, Beiko RG., Philos Trans R Soc Lond B Biol Sci 364(1527), 2009
PMID: 19571244
NeMeSys: a biological resource for narrowing the gap between sequence and function in the human pathogen Neisseria meningitidis.
Rusniok C, Vallenet D, Floquet S, Ewles H, Mouzé-Soulama C, Brown D, Lajus A, Buchrieser C, Médigue C, Glaser P, Pelicic V., Genome Biol 10(10), 2009
PMID: 19818133
Phylogeographic reconstruction of a bacterial species with high levels of lateral gene transfer.
Pearson T, Giffard P, Beckstrom-Sternberg S, Auerbach R, Hornstra H, Tuanyok A, Price EP, Glass MB, Leadem B, Beckstrom-Sternberg JS, Allan GJ, Foster JT, Wagner DM, Okinaka RT, Sim SH, Pearson O, Wu Z, Chang J, Kaul R, Hoffmaster AR, Brettin TS, Robison RA, Mayo M, Gee JE, Tan P, Currie BJ, Keim P., BMC Biol 7(), 2009
PMID: 19922616
Molecular characterization of erythromycin-resistant Streptococcus agalactiae strains.
Domelier AS, van der Mee-Marquet N, Arnault L, Mereghetti L, Lanotte P, Rosenau A, Lartigue MF, Quentin R., J Antimicrob Chemother 62(6), 2008
PMID: 18786936
Comparative genomics: the bacterial pan-genome.
Tettelin H, Riley D, Cattuto C, Medini D., Curr Opin Microbiol 11(5), 2008
PMID: 19086349
Population genomics: diversity and virulence in the Neisseria.
Maiden MC., Curr Opin Microbiol 11(5), 2008
PMID: 18822386
Association of a bacteriophage with meningococcal disease in young adults.
Bille E, Ure R, Gray SJ, Kaczmarski EB, McCarthy ND, Nassif X, Maiden MC, Tinsley CR., PLoS One 3(12), 2008
PMID: 19065260

49 References

Daten bereitgestellt von Europe PubMed Central.

Meningococcal disease.
Rosenstein NE, Perkins BA, Stephens DS, Popovic T, Hughes JM., N. Engl. J. Med. 344(18), 2001
PMID: 11333996
Multilocus sequence typing: a portable approach to the identification of clones within populations of pathogenic microorganisms.
Maiden MC, Bygraves JA, Feil E, Morelli G, Russell JE, Urwin R, Zhang Q, Zhou J, Zurth K, Caugant DA, Feavers IM, Achtman M, Spratt BG., Proc. Natl. Acad. Sci. U.S.A. 95(6), 1998
PMID: 9501229
Genetic analysis of meningococci carried by children and young adults.
Claus H, Maiden MC, Wilson DJ, McCarthy ND, Jolley KA, Urwin R, Hessler F, Frosch M, Vogel U., J. Infect. Dis. 191(8), 2005
PMID: 15776372
Carried meningococci in the Czech Republic: a diverse recombining population.
Jolley KA, Kalmusova J, Feil EJ, Gupta S, Musilek M, Kriz P, Maiden MC., J. Clin. Microbiol. 38(12), 2000
PMID: 11101585
Distribution of serogroups and genotypes among disease-associated and carried isolates of Neisseria meningitidis from the Czech Republic, Greece, and Norway.
Yazdankhah SP, Kriz P, Tzanakaki G, Kremastinou J, Kalmusova J, Musilek M, Alvestad T, Jolley KA, Wilson DJ, McCarthy ND, Caugant DA, Maiden MC., J. Clin. Microbiol. 42(11), 2004
PMID: 15528708

Bourdoulous S, Nassif X., 2006
Spatiotemporal analysis of invasive meningococcal disease, Germany.
Elias J, Harmsen D, Claus H, Hellenbrand W, Frosch M, Vogel U., Emerging Infect. Dis. 12(11), 2006
PMID: 17283618

Frosch M, Vogel U., 2006

Maiden MC, Caugant DA., 2006
Many carried meningococci lack the genes required for capsule synthesis and transport.
Claus H, Maiden MC, Maag R, Frosch M, Vogel U., Microbiology (Reading, Engl.) 148(Pt 6), 2002
PMID: 12055301
Meningococcal genetic variation mechanisms viewed through comparative analysis of serogroup C strain FAM18.
Bentley SD, Vernikos GS, Snyder LA, Churcher C, Arrowsmith C, Chillingworth T, Cronin A, Davis PH, Holroyd NE, Jagels K, Maddison M, Moule S, Rabbinowitsch E, Sharp S, Unwin L, Whitehead S, Quail MA, Achtman M, Barrell B, Saunders NJ, Parkhill J., PLoS Genet. 3(2), 2006
PMID: 17305430
Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491.
Parkhill J, Achtman M, James KD, Bentley SD, Churcher C, Klee SR, Morelli G, Basham D, Brown D, Chillingworth T, Davies RM, Davis P, Devlin K, Feltwell T, Hamlin N, Holroyd S, Jagels K, Leather S, Moule S, Mungall K, Quail MA, Rajandream MA, Rutherford KM, Simmonds M, Skelton J, Whitehead S, Spratt BG, Barrell BG., Nature 404(6777), 2000
PMID: 10761919
Complete genome sequence of Neisseria meningitidis serogroup B strain MC58.
Tettelin H, Saunders NJ, Heidelberg J, Jeffries AC, Nelson KE, Eisen JA, Ketchum KA, Hood DW, Peden JF, Dodson RJ, Nelson WC, Gwinn ML, DeBoy R, Peterson JD, Hickey EK, Haft DH, Salzberg SL, White O, Fleischmann RD, Dougherty BA, Mason T, Ciecko A, Parksey DS, Blair E, Cittone H, Clark EB, Cotton MD, Utterback TR, Khouri H, Qin H, Vamathevan J, Gill J, Scarlato V, Masignani V, Pizza M, Grandi G, Sun L, Smith HO, Fraser CM, Moxon ER, Rappuoli R, Venter JC., Science 287(5459), 2000
PMID: 10710307
A chromosomally integrated bacteriophage in invasive meningococci.
Bille E, Zahar JR, Perrin A, Morelle S, Kriz P, Jolley KA, Maiden MC, Dervin C, Nassif X, Tinsley CR., J. Exp. Med. 201(12), 2005
PMID: 15967821
Comparative genomics of Neisseria meningitidis: core genome, islands of horizontal transfer and pathogen-specific genes.
Dunning Hotopp JC, Grifantini R, Kumar N, Tzeng YL, Fouts D, Frigimelica E, Draghi M, Giuliani MM, Rappuoli R, Stephens DS, Grandi G, Tettelin H., Microbiology (Reading, Engl.) 152(Pt 12), 2006
PMID: 17159225
Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: implications for the microbial "pan-genome".
Tettelin H, Masignani V, Cieslewicz MJ, Donati C, Medini D, Ward NL, Angiuoli SV, Crabtree J, Jones AL, Durkin AS, Deboy RT, Davidsen TM, Mora M, Scarselli M, Margarit y Ros I, Peterson JD, Hauser CR, Sundaram JP, Nelson WC, Madupu R, Brinkac LM, Dodson RJ, Rosovitz MJ, Sullivan SA, Daugherty SC, Haft DH, Selengut J, Gwinn ML, Zhou L, Zafar N, Khouri H, Radune D, Dimitrov G, Watkins K, O'Connor KJ, Smith S, Utterback TR, White O, Rubens CE, Grandi G, Madoff LC, Kasper DL, Telford JL, Wessels MR, Rappuoli R, Fraser CM., Proc. Natl. Acad. Sci. U.S.A. 102(39), 2005
PMID: 16172379
Identification of pathogen-specific genes through microarray analysis of pathogenic and commensal Neisseria species.
Stabler RA, Marsden GL, Witney AA, Li Y, Bentley SD, Tang CM, Hinds J., Microbiology (Reading, Engl.) 151(Pt 9), 2005
PMID: 16151203

Schoen C, Claus H, Vogel U, Frosch M., 2006
A functional two-partner secretion system contributes to adhesion of Neisseria meningitidis to epithelial cells.
Schmitt C, Turner D, Boesl M, Abele M, Frosch M, Kurzai O., J. Bacteriol. 189(22), 2007
PMID: 17873034
Previously unrecognized vaccine candidates against group B meningococcus identified by DNA microarrays.
Grifantini R, Bartolini E, Muzzi A, Draghi M, Frigimelica E, Berger J, Ratti G, Petracca R, Galli G, Agnusdei M, Giuliani MM, Santini L, Brunelli B, Tettelin H, Rappuoli R, Randazzo F, Grandi G., Nat. Biotechnol. 20(9), 2002
PMID: 12172557
Allelic polymorphism and site-specific recombination in the opc locus of Neisseria meningitidis.
Seiler A, Reinhardt R, Sarkari J, Caugant DA, Achtman M., Mol. Microbiol. 19(4), 1996
PMID: 8820653
Analysis of the Piv recombinase-related gene family of Neisseria gonorrhoeae.
Skaar EP, Lecuyer B, Lenich AG, Lazio MP, Perkins-Balding D, Seifert HS, Karls AC., J. Bacteriol. 187(4), 2005
PMID: 15687191
Networks and groups within the genus Neisseria: analysis of argF, recA, rho, and 16S rRNA sequences from human Neisseria species.
Smith NH, Holmes EC, Donovan GM, Carpenter GA, Spratt BG., Mol. Biol. Evol. 16(6), 1999
PMID: 10368955
Mauve: multiple alignment of conserved genomic sequence with rearrangements.
Darling AC, Mau B, Blattner FR, Perna NT., Genome Res. 14(7), 2004
PMID: 15231754
Origin and fate of repeats in bacteria.
Achaz G, Rocha EP, Netter P, Coissac E., Nucleic Acids Res. 30(13), 2002
PMID: 12087185
Natural genetic exchange between Haemophilus and Neisseria: intergeneric transfer of chromosomal genes between major human pathogens.
Kroll JS, Wilks KE, Farrant JL, Langford PR., Proc. Natl. Acad. Sci. U.S.A. 95(21), 1998
PMID: 9770495
The evolution of human pathogens: examples and clinical implications.
Vogel U, Claus H., Int. J. Med. Microbiol. 290(6), 2000
PMID: 11100825

Cartwright K., 2006
Accurate multiplex polony sequencing of an evolved bacterial genome.
Shendure J, Porreca GJ, Reppas NB, Lin X, McCutcheon JP, Rosenbaum AM, Wang MD, Zhang K, Mitra RD, Church GM., Science 309(5741), 2005
PMID: 16081699
GenDB--an open source genome annotation system for prokaryote genomes.
Meyer F, Goesmann A, McHardy AC, Bartels D, Bekel T, Clausen J, Kalinowski J, Linke B, Rupp O, Giegerich R, Puhler A., Nucleic Acids Res. 31(8), 2003
PMID: 12682369
Basic local alignment search tool.
Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ., J. Mol. Biol. 215(3), 1990
PMID: 2231712
ISfinder: the reference centre for bacterial insertion sequences.
Siguier P, Perochon J, Lestrade L, Mahillon J, Chandler M., Nucleic Acids Res. 34(Database issue), 2006
PMID: 16381877
Cluster analysis and display of genome-wide expression patterns.
Eisen MB, Spellman PT, Brown PO, Botstein D., Proc. Natl. Acad. Sci. U.S.A. 95(25), 1998
PMID: 9843981
ACT: the Artemis Comparison Tool.
Carver TJ, Rutherford KM, Berriman M, Rajandream MA, Barrell BG, Parkhill J., Bioinformatics 21(16), 2005
PMID: 15976072
Site-specific insertion of IS1301 and distribution in Neisseria meningitidis strains.
Hilse R, Hammerschmidt S, Bautsch W, Frosch M., J. Bacteriol. 178(9), 1996
PMID: 8626318
SPRING: a tool for the analysis of genome rearrangement using reversals and block-interchanges.
Lin YC, Lu CL, Liu YC, Tang CY., Nucleic Acids Res. 34(Web Server issue), 2006
PMID: 16845100
SplitsTree: analyzing and visualizing evolutionary data.
Huson DH., Bioinformatics 14(1), 1998
PMID: 9520503
Phylogenetic trees based on gene content.
Huson DH, Steel M., Bioinformatics 20(13), 2004
PMID: 15044248

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